Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression

Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been...

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Autores:
Marín Palma, Damariz
Castro, Gustavo A.
Cardona Arias, Jaiberth Antonio
Urcuqui Inchima, Silvio
Hernández López, Juan Carlos
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad Cooperativa de Colombia
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Repositorio UCC
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OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/15473
Acceso en línea:
https://hdl.handle.net/20.500.12494/15473
Palabra clave:
High-density lipoproteins
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openAccess
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id COOPER2_a8bcb87f1a1daff4c910c70df23de462
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/15473
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
title Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
spellingShingle Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
High-density lipoproteins
title_short Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
title_full Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
title_fullStr Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
title_full_unstemmed Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
title_sort Lower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progression
dc.creator.fl_str_mv Marín Palma, Damariz
Castro, Gustavo A.
Cardona Arias, Jaiberth Antonio
Urcuqui Inchima, Silvio
Hernández López, Juan Carlos
dc.contributor.author.none.fl_str_mv Marín Palma, Damariz
Castro, Gustavo A.
Cardona Arias, Jaiberth Antonio
Urcuqui Inchima, Silvio
Hernández López, Juan Carlos
dc.subject.spa.fl_str_mv High-density lipoproteins
topic High-density lipoproteins
description Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection. Methodology: A cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1β, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Results: HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1β, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1β, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found. Conclusion: In summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018-06-14
dc.date.accessioned.none.fl_str_mv 2019-12-09T20:31:52Z
dc.date.available.none.fl_str_mv 2019-12-09T20:31:52Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.spa.fl_str_mv 1664-3224
dc.identifier.uri.spa.fl_str_mv 10.3389/fimmu.2018.01350
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/15473
dc.identifier.bibliographicCitation.spa.fl_str_mv Marín-Palma D, Castro GA, Cardona-Arias JA, Urcuqui-Inchima S and Hernandez JC (2018) Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression. Front. Immunol. 9:1350. Recuperado de:
identifier_str_mv 1664-3224
10.3389/fimmu.2018.01350
Marín-Palma D, Castro GA, Cardona-Arias JA, Urcuqui-Inchima S and Hernandez JC (2018) Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression. Front. Immunol. 9:1350. Recuperado de:
url https://hdl.handle.net/20.500.12494/15473
dc.relation.isversionof.spa.fl_str_mv https://www.frontiersin.org/articles/10.3389/fimmu.2018.01350/full
dc.relation.ispartofjournal.spa.fl_str_mv Frontiers in Immunology
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dc.rights.license.none.fl_str_mv Atribución
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
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http://purl.org/coar/access_right/c_abf2
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dc.format.extent.spa.fl_str_mv 1-12
dc.coverage.temporal.spa.fl_str_mv 9 (1350)
dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
dc.publisher.program.spa.fl_str_mv Medicina
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spelling Marín Palma, DamarizCastro, Gustavo A.Cardona Arias, Jaiberth AntonioUrcuqui Inchima, SilvioHernández López, Juan Carlos9 (1350)2019-12-09T20:31:52Z2019-12-09T20:31:52Z2018-06-141664-322410.3389/fimmu.2018.01350https://hdl.handle.net/20.500.12494/15473Marín-Palma D, Castro GA, Cardona-Arias JA, Urcuqui-Inchima S and Hernandez JC (2018) Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression. Front. Immunol. 9:1350. Recuperado de:Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection. Methodology: A cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1β, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Results: HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1β, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1β, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found. Conclusion: In summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection.https://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000283088http://orcid.org/0000-0002-9200-5698https://scienti.colciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000011355juanc.hernandezl@campusucc.edu.co1-12Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000MedicinaMedellínhttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01350/fullFrontiers in Immunology1. Salemi M. The intra-host evolutionary and population dynamics of human immunodeficiency virus type 1: a phylogenetic perspective. Infect Dis Rep (2013) 5(Suppl 1):e3. doi:10.4081/idr.2013.s1.e32. UNAIDS. 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Clin Immunol (2002) 104(3):242–7. doi:10.1006/clim. 2002.5231High-density lipoproteinsLower High-Density lipoproteins levels during human immunodeficiency virus type 1 Infection are associated with increased inflammatory markers and disease progressionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINALHDL VIH Frontiers 2018.pdfHDL VIH Frontiers 2018.pdfapplication/pdf1261250https://repository.ucc.edu.co/bitstreams/9db4ac97-0685-4737-8e44-4376bb5792da/download75f93b1570a800dc93b18356a3b5ab60MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/1df02023-ac7d-4aa7-aa03-441c0b8aabdc/download3bce4f7ab09dfc588f126e1e36e98a45MD52TEXTHDL VIH Frontiers 2018.pdf.txtHDL VIH Frontiers 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