Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos

Los biomarcadores son sustancias biológicas utilizadas para indicar el estado biológico de un organismo, es decir, procesos fisiológicos, estados patológicos o respuestas a un fármaco, de esta forma, son sustancias que ayudan a vislumbrar aspectos de diferentes patologías como su tratamiento, diagno...

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Autores:: Barcenas Olaya, Angelica Maria

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2020

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

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dc.title.spa.fl_str_mv	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
title	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
spellingShingle	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos Caninos Diagnostico Biomarcadores Sindrome de disfuncion cognitiva TG 2020 MVZ 15858 Canines Diagnosis Biomarkers Cognitive dysfunction syndrome
title_short	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
title_full	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
title_fullStr	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
title_full_unstemmed	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
title_sort	Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos
dc.creator.fl_str_mv	Barcenas Olaya, Angelica Maria
dc.contributor.advisor.none.fl_str_mv	Trujillo Piso, Dunia Yisela
dc.contributor.author.none.fl_str_mv	Barcenas Olaya, Angelica Maria
dc.subject.spa.fl_str_mv	Caninos Diagnostico Biomarcadores Sindrome de disfuncion cognitiva
topic	Caninos Diagnostico Biomarcadores Sindrome de disfuncion cognitiva TG 2020 MVZ 15858 Canines Diagnosis Biomarkers Cognitive dysfunction syndrome
dc.subject.classification.spa.fl_str_mv	TG 2020 MVZ 15858
dc.subject.other.spa.fl_str_mv	Canines Diagnosis Biomarkers Cognitive dysfunction syndrome
description	Los biomarcadores son sustancias biológicas utilizadas para indicar el estado biológico de un organismo, es decir, procesos fisiológicos, estados patológicos o respuestas a un fármaco, de esta forma, son sustancias que ayudan a vislumbrar aspectos de diferentes patologías como su tratamiento, diagnostico, progresión de la enfermedad y eficacia del tratamiento. La presente revisión tiene como objetivo compilar aspectos importantes acerca del uso de biomarcadores en el diagnóstico temprano del síndrome de disfunción cognitiva en perros; teniendo en cuenta su fisiopatología, el uso de biomarcadores específicos como lo es la medición de β-amiloide en plasma, entre otros.
publishDate	2020
dc.date.accessioned.none.fl_str_mv	2020-01-13T21:21:50Z
dc.date.available.none.fl_str_mv	2020-01-13T21:21:50Z
dc.date.issued.none.fl_str_mv	2020
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
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dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/15858
dc.identifier.bibliographicCitation.spa.fl_str_mv	Barcenas Olaya, A. M. (2020). Uso de biomarcadores bioquimicos para el diagnostico temprano del sindrome de disfuncion cognitiva en caninos. (Tesis de pregrado). Recuperado de: http://hdl.handle.net/20.500.12494/15858
url	https://hdl.handle.net/20.500.12494/15858
identifier_str_mv	Barcenas Olaya, A. M. (2020). Uso de biomarcadores bioquimicos para el diagnostico temprano del sindrome de disfuncion cognitiva en caninos. (Tesis de pregrado). Recuperado de: http://hdl.handle.net/20.500.12494/15858
dc.relation.references.spa.fl_str_mv	Adams, B., Chan, A., Callahan, H., & Milgram, N. (2000). The canine as a model of human cognitive aging: recent developments. Elsevier, 24, 675-692. Obtenido de https://doi.org/10.1016/S0278-5846(00)00101-9 Araujo, J., Landsberg, G., Milgram, N., & Miolo, A. (Abril de 2008). Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. Can Vet J, 49(4), 379-385. Obtenido de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275342/pdf/cvj49pg379.pdf Araujo, J., Rivera, C., Milgram , N., & Sandin, J. (Julio de 2009). Pharmacological Validation Of The Canine Model Of Alzheimer's Disease: Donepezil Improves Memory In Cognitively Impaired Aged Beagle Dogs. Alzheimer's & Dementia, 5(4), e23. Obtenido de https://doi.org/10.1016/j.jalz.2009.07.095 Araujo, J., Studzinski, C., & Milgram, N. (Marzo de 2005). Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(3), 411-422. doi:10.1016/j.pnpbp.2004.12.008 Avila, J. (2002). Las proteínas implicadas en la enfermedad de Alzheimer. Farmaindustria. Azcona, G., Garcia-Belenguer, S., Chacon, G., Rosado, B., Leon, M., & Palacio, J. (2009). Prevalence and risk factors of behavioural changes associated with agerelated cognitive impairment in geriatric dogs. J. Small Anim Practice, 50, 87-91. Obtenido de 10.1111/j.1748-5827.2008.00718.x Bernedo, V., Insua, D., Suarez, M., Santamarina, G., Sarasa, M., & Pesini, P. (Abril de 2009). Beta-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog. J Comp Neurol, 513(4), 417-429. doi:10.1002/cne.21985 Borras, D., Ferrer, I., & Pumarola, M. (1999). Age-related Changes in the Brain of the Dog. Vet Pathol, 36, 202-211. Obtenido de https://journals.sagepub.com/doi/pdf/10.1354/vp.36-3-202 Bottiglieri, T. (Noviembre de 2002). S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule. Am J Clin Nutr, 76(5). doi:10.1093/ajcn/76/5.1151S Carrillo, M., Ivy, G., Milgram, N., Head, E., Wu, P., & Kitani, K. (1994). (-)deprenyl increases activities of Superoxide Dismutase (SOD) in striatum of dog brain. Life Sciences, 54(20), 1483-1489. Obtenido de https://doi.org/10.1016/0024-3205(94)90015-9 Cummings, B., Head, E., Ruhel, W., Milgram, N., & Cotman, C. (1996). The canine as an animal model of human aging and dementia. Neurobiol Aging, 17. Obtenido de https://doi.org/10.1016/0197-4580(95)02060-8 Doty, R., Shaman, P., Applebaum, S., Giberson, R., Siksorski, L., & Rosenberg, L. (1984). Smell identification ability: changes with age. Science, 226, 1441-1443. doi:10.1126/science.6505700 Gonzales Martinez, A. (Junio de 2014). Estudio del Sindrome de Disfuncion Cognitiva en el Perro. 32-35. Obtenido de https://pdfs.semanticscholar.org/98e7/36c441480590266090bd624332f6351a8ff0.pdf Gonzales Martinez, A., Rosado, B., Garcia Belenguer, S., & Suarez, M. (2012). Síndrome de disfunción cognitiva en el perro geriátrico. Clin. Vet. Peq. Anim, 32(3), 159-167. Obtenido de https://ddd.uab.cat/pub/clivetpeqani/clivetpeqani_a2012v32n3/clivetpeqaniv32n3p159.pdf Guillozet, A., Weintraub, S., Mash, D., & Mesulam, M. (Mayo de 2003). Neurofibrillary Tangles, Amyloid, and Memory in Aging and Mild Cognitive Impairment. Arch Neurol, 60(5), 729-736. doi:10.1001/archneur.60.5.729 Head, E. (2007). Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Ann N Y Acad Sci, 1114, 398-406. Obtenido de 10.1196/annals.1396.004 Head, E., & Milgram, N. (Noviembre de 1992). Changes in spontaneous behavior in the dog following oral administration of L-deprenyl. Pharmacology Biochemistry and Behavior, 43(3), 749-757. Obtenido de https://doi.org/10.1016/0091-3057(92)90404-4 Head, E., Callahan, H., Cummings, B., Cotman, C., Ruehl, W., Muggenberg, B., & Milgram, N. (1997). Open Field Activity and Human Interaction as a Function of Age and Breed in Dogs. Physiology & Behavior, 62(5), 963-971. Obtenido de https://doi.org/10.1016/S0031-9384(97)00198-4 Head, E., Callahan, H., Muggenburg, A., Cotman, W., & Milgram, N. (1998). Visual-Discrimination Learning Ability and b-Amyloid Accumulation in the Dog. Neurobiology of Aging, 19(5), 415-425. Obtenido de https://doi.org/10.1016/S0197-4580(98)00084-0 Head, E., Pop, V., & Sarzosa, F. (2010). Amyloid B-peptide and oligomers in the brain and CSF of aged. J Alzheimers Dis, 20, 637-646. doi:10.3233/JAD-2010-1397 Heinonen, E., & Lammintausta, R. (1991). A review of the pharmacology of selegiline. Acta Neurol Scand Suppl, 136, 44-59. doi:10.1111/j.1600-0404.1991.tb05020.x Hoover, B., Reed, M., Su, J., Penrod, R., Kotilinek, L., Grant, M., . . . Liao, D. (22 de Diciembre de 2010). Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron, 68(6), 1067-1081. doi:10.1016/j.neuron.2010.11.030 Horrocks, L., & Yeo, Y. (1999). HEALTH BENEFITS OF DOCOSAHEXAENOIC ACID DHA ( ). Pharmacological Research, 40(3), 211- 225. doi: 10.1006/phrs.1999.0495 Humpel, C. (Enero de 2011). Identifying and validating biomarkers for Alzheimer's disease. Trends Biotechnol, 29(1), 26–32. Obtenido de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016495/ Jiang, Y., Huang, H., Abner, E., Broster, L., Jicha, G., Schmitt, F., . . . Ding, M. (Febrero de 2016). Alzheimer's Biomarkers are Correlated with Brain Connectivity in Older Adults Differentially during Resting and Task States. Front Aging Neurosci, 8(15), 1-12. doi:10.3389/fnagi.2016.00015 Kidd, P. (1999). A Review of Nutrients and Botanicals in the Integrative Management of Cognitive Dysfunction. Alternative Medicine Review, 4(3), 144-161. Obtenido de http://archive.foundationalmedicinereview.com/publications/4/3/144.pdf Knoll, J. (1998). (-)Deprenyl (Selegiline), a Catecholaminergic Activity Enhancer (CAE) Substance Acting in the Brain . Pharmacology & Toxicology, 82, 57-66. doi:10.1111/j.1600-0773.1998.tb01399.x Landsberg, G. (Marzo de 2005). Therapeutic agents for the treatment of cognitive dysfunction syndrome in senior dogs. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(3), 471-479. Obtenido de https://doi.org/10.1016/j.pnpbp.2004.12.012 Landsberg, G. (2006). Therapeutic options for cognitive decline in senior pets. J Am Anim Hosp Assoc, 42(6), 407-413. doi:10.5326/0420407 Landsberg, G., & Araujo, J. (2005). Behavior problems in geriatric pets. Vet Clin Small Anim, 35, 675-698. Obtenido de https://doi.org/10.1016/j.cvsm.2004.12.008 Landsberg, G., DePorter, T., & Araujo, J. (Mayo de 2011). Clinical Signs and Management of Anxiety, Sleeplessness, and Cognitive Dysfunction in the Senior Pet. Veterinary Clinics of North America: Small Animal Practice, 41(3), 565-590. Obtenido de https://doi.org/10.1016/j.cvsm.2011.03.017 Lock, E., & Bonventre, J. (Marzo de 2008). Biomarkers in translation; past, present and future. Toxicology, 243(3), 163-166. doi:10.1016/j.tox.2007.12.004 Markus, H., Ring, h., Kouris, K., & Costa, D. (1993). Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly: an HMPAO SPECT study. Nucl Med Commun, 14, 628-633. doi:10.1097/00006231-199308000-00002 McMillan, F. (Mayo/Junio de 2003). Maximizing Quality of Life in III Animals. Journal of the American Animal Hospital Association, 39(3), 227-235. Obtenido de https://doi.org/10.5326/0390227 Mentzel, R. (s.f). Demencia Senil Canina. 1-5. Buenos Aires, Argentina. Obtenido de https://www.agilityeuskadi.com/documentos/Demencia%20Senil%20Canina.pdf Milgram, N., Head, E., Zicker, S., Ikeda-Douglas, C., Murphey, H., Muggenberg, B., . . . Cotman, C. (Mayo de 2004). Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental Gerontology, 39(5), 753-765. Obtenido de https://doi.org/10.1016/j.exger.2004.01.007 Neilson, J., Hart, B., Cliff, K., & Ruehl, W. (2001). Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association, 218(11), 1787 - 1791. doi:10.2460/javma.2001.218.1787 Osella, M., Re, G., & Odore, R. (2007). Canine cognitive dysfunction syndrome:Prevalence, clinical signs and treatment with a neuroprotective nutraceutical. Appl Anim Behav Sci, 105, 297-310. Peremans, K., Audenaert, K., Blanckaert, P., Jacobs, F., Coopman, F., Verschooten, F., . . . Dierckx, R. (2002). Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 26, 1393 – 1404. Obtenido de https://doi.org/10.1016/S0278-5846(02)00306-8 Ruehl, W., Bruyette, D., DePaoli, A., Cotman, C., Head, E., Milgram, N., & Cummings, B. (1995). Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer’s disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Elsevier , 106, 217-225. Obtenido de 10.1016/s0079-6123(08)61218-2 Scheff, S., Price, D., Schmitt, F., DeKosky, S., & Mufson, E. (Mayo de 2007). Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology, 68(18), 1501-1508. doi:10.1212/01.wnl.0000260698.46517.8f Seshadri, S., Beiser, A., Selhub, J., Jacques, P., Rosenberg, I., D'Agostino, R., . . . Wolf, P. (Febrero de 2002). Plasma homocysteine as a risk factor for dementia and Alzheimer´s disease. N Engl J Med, 346(7), 476-483. doi:10.1056/NEJMoa011613 Siwak, C., Callahan, H., & Milgram, N. (Julio de 2000). Adrafinil: Effects on behavior and cognition in aged canines. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 24(5), 709-726. Obtenido de https://doi.org/10.1016/S0278-5846(00)00103-2 Siwak, C., Gruet, H., Woehrlé, D., Muggenburg, D., Murphey, P., & Milgram, N. (Noviembre de 2000). Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. American Journal of Veterinary Research, 61(11), 1410-1414. Obtenido de https://doi.org/10.2460/ajvr.2000.61.1410 Siwak, C., Tapp, D., & Milgam, N. (2001). Effect of Age and Level of Cognitive Function on Spontaneous and Exploratory Behaviors in the Beagle Dog. LEARNING & MEMORY, 8, 317–325. doi:10.1101/lm.41701 Siwak, C., Tapp, D., & Milgram, N. (Agosto de 2003). Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs. Pharmacology Biochemistry nad Behavior, 76(1), 161-168. Obtenido de https://doi.org/10.1016/S0091-3057(03)00211-9 Su, M., Head, E., & Brooks, w. (1998). MR imaging of anatomic and vascular characteristics in a canine model of human again. Neurobiol Agin, 19, 479-485. Tapp, D., Siwak, C., Qiang Gao, F., Yuan Chiou, J., Black, S., Head, E., . . . Ying Su, M. (22 de Septiembre de 2004). The Journal of Neuroscience, 24(38), 8205– 8213. Obtenido de https://doi.org/10.1523/JNEUROSCI.1339-04.2004 Vermeire, S., Audenaert , K., Vandermeulen, E., Waelbers, T., De Spiegeleer, B., van Bree, H., & Peremans, K. (2011). Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs. The Veterinary Journal , 188, 356–358. Obtenido de https://doi.org/10.1016/j.tvjl.2010.05.020 Yalcin, E., Kasap, S., & Demir, G. (2010). Prevalence of behavioral changes associated with Age-Related Cognitive Impairment in Geriatric Dogs, Bursa, Turkey. Journal of Animal and Veterinary Advances, 9(13), 1828-1832. doi:10.3923/javaa.2010.1828.1832 Yu, W., & Lu, B. (2012). Synapses and dendritic spines as pathogenic targets in Alzheimer's disease. Neural Plast, 2012, 1-8. doi:10.1155/2012/247150
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spelling	Trujillo Piso, Dunia YiselaBarcenas Olaya, Angelica Maria2020-01-13T21:21:50Z2020-01-13T21:21:50Z2020https://hdl.handle.net/20.500.12494/15858Barcenas Olaya, A. M. (2020). Uso de biomarcadores bioquimicos para el diagnostico temprano del sindrome de disfuncion cognitiva en caninos. (Tesis de pregrado). Recuperado de: http://hdl.handle.net/20.500.12494/15858Los biomarcadores son sustancias biológicas utilizadas para indicar el estado biológico de un organismo, es decir, procesos fisiológicos, estados patológicos o respuestas a un fármaco, de esta forma, son sustancias que ayudan a vislumbrar aspectos de diferentes patologías como su tratamiento, diagnostico, progresión de la enfermedad y eficacia del tratamiento. La presente revisión tiene como objetivo compilar aspectos importantes acerca del uso de biomarcadores en el diagnóstico temprano del síndrome de disfunción cognitiva en perros; teniendo en cuenta su fisiopatología, el uso de biomarcadores específicos como lo es la medición de β-amiloide en plasma, entre otros.Biomarkers are biological substances used to indicate the biological state of an organism, that is, physiological processes, pathological states or responses to a drug, in this way, they are substances that help to glimpse aspects of different pathologies such as their treatment, diagnosis, progression of the disease and efficacy of the treatment. This review aims to compile important aspects about the use of biomarkers in early diagnosis of cognitive dysfunction syndrome in dogs; taking into account its pathophysiology, the use of specific biomarkers such as the measurement of β – amyloid in plasma, among others.angelica.barcenas@campusucc.edu.co19 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéCaninosDiagnosticoBiomarcadoresSindrome de disfuncion cognitivaTG 2020 MVZ 15858CaninesDiagnosisBiomarkersCognitive dysfunction syndromeUso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninosTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Adams, B., Chan, A., Callahan, H., & Milgram, N. (2000). The canine as a model of human cognitive aging: recent developments. Elsevier, 24, 675-692. Obtenido de https://doi.org/10.1016/S0278-5846(00)00101-9Araujo, J., Landsberg, G., Milgram, N., & Miolo, A. (Abril de 2008). Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. Can Vet J, 49(4), 379-385. Obtenido de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275342/pdf/cvj49pg379.pdfAraujo, J., Rivera, C., Milgram , N., & Sandin, J. (Julio de 2009). Pharmacological Validation Of The Canine Model Of Alzheimer's Disease: Donepezil Improves Memory In Cognitively Impaired Aged Beagle Dogs. Alzheimer's & Dementia, 5(4), e23. Obtenido de https://doi.org/10.1016/j.jalz.2009.07.095Araujo, J., Studzinski, C., & Milgram, N. (Marzo de 2005). Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(3), 411-422. doi:10.1016/j.pnpbp.2004.12.008Avila, J. (2002). Las proteínas implicadas en la enfermedad de Alzheimer. Farmaindustria.Azcona, G., Garcia-Belenguer, S., Chacon, G., Rosado, B., Leon, M., & Palacio, J. (2009). Prevalence and risk factors of behavioural changes associated with agerelated cognitive impairment in geriatric dogs. J. Small Anim Practice, 50, 87-91. Obtenido de 10.1111/j.1748-5827.2008.00718.xBernedo, V., Insua, D., Suarez, M., Santamarina, G., Sarasa, M., & Pesini, P. (Abril de 2009). Beta-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog. J Comp Neurol, 513(4), 417-429. doi:10.1002/cne.21985Borras, D., Ferrer, I., & Pumarola, M. (1999). Age-related Changes in the Brain of the Dog. Vet Pathol, 36, 202-211. Obtenido de https://journals.sagepub.com/doi/pdf/10.1354/vp.36-3-202Bottiglieri, T. (Noviembre de 2002). S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule. Am J Clin Nutr, 76(5). doi:10.1093/ajcn/76/5.1151SCarrillo, M., Ivy, G., Milgram, N., Head, E., Wu, P., & Kitani, K. (1994). (-)deprenyl increases activities of Superoxide Dismutase (SOD) in striatum of dog brain. Life Sciences, 54(20), 1483-1489. Obtenido de https://doi.org/10.1016/0024-3205(94)90015-9Cummings, B., Head, E., Ruhel, W., Milgram, N., & Cotman, C. (1996). The canine as an animal model of human aging and dementia. Neurobiol Aging, 17. Obtenido de https://doi.org/10.1016/0197-4580(95)02060-8Doty, R., Shaman, P., Applebaum, S., Giberson, R., Siksorski, L., & Rosenberg, L. (1984). Smell identification ability: changes with age. Science, 226, 1441-1443. doi:10.1126/science.6505700Gonzales Martinez, A. (Junio de 2014). Estudio del Sindrome de Disfuncion Cognitiva en el Perro. 32-35. 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Uso de biomarcadores bioquímicos para el diagnóstico temprano del síndrome de disfunción cognitiva en caninos

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