Extended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures

Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations. In particular, a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order four correlating the interaction parameter W with the Hildebrand solubility parameter of solvent mixtures without drug. The predictive character of EHSA was the same as that obtained by direct correlation of drug solubilities with the same descriptor of polarity of the cosolvent mixtures. © 2016, Universidad Nacional de Colombia. All rights reserved.

• Autores: Delgado, Daniel Ricardo; Peña M.Á.; Martínez F.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2016
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/42212
• Acceso en línea: https://doi.org/10.25054/16576799.1925; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949870876&doi=10.17533%2fudea.iatreia.v29n1a04&partnerID=40&md5=3ade9af3518d879e86ffcf3d541af2ce; https://hdl.handle.net/20.500.12494/42212
• Palabra clave: Binary mixtures; Ethanol; Extended Hildebrand solubility approach; Hildebrand solubility parameter; Sulfonamides
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb