Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control

Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4...

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Autores:
Taborda, N. A.
Hernández López, Juan Carlos
Lajoie, J.
Juno, J. A.
Kimani, J.
Rugeles, M. T.
Fowke, K. R.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49675
Acceso en línea:
https://doi.org/10.1089/aid.2014.0325
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930240290&doi=10.1089%2faid.2014.0325&partnerID=40&md5=f3c7969be4c2956dce9c0af35db4d0ce
https://hdl.handle.net/20.500.12494/49675
Palabra clave:
CD69 ANTIGEN
CYTOKINE
GAMMA INTERFERON INDUCIBLE PROTEIN 10
LYMPHOCYTE ACTIVATION GENE 3 PROTEIN
PROGRAMMED DEATH 1 RECEPTOR
PROTEIN
PROTEIN TIM 3
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
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oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49675
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Taborda, N. A.Hernández López, Juan Carlos Lajoie, J.Juno, J. A.Kimani, J.Rugeles, M. T.Fowke, K. R.2023-05-24T16:21:37Z2023-05-24T16:21:37Z29/05/2015https://doi.org/10.1089/aid.2014.0325https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930240290&doi=10.1089%2faid.2014.0325&partnerID=40&md5=f3c7969be4c2956dce9c0af35db4d0ce08892229https://hdl.handle.net/20.500.12494/49675Taborda N.A.,Hernandez Lopez Juan carlos,Lajoie J.,Juno J.A.,Kimani J.,Rugeles M.T.,Fowke K.R..Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control.AIDS RES HUM RETROV. 2015. 31. (6):p. 636-640Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4+ T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF-a and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion. © 2015 Mary Ann Liebert, Inc.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co636-640Mary Ann Liebert Inc.CD69 ANTIGENCYTOKINEGAMMA INTERFERON INDUCIBLE PROTEIN 10LYMPHOCYTE ACTIVATION GENE 3 PROTEINPROGRAMMED DEATH 1 RECEPTORPROTEINPROTEIN TIM 3Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral controlArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAIDS RES HUM RETROVinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49675oai:repository.ucc.edu.co:20.500.12494/496752024-08-20 16:22:16.075metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
spellingShingle Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
CD69 ANTIGEN
CYTOKINE
GAMMA INTERFERON INDUCIBLE PROTEIN 10
LYMPHOCYTE ACTIVATION GENE 3 PROTEIN
PROGRAMMED DEATH 1 RECEPTOR
PROTEIN
PROTEIN TIM 3
title_short Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_full Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_fullStr Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_full_unstemmed Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_sort Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
dc.creator.fl_str_mv Taborda, N. A.
Hernández López, Juan Carlos
Lajoie, J.
Juno, J. A.
Kimani, J.
Rugeles, M. T.
Fowke, K. R.
dc.contributor.author.none.fl_str_mv Taborda, N. A.
Hernández López, Juan Carlos
Lajoie, J.
Juno, J. A.
Kimani, J.
Rugeles, M. T.
Fowke, K. R.
dc.subject.spa.fl_str_mv CD69 ANTIGEN
CYTOKINE
GAMMA INTERFERON INDUCIBLE PROTEIN 10
LYMPHOCYTE ACTIVATION GENE 3 PROTEIN
PROGRAMMED DEATH 1 RECEPTOR
PROTEIN
PROTEIN TIM 3
topic CD69 ANTIGEN
CYTOKINE
GAMMA INTERFERON INDUCIBLE PROTEIN 10
LYMPHOCYTE ACTIVATION GENE 3 PROTEIN
PROGRAMMED DEATH 1 RECEPTOR
PROTEIN
PROTEIN TIM 3
description Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4+ T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF-a and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion. © 2015 Mary Ann Liebert, Inc.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:37Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:37Z
dc.date.issued.none.fl_str_mv 29/05/2015
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1089/aid.2014.0325
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930240290&doi=10.1089%2faid.2014.0325&partnerID=40&md5=f3c7969be4c2956dce9c0af35db4d0ce
dc.identifier.issn.spa.fl_str_mv 08892229
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49675
dc.identifier.bibliographicCitation.spa.fl_str_mv Taborda N.A.,Hernandez Lopez Juan carlos,Lajoie J.,Juno J.A.,Kimani J.,Rugeles M.T.,Fowke K.R..Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control.AIDS RES HUM RETROV. 2015. 31. (6):p. 636-640
url https://doi.org/10.1089/aid.2014.0325
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930240290&doi=10.1089%2faid.2014.0325&partnerID=40&md5=f3c7969be4c2956dce9c0af35db4d0ce
https://hdl.handle.net/20.500.12494/49675
identifier_str_mv 08892229
Taborda N.A.,Hernandez Lopez Juan carlos,Lajoie J.,Juno J.A.,Kimani J.,Rugeles M.T.,Fowke K.R..Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control.AIDS RES HUM RETROV. 2015. 31. (6):p. 636-640
dc.relation.ispartofjournal.spa.fl_str_mv AIDS RES HUM RETROV
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 636-640
dc.publisher.spa.fl_str_mv Mary Ann Liebert Inc.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247238831964160

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