Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis

Se realizo un análisis de literatura a nivel sistemático en donde se consideraron artículos científicos referente a la temática empleada, con apoyo en la revisión literaria referente a la descripción breve de la anatomía de la yegua, descripción de patógeno, presentación de la enfermedad, fisiopatol...

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Autores:: Hernández, Carlo
Contreras, María Paula

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2021

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

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repository_id_str
dc.title.spa.fl_str_mv	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
title	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
spellingShingle	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis Metritis equina Laminitis Síndrome Tratamiento Diagnóstico Endotoxemia TG 2021 MVZ 41071 Equine metritis Laminitis Syndrome Treatment Diagnosis Endotoxemia
title_short	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
title_full	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
title_fullStr	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
title_full_unstemmed	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
title_sort	Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis
dc.creator.fl_str_mv	Hernández, Carlo Contreras, María Paula
dc.contributor.advisor.none.fl_str_mv	Bonilla Izquierdo, Alexander
dc.contributor.author.none.fl_str_mv	Hernández, Carlo Contreras, María Paula
dc.subject.spa.fl_str_mv	Metritis equina Laminitis Síndrome Tratamiento Diagnóstico Endotoxemia
topic	Metritis equina Laminitis Síndrome Tratamiento Diagnóstico Endotoxemia TG 2021 MVZ 41071 Equine metritis Laminitis Syndrome Treatment Diagnosis Endotoxemia
dc.subject.classification.spa.fl_str_mv	TG 2021 MVZ 41071
dc.subject.other.spa.fl_str_mv	Equine metritis Laminitis Syndrome Treatment Diagnosis Endotoxemia
description	Se realizo un análisis de literatura a nivel sistemático en donde se consideraron artículos científicos referente a la temática empleada, con apoyo en la revisión literaria referente a la descripción breve de la anatomía de la yegua, descripción de patógeno, presentación de la enfermedad, fisiopatología, signos clínicos, herramientas diagnosticas, tratamientos preventivos y de control. La metritis en las yeguas es un reto para el profesional veterinario en donde la toma de decisiones frente a la patología juega un papel fundamental para acabar con la infección o posteriormente el avance de esta misma con consecuencias muy graves para la yegua. Las consideraciones clínicas frente a un cuadro de metritis en yeguas pueden llegar a ser de vital importancia, ya que el manejo de la infección nos presentara dos caminos a recorrer; como lo es la solución a la metritis o el segundo camino será la presentación de un síndrome secundario que nos lleve a una endotoxemia concluyendo en un cuadro laminitico. En la siguiente revisión literaria nos basamos en los acontecimientos clínicos antes llegar a presentar un cuadro de laminitis posterior a una infección por metritis, a lo que se le conoce como síndrome metritis, endotoxemia, laminitis.
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-12-09T14:44:36Z
dc.date.available.none.fl_str_mv	2021-11-24 2021-12-09T14:44:36Z
dc.date.issued.none.fl_str_mv	2021-11-24
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
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dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
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dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41071
dc.identifier.bibliographicCitation.spa.fl_str_mv	Hernández, C. y Contreras, M. P. (2021). Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/41071
url	https://hdl.handle.net/20.500.12494/41071
identifier_str_mv	Hernández, C. y Contreras, M. P. (2021). Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/41071
dc.relation.references.spa.fl_str_mv	Anzai R, Wada R, Okuda T. Metritis contagiosa equina. Vet México. 1983;14(3):181–91. Brinsko SP, Varner DD, Meyers SA. The effect of postbreeding uterine lavage on pregnancy rate. 1990;33(2):465–75. Sánchez LM, Fernando D, Vega R, Velázquez E, Muñoz CR, Lorena A, et al. Metritis Equina Contagiosa en yeguas de la Raza Española ( Contagious Equine Metritis in mares of the Spanish Race ). 2005;VI:1–6. Schulman ML, May CE, Keys B, Guthrie AJ. Contagious equine metritis: Artificial reproduction changes the epidemiologic paradigm. Vet Microbiol. 2013;167(1–2):2–8. Carnota S. Endometritis en la yegua: diagnóstico y tratamiento. 2019;1–50. Available from: https://minerva.usc.es/xmlui/bitstream/handle/10347/20539/TFG_VET_2019_Carnota_Martinez_Sara.pdf?sequence=1&isAllowed=y arlos C, Melba R-, Marco R, López F, Gilberto F. Revisión : El Ciclo Reproductivo de la Yegua Mare Reproductive Cycle : A Review INTRODUCCIÓN Las yeguas se reproducen en forma estacional con fotoperiodo alto ( muchas horas luz / día ò primavera-verano ), y así presentan sus partos en la temporada más ad. 2018;8(3):14–41. Gastal EL, Gastal MO, Ginther OJ. Serrated granulosa and other discrete ultrasound indicators of impending ovulation in mares. J Equine Vet Sci. 2006;26(2):67–73. Gastal EL, Gastal MO, Bergfelt DR, Ginther OJ. Role of diameter differences among follicles in selection of a future dominant follicle in mares. Biol Reprod. 1997;57(6):1320–7. Fitzgerald BP, McManus CJ. Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare. Biol Reprod. 2000;63(1):335–40. Gastal EL, Gastal MO, Wiltbank MC, Ginther OJ. Follicle deviation and intrafollicular and systemic estradiol concentrations in mares. Biol Reprod. 1999;61(1):31–9. 11. Gastal EL, Gastal MO, Donadeu FX, Acosta TJ, Beg MA, Ginther OJ. Temporal relationships among LH, estradiol, and follicle vascularization preceding the first compared with later ovulations during the year in mares. Anim Reprod Sci. 2007;102(3–4):314–21. 12. Beehan DP, Mckinnon AO, Act D. How to Diagnose Common Equine Reproductive Chromogenic Agar. AAEP Proc. 2009;55:320–5. 13. Soto J. Manejo Reproductivo de la yegua. Rev Complut Ciencias Vet. 2006;1:199. 14. E.L. GastaLl M.O. Gastal,:! G.P. Nogueira 3 D.R. Bergfeltl and O.J. Gintherl, 1. TEMPORAL INTERRELATIONSHIPS AMONG LUTEOLYSIS, FSH AND LH CONCENTRATIONS AND FOLLICLE DEVIATION IN MARES E.L. 2000;(1645):1–76. 15. Bergfelt DR, Gastal EL, Ginther OJ. Response of estradiol and inhibin to experimentally reduced luteinizing hormone during follicle deviation in mares. Biol Reprod. 2001;65(2):426–32. Gastal EL, Gastal MO, Donadeu FX, Acosta TJ, Beg MA, Ginther OJ. Temporal relationships among LH, estradiol, and follicle vascularization preceding the first compared with later ovulations during the year in mares. Anim Reprod Sci. 2007;102(3–4):314–21. Beehan DP, Mckinnon AO, Act D. How to Diagnose Common Equine Reproductive Chromogenic Agar. AAEP Proc. 2009;55:320–5. Soto J. Manejo Reproductivo de la yegua. Rev Complut Ciencias Vet. 2006;1:199. E.L. GastaLl M.O. Gastal,:! G.P. Nogueira 3 D.R. Bergfeltl and O.J. Gintherl, 1. TEMPORAL INTERRELATIONSHIPS AMONG LUTEOLYSIS, FSH AND LH CONCENTRATIONS AND FOLLICLE DEVIATION IN MARES E.L. 2000;(1645):1–76. Bergfelt DR, Gastal EL, Ginther OJ. Response of estradiol and inhibin to experimentally reduced luteinizing hormone during follicle deviation in mares. Biol Reprod. 2001;65(2):426–32. 16. Steven P. Brinsko, Charles C. Love, Dickson D. Varner, Terry L. Blanchard JS. Manual of equine reproduction. 1377. 68–70 p. 17. J URM, Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Sn S, et al. Microbial biofilms. 18. Animal S, Programa SA, Animal S, Doctoral T, Guerrero BP. estudio microbiologico de infertilidad n yeguas. 19. Centre VS, Science F. Equine post-breeding endometritis : A review. 2008;61(3):1999–2004. 20. Rojer H, Aurich C. Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen. Reprod Domest Anim. 2010;45(6):2009–11. 21. Narváez A, Aroca J, Alda P, Macías V, Lounnas M, Noya O, et al. Reporte de caso metritis en yegua. El Misionero del Agro [Internet]. 2017;3–16. Available from: https://ri.conicet.gov.ar/bitstream/handle/11336/64219/CONICET_Digital_Nro.486ee4d7-d8de-45bf-9fca-2d3e4f67e468_A.pdf?sequence=2&isAllowed=y Steven P. Brinsko, Charles C. Love, Dickson D. Varner, Terry L. Blanchard JS. Manual of equine reproduction. 1377. 68–70 p. J URM, Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Sn S, et al. Microbial biofilms. Animal S, Programa SA, Animal S, Doctoral T, Guerrero BP. estudio microbiologico de infertilidad n yeguas. Centre VS, Science F. Equine post-breeding endometritis : A review. 2008;61(3):1999–2004. Rojer H, Aurich C. Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen. Reprod Domest Anim. 2010;45(6):2009–11. Narváez A, Aroca J, Alda P, Macías V, Lounnas M, Noya O, et Asbury AC. Uterine defense mechanisms in the mare: The use of intrauterine plasma in the management of endometritis. Theriogenology. 1984;21(2):387–93. M. G, A. D, M.A. O, J. T, J. S, J.L. N. sindrome metritis laminitis. Med Vet [Internet]. 1984; Available from: https://www.lasalle.edu.co/pregrado/medicina-veterinaria%0Ahttp://agris.fao.org/agris-search/search.do;jsessionid=580D82E82C236CCADB6E9C2FEF045397?request_locale=es&recordID=ES19940089485&sourceQuery=&query=&sortField=&sortOrder=&agrovocString=&advQuery=& 24. Acosta TJ, Beg MA, Ginther OJ. Aberrant blood flow area and plasma gonadotropin concentrations during the development of dominant-sized transitional anovulatory follicles in mares. Biol Reprod. 2004;71(2):637–42. 25. Campero CM. Cultivos de cervix en yeguas SPC. 2015;(January 1981). 26. Barbacini S, Necchi D, Zavaglia G, Squires EL. Retrospective Study on the Incidence of Postinsemination Uterine Fluid in Mares Inseminated with Frozen/Thawed Semen. J Equine Vet Sci. 2003;23(11):493–6. 27. Buczkowska J, Kozdrowski R, Nowak M, Ra A, Siemieniuch MJ. Comparison of the biopsy and cytobrush techniques for diagnosis of subclinical endometritis in mares. 2014;1–6. 28. Buczkowska J, Kozdrowski R, Sikora M, Matusz A, Dnia WD. NON-TRADITIONAL TREATMENTS FOR ENDOMETRITIS IN MARES. 2015;(4):285–93. Acosta TJ, Beg MA, Ginther OJ. Aberrant blood flow area and plasma gonadotropin concentrations during the development of dominant-sized transitional anovulatory follicles in mares. Biol Reprod. 2004;71(2):637–42. Campero CM. Cultivos de cervix en yeguas SPC. 2015;(January 1981). Barbacini S, Necchi D, Zavaglia G, Squires EL. Retrospective Study on the Incidence of Postinsemination Uterine Fluid in Mares Inseminated with Frozen/Thawed Semen. J Equine Vet Sci. 2003;23(11):493–6. Buczkowska J, Kozdrowski R, Nowak M, Ra A, Siemieniuch MJ. Comparison of the biopsy and cytobrush techniques for diagnosis of subclinical endometritis in mares. 2014;1–6. Buczkowska J, Kozdrowski R, Sikora M, Matusz A, Dnia WD. NON-TRADITIONAL TREATMENTS FOR ENDOMETRITIS IN MARES. Causey RC. Making sense of equine uterine infections : The many faces of physical clearance. 2006;172:405–21. Caissie MD. N-acetyl cysteine as a potential treatment for persistent breeding-induced endometritis in the mare. 2019; Christoffersen M, Brandis L, Samuelsson J, Bojesen AM. Theriogenology Diagnostic double-guarded low-volume uterine lavage in mares. Theriogenology [Internet]. 2015;83(2):222–7. Available from: http://dx.doi.org/10.1016/j.theriogenology.2014.09.008 Christoffersen M, Brandis L, Samuelsson J, Bojesen AM. Theriogenology Diagnostic double-guarded low-volume uterine lavage in mares. Theriogenology [Internet]. 2015;83(2):222–7. Available from: http://dx.doi.org/10.1016/j.theriogenology.2014.09.008 Christoffersen M, Woodward EM, Bojesen AM, Petersen MR, Squires EL. Effect of immunomodulatory therapy on the endometrial inflammatory response to induced infectious endometritis in susceptible mares. THE [Internet]. 2012;78(5):991–1004. Available from: http://dx.doi.org/10.1016/j.theriogenology.2012.04.016 Ascanio JJD, Chweizer CS, Ey WBL. Equine fungal endometritis. 2001;13:324–9. Chiba A, Ujiie Y, Aoki T. Relationship between the presence of intrauterine fluid and cervical bacteria in heavy draft mares before and after mating. VENTURINO AMDMVSP. EFECTO DE LA INMUNOMODULACIÓN SOBRE LA EXPRESIÓN DE LA CICLOOXIGENASA 2 Y EL CONTENIDO Y DISTRIBUCIÓN DE CÉLULAS INMUNES EN ENDOMETRIO DE YEGUAS RESISTENTES A ENDOMETRITIS. 2014;1–43. Blanchard TL, Vaala WE, Straughn AJ. RI SEPTIC / TOXIC METRITIS AND LAMINITIS IN A POSTPARTURIENT MARE : CASE REPORT. Sevinga M, Barkema HW, Hesselink JW. Retained placenta in Friesian mares : reproductive performance after foal heat breeding versus breeding in a subsequent heat. 2001;17. 38. Eades SC, Holm AMS, Moore RM. A Review of the Pathophysiology and Treatment of Acute Laminitis : Pathophysiologic and Therapeutic Implications of Endothelin-1. 2002;48:353–61. 39. Godoy A, García A. Infosura en Equinos. 2011;11–26. 40. Schöniger S, Schoon H. The Healthy and Diseased Equine Endometrium : A Review of Morphological Features and Molecular Analyses. 2020;1–22. 41. Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding ‐ Induced Endometritis in Mares ‐ a Multifaceted Challenge : From Clinical Aspects to Immunopathogenesis and Pathobiology. 2020; 42. Arnes AJB. Case Report Use of prostaglandin E 1 to induce cervical relaxation in a maiden mare with post breeding endometritis Case details. 2003;15:172–4. 43. Kristula MA1 SB. Diagnóstico y tratamiento de cuatro sementales, portadores del organismo de metritis contagiosa - reporte de caso. 2004;61:595–601. Available from: http://repositorio.uaaan.mx:8080/xmlui/bitstream/handle/123456789/3137/EDUARDO DARINEL HERNANDEZ SERRANO.pdf?sequence=1 Nielsen JM, Troedsson MH, Pedersen MR, Bojesen M, Lehn-jensen H, Zent WW. Diagnosis of Endometritis in the Mare Based on Bacteriological and Cytological Examinations of the Endometrium : Comparison of Results Obtained by Swabs and Biopsies. 2010;30(1):27–30. Overbeck W, Witte TS, Heuwieser W. Comparison of three diagnostic methods to identify subclinical endometritis in mares. THE [Internet]. 2011;75(7):1311–8. Available from: http://dx.doi.org/10.1016/j.theriogenology.2010.12.002 Liu IKM, Cheung ATW. The Functional from Competence of Uterine-derived Polymorphonuclear Mares Resistant and Susceptible to Chronic Uterine A Sequential Migration Analysis ’ Neutrophils Infection : ( PM N ). 1986;1174:1168–74. 47. Tukia E, Wagner B, Vainio K, Mönki J, Kareskoski M. The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis. J Equine Vet Sci. 2021;98. 48. Pycock JF, Newcombe JR. Papers and Articles. 1996; 49. Rebordão MR, Carneiro C, Alexandre-pires G, Brito P, Pereira C. Neutrophil extracellular traps formation by bacteria causing endometritis in the mare. J Reprod Immunol [Internet]. 2014; Available from: http://dx.doi.org/10.1016/j.jri.2014.08.003 50. Rasmussen CD, Haugaard MM, Petersen MR, Nielsen JM, Pedersen HG, Bojesen AM. Streptococcus equi subsp . zooepidemicus isolates from equine infectious endometritis belong to a distinct genetic group. 2013;1–8. Tukia E, Wagner B, Vainio K, Mönki J, Kareskoski M. The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis. J Equine Vet Sci. 2021;98. Pycock JF, Newcombe JR. Papers and Articles. 1996; Rebordão MR, Carneiro C, Alexandre-pires G, Brito P, Pereira C. Neutrophil extracellular traps formation by bacteria causing endometritis in the mare. J Reprod Immunol [Internet]. 2014; Available from: http://dx.doi.org/10.1016/j.jri.2014.08.003 Rasmussen CD, Haugaard MM, Bucca S, Carli A, Buckley T, Dolci G, Fogarty U. The use of dexamethasone administered to mares at breeding time in the modulation of persistent mating induced endometritis. Theriogenology. 2008;70(7):1093–100. Reitzenstein M Von, Callahan MA, Hansen PJ, Leblanc MM. Aberrations in uterine contractile patterns in mares with delayed uterine clearance after administration of detomidine and oxytocin. 2002;58:887–98.
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spelling	Bonilla Izquierdo, Alexander Hernández, CarloContreras, María Paula2021-12-09T14:44:36Z2021-11-242021-12-09T14:44:36Z2021-11-24https://hdl.handle.net/20.500.12494/41071Hernández, C. y Contreras, M. P. (2021). Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/41071Se realizo un análisis de literatura a nivel sistemático en donde se consideraron artículos científicos referente a la temática empleada, con apoyo en la revisión literaria referente a la descripción breve de la anatomía de la yegua, descripción de patógeno, presentación de la enfermedad, fisiopatología, signos clínicos, herramientas diagnosticas, tratamientos preventivos y de control. La metritis en las yeguas es un reto para el profesional veterinario en donde la toma de decisiones frente a la patología juega un papel fundamental para acabar con la infección o posteriormente el avance de esta misma con consecuencias muy graves para la yegua. Las consideraciones clínicas frente a un cuadro de metritis en yeguas pueden llegar a ser de vital importancia, ya que el manejo de la infección nos presentara dos caminos a recorrer; como lo es la solución a la metritis o el segundo camino será la presentación de un síndrome secundario que nos lleve a una endotoxemia concluyendo en un cuadro laminitico. En la siguiente revisión literaria nos basamos en los acontecimientos clínicos antes llegar a presentar un cuadro de laminitis posterior a una infección por metritis, a lo que se le conoce como síndrome metritis, endotoxemia, laminitis.A systematic literature analysis was carried out, considering scientific articles related to the subject matter used, with support in the literature review regarding the brief description of the anatomy of the mare, description of the pathogen, presentation of the disease, pathophysiology, clinical signs, diagnostic tools, preventive and control treatments. Metritis in mares is a challenge for the veterinary professional where the decision making in front of the pathology plays a fundamental role to end the infection or later the advance of the infection with very serious consequences for the mare. The clinical considerations in the face of metritis in mares can be of vital importance, since the management of the infection will present us with two paths to follow as is the solution to the metritis or the second path will be the presentation of a secondary syndrome that leads to an endotoxemia concluding in a laminitic picture. In the following literature review we are based on the clinical events before presenting a picture of laminitis following a metritis infection, which is known as metritis syndrome, endotoxemia, laminitis.carlo.hernandeza@campusucc.edu.comaria.contrerasa@campusucc.edu.co21 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéMetritis equinaLaminitisSíndromeTratamientoDiagnósticoEndotoxemiaTG 2021 MVZ 41071Equine metritisLaminitisSyndromeTreatmentDiagnosisEndotoxemiaMetritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitisTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Anzai R, Wada R, Okuda T. Metritis contagiosa equina. Vet México. 1983;14(3):181–91.Brinsko SP, Varner DD, Meyers SA. The effect of postbreeding uterine lavage on pregnancy rate. 1990;33(2):465–75.Sánchez LM, Fernando D, Vega R, Velázquez E, Muñoz CR, Lorena A, et al. Metritis Equina Contagiosa en yeguas de la Raza Española ( Contagious Equine Metritis in mares of the Spanish Race ). 2005;VI:1–6.Schulman ML, May CE, Keys B, Guthrie AJ. Contagious equine metritis: Artificial reproduction changes the epidemiologic paradigm. Vet Microbiol. 2013;167(1–2):2–8.Carnota S. Endometritis en la yegua: diagnóstico y tratamiento. 2019;1–50. Available from: https://minerva.usc.es/xmlui/bitstream/handle/10347/20539/TFG_VET_2019_Carnota_Martinez_Sara.pdf?sequence=1&isAllowed=yarlos C, Melba R-, Marco R, López F, Gilberto F. Revisión : El Ciclo Reproductivo de la Yegua Mare Reproductive Cycle : A Review INTRODUCCIÓN Las yeguas se reproducen en forma estacional con fotoperiodo alto ( muchas horas luz / día ò primavera-verano ), y así presentan sus partos en la temporada más ad. 2018;8(3):14–41.Gastal EL, Gastal MO, Ginther OJ. Serrated granulosa and other discrete ultrasound indicators of impending ovulation in mares. J Equine Vet Sci. 2006;26(2):67–73.Gastal EL, Gastal MO, Bergfelt DR, Ginther OJ. Role of diameter differences among follicles in selection of a future dominant follicle in mares. Biol Reprod. 1997;57(6):1320–7.Fitzgerald BP, McManus CJ. Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare. Biol Reprod. 2000;63(1):335–40.Gastal EL, Gastal MO, Wiltbank MC, Ginther OJ. Follicle deviation and intrafollicular and systemic estradiol concentrations in mares. Biol Reprod. 1999;61(1):31–9. 11. Gastal EL, Gastal MO, Donadeu FX, Acosta TJ, Beg MA, Ginther OJ. Temporal relationships among LH, estradiol, and follicle vascularization preceding the first compared with later ovulations during the year in mares. Anim Reprod Sci. 2007;102(3–4):314–21. 12. Beehan DP, Mckinnon AO, Act D. How to Diagnose Common Equine Reproductive Chromogenic Agar. AAEP Proc. 2009;55:320–5. 13. Soto J. Manejo Reproductivo de la yegua. Rev Complut Ciencias Vet. 2006;1:199. 14. E.L. GastaLl M.O. Gastal,:! G.P. Nogueira 3 D.R. Bergfeltl and O.J. Gintherl, 1. TEMPORAL INTERRELATIONSHIPS AMONG LUTEOLYSIS, FSH AND LH CONCENTRATIONS AND FOLLICLE DEVIATION IN MARES E.L. 2000;(1645):1–76. 15. Bergfelt DR, Gastal EL, Ginther OJ. Response of estradiol and inhibin to experimentally reduced luteinizing hormone during follicle deviation in mares. Biol Reprod. 2001;65(2):426–32.Gastal EL, Gastal MO, Donadeu FX, Acosta TJ, Beg MA, Ginther OJ. Temporal relationships among LH, estradiol, and follicle vascularization preceding the first compared with later ovulations during the year in mares. Anim Reprod Sci. 2007;102(3–4):314–21.Beehan DP, Mckinnon AO, Act D. How to Diagnose Common Equine Reproductive Chromogenic Agar. AAEP Proc. 2009;55:320–5.Soto J. Manejo Reproductivo de la yegua. Rev Complut Ciencias Vet. 2006;1:199.E.L. GastaLl M.O. Gastal,:! G.P. Nogueira 3 D.R. Bergfeltl and O.J. Gintherl, 1. TEMPORAL INTERRELATIONSHIPS AMONG LUTEOLYSIS, FSH AND LH CONCENTRATIONS AND FOLLICLE DEVIATION IN MARES E.L. 2000;(1645):1–76.Bergfelt DR, Gastal EL, Ginther OJ. Response of estradiol and inhibin to experimentally reduced luteinizing hormone during follicle deviation in mares. Biol Reprod. 2001;65(2):426–32. 16. Steven P. Brinsko, Charles C. Love, Dickson D. Varner, Terry L. Blanchard JS. Manual of equine reproduction. 1377. 68–70 p. 17. J URM, Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Sn S, et al. Microbial biofilms. 18. Animal S, Programa SA, Animal S, Doctoral T, Guerrero BP. estudio microbiologico de infertilidad n yeguas. 19. Centre VS, Science F. Equine post-breeding endometritis : A review. 2008;61(3):1999–2004. 20. Rojer H, Aurich C. Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen. Reprod Domest Anim. 2010;45(6):2009–11. 21. Narváez A, Aroca J, Alda P, Macías V, Lounnas M, Noya O, et al. Reporte de caso metritis en yegua. El Misionero del Agro [Internet]. 2017;3–16. Available from: https://ri.conicet.gov.ar/bitstream/handle/11336/64219/CONICET_Digital_Nro.486ee4d7-d8de-45bf-9fca-2d3e4f67e468_A.pdf?sequence=2&isAllowed=ySteven P. Brinsko, Charles C. Love, Dickson D. Varner, Terry L. Blanchard JS. Manual of equine reproduction. 1377. 68–70 p.J URM, Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Sn S, et al. Microbial biofilms.Animal S, Programa SA, Animal S, Doctoral T, Guerrero BP. estudio microbiologico de infertilidad n yeguas.Centre VS, Science F. Equine post-breeding endometritis : A review. 2008;61(3):1999–2004.Rojer H, Aurich C. Treatment of persistent mating-induced endometritis in mares with the non-steroid anti-inflammatory drug vedaprofen. Reprod Domest Anim. 2010;45(6):2009–11.Narváez A, Aroca J, Alda P, Macías V, Lounnas M, Noya O, etAsbury AC. Uterine defense mechanisms in the mare: The use of intrauterine plasma in the management of endometritis. Theriogenology. 1984;21(2):387–93.M. G, A. D, M.A. O, J. T, J. S, J.L. N. sindrome metritis laminitis. Med Vet [Internet]. 1984; Available from: https://www.lasalle.edu.co/pregrado/medicina-veterinaria%0Ahttp://agris.fao.org/agris-search/search.do;jsessionid=580D82E82C236CCADB6E9C2FEF045397?request_locale=es&recordID=ES19940089485&sourceQuery=&query=&sortField=&sortOrder=&agrovocString=&advQuery=& 24. Acosta TJ, Beg MA, Ginther OJ. Aberrant blood flow area and plasma gonadotropin concentrations during the development of dominant-sized transitional anovulatory follicles in mares. Biol Reprod. 2004;71(2):637–42. 25. Campero CM. Cultivos de cervix en yeguas SPC. 2015;(January 1981). 26. Barbacini S, Necchi D, Zavaglia G, Squires EL. Retrospective Study on the Incidence of Postinsemination Uterine Fluid in Mares Inseminated with Frozen/Thawed Semen. J Equine Vet Sci. 2003;23(11):493–6. 27. Buczkowska J, Kozdrowski R, Nowak M, Ra A, Siemieniuch MJ. Comparison of the biopsy and cytobrush techniques for diagnosis of subclinical endometritis in mares. 2014;1–6. 28. Buczkowska J, Kozdrowski R, Sikora M, Matusz A, Dnia WD. NON-TRADITIONAL TREATMENTS FOR ENDOMETRITIS IN MARES. 2015;(4):285–93.Acosta TJ, Beg MA, Ginther OJ. Aberrant blood flow area and plasma gonadotropin concentrations during the development of dominant-sized transitional anovulatory follicles in mares. Biol Reprod. 2004;71(2):637–42.Campero CM. Cultivos de cervix en yeguas SPC. 2015;(January 1981).Barbacini S, Necchi D, Zavaglia G, Squires EL. Retrospective Study on the Incidence of Postinsemination Uterine Fluid in Mares Inseminated with Frozen/Thawed Semen. J Equine Vet Sci. 2003;23(11):493–6.Buczkowska J, Kozdrowski R, Nowak M, Ra A, Siemieniuch MJ. Comparison of the biopsy and cytobrush techniques for diagnosis of subclinical endometritis in mares. 2014;1–6.Buczkowska J, Kozdrowski R, Sikora M, Matusz A, Dnia WD. NON-TRADITIONAL TREATMENTS FOR ENDOMETRITIS IN MARES.Causey RC. Making sense of equine uterine infections : The many faces of physical clearance. 2006;172:405–21.Caissie MD. N-acetyl cysteine as a potential treatment for persistent breeding-induced endometritis in the mare. 2019;Christoffersen M, Brandis L, Samuelsson J, Bojesen AM. Theriogenology Diagnostic double-guarded low-volume uterine lavage in mares. Theriogenology [Internet]. 2015;83(2):222–7. Available from: http://dx.doi.org/10.1016/j.theriogenology.2014.09.008Christoffersen M, Brandis L, Samuelsson J, Bojesen AM. Theriogenology Diagnostic double-guarded low-volume uterine lavage in mares. Theriogenology [Internet]. 2015;83(2):222–7. Available from: http://dx.doi.org/10.1016/j.theriogenology.2014.09.008Christoffersen M, Woodward EM, Bojesen AM, Petersen MR, Squires EL. Effect of immunomodulatory therapy on the endometrial inflammatory response to induced infectious endometritis in susceptible mares. THE [Internet]. 2012;78(5):991–1004. Available from: http://dx.doi.org/10.1016/j.theriogenology.2012.04.016Ascanio JJD, Chweizer CS, Ey WBL. Equine fungal endometritis. 2001;13:324–9.Chiba A, Ujiie Y, Aoki T. Relationship between the presence of intrauterine fluid and cervical bacteria in heavy draft mares before and after mating.VENTURINO AMDMVSP. EFECTO DE LA INMUNOMODULACIÓN SOBRE LA EXPRESIÓN DE LA CICLOOXIGENASA 2 Y EL CONTENIDO Y DISTRIBUCIÓN DE CÉLULAS INMUNES EN ENDOMETRIO DE YEGUAS RESISTENTES A ENDOMETRITIS. 2014;1–43.Blanchard TL, Vaala WE, Straughn AJ. RI SEPTIC / TOXIC METRITIS AND LAMINITIS IN A POSTPARTURIENT MARE : CASE REPORT.Sevinga M, Barkema HW, Hesselink JW. Retained placenta in Friesian mares : reproductive performance after foal heat breeding versus breeding in a subsequent heat. 2001;17. 38. Eades SC, Holm AMS, Moore RM. A Review of the Pathophysiology and Treatment of Acute Laminitis : Pathophysiologic and Therapeutic Implications of Endothelin-1. 2002;48:353–61. 39. Godoy A, García A. Infosura en Equinos. 2011;11–26. 40. Schöniger S, Schoon H. The Healthy and Diseased Equine Endometrium : A Review of Morphological Features and Molecular Analyses. 2020;1–22. 41. Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding ‐ Induced Endometritis in Mares ‐ a Multifaceted Challenge : From Clinical Aspects to Immunopathogenesis and Pathobiology. 2020; 42. Arnes AJB. Case Report Use of prostaglandin E 1 to induce cervical relaxation in a maiden mare with post breeding endometritis Case details. 2003;15:172–4. 43. Kristula MA1 SB. Diagnóstico y tratamiento de cuatro sementales, portadores del organismo de metritis contagiosa - reporte de caso. 2004;61:595–601. Available from: http://repositorio.uaaan.mx:8080/xmlui/bitstream/handle/123456789/3137/EDUARDO DARINEL HERNANDEZ SERRANO.pdf?sequence=1Nielsen JM, Troedsson MH, Pedersen MR, Bojesen M, Lehn-jensen H, Zent WW. Diagnosis of Endometritis in the Mare Based on Bacteriological and Cytological Examinations of the Endometrium : Comparison of Results Obtained by Swabs and Biopsies. 2010;30(1):27–30.Overbeck W, Witte TS, Heuwieser W. Comparison of three diagnostic methods to identify subclinical endometritis in mares. THE [Internet]. 2011;75(7):1311–8. Available from: http://dx.doi.org/10.1016/j.theriogenology.2010.12.002Liu IKM, Cheung ATW. The Functional from Competence of Uterine-derived Polymorphonuclear Mares Resistant and Susceptible to Chronic Uterine A Sequential Migration Analysis ’ Neutrophils Infection : ( PM N ). 1986;1174:1168–74. 47. Tukia E, Wagner B, Vainio K, Mönki J, Kareskoski M. The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis. J Equine Vet Sci. 2021;98. 48. Pycock JF, Newcombe JR. Papers and Articles. 1996; 49. Rebordão MR, Carneiro C, Alexandre-pires G, Brito P, Pereira C. Neutrophil extracellular traps formation by bacteria causing endometritis in the mare. J Reprod Immunol [Internet]. 2014; Available from: http://dx.doi.org/10.1016/j.jri.2014.08.003 50. Rasmussen CD, Haugaard MM, Petersen MR, Nielsen JM, Pedersen HG, Bojesen AM. Streptococcus equi subsp . zooepidemicus isolates from equine infectious endometritis belong to a distinct genetic group. 2013;1–8.Tukia E, Wagner B, Vainio K, Mönki J, Kareskoski M. The Effect of Uterine Lavage on Soluble CD14, Chemokine Ligand 2, and Interleukin 10 Levels in Mares With Postpartum Metritis. J Equine Vet Sci. 2021;98.Pycock JF, Newcombe JR. Papers and Articles. 1996;Rebordão MR, Carneiro C, Alexandre-pires G, Brito P, Pereira C. Neutrophil extracellular traps formation by bacteria causing endometritis in the mare. J Reprod Immunol [Internet]. 2014; Available from: http://dx.doi.org/10.1016/j.jri.2014.08.003Rasmussen CD, Haugaard MM,Bucca S, Carli A, Buckley T, Dolci G, Fogarty U. The use of dexamethasone administered to mares at breeding time in the modulation of persistent mating induced endometritis. Theriogenology. 2008;70(7):1093–100.Reitzenstein M Von, Callahan MA, Hansen PJ, Leblanc MM. 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Metritis equina: acontecimientos clínicos antes de llegar a presentar un cuadro de laminitis

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