Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations.

The triggering of severe dengue has been associated with an exacerbated inflammatory process characterized by the production of pro-inflammatory cytokines such as IL-1/IL-18, which are the product of inflammasome activation. Furthermore, alteration in the levels of high-density (HDL) and low-density lipoproteins (LDL) has been observed; and HDL are known to have immunomodulatory properties, including the regulation of inflammasomes. While HDL would be expected to counteract hyperactivation of the inflammasome, the relationship between HDL and dengue severity, has not previously been explored.

• Autores: Marin-Palma, Damariz; Sirois, Cherilyn M; Urcuqui-Inchima, Silvio; Hernández López, Juan Carlos
• Tipo de recurso: Article of journal
• Fecha de publicación: 2019
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41921
• Acceso en línea: https://doi.org/10.17981/econcuc.37.2.2016.09; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009992343&doi=10.1016%2fj.vetmic.2016.12.039&partnerID=40&md5=7039d94e76ca6d3c37f3b36a52faa9b2; https://hdl.handle.net/20.500.12494/41921
• Palabra clave: C reactive protein; carrier proteins and binding proteins; cryopyrin; high density lipoprotein; inflammasome; interleukin 10; interleukin 18; interleukin 1beta; interleukin 1beta converting enzyme; interleukin 6; lipoprotein; low density lipoprotein; messenger RNA; protein NLRC4; protein NLRP1; tumor necrosis factor; unclassified drug; adult; Article; clinical article; controlled study; cross-sectional study; dengue; disease severity; female; gene expression; human; human cell; inflammation; male; peripheral blood mononuclear cell; protein blood level
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb