Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as V...

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Autores:: Gonzalez SM
Aguilar-Jimenez W
Trujillo-Gil E
Zapata Builes, Wildeman
Su RC
Ball TB
Rugeles MT

Tipo de recurso:: Article of journal

Fecha de publicación:: 2023

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

id	COOPER2_a5abe82f6ccd4b0a785117e412d35ce5
oai_identifier_str	oai:repository.ucc.edu.co:20.500.12494/50862
network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
spelling	Gonzalez SMAguilar-Jimenez WTrujillo-Gil EZapata Builes, WildemanSu RCBall TBRugeles MT2023-05-24T16:30:10Z2023-05-24T16:30:10Z24/09/2019https://doi.org/10.1371/journal.pone.0222878https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072621197&doi=10.1371%2fjournal.pone.0222878&partnerID=40&md5=b78f8c6531c0f729ab14e3d5dc1a894319326203https://hdl.handle.net/20.500.12494/50862Gonzalez SM,Aguilar-Jimenez W,Trujillo-Gil E,Zapata Builes Wildeman,Su RC,Ball TB,Rugeles MT.Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes..Plos One. 2019. 14. (9): e0222878Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as Vitamin D (VitD) may reduce HIV-1 transmission and might be used as a safe and cost-effective strategy for prevention. Considering this, we examined the in vitro effect of the treatment of peripheral blood mononuclear cells (PBMCs) with the active form of VitD, calcitriol, on cellular activation, function and susceptibility of CD4+ T cells to HIV-1 infection.0000-0002-7351-8738wildeman.zapatab@campusucc.edu.coe0222878Public Library of ScienceADP RIBOSYL CYCLASE/CYCLIC ADP RIBOSE HYDROLASE 1ANTIMICROBIAL CATIONIC PEPTIDEAPOBEC3G GENEAPOBEC3G PROTEIN, HUMANAPOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3GARTICLEBLOODCALCITRIOLCAMP GENECANADACAP18 LIPOPOLYSACCHARIDE-BINDING PROTEINCATHELICIDINCD4+ T LYMPHOCYTECELL CLONINGCELL CULTURECOHORT ANALYSISCOLOMBIACONTROLLED STUDYDRUG EFFECTFEMALEGRANZYMEHLA DR ANTIGENHUMANHUMAN CELLHUMAN IMMUNODEFICIEHUMAN IMMUNODEFICIENCY VIRUS INFECTIONIMMUNOGLOBULIN ENHANCER BINDING PROTEINIMMUNOMODULATIONIN VITRO STUDYINFECTION SENSITIVITYINTERLEUKIN 2LYMPHOCYTE ACTIVATIONLYMPHOCYTE FUNCTIONMACROPHAGE INFLAMMATORY PROTEIN 1BETAMALEPERIPHERAL BLOOD MONONUCLEAR CELLPROTEIN EXPRESSIONSERODIAGNOSIST LYMPHOCYTE SUBPOPULATIONVIRAL TROPISMVIRUS GENEVIRUS RECEPTORVIRUS STRAINVITAMINVitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.Artículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionPlos Oneinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/50862oai:repository.ucc.edu.co:20.500.12494/508622024-08-20 16:19:51.422metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
spellingShingle	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes. ADP RIBOSYL CYCLASE/CYCLIC ADP RIBOSE HYDROLASE 1 ANTIMICROBIAL CATIONIC PEPTIDE APOBEC3G GENE APOBEC3G PROTEIN, HUMAN APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G ARTICLE BLOOD CALCITRIOL CAMP GENE CANADA CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN CATHELICIDIN CD4+ T LYMPHOCYTE CELL CLONING CELL CULTURE COHORT ANALYSIS COLOMBIA CONTROLLED STUDY DRUG EFFECT FEMALE GRANZYME HLA DR ANTIGEN HUMAN HUMAN CELL HUMAN IMMUNODEFICIE HUMAN IMMUNODEFICIENCY VIRUS INFECTION IMMUNOGLOBULIN ENHANCER BINDING PROTEIN IMMUNOMODULATION IN VITRO STUDY INFECTION SENSITIVITY INTERLEUKIN 2 LYMPHOCYTE ACTIVATION LYMPHOCYTE FUNCTION MACROPHAGE INFLAMMATORY PROTEIN 1BETA MALE PERIPHERAL BLOOD MONONUCLEAR CELL PROTEIN EXPRESSION SERODIAGNOSIS T LYMPHOCYTE SUBPOPULATION VIRAL TROPISM VIRUS GENE VIRUS RECEPTOR VIRUS STRAIN VITAMIN
title_short	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_full	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_fullStr	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_full_unstemmed	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
title_sort	Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.
dc.creator.fl_str_mv	Gonzalez SM Aguilar-Jimenez W Trujillo-Gil E Zapata Builes, Wildeman Su RC Ball TB Rugeles MT
dc.contributor.author.none.fl_str_mv	Gonzalez SM Aguilar-Jimenez W Trujillo-Gil E Zapata Builes, Wildeman Su RC Ball TB Rugeles MT
dc.subject.spa.fl_str_mv	ADP RIBOSYL CYCLASE/CYCLIC ADP RIBOSE HYDROLASE 1 ANTIMICROBIAL CATIONIC PEPTIDE APOBEC3G GENE APOBEC3G PROTEIN, HUMAN APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G ARTICLE BLOOD CALCITRIOL CAMP GENE CANADA CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN CATHELICIDIN CD4+ T LYMPHOCYTE CELL CLONING CELL CULTURE COHORT ANALYSIS COLOMBIA CONTROLLED STUDY DRUG EFFECT FEMALE GRANZYME HLA DR ANTIGEN HUMAN HUMAN CELL HUMAN IMMUNODEFICIE HUMAN IMMUNODEFICIENCY VIRUS INFECTION IMMUNOGLOBULIN ENHANCER BINDING PROTEIN IMMUNOMODULATION IN VITRO STUDY INFECTION SENSITIVITY INTERLEUKIN 2 LYMPHOCYTE ACTIVATION LYMPHOCYTE FUNCTION MACROPHAGE INFLAMMATORY PROTEIN 1BETA MALE PERIPHERAL BLOOD MONONUCLEAR CELL PROTEIN EXPRESSION SERODIAGNOSIS T LYMPHOCYTE SUBPOPULATION VIRAL TROPISM VIRUS GENE VIRUS RECEPTOR VIRUS STRAIN VITAMIN
topic	ADP RIBOSYL CYCLASE/CYCLIC ADP RIBOSE HYDROLASE 1 ANTIMICROBIAL CATIONIC PEPTIDE APOBEC3G GENE APOBEC3G PROTEIN, HUMAN APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G ARTICLE BLOOD CALCITRIOL CAMP GENE CANADA CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN CATHELICIDIN CD4+ T LYMPHOCYTE CELL CLONING CELL CULTURE COHORT ANALYSIS COLOMBIA CONTROLLED STUDY DRUG EFFECT FEMALE GRANZYME HLA DR ANTIGEN HUMAN HUMAN CELL HUMAN IMMUNODEFICIE HUMAN IMMUNODEFICIENCY VIRUS INFECTION IMMUNOGLOBULIN ENHANCER BINDING PROTEIN IMMUNOMODULATION IN VITRO STUDY INFECTION SENSITIVITY INTERLEUKIN 2 LYMPHOCYTE ACTIVATION LYMPHOCYTE FUNCTION MACROPHAGE INFLAMMATORY PROTEIN 1BETA MALE PERIPHERAL BLOOD MONONUCLEAR CELL PROTEIN EXPRESSION SERODIAGNOSIS T LYMPHOCYTE SUBPOPULATION VIRAL TROPISM VIRUS GENE VIRUS RECEPTOR VIRUS STRAIN VITAMIN
description	Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as Vitamin D (VitD) may reduce HIV-1 transmission and might be used as a safe and cost-effective strategy for prevention. Considering this, we examined the in vitro effect of the treatment of peripheral blood mononuclear cells (PBMCs) with the active form of VitD, calcitriol, on cellular activation, function and susceptibility of CD4+ T cells to HIV-1 infection.
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-05-24T16:30:10Z
dc.date.available.none.fl_str_mv	2023-05-24T16:30:10Z
dc.date.issued.none.fl_str_mv	24/09/2019
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.1371/journal.pone.0222878 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072621197&doi=10.1371%2fjournal.pone.0222878&partnerID=40&md5=b78f8c6531c0f729ab14e3d5dc1a8943
dc.identifier.issn.spa.fl_str_mv	19326203
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/50862
dc.identifier.bibliographicCitation.spa.fl_str_mv	Gonzalez SM,Aguilar-Jimenez W,Trujillo-Gil E,Zapata Builes Wildeman,Su RC,Ball TB,Rugeles MT.Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes..Plos One. 2019. 14. (9): e0222878
url	https://doi.org/10.1371/journal.pone.0222878 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072621197&doi=10.1371%2fjournal.pone.0222878&partnerID=40&md5=b78f8c6531c0f729ab14e3d5dc1a8943 https://hdl.handle.net/20.500.12494/50862
identifier_str_mv	19326203 Gonzalez SM,Aguilar-Jimenez W,Trujillo-Gil E,Zapata Builes Wildeman,Su RC,Ball TB,Rugeles MT.Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes..Plos One. 2019. 14. (9): e0222878
dc.relation.ispartofjournal.spa.fl_str_mv	Plos One
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv	http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
rights_invalid_str_mv	http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv	e0222878
dc.publisher.spa.fl_str_mv	Public Library of Science
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814246997175042048

Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

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