Inmunopatología de Peritonitis Infecciosa Felina (PIF)

El desarrollo de la Peritonitis Infecciosa Felina (PIF), dependerá de dos factores, la respuesta inmunológica y la mutación genómica del virus. Teniendo en cuenta, la respuesta inmune del animal, se ha comprobado que la protección frente a PIF está dada por la inmunidad celular, por el contrario, la...

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Autores:
Vargas Ortiz, Lizeth Camila
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/53888
Acceso en línea:
https://hdl.handle.net/20.500.12494/53888
Palabra clave:
Inmunopatología, FCoV, PIF, felino, anticuerpos
TG 2023 MVZ
Immunopathology
FCoV
FIP
Feline
Antibodies
Rights
openAccess
License
Atribución – Sin Derivar
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network_name_str Repositorio UCC
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dc.title.none.fl_str_mv Inmunopatología de Peritonitis Infecciosa Felina (PIF)
title Inmunopatología de Peritonitis Infecciosa Felina (PIF)
spellingShingle Inmunopatología de Peritonitis Infecciosa Felina (PIF)
Inmunopatología, FCoV, PIF, felino, anticuerpos
TG 2023 MVZ
Immunopathology
FCoV
FIP
Feline
Antibodies
title_short Inmunopatología de Peritonitis Infecciosa Felina (PIF)
title_full Inmunopatología de Peritonitis Infecciosa Felina (PIF)
title_fullStr Inmunopatología de Peritonitis Infecciosa Felina (PIF)
title_full_unstemmed Inmunopatología de Peritonitis Infecciosa Felina (PIF)
title_sort Inmunopatología de Peritonitis Infecciosa Felina (PIF)
dc.creator.fl_str_mv Vargas Ortiz, Lizeth Camila
dc.contributor.advisor.none.fl_str_mv Plazas Hernández, Fernely Augusto
Padilla Barreto, Mónica Yamile
dc.contributor.author.none.fl_str_mv Vargas Ortiz, Lizeth Camila
dc.subject.none.fl_str_mv Inmunopatología, FCoV, PIF, felino, anticuerpos
topic Inmunopatología, FCoV, PIF, felino, anticuerpos
TG 2023 MVZ
Immunopathology
FCoV
FIP
Feline
Antibodies
dc.subject.classification.none.fl_str_mv TG 2023 MVZ
dc.subject.other.none.fl_str_mv Immunopathology
FCoV
FIP
Feline
Antibodies
description El desarrollo de la Peritonitis Infecciosa Felina (PIF), dependerá de dos factores, la respuesta inmunológica y la mutación genómica del virus. Teniendo en cuenta, la respuesta inmune del animal, se ha comprobado que la protección frente a PIF está dada por la inmunidad celular, por el contrario, la inmunidad humoral no genera un efecto protector contra la infección, es por ello que, al generarse el contagio, el cuerpo tiene tres maneras de enfrentar la enfermedad, la primera es aquella en la que el gato puede generar una respuesta inmune celular fuerte, aquí, los niveles de anticuerpos estarán bajos, en esta reacción se acrecientan las posibilidades de superar la enfermedad, presentándose una rehabilitación completa o el desarrollo de un proceso subclínico, la segunda hace referencia a una respuesta de tipo humoral fuerte, con presencia de una inmunidad celular parcial, aquí el paciente desarrollará la forma no efusiva de FIP y en tercer lugar encontramos que se presenta una respuesta humoral fuerte, pero aquí la inmunidad celular será casi nula o totalmente ausente, por lo tanto, habrá un desarrollo de la forma efusiva de FIP.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-12-19T15:10:03Z
dc.date.available.none.fl_str_mv 2023-12-19T15:10:03Z
2023
dc.date.issued.none.fl_str_mv 2023-12-19
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/53888
dc.identifier.bibliographicCitation.none.fl_str_mv Vargas Ortiz, L. C. (2023). Inmunopatología de Peritonitis Infecciosa Felina (PIF). [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC.
url https://hdl.handle.net/20.500.12494/53888
identifier_str_mv Vargas Ortiz, L. C. (2023). Inmunopatología de Peritonitis Infecciosa Felina (PIF). [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC.
dc.relation.references.none.fl_str_mv Barker EN, Tasker S. Advances in Molecular Diagnostics and Treatment of Feline Infectious Peritonitis. Advances In Small Animal Care [Internet]. 2020 Nov 9 [cited 2022 Nov 2];1. Available from: https://researchinformation.bris.ac.uk/ws/portalfiles/p ortal/265740660/ASAC_FIP_Accepte d.pdf
González Pérez MP. Peritonitis Infecciosa Felina [Internet]. [Montevideo]: Universidad de la Republica; 2010 [cited 2022 Oct 24]. Available from: https://www.colibri.udelar.edu.uy/jspu i/bitstream/20.500.12008/19885/1/FV28749.pdf
Pedersen NC. An Update on Feline Infectious Peritonitis: Virology and
Immunopathogenesis. The Veterinary Journal [Internet]. 2014 Aug 1 [cited 2022 Oct 24];201(2):123–32. Available from: https://www.sciencedirect.com/scienc e/article/pii/S1090023314001786
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Decaro N, Mari V, Lanave G, Lorusso E, Lucente MS, Desario C, et al. Mutation Analysis of the Spike Protein in Italian Feline Infectious Peritonitis Virus and Feline Enteric Coronavirus Sequences. Res Vet Sci [Internet]. 2021 Mar 1 [cited 2022 Dec 10];135:15–9. Available from: https://pubmed.ncbi.nlm.nih.gov/3341 8186/
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Herrewegh AAPM, Smeenk I, Horzinek MC, Rottier PJM, de Groot RJ. Feline Coronavirus Type II Strains 79-1683 and 79-1146 Originate from a Double Recombination between Feline Coronavirus Type I and Canine Coronavirus. J Virol [Internet]. 1998 May [cited 2023 Apr 11];72(5):4508– 14. Available from: https://journals.asm.org/doi/10.1128/J VI.72.5.4508-4514.1998
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Kumari S, Mg S, Mayor S. Endocytosis Unplugged: Multiple Waysto Enter the Cell. Cell Research 2010 20:3 [Internet]. 2010 Feb 2 [cited 2022 Nov 13];20(3):256–75. Available from: https://www.nature.com/articles/cr201 019
Tusell SM, Schittone SA, Holmes K v. Mutational Analysis of Aminopeptidase N, a Receptor for Several Group 1 Coronaviruses, Identifies Key Determinants of Viral Host Range. J Virol [Internet]. 2007 Feb [cited 2022 Oct 29];81(3):1261. Available from: /pmc/articles/PMC1797531/
Kipar A, Meli ML, Baptiste KE, Bowker LJ, Lutz H. Sites of feline coronavirus persistence in healthy cats. Kipar, A; Meli, M L; Baptiste, K E; Bowker, L J; Lutz, H (2010) Sites of feline coronavirus persistence in healthy cats Journal of General Virology, 91(7):1698-1707 [Internet]. 2010 Jul [cited 2022 Nov 1];91(7):1698–707. Available from: https://www.zora.uzh.ch/id/eprint/360 31/
Malbon AJ, Fonfara S, Meli ML, Hahn S, Egberink H, Kipar A. Feline Infectious Peritonitis as a Systemic Inflammatory Disease: Contribution of Liver and Heart to the Pathogenesis. Viruses [Internet]. 2019 Dec 10 [cited 2022 Nov 1];11(12). Available from: /pmc/articles/PMC6949997/
Palmero colado ML, Carballés Pérez V. Andador del Palacio de Larrinaga, 2-50013 Zaragoza-España n. SERVET [Internet]. 2010 [cited 2022 Nov 1];2– 5. Available from: https://gattos.net/images/Publicacione s/Marisa/Libros/enfermedadesfelinas_ pvp.pdf
Malbon AJ, Michalopoulou E, Meli ML, Barker EN, Tasker S, Baptiste K, et al. Colony Stimulating Factors in Early Feline Infectious Peritonitis Virus Infection of Monocytes and in End Stage Feline Infectious Peritonitis; A Combined In Vivo and In Vitro Approach. Pathogens [Internet]. 2020 Nov 1 [cited 2022 Nov 11];9(11):1–22. Available from: /pmc/articles/PMC7692899/
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Prieto Acuña M. Actualizacion de la Peritonitis Infecciosa Felina. Academia [Internet]. 2012 [cited 2022 Nov 3]; Available from: https://www.academia.edu/download/ 59154128/ACTUALIZACION_DE_P ERITONITIS_INFECCIOSA_FELIN A_75-8220190507-48053-1tfz82k.pdf
Takano T, Hohdatsu T, Toda A, Tanabe M, Koyama H. TNF-alpha, Produced by Feline Infectious Peritonitis Virus (FIPV) Infected Macrophages, Upregulates Expression of Type II FIPV Receptor Feline Aminopeptidase N in Feline Macrophages. Virology [Internet]. 2007 Jul 7 [cited 2022 Nov 3];364(1):64. Available from: /pmc/articles/PMC7103289/
Takano T, Azuma N, Satoh M, Toda A, Hashida Y, Satoh R, et al. Neutrophil Survival Factors (TNF-alpha, GMCSF, and G-CSF) Produced by Macrophages in Cats Infected with Feline Infectious Peritonitis Virus Contribute to the Pathogenesis of Granulomatous Lesions. Arch Virol [Internet]. 2009 May [cited 2022 Nov 11];154(5):775. Available from: /pmc/articles/PMC7086964/
Takano T, Hohdatsu T, Hashida Y, Kaneko Y, Tanabe M, Koyama H. A “Possible” Involvement of TNF-alpha in Apoptosis Induction in Peripheral Blood Lymphocytes of Cats with Feline Infectious Peritonitis. Vet Microbiol [Internet]. 2007 Jan 1 [cited 2022 Nov 11];119(2):121. Available from: /pmc/articles/PMC7117258/
Takano T, Katoh Y, Doki T, Hohdatsu T. Effect of Chloroquine on Feline Infectious Peritonitis Virus Infection in Vitro and in Vivo. Antiviral Res [Internet]. 2013 Aug [cited 2022 Nov 11];99(2):100. Available from: /pmc/articles/PMC7114111/
Doki T, Toda M, Hasegawa N, Hohdatsu T, Takano T. Therapeutic Effect of an Anti-human-TNF-alpha Antibody and Itraconazole onFeline Infectious Peritonitis. Arch Virol [Internet]. 2020 May 1 [cited 2022 Nov 11];165(5):1197–206. Available from: https://link.springer.com/article/10.10 07/s00705-020-04605-7
Vermeulen BL, Devriendt B, Olyslaegers DA, Dedeurwaerder A, Desmarets LM, Favoreel HW, et al. Suppression of NK Cells and Regulatory T Lymphocytes in Cats Naturally Infected with Feline Infectious Peritonitis Virus. Vet Microbiol [Internet]. 2013 May 5 [cited 2022 Nov 3];164(1):46. Available from: /pmc/articles/PMC7117246/
Gunn-Moore DA, Caney SMA, Gruffydd-Jones TJ, Helps CR, Harbour DA. Antibody and Cytokine Responses in Kittens During the Development of Feline Infectious Peritonitis (FIP). Vet Immunol Immunopathol [Internet]. 1998 Oct 10 [cited 2022 Nov 3];65(2):221. Available from: /pmc/articles/PMC7120021/
Dean GA, Olivry T, Stanton C, Pedersen NC. In Vivo Cytokine Response to Experimental Feline Infectious Peritonitis Virus Infection. Vet Microbiol [Internet]. 2003 Dec 12 [cited 2022 Nov 3];97(1):1. Available from: /pmc/articles/PMC7117329/
Kiss I, Poland AM, Pedersen NC. Disease Outcome and Cytokine Responses in Cats Immunized with an Avirulent Feline Infectious Peritonitis Virus (FIPV)-UCD1 and Challenge Exposed with Virulent FIPV-UCD8. J Feline Med Surg [Internet]. 2004 [cited 2022 Nov 3];6(2):89. Available from: /pmc/articles/PMC7128844/
Berg AL, Ekman K, Belák S, Berg M. Cellular Composition and Interferon-γ Expression of the Local Inflammatory Response in Feline Infectious Peritonitis (FIP). Vet Microbiol [Internet]. 2005 Nov 11 [cited 2022 Nov 3];111(1):15. Available from: /pmc/articles/PMC7117157/
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Addie DD, Paltrinieri S, Pedersen NC. Recommendations from Workshops of the Second International Feline Coronavirus Feline Infectious Peritonitis Symposium. J Feline Med Surg [Internet]. 2004 [cited 2022 Dec 10];6(2):125. Available from: /pmc/articles/PMC7129416/
Shuid AN, Safi N, Haghani A, Mehrbod P, Haron MSR, Tan SW, et al. Apoptosis Transcriptional Mechanism of Feline Infectious Peritonitis Virus Infected Cells. Nature Public Healt Emergncy Collection [Internet]. 2015 Nov 30 [cited 2022 Nov 13];20(11):1457. Available from: /pmc/articles/PMC7088095/
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Malbon AJ, Meli ML, Barker EN, Davidson AD, Tasker S, Kipar A. Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis? J Comp Pathol [Internet]. 2019 Jan 1 [cited 2022 Nov 13];166:69. Available from: /pmc/articles/PMC7094650/
Chen S, Tian J, Li Z, Kang H, Zhang J, Huang J, et al. Feline Infectious Peritonitis Virus Nsp5 Inhibits Type I Interferon Production by Cleaving NEMO at Multiple Sites. Virues [Internet]. 2020 Jan 12 [cited 2022 Nov 13]; Available from: www.mdpi.com/journal/viruses
Mesquita LP, Hora AS, de Siqueira A, Salvagni FA, Brandão PE, Maiorka PC. Glial Response in the Central Nervous System of Cats with Feline Infectious Peritonitis. J Feline Med Surg [Internet]. 2016 Dec 1 [cited 2022 Nov 13];18(12):1023–30. Available from: https://pubmed.ncbi.nlm.nih.gov/2658 1471/
Cornelissen E, Dewerchin HL, van Hamme E, Nauwynck HJ. Absence of Antibody Dependent, Complement Mediated Lysis of Feline Infectious Peritonitis Virus Infected Cells. Virus Res [Internet]. 2009 Sep [cited 2022 Nov 13];144(1):285. Available from: /pmc/articles/PMC7114424/
Dewerchin HL, Desmarets LM, Noppe Y, Nauwynck HJ. Myosins 1 and 6, Myosin Light Chain Kinase, Actin and Microtubules Cooperate During Antibody Mediated Internalisation and Trafficking of Membrane Expressed Viral Antigens in Feline Infectious Peritonitis Virus Infected Monocytes. Vet Res [Internet]. 2014 Feb 12 [cited 2022 Nov 13];45(1):17. Available from: /pmc/articles/PMC3937040/
Castellanos Moreno YC, Hernandez Ramirez SG. Revisión de literatura de la peritonitis infecciosa felina - Universidad Cooperativa de Colombia. Repositorio ucc [Internet]. 2021 Jun 21 [cited 2022 Nov 13];1–14. Available from: http://repository.ucc.edu.co/bitstream/ 20.500.12494/34721/4/2021- CastellanosyHernandez_FCoV_FECo V_VPIF.pdf
August JR. Feline Infectious Peritonitis. An Immune Mediated Coronaviral Vasculitis. Veterinary Clinics of North America - Small Animal Practice. 1984;14(5):971–84
Tizard IR, Schubot RM. Introducción a la Inmunología Veterinaria [Internet]. Octava. Diorki Servicios Integrales de Edición, editor. Barcelona: Elsevier; 2009 [cited 2022 Dec 11]. 87–97 p. Available from: https://www.academia.edu/42262995/I nmunolog%C3%ADa_veterinaria
Watanabe R, Eckstrand C, Liu H, Pedersen NC. Characterization of Peritoneal Cells From Cats with Experimentally Induced Feline Infectious Peritonitis (FIP) Using RNA-seq. Vet Res [Internet]. 2018 Aug 7 [cited 2022 Nov 13];49(1):81. Available from: /pmc/articles/PMC6081860/
Lutz M, Steiner AR, Cattori V, Hofmann-Lehmann R, Lutz H, Kipar A, et al. FCoV Viral Sequences of Systemically Infected Healthy Cats Lack Gene Mutations Previously Linked to the Development of FIP. Pathogens [Internet]. 2020 Aug 1 [cited 2022 Nov 11];9(8):1–20. Available from: /pmc/articles/PMC7459962/
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spelling Plazas Hernández, Fernely AugustoPadilla Barreto, Mónica YamileVargas Ortiz, Lizeth Camila2023-12-19T15:10:03Z2023-12-19T15:10:03Z20232023-12-19https://hdl.handle.net/20.500.12494/53888Vargas Ortiz, L. C. (2023). Inmunopatología de Peritonitis Infecciosa Felina (PIF). [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC.El desarrollo de la Peritonitis Infecciosa Felina (PIF), dependerá de dos factores, la respuesta inmunológica y la mutación genómica del virus. Teniendo en cuenta, la respuesta inmune del animal, se ha comprobado que la protección frente a PIF está dada por la inmunidad celular, por el contrario, la inmunidad humoral no genera un efecto protector contra la infección, es por ello que, al generarse el contagio, el cuerpo tiene tres maneras de enfrentar la enfermedad, la primera es aquella en la que el gato puede generar una respuesta inmune celular fuerte, aquí, los niveles de anticuerpos estarán bajos, en esta reacción se acrecientan las posibilidades de superar la enfermedad, presentándose una rehabilitación completa o el desarrollo de un proceso subclínico, la segunda hace referencia a una respuesta de tipo humoral fuerte, con presencia de una inmunidad celular parcial, aquí el paciente desarrollará la forma no efusiva de FIP y en tercer lugar encontramos que se presenta una respuesta humoral fuerte, pero aquí la inmunidad celular será casi nula o totalmente ausente, por lo tanto, habrá un desarrollo de la forma efusiva de FIP.The development of Feline Infectious Peritonitis (FIP) will depend on two factors, the immune response, and the genomic mutation of the virus. Taking into account the immune response of the animal, it has been verified that protection against PIF is given by cellular immunity, on the contrary, humoral immunity does not generate a protective effect against infection, which is why, when generating the contagion, the body has three ways to deal with the disease, the first is one in which the cat can generate a strong cellular immune response, here, the levels of antibodies will be low, in this reaction the chances of overcoming the disease increase, presenting a complete rehabilitation or the development of a subclinical process, the second refers to a strong humoral response, with the presence of partial cellular immunity, here the patient will develop the non-effusive form of FIP and thirdly we find that it occurs a strong humoral response, but here the cellular immunity will be almost null or totally absent, therefore, there will be a development of the effusive form of FIP.1. Resumen. -- 2. Introducción. -- 3. Etiología. -- 3.1. Cepas. -- 4. Inmunopatología. -- 4.1. Respuesta Inmune Celular (Th1). -- 4.2. Respuesta Inmune Humoral (Th2). -- 4.3. Apoptosis. - 5. Discusión. -- 6. Conclusión. -- 7. Referencias.lizeth.vargaso@campusucc.edu.co20 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéInmunopatología, FCoV, PIF, felino, anticuerposTG 2023 MVZImmunopathologyFCoVFIPFelineAntibodiesInmunopatología de Peritonitis Infecciosa Felina (PIF)Trabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Barker EN, Tasker S. Advances in Molecular Diagnostics and Treatment of Feline Infectious Peritonitis. Advances In Small Animal Care [Internet]. 2020 Nov 9 [cited 2022 Nov 2];1. 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