Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática
La exposición excesiva al fluoruro está asociada efectos adversos en la salud humana, en ese sentido, la presente revisión sistemática tuvo como Objetivo: Analizar las investigaciones publicadas relacionadas con los efectos del consumo excesivo de fluoruro en la salud humana, a partir de una revisió...
- Autores:
-
Lara Garcia, Liceth Marina
Carrillo Gaona, Glender Stiven
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_f744
- Fecha de publicación:
- 2021
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/37027
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/37027
- Palabra clave:
- Flúor
Enfermedades
Efectos adversos
TG 2021 ODO 37027
Fluorine
Diseases
Adverse effects
- Rights
- openAccess
- License
- Atribución – No comercial – Sin Derivar
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Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| title |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| spellingShingle |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática Flúor Enfermedades Efectos adversos TG 2021 ODO 37027 Fluorine Diseases Adverse effects |
| title_short |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| title_full |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| title_fullStr |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| title_full_unstemmed |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| title_sort |
Efectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemática |
| dc.creator.fl_str_mv |
Lara Garcia, Liceth Marina Carrillo Gaona, Glender Stiven |
| dc.contributor.advisor.none.fl_str_mv |
Gómez Scarpetta, Ruth Ángela |
| dc.contributor.author.none.fl_str_mv |
Lara Garcia, Liceth Marina Carrillo Gaona, Glender Stiven |
| dc.subject.spa.fl_str_mv |
Flúor Enfermedades Efectos adversos |
| topic |
Flúor Enfermedades Efectos adversos TG 2021 ODO 37027 Fluorine Diseases Adverse effects |
| dc.subject.classification.spa.fl_str_mv |
TG 2021 ODO 37027 |
| dc.subject.other.spa.fl_str_mv |
Fluorine Diseases Adverse effects |
| description |
La exposición excesiva al fluoruro está asociada efectos adversos en la salud humana, en ese sentido, la presente revisión sistemática tuvo como Objetivo: Analizar las investigaciones publicadas relacionadas con los efectos del consumo excesivo de fluoruro en la salud humana, a partir de una revisión sistemática de la literatura. Materiales y métodos: Se realizó una búsqueda bibliográfica durante 7 meses en las bases de datos de Medline (Pubmed), Scielo, y Springer, utilizando las palabras claves: fluorine and diseases, fluoride-effects y fluorine-diseases y operador boleano AND. Los criterios de inclusión utilizados en la búsqueda de los artículos científicos fueron: Estudios primarios y secundarios en idioma español e inglés; Fecha de publicación de los trabajos de investigación científicas, desde el 2011 al 2021; Estudios de tipo observacionales, dirigidos a seres humanos, de diferentes partes del mundo y para cualquier grupo etario. La exclusión de la literatura gris, las revisiones narrativas y las tesis. Resultados: De 87 publicaciones, relacionadas con la estrategia de búsqueda, se escogieron 22 artículos completos que cumplían los criterios de inclusión y la evaluación de calidad según tipo de estudio. Los estudios analizados sugirieron una relación entre el exceso de fluoruro y las enfermedades Osteo-Esqueléticos, enfermedades Cardiometabolicas, oculares, hematológicas, endocrinas, renales y neurológicos y una correlación inversamente proporcional entre el exceso de fluoruro y el cociente intelectual Conclusión. El fluoruro en altas concentraciones y por tiempos prolongados está relacionado con efectos adversos en la salud humana, afectando más comúnmente a los niños y los jóvenes. Palabras clave: flúor y enfermedades, efectos del flúor, enfermedades del flúor. Introducción |
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2021 |
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2021-11-30T21:03:23Z |
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2021-11-20 |
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Acta de memorias |
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http://purl.org/coar/resource_type/c_8042 |
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Lara García, L. M. y Carrillo Gaona G. S. (2021). Efectos adversos del consumo excesivo de flúor en la salud humana, revisión sistemática [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia.http://hdl.handle.net/20.500.12494/37027 |
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Lara García, L. M. y Carrillo Gaona G. S. (2021). Efectos adversos del consumo excesivo de flúor en la salud humana, revisión sistemática [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia.http://hdl.handle.net/20.500.12494/37027 |
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Malin AJ, Bose S, Busgang SA, Gennings C, Thorpy M, Wright RO, et al. Fluoride exposure and sleep patterns among older adolescents in the United States: A cross- sectional study of NHANES 2015-2016. Environ Heal A Glob Access Sci Source. 2019;18(1):1–9. Zaror C, Vallejos C, Corsini G, de la Puente C, Velásquez M, Tessada-Sepúlveda R, et al. Revisión Sistemática sobre los Efectos Adversos de la Fluoración del Agua. Int J Odontostomatol. 2015;9(1):165–71. Malin AJ, Till C. Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: An ecological association Children’s Environmental Health. Environ Heal A Glob Access Sci Source. 2015;14(1):1–10. Waugh DT. The contribution of fluoride to the pathogenesis of eye diseases: Molecular mechanisms and implications for public health. Int J Environ Res Public Health. 2019;16(5) Tao H, Yang L, Ping A, Quan L, Yang X, Zhang Y, et al. Interpretation of AMSTAR 2: A critical appraisal tool for systematic reviews that include randomized or non- randomized studies of healthcare interventions. Chinese J Evidence-Based Med. 2018;18(1):101–8. Carson Ka-Lok Lo, Dominik Mertz, Mark Loeb.Newcastle-Ottawa Scale: comparing reviewers’ to authors’. assessments.BMC Medical Research Methodology. 2014; 14: 45. Rostom A, Dubé C, Cranney A, et al. Appendix D. Quality Assessment Forms. NCBI _[Internet] 2004 [09 de septiembre del 2021]; https://www.ncbi.nlm.nih.gov/books/NBK35156/ Mohammadi AA, Yousefi M, Yaseri M, Jalilzadeh M, Mahvi AH. Skeletal fluorosis in relation to drinking water in rural areas of West Azerbaijan, Iran. Sci Rep [Internet]. 2017;7(1):4–10. Available from: http://dx.doi.org/10.1038/s41598-017-17328-8 Levy M, Leclerc BS. Fluoride in drinking water and osteosarcoma incidence rates in the continental United States among children and adolescents. Cáncer Epidemiol. 2012;36(2):83–8. Liu Y, Téllez-Rojo M, Sánchez BN, Ettinger AS, Osorio-Yáñez C, Solano M, et al. Association between fluoride exposure and cardiometabolic risk in peripubertal 37 Mexican children. Environ Int [Internet]. 2020;134(October 2019):105302. Available from: https://doi.org/10.1016/j.envint.2019.105302 Chaitanya NC, Karunakar P, Allam NS, Priya MH, Alekhya B, Nauseen S. A systematic analysis on possibility of water fluoridation causing hypothyroidism. Indian J Dent Res. 2017;29(2):212–6 Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, et al. Threshold effects of moderately excessive fluoride exposure on children’s health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int [Internet]. 2018;118(May):116–24. Available from: https://doi.org/10.1016/j.envint.2018.05.042 Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in england? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015;69(7):619–24. Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Environ Int [Internet]. 2018;121(September):667–74. Available from: https://doi.org/10.1016/j.envint.2018.09.026 Waugh DT. Fluoride exposure induces inhibition of sodium/iodide symporter (NIS) contributing to impaired iodine absorption and iodine deficiency: Molecular mechanisms of inhibition and implications for public health. Int J Environ Res Public Health. 2019;16(6). Pornprasert S, Wanachantararak P, Kantawong F, Chamnanprai S, Kongpan C, Pienthai N, et al. Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Environ Geochem Health. 2017;39(4):751–8. Sun L, Gao Y, Liu H, Zhang W, Ding Y, Li B, et al. An assessment of the relationship between excess fluoride intake from drinking water and essential hypertension in adults residing in fluoride endemic areas. Sci Total Environ [Internet]. 2013; 443:864–9. Available from: http://dx.doi.org/10.1016/j.scitotenv.2012.11.021 Fernando WBNT, Nanayakkara N, Gunarathne L, Chandrajith R. Serum and urine fluoride levels in populations of high environmental fluoride exposure with endemic CKDu: a case–control study from Sri Lanka. Environ Geochem Health [Internet]. 2020;42(5):1497–504. Available from: https://doi.org/10.1007/s10653- 019-00444-x Nanayakkara S, Senevirathna STMLD, Harada KH, Chandrajith R, Nanayakkara N, Koizumi A. The Influence of fluoride on chronic kidney disease of uncertain aetiology (CKDu) in Sri Lanka. Chemosphere [Internet]. 2020; 257:127186. Available from: https://doi.org/10.1016/j.chemosphere.2020.127186 Wasana HMS, Aluthpatabendi D, Kularatne WMTD, Wijekoon P, Weerasooriya R, Bandara J. Drinking water quality and chronic kidney disease of unknown etiology (CKDu): synergic effects of fluoride, cadmium and hardness of water. Environ Geochem Health. 2016;38(1):157–68. Jiménez-Córdova MI, González-Horta C, Ayllón-Vergara JC, Arreola-Mendoza L, Aguilar-Madrid G, Villareal-Vega EE, et al. Evaluation of vascular and kidney injury biomarkers in Mexican children exposed to inorganic fluoride. Environ Res [Internet]. 2019;169(July 2018):220–8. Available from: https://doi.org/10.1016/j.envres.2018.10.028 Jiménez-Córdova MI, Cárdenas-González M, Aguilar-Madrid G, Sanchez-Peña LC, Barrera-Hernández Á, Domínguez-Guerrero IA, et al. Evaluation of kidney injury biomarkers in an adult Mexican population environmentally exposed to fluoride and low arsenic levels. Toxicol Appl Pharmacol [Internet]. 2018; 352:97–106. Available from: https://doi.org/10.1016/j.taap.2018.05.027 Sebastian ST, Sunitha S. A cross-sectional study to assess the intelligence quotient (IQ) of school going children aged 10-12 years in villages of Mysore district, India with different fluoride levels. J Indian Soc Pedod Prev Dent. 2015;33(4):30711.Principio del formulario Duan Q, Jiao J, Chen X, Wang X. Association between water fluoride and the level of children’s intelligence: a dose–response meta-analysis. Public Health [Internet]. 2018; 154:87–97. Available from: https://doi.org/10.1016/j.puhe.2017.08.013. |
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Gómez Scarpetta, Ruth ÁngelaLara Garcia, Liceth MarinaCarrillo Gaona, Glender Stiven2021-11-30T21:03:23Z2021-11-30T21:03:23Z2021-11-20https://hdl.handle.net/20.500.12494/37027Lara García, L. M. y Carrillo Gaona G. S. (2021). Efectos adversos del consumo excesivo de flúor en la salud humana, revisión sistemática [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia.http://hdl.handle.net/20.500.12494/37027La exposición excesiva al fluoruro está asociada efectos adversos en la salud humana, en ese sentido, la presente revisión sistemática tuvo como Objetivo: Analizar las investigaciones publicadas relacionadas con los efectos del consumo excesivo de fluoruro en la salud humana, a partir de una revisión sistemática de la literatura. Materiales y métodos: Se realizó una búsqueda bibliográfica durante 7 meses en las bases de datos de Medline (Pubmed), Scielo, y Springer, utilizando las palabras claves: fluorine and diseases, fluoride-effects y fluorine-diseases y operador boleano AND. Los criterios de inclusión utilizados en la búsqueda de los artículos científicos fueron: Estudios primarios y secundarios en idioma español e inglés; Fecha de publicación de los trabajos de investigación científicas, desde el 2011 al 2021; Estudios de tipo observacionales, dirigidos a seres humanos, de diferentes partes del mundo y para cualquier grupo etario. La exclusión de la literatura gris, las revisiones narrativas y las tesis. Resultados: De 87 publicaciones, relacionadas con la estrategia de búsqueda, se escogieron 22 artículos completos que cumplían los criterios de inclusión y la evaluación de calidad según tipo de estudio. Los estudios analizados sugirieron una relación entre el exceso de fluoruro y las enfermedades Osteo-Esqueléticos, enfermedades Cardiometabolicas, oculares, hematológicas, endocrinas, renales y neurológicos y una correlación inversamente proporcional entre el exceso de fluoruro y el cociente intelectual Conclusión. El fluoruro en altas concentraciones y por tiempos prolongados está relacionado con efectos adversos en la salud humana, afectando más comúnmente a los niños y los jóvenes. Palabras clave: flúor y enfermedades, efectos del flúor, enfermedades del flúor. IntroducciónExcessive exposure to fluoride is associated with adverse effects on human health, in this sense, the present systematic review aimed to: Analyze published research related to the effects of excessive consumption of fluoride on human health, based on a systematic review of literature. Materials and methods: A bibliographic search was carried out for 7 months in the databases of Medline (Pubmed), Scielo, and Springer, using the keywords: fluorine and diseases, fluoride-effects and fluorine-diseases and the Boolean AND operator. The inclusion criteria used in the search for scientific articles were: Primary and secondary studies in Spanish and English; Date of publication of scientific research papers, from 2011 to 2021; Observational studies, aimed at human beings, from different parts of the world and for any age group. The exclusion of gray literature, narrative reviews and theses. Results: From 87 publications related to the search strategy, 22 complete articles were chosen that met the inclusion criteria and the quality assessment according to type of study. The analyzed studies suggested a relationship between excess fluoride and Osteo-Skeletal diseases, Cardiometabolic, ocular, hematological, endocrine, renal and neurological diseases and an inversely proportional correlation between excess fluoride and the IQ. Conclusion. Fluoride in high concentrations and for long periods of time is associated with adverse effects on human health, most commonly affecting children and young people. Key words: fluoride and diseases, effects of fluoride, fluoride diseases.1. Resumen. -- 2. Introducción. -- 3. Materiales y métodos. -- 4. Resultados. -- 5. Discusión -- 6. Conclusión. -- 7. Recomendaciones. -- 8. Limitaciones. -- 9. Conflicto de interés. -- 10. Referencias bibliográficas.Liceth.larag@campusucc.edu.coGlender.carrillog@campusucc.edu.co40 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Odontología, VillavicencioOdontologíaVillavicencioFlúorEnfermedadesEfectos adversosTG 2021 ODO 37027FluorineDiseasesAdverse effectsEfectos adversos del consumo excesivo del flúor en la salud humana, revisión sistemáticaActa de memoriashttp://purl.org/coar/resource_type/c_f744http://purl.org/coar/resource_type/c_8042info:eu-repo/semantics/workingPaperinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Malin AJ, Bose S, Busgang SA, Gennings C, Thorpy M, Wright RO, et al. Fluoride exposure and sleep patterns among older adolescents in the United States: A cross- sectional study of NHANES 2015-2016. Environ Heal A Glob Access Sci Source. 2019;18(1):1–9.Zaror C, Vallejos C, Corsini G, de la Puente C, Velásquez M, Tessada-Sepúlveda R, et al. Revisión Sistemática sobre los Efectos Adversos de la Fluoración del Agua. Int J Odontostomatol. 2015;9(1):165–71.Malin AJ, Till C. Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: An ecological association Children’s Environmental Health. Environ Heal A Glob Access Sci Source. 2015;14(1):1–10.Waugh DT. The contribution of fluoride to the pathogenesis of eye diseases: Molecular mechanisms and implications for public health. Int J Environ Res Public Health. 2019;16(5)Tao H, Yang L, Ping A, Quan L, Yang X, Zhang Y, et al. Interpretation of AMSTAR 2: A critical appraisal tool for systematic reviews that include randomized or non- randomized studies of healthcare interventions. Chinese J Evidence-Based Med. 2018;18(1):101–8.Carson Ka-Lok Lo, Dominik Mertz, Mark Loeb.Newcastle-Ottawa Scale: comparing reviewers’ to authors’. assessments.BMC Medical Research Methodology. 2014; 14: 45.Rostom A, Dubé C, Cranney A, et al. Appendix D. Quality Assessment Forms. NCBI _[Internet] 2004 [09 de septiembre del 2021]; https://www.ncbi.nlm.nih.gov/books/NBK35156/Mohammadi AA, Yousefi M, Yaseri M, Jalilzadeh M, Mahvi AH. Skeletal fluorosis in relation to drinking water in rural areas of West Azerbaijan, Iran. Sci Rep [Internet]. 2017;7(1):4–10. Available from: http://dx.doi.org/10.1038/s41598-017-17328-8Levy M, Leclerc BS. Fluoride in drinking water and osteosarcoma incidence rates in the continental United States among children and adolescents. Cáncer Epidemiol. 2012;36(2):83–8.Liu Y, Téllez-Rojo M, Sánchez BN, Ettinger AS, Osorio-Yáñez C, Solano M, et al. Association between fluoride exposure and cardiometabolic risk in peripubertal 37 Mexican children. Environ Int [Internet]. 2020;134(October 2019):105302. Available from: https://doi.org/10.1016/j.envint.2019.105302Chaitanya NC, Karunakar P, Allam NS, Priya MH, Alekhya B, Nauseen S. A systematic analysis on possibility of water fluoridation causing hypothyroidism. Indian J Dent Res. 2017;29(2):212–6Yu X, Chen J, Li Y, Liu H, Hou C, Zeng Q, et al. Threshold effects of moderately excessive fluoride exposure on children’s health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int [Internet]. 2018;118(May):116–24. Available from: https://doi.org/10.1016/j.envint.2018.05.042Peckham S, Lowery D, Spencer S. Are fluoride levels in drinking water associated with hypothyroidism prevalence in england? A large observational study of GP practice data and fluoride levels in drinking water. J Epidemiol Community Health. 2015;69(7):619–24.Malin AJ, Riddell J, McCague H, Till C. Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status. Environ Int [Internet]. 2018;121(September):667–74. Available from: https://doi.org/10.1016/j.envint.2018.09.026Waugh DT. Fluoride exposure induces inhibition of sodium/iodide symporter (NIS) contributing to impaired iodine absorption and iodine deficiency: Molecular mechanisms of inhibition and implications for public health. Int J Environ Res Public Health. 2019;16(6).Pornprasert S, Wanachantararak P, Kantawong F, Chamnanprai S, Kongpan C, Pienthai N, et al. Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Environ Geochem Health. 2017;39(4):751–8.Sun L, Gao Y, Liu H, Zhang W, Ding Y, Li B, et al. An assessment of the relationship between excess fluoride intake from drinking water and essential hypertension in adults residing in fluoride endemic areas. Sci Total Environ [Internet]. 2013; 443:864–9. Available from: http://dx.doi.org/10.1016/j.scitotenv.2012.11.021Fernando WBNT, Nanayakkara N, Gunarathne L, Chandrajith R. Serum and urine fluoride levels in populations of high environmental fluoride exposure with endemic CKDu: a case–control study from Sri Lanka. Environ Geochem Health [Internet]. 2020;42(5):1497–504. Available from: https://doi.org/10.1007/s10653- 019-00444-xNanayakkara S, Senevirathna STMLD, Harada KH, Chandrajith R, Nanayakkara N, Koizumi A. The Influence of fluoride on chronic kidney disease of uncertain aetiology (CKDu) in Sri Lanka. Chemosphere [Internet]. 2020; 257:127186. Available from: https://doi.org/10.1016/j.chemosphere.2020.127186Wasana HMS, Aluthpatabendi D, Kularatne WMTD, Wijekoon P, Weerasooriya R, Bandara J. Drinking water quality and chronic kidney disease of unknown etiology (CKDu): synergic effects of fluoride, cadmium and hardness of water. Environ Geochem Health. 2016;38(1):157–68.Jiménez-Córdova MI, González-Horta C, Ayllón-Vergara JC, Arreola-Mendoza L, Aguilar-Madrid G, Villareal-Vega EE, et al. Evaluation of vascular and kidney injury biomarkers in Mexican children exposed to inorganic fluoride. Environ Res [Internet]. 2019;169(July 2018):220–8. Available from: https://doi.org/10.1016/j.envres.2018.10.028Jiménez-Córdova MI, Cárdenas-González M, Aguilar-Madrid G, Sanchez-Peña LC, Barrera-Hernández Á, Domínguez-Guerrero IA, et al. Evaluation of kidney injury biomarkers in an adult Mexican population environmentally exposed to fluoride and low arsenic levels. Toxicol Appl Pharmacol [Internet]. 2018; 352:97–106. Available from: https://doi.org/10.1016/j.taap.2018.05.027Sebastian ST, Sunitha S. A cross-sectional study to assess the intelligence quotient (IQ) of school going children aged 10-12 years in villages of Mysore district, India with different fluoride levels. J Indian Soc Pedod Prev Dent. 2015;33(4):30711.Principio del formularioDuan Q, Jiao J, Chen X, Wang X. Association between water fluoride and the level of children’s intelligence: a dose–response meta-analysis. Public Health [Internet]. 2018; 154:87–97. 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