Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes.

Mucosal immune activation, in the context of sexual transmission of HIV-1 infection, is crucial, as the increased presence of activated T cells enhance susceptibility to infection. In this regard, it has been proposed that immunomodulatory compounds capable of modulating immune activation, such as Vitamin D (VitD) may reduce HIV-1 transmission and might be used as a safe and cost-effective strategy for prevention. Considering this, we examined the in vitro effect of the treatment of peripheral blood mononuclear cells (PBMCs) with the active form of VitD, calcitriol, on cellular activation, function and susceptibility of CD4+ T cells to HIV-1 infection.

• Autores: Gonzalez SM; Aguilar-Jimenez W; Trujillo-Gil E; Zapata Builes, Wildeman; Su RC; Ball TB; Rugeles MT
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/50862
• Acceso en línea: https://doi.org/10.1371/journal.pone.0222878; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072621197&doi=10.1371%2fjournal.pone.0222878&partnerID=40&md5=b78f8c6531c0f729ab14e3d5dc1a8943; https://hdl.handle.net/20.500.12494/50862
• Palabra clave: ADP RIBOSYL CYCLASE/CYCLIC ADP RIBOSE HYDROLASE 1; ANTIMICROBIAL CATIONIC PEPTIDE; APOBEC3G GENE; APOBEC3G PROTEIN, HUMAN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; ARTICLE; BLOOD; CALCITRIOL; CAMP GENE; CANADA; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; CATHELICIDIN; CD4+ T LYMPHOCYTE; CELL CLONING; CELL CULTURE; COHORT ANALYSIS; COLOMBIA; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GRANZYME; HLA DR ANTIGEN; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATION; IN VITRO STUDY; INFECTION SENSITIVITY; INTERLEUKIN 2; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; SERODIAGNOSIS; T LYMPHOCYTE SUBPOPULATION; VIRAL TROPISM; VIRUS GENE; VIRUS RECEPTOR; VIRUS STRAIN; VITAMIN
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2