Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1
Debido a que la terapia antirretroviral no logra controlar la activación inmune asociada a la infección por VIH-1, el estudio de moléculas inmunomoduladoras puede proporcionar alternativas para su control. En este sentido, el propósito de este estudio fue evaluar la expresión transcripcional de molé...
- Autores:
-
Arboleda Álvarez, Nataly
Sánchez Gómez, Catalina
Arias Pérez, Rubén Darío
Flórez Álvarez, Lizdany
Marín Palma, Damariz
Taborda, Natalia Andrea
Hernández López, Juan Carlos
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/44468
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/44468
- Palabra clave:
- HIV-1
high-density lipoproteins
ABCA transporters
inflammation
- Rights
- openAccess
- License
- Atribución
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| dc.title.spa.fl_str_mv |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| title |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| spellingShingle |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 HIV-1 high-density lipoproteins ABCA transporters inflammation |
| title_short |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| title_full |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| title_fullStr |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| title_full_unstemmed |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| title_sort |
Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1 |
| dc.creator.fl_str_mv |
Arboleda Álvarez, Nataly Sánchez Gómez, Catalina Arias Pérez, Rubén Darío Flórez Álvarez, Lizdany Marín Palma, Damariz Taborda, Natalia Andrea Hernández López, Juan Carlos |
| dc.contributor.author.none.fl_str_mv |
Arboleda Álvarez, Nataly Sánchez Gómez, Catalina Arias Pérez, Rubén Darío Flórez Álvarez, Lizdany Marín Palma, Damariz Taborda, Natalia Andrea Hernández López, Juan Carlos |
| dc.subject.spa.fl_str_mv |
HIV-1 high-density lipoproteins ABCA transporters inflammation |
| topic |
HIV-1 high-density lipoproteins ABCA transporters inflammation |
| description |
Debido a que la terapia antirretroviral no logra controlar la activación inmune asociada a la infección por VIH-1, el estudio de moléculas inmunomoduladoras puede proporcionar alternativas para su control. En este sentido, el propósito de este estudio fue evaluar la expresión transcripcional de moléculas asociadas con el metabolismo del colesterol-HDL (C-HDL) y con la respuesta inflamatoria mediada por el inflamasoma NLRP3 en pacientes infectados con VIH-1. En este estudio transversal, se incluyeron 23 pacientes VIH-1 sin tratamiento antirretroviral, con diferentes estadios de progresión, 7 de los cuales son controladores (Carga viral <2000 copias/mL) y 16 progresores (Carga viral >2000 copias/mL), además de 7 controles sanos. En células mononucleares de sangre periférica, se cuantificaron los niveles de la expresión transcripcional de ABCA-1, ABCA-3, Caspasa-5 y TXNIP mediante RT-PCR. Se evaluó la asociación de estos parámetros con variables demográficas y de laboratorio, y se encontró que los individuos VIH-1 progresores mostraron niveles significativamente menores de TXNIP y ABCA-3, sugiriendo que durante la infección por VIH-1 se produce una alteración en la expresión de estas moléculas. Dada la complejidad de las interacciones inmuno-metabólicas durante la infección por VIH-1, se necesitan estudios adicionales para establecer los mecanismos precisos involucrados en estas alteraciones. |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021-01 |
| dc.date.accessioned.none.fl_str_mv |
2022-04-01T20:46:18Z |
| dc.date.available.none.fl_str_mv |
2022-04-01T20:46:18Z |
| dc.type.none.fl_str_mv |
Artículos Científicos |
| dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.uri.spa.fl_str_mv |
10.5281/zenodo.4780969 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/44468 |
| dc.identifier.bibliographicCitation.spa.fl_str_mv |
Arias Pérez RD, Arboleda Álvarez N, Sánchez Gómez C, FlorezAlvarez L, Marín Palma D, Taborda NA, Hernández JC. (2021). Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1. Kasmera. 2021;49(1):e49133736. doi: 10.5281/zenodo.4780969 |
| identifier_str_mv |
10.5281/zenodo.4780969 Arias Pérez RD, Arboleda Álvarez N, Sánchez Gómez C, FlorezAlvarez L, Marín Palma D, Taborda NA, Hernández JC. (2021). Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1. Kasmera. 2021;49(1):e49133736. doi: 10.5281/zenodo.4780969 |
| url |
https://hdl.handle.net/20.500.12494/44468 |
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https://zenodo.org/record/4780969#.YkSa3CjMLfs |
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Kasmera |
| dc.relation.references.spa.fl_str_mv |
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Arboleda Álvarez, NatalySánchez Gómez, CatalinaArias Pérez, Rubén DaríoFlórez Álvarez, LizdanyMarín Palma, DamarizTaborda, Natalia AndreaHernández López, Juan Carlos 492022-04-01T20:46:18Z2022-04-01T20:46:18Z2021-0110.5281/zenodo.4780969https://hdl.handle.net/20.500.12494/44468Arias Pérez RD, Arboleda Álvarez N, Sánchez Gómez C, FlorezAlvarez L, Marín Palma D, Taborda NA, Hernández JC. (2021). Alteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1. Kasmera. 2021;49(1):e49133736. doi: 10.5281/zenodo.4780969Debido a que la terapia antirretroviral no logra controlar la activación inmune asociada a la infección por VIH-1, el estudio de moléculas inmunomoduladoras puede proporcionar alternativas para su control. En este sentido, el propósito de este estudio fue evaluar la expresión transcripcional de moléculas asociadas con el metabolismo del colesterol-HDL (C-HDL) y con la respuesta inflamatoria mediada por el inflamasoma NLRP3 en pacientes infectados con VIH-1. En este estudio transversal, se incluyeron 23 pacientes VIH-1 sin tratamiento antirretroviral, con diferentes estadios de progresión, 7 de los cuales son controladores (Carga viral <2000 copias/mL) y 16 progresores (Carga viral >2000 copias/mL), además de 7 controles sanos. En células mononucleares de sangre periférica, se cuantificaron los niveles de la expresión transcripcional de ABCA-1, ABCA-3, Caspasa-5 y TXNIP mediante RT-PCR. Se evaluó la asociación de estos parámetros con variables demográficas y de laboratorio, y se encontró que los individuos VIH-1 progresores mostraron niveles significativamente menores de TXNIP y ABCA-3, sugiriendo que durante la infección por VIH-1 se produce una alteración en la expresión de estas moléculas. Dada la complejidad de las interacciones inmuno-metabólicas durante la infección por VIH-1, se necesitan estudios adicionales para establecer los mecanismos precisos involucrados en estas alteraciones.https://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000283088http://orcid.org/0000-0002-9200-5698https://scienti.colciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000011355juanc.hernandezl@campusucc.edu.co1-13Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y EnvigadoMedicinaMedellínhttps://zenodo.org/record/4780969#.YkSa3CjMLfsKasmeraONUSIDA [Internet]. [citado 15 de febrero de 2021]. 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Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers. PLoS One [Internet]. 2015;10(8):e0136292. Disponible en: https://doi.org/10.1371/journal.pone.0136292 DOI: 10.1371/journal.pone.0136292 PMID 26291824 PMCID PMC4546229 Google Académico Microsoft AcadémicoFeria MG, Taborda NA, Hernandez JC, Rugeles MT. HIV replication is associated to inflammasomes activation, IL1β, IL-18 and caspase-1 expression in GALT and peripheral blood. PLoS One [Internet]. 2018;13(4):e0192845. Disponible en: https://doi.org/10.1371/journal.pone.0192845 DOBorrow P. Innate immunity in acute HIV-1 infection. Curr Opin HIV AIDS [Internet]. 2011;6(5):353-63. Disponible en: https://journals.lww.com/cohivandaids/Fulltext/2011/09000/Innate_immunity_in_acute _HIV_1_infection.4.aspx DOI: 10.1097/COH.0b013e3283495996 PMID 21734567 PMCID PMC3266478 Google Académico Microsoft AcadémicoAbad-Fernández M, Vallejo A, Hernández-Novoa B, Díaz L, Gutiérrez C, Madrid N, et al. 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Cardiovascular markers of inflammation and serum lipid levels in HIV-infected patients with undetectable viremia. Sci Rep [Internet]. 2018;8(1):6113. Disponible en: https://doi.org/10.1038/s41598-018-24446-4 DOI: 10.1038/s41598-018-24446-4 PMID 29666424 PMCID PMC5904142 Google Académico Microsoft AcadémicoZhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxininteracting protein links oxidative stress to inflammasome activation. Nat Immunol [Internet]. 2010;11(2):136-40. Disponible en: https://doi.org/10.1038/ni.1831 DOI: 10.1038/ni.1831 PMID 20023662 Google Académico Microsoft AcadémicoKim DO, Byun J-E, Seong H-A, Yoon SR, Choi I, Jung H. Thioredoxin-interacting protein-derived peptide (TN13)inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling. Biochem Biophys Res Commun [Internet]. 2018;507(1):489-95. Disponible en: https://www.sciencedirect.com/science/article/pii/S0006 291X18324847 DOI: 10.1016/j.bbrc.2018.11.069 PMID 30448175 Google Académico Microsoft AcadémicoHe K, Zhu X, Liu Y, Miao C, Wang T, Li P, et al. Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for nonalcoholic fatty liver disease development. Oncotarget [Internet]. 2017;8(23):37657-72. Disponible en: https://www.oncotarget.com/article/17489/text/ DOI: 10.18632/oncotarget.17489 PMID 28499273 PMCID PMC5514938 Google Académico Microsoft AcadémicoViganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A. Human caspase-4 and caspase5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun [Internet]. 2015;6(1):8761. Disponible en: https://doi.org/10.1038/ncomms9761 DOI: 10.1038/ncomms9761 PMID 26508369 PMCID PMC4640152 Google Académico Microsoft AcadémicoMan SM, Karki R, Kanneganti T-D. 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Disponible en: https://www.sciencedirect.com/science/article/pii/S1521661 602952319 DOI: 10.1006/clim.2002.5231 PMID 12217334 Google AcadémicoHIV-1high-density lipoproteinsABCA transportersinflammationAlteración en la expresión de proteínas transportadoras de colesterol y moléculas inmunomoduladoras en pacientes con VIH-1Artículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/92a68109-6296-4da8-bc73-4bb20b79f509/download3bce4f7ab09dfc588f126e1e36e98a45MD52ORIGINALKasmera 2021.pdfKasmera 2021.pdfArtículoapplication/pdf580208https://repository.ucc.edu.co/bitstreams/c9948f07-9d8b-41db-91af-5ef9f3e36b01/downloadf097dc22ff66dff965b53409f4169fdaMD51THUMBNAILKasmera 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