Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor

La osteoartritis (OA), una enfermedad articular degenerativa es una de las patologías con mayor incidencia clínica en animales de compañía que no está asociada con la raza, sexo o edad. Se trata de un proceso multifactorial caracterizado por ser progresivo y debilitante a la vez que disminuye la cal...

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Autores:
Pérez Pinzón, Karoll Juliana
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
spa
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/56108
Acceso en línea:
https://hdl.handle.net/20.500.12494/56108
Palabra clave:
enfermedades articulares
Acción analgésica
Tratamiento alternativo
Joint diseases
Analgesic action
Alternative treatment
Rights
embargoedAccess
License
http://creativecommons.org/licenses/by-nc-nd/4.0/
id COOPER2_bf3df58ff7ae450443302dbe6112ac63
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/56108
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
title Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
spellingShingle Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
enfermedades articulares
Acción analgésica
Tratamiento alternativo
Joint diseases
Analgesic action
Alternative treatment
title_short Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
title_full Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
title_fullStr Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
title_full_unstemmed Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
title_sort Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor
dc.creator.fl_str_mv Pérez Pinzón, Karoll Juliana
dc.contributor.advisor.none.fl_str_mv Serrano Mujica, Lady Katerine
dc.contributor.author.none.fl_str_mv Pérez Pinzón, Karoll Juliana
dc.subject.proposal.spa.fl_str_mv enfermedades articulares
Acción analgésica
Tratamiento alternativo
topic enfermedades articulares
Acción analgésica
Tratamiento alternativo
Joint diseases
Analgesic action
Alternative treatment
dc.subject.proposal.eng.fl_str_mv Joint diseases
Analgesic action
Alternative treatment
description La osteoartritis (OA), una enfermedad articular degenerativa es una de las patologías con mayor incidencia clínica en animales de compañía que no está asociada con la raza, sexo o edad. Se trata de un proceso multifactorial caracterizado por ser progresivo y debilitante a la vez que disminuye la calidad de vida de los pacientes y por no tener cura lo que se busca al tratarla es disminuir el dolor que genera. En esta enfermedad se produce degeneración del cartílago articular que es lo que produce el dolor crónico que es la parte tratable de la enfermedad, para esto se han implementado tratamientos paliativos con medicamentos de acción analgésica como lo son el meloxicam, ketoprofeno o carprofeno, pero su uso durante un tiempo prolongado termina desencadenado efectos adversos y comprometiendo la salud del paciente aún más; en búsqueda de tratamientos alternativos para el manejo de la OA es que se desarrolla la presente revisión de literatura, para obtener más bases teóricas sobre la implementación terapéutica de la toxina botulínica A (BoNT/A) para el manejo dolor crónico en enfermedades articulares, como la OA, información recopilada de diferente bases de datos, en donde se puedan evidenciar los efectos favorables de la utilización de BoNT/A en la disminución del dolor crónico.
publishDate 2023
dc.date.issued.none.fl_str_mv 2023-12-06
dc.date.accessioned.none.fl_str_mv 2024-06-26T13:49:54Z
dc.date.available.none.fl_str_mv 2024-12-30
2024-06-26T13:49:54Z
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.content.none.fl_str_mv Text
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/TP
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
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dc.identifier.citation.spa.fl_str_mv Pérez Pinzón, K. J. (2024). Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia. https://hdl.handle.net/20.500.12494/56108
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/56108
identifier_str_mv Pérez Pinzón, K. J. (2024). Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia. https://hdl.handle.net/20.500.12494/56108
url https://hdl.handle.net/20.500.12494/56108
dc.language.iso.none.fl_str_mv spa
language spa
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spelling Serrano Mujica, Lady KaterinePérez Pinzón, Karoll Juliana2024-06-26T13:49:54Z2024-12-302024-06-26T13:49:54Z2023-12-06Pérez Pinzón, K. J. (2024). Revisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolor. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia. https://hdl.handle.net/20.500.12494/56108https://hdl.handle.net/20.500.12494/56108La osteoartritis (OA), una enfermedad articular degenerativa es una de las patologías con mayor incidencia clínica en animales de compañía que no está asociada con la raza, sexo o edad. Se trata de un proceso multifactorial caracterizado por ser progresivo y debilitante a la vez que disminuye la calidad de vida de los pacientes y por no tener cura lo que se busca al tratarla es disminuir el dolor que genera. En esta enfermedad se produce degeneración del cartílago articular que es lo que produce el dolor crónico que es la parte tratable de la enfermedad, para esto se han implementado tratamientos paliativos con medicamentos de acción analgésica como lo son el meloxicam, ketoprofeno o carprofeno, pero su uso durante un tiempo prolongado termina desencadenado efectos adversos y comprometiendo la salud del paciente aún más; en búsqueda de tratamientos alternativos para el manejo de la OA es que se desarrolla la presente revisión de literatura, para obtener más bases teóricas sobre la implementación terapéutica de la toxina botulínica A (BoNT/A) para el manejo dolor crónico en enfermedades articulares, como la OA, información recopilada de diferente bases de datos, en donde se puedan evidenciar los efectos favorables de la utilización de BoNT/A en la disminución del dolor crónico.Osteoarthritis (OA), a degenerative joint disease, is one of the pathologies with the highest clinical incidence in companion animals that is not associated with breed, sex or age. It is a multifactorial process characterized by being progressive and debilitating while decreasing the quality of life of patients and, since it has no cure, the only goal in treating it is to reduce the pain it causes. In this disease, is the degeneration of the articular cartilage what produces chronic pain which is the treatable part of the disease, is for that part that palliative treatments have been implemented with analgesic drugs such as meloxicam, ketoprofen or carprofen, but its use for a long time ends up causing adverse effects and compromising the health of the patient even more; for that reason the present literature review is being made, to search for alternative treatments for the management of OA and obtain more theorical bases on the therapeutic implementation of botulinum toxin A (BoNT/A) for the management of chronic pain in joint diseases, such as OA, thanks to information collected from different databases, where the favorable effects of the use of BoNT/A in the reduction of chronic pain can be evidenced.Resumen. -- Siglas. -- Introducción. -- Planteamiento del problema. -- Justificación. -- Objetivos. -- Objetivo general. -- Objetivos específicos. -- Marco conceptual. -- Osteoartritis. -- Caracterización de la enfermedad. -- Epidemiología. -- Fenómeno del dolor. -- Manejo del dolor en la OA. -- Cannabis. -- Manejo alimenticio y suplementación. -- Coloide. -- AINE / AIEs. -- Ácido hialurónico o hialuronato de sodio. -- Tratamiento y manejo quirúrgico. -- Toxina botulínica A. -- Toxina botulínica A en la inflamación y el dolor. -- Antecedentes. -- Bases teóricas. -- Consideraciones bioéticas. -- Discusión. -- Conclusiones. -- Recomendaciones. -- Bibliografía.PregradoMedico Veterinario105 p.application/pdfspaUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, BucaramangaMedicina veterinaria y zootecniaCiencias de la SaludBucaramangaBucaramangahttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://purl.org/coar/access_right/c_f1cfRevisión sistemática de literatura sobre el tratamiento con toxina botulínica a (bont/a) en la osteoartritis en caninos para el control del dolorTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fTextinfo:eu-repo/semantics/bachelorThesishttp://purl.org/redcol/resource_type/TPinfo:eu-repo/semantics/acceptedVersionGarcía-Partida J, Berrocoso E, Micó J. Experimental models for pain evaluation in osteoarthritis. Revista de la Sociedad Española del DOLOR. 2021;: p. 18-30Burns K. JAVMA news. [Online].; 2020 [cited 2021 febrero 22. Available from: https://www.avma.org/javma-news/2021-01-01/getting-ahead-osteoarthritis- pets#:~:text=is%20severe%20osteoarthritis.- ,Dr.,for%20an%20increase%20in%20exerciseNganvongpanit K, Boonsri B, Sripratak T, Markmee P. Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs. he Journal of Veterinary Science. 2013;: p. 1-13.Mabry K, Hill T, Tolbert K. Prevalence of gastrointestinal lesions in dogs chronically treated with non steroidalanti‐inflammatory drugs. Journal of Veterinary Internal Medicine. 2021;: p. 1-15.Masters A, Berger D, Ware W, Langenfeld N, Coetzee J, Mochel J, et al. Effects of short-termanti-inflammatory glucocorticoid treatment on clinicopathologic, echocardiographic, and hemodynamic variables in systemically healthy dogs. 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Safety and Synovial Inflammatory Response After Intra-articular Injection of Botulinum Toxin Type A in Healthy Horses. Journal of Equine Veterinary Science. 2022.Durán S, Soto J, Allen J, Durán N, García P. Osteoarthritis of the hip conservative treatment with type A botulinum toxin. Gaceta Medica de Mexico. 2019;: p. 44-48.Trepanier L. 2013 WSAVA Congress Proceedings Online (WSAVA 2013). [Online].; 2013 [cited 2023 febrero 26. Available from: https://www.vin.com/apputil/content/defaultadv1.aspx?pId=11372&meta=generic& catId=35316&id=5709854&ind=259&objTypeID=17.Mejia S, Duerr F, Griffenhagen G, McGrath S. Evaluation of the Effect of Cannabidiol on Naturally Occurring Osteoarthritis-Associated Pain: A Pilot Study in Dogs. Journal of the American Animal Hospital Association. 2021;: p. 81-90.Belshaw Z, Asher L, Dean R. 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Topics in Companion Animal Medicine. 2010;: p. 20-25.Budsberg S. Doenças musculoesqueléticas. Terapêutica clínica em pequenosanimais. 1996;: p. 256-278.Lees P. Pharmacology of drugs used to treat osteoarthritis in veterinary practice. Inflammopharmacology. 2003;: p. 385-399.Gilbert S, Langenbach A, Little D, Pease A, Ru H. Stifle joint osteoarthritis at the time of diagnosis of cranial cruciate ligament injury is higher in Boxers and in dogs weighing more than 35 kilograms. Veterinary Radiology and Ultrasound. 2017;: p. 280-288.Gencoglu H, Orhan C, Sahin E, Sahin K. Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. animals. 2020;: p. 1-33.Tellegen A, Dessing A, Houben K, Riemers F, Creemers L, Mastbergen S, et al. Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter. Journal of Orthopaedic Research. 2019;: p. 1-21.Anderson K, O'Neill D, Brodbelt D, Church D, Meeson R, Sargan D, et al. Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care. SCIENTIFIC REPORTS. 2018;: p. 1-26.Wright A, Amodie D, Cernicchiaro N, Lascelles B, Pavlock A, Roberts C, et al. Identification of canine osteoarthritis using an owner-reported questionnaire and treatment monitoring using functional mobility tests. The Journal of Small Animal Practice. 2022;: p. 1-20.Bell A. The neurobiology of acute pain. The Veterinary Journal. 2018;: p. 55-62.Roversi K, Silva N, Roversi K, Griffith M, Boutopoulos C, Prediger R, et al. Neuro- Immunity and Gut Dysbiosis Drive Parkinson’s Disease-Induced Pain. Frontiers in Immunology. 2021;: p. 1-34.Babos M, Grady B, Wisnoff W, MacGhee C. Pathophysiology of pain. Disease-a- Month. 2013;: p. 330-358.Anwar K. Pathophysiology of pain. Disease-a-Month. 2019;: p. 324-329.Pye C, Bruniges N, Peffers M, Comerford E. Advances in the pharmaceutical treatment options for canine osteoarthritis. The Journal of Small Animal Practice. 2022;: p. 1-38.Gamble L, Boesch J, Frye C, Schwark W, Maan S, Wolfe L, et al. Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. Frontiers in Veterinary Science. 2018;: p. 1-20.Yu C, Rupasinghe H. Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation. Research in Veterinary Science. 2021;: p. 38-46.Cortés A, Rojas D, Outeda N, Alvarado A, Burnes J, Hernández A, et al. The role of cannabinoids in pain modulation in companion animals. Frontiers in Veterinary Science. 2022;: p. 1-32.Johnston S, McLaughlin R, Budsberg S. Nonsurgical management of osteoarthritis in dogs. Veterinary Clinics of North America: Small Animal Practice. 2008;: p. 1449-1470.Forrest S. Multimodal management of canine arthritis. Proceedings of the North American Veterinary Conference. 2009.Comblain F, Serisier S, Barthelemy N, Balligand M, Henrotin Y. Review of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014. Journal of Veterinary Pharmacology and Therapeutics. 2016;: p. 1-15.Martello E, Bigliati M, Adami R, Biasibetti E, Bisanzio D, Meineri G, et al. Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized placebo- controlled, double-blind clinical trial. PLoS One. 2022;: p. 1-14.Comblain F, Barthélémy N, Lefèbvre M, Schwartz C, Lesponne I, Serisier S, et al. A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis. BMC Veterinary Research. 2017;: p. 1-21.Donecker J, Fabiani M, Gaschen L, Aulakh K. Treatment response in dogs with naturally occurring grade 3 elbow osteoarthritis following intra-articular injection of 117mSn (tin) colloid. PLoS One. 2021;: p. 1-29.Cendrós J, Salichs M, Encina G, Vela J, Homedes J. Pharmacology of enflicoxib, a new coxib drug: Efficacy and dose determination by clinical and pharmacokinetic- guided approach for the treatment of osteoarthritis in dogs based on an acute arthritis induction model. Veterinary Medicine and Science. 2022;: p. 1-25.Stefani R, Lee A, Tan A, Halder S, Hu Y, Guo X, et al. Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair. Acta biomaterialia. 2020;: p. 1-29.Carapeba G, Cavaleti P, Nicácio G, Brinholi R, Giuffrida R, Cassu R. Intra- Articular Hyaluronic Acid Compared to Traditional Conservative Treatment in Dogs with Osteoarthritis Associated with Hip Dysplasia. Hindawi. 2016;: p. 1-19.Sconza C, Leonardi G, Carfi C, Kon E,RS, Scaturro D, Mauro G, et al. Intra- Articular Injection of Botulinum Toxin for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials. International Journal of Molecular Sciences. 2023;: p. 1-21.Whitcup S. The History of Botulinum Toxins in Medicine: A Thousand Year Journey. Handbook of Experimental Pharmacology. 2019;: p. 3-10.Becker W. Botulinum Toxin in the Treatment of Headache. Toxins. 2020;: p. 1-21.Ismiarto Y, Prasetiyo G. Efficacy and Safety of Intra-Articular Botulinum Toxin A Injection for Knee Osteoarthritis: A Systematic Review, Meta-Analysis, and Meta- Regression of Clinical Trials. JB & JS OPEN ACCESS. 2023;: p. 1-15.Kesary Y, Singh V, Frenkel T, Greenberg A, Dekel S, Schwarzkopf R, et al. Botulinum toxin injections as salvage therapy is beneficial for management of patellofemoral pain syndrome. Knee Surgery & Related Research. 2021;: p. 33-39.Chen J, TA, Lin S, Tang S. Anterior knee pain caused by patellofemoral pain syndrome can be relieved by Botulinum toxin type A injection. Clinical Neurology and Neurosurgery. 2015;: p. 27-29.Rezasoltani Z, Azizi S, Najafi S, Sanati E, Dadarkhah A, Abdorrazaghi F. 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