Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia

Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of d...

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Autores:
Laiton-Donato K.
Alvarez D.A.
Peláez-Carvajal D.
Mercado M.
Ajami N.J.
Bosch I.
Usme Ciro, José Aldemar
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/50888
Acceso en línea:
https://doi.org/10.1186/s12985-019-1170-4
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065464529&doi=10.1186%2fs12985-019-1170-4&partnerID=40&md5=84ab110d9fc2b3160f206ea924d62679
https://hdl.handle.net/20.500.12494/50888
Palabra clave:
ADOLESCENT
ADULT
ARTICLE
BIOBANK
BIOLOGICAL SPECIMEN BANKS
BLOOD
CLINICAL ARTICLE
COLOMBIA
CHILD
CHILD, PRESCHOOL
DENGUE
DENGUE VIRUS
ENVELOPE GENE
FEMALE
GENE SEQUENCE
GENETIC VARIABILITY
GENETIC VARIATION
GENETICS
GENOTYPE
GEOGRAPHY
HIGH THROUGHPUT SEQUENCING
HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING
HUMAN
HUMANS
MALE
MIDDLE AGED
NONHUMAN
NUCLEOTIDE SEQUENCE
PHYLOGENY
PRESCHOOL CHILD
RETROSPECTIVE STUDIES
RETROSPECTIVE STUDY
RNA, VIRAL
SEROGROUP
SEROTYPE
SEVERE DENGUE
VIRAL ENVELOPE PROTEINS
VIROLOGY
VIRUS CHARACTERIZATION
VIRUS ENVELOPE PROTEIN
VIRUS GENE
VIRUS ISOLATION
VIRUS RNA
YOUNG ADULT
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_97caa228b9db270362547438c8d97306
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/50888
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Laiton-Donato K.Alvarez D.A.Peláez-Carvajal D.Mercado M.Ajami N.J.Bosch I.Usme Ciro, José Aldemar2023-05-24T16:30:12Z2023-05-24T16:30:12Z01/01/2019https://doi.org/10.1186/s12985-019-1170-4https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065464529&doi=10.1186%2fs12985-019-1170-4&partnerID=40&md5=84ab110d9fc2b3160f206ea924d626791743422Xhttps://hdl.handle.net/20.500.12494/50888Laiton-Donato K.,Alvarez D.A.,Peláez-Carvajal D.,Mercado M.,Ajami N.J.,Bosch I.,Usme Ciro Jose aldemar.Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia.VIROL J. 2019. 16. (1): 62Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013-2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. © 2019 The Author(s).0000-0002-8093-0544jose.usmec@campusucc.edu.co62BioMed CentralADOLESCENTADULTARTICLEBIOBANKBIOLOGICAL SPECIMEN BANKSBLOODCLINICAL ARTICLECOLOMBIACHILDCHILD, PRESCHOOLDENGUEDENGUE VIRUSENVELOPE GENEFEMALEGENE SEQUENCEGENETIC VARIABILITYGENETIC VARIATIONGENETICSGENOTYPEGEOGRAPHYHIGH THROUGHPUT SEQUENCINGHIGH-THROUGHPUT NUCLEOTIDE SEQUENCINGHUMANHUMANSMALEMIDDLE AGEDNONHUMANNUCLEOTIDE SEQUENCEPHYLOGENYPRESCHOOL CHILDRETROSPECTIVE STUDIESRETROSPECTIVE STUDYRNA, VIRALSEROGROUPSEROTYPESEVERE DENGUEVIRAL ENVELOPE PROTEINSVIROLOGYVIRUS CHARACTERIZATIONVIRUS ENVELOPE PROTEINVIRUS GENEVIRUS ISOLATIONVIRUS RNAYOUNG ADULTMolecular characterization of dengue virus reveals regional diversification of serotype 2 in ColombiaArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionVIROL Jinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/50888oai:repository.ucc.edu.co:20.500.12494/508882024-08-20 16:21:17.115metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
spellingShingle Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
ADOLESCENT
ADULT
ARTICLE
BIOBANK
BIOLOGICAL SPECIMEN BANKS
BLOOD
CLINICAL ARTICLE
COLOMBIA
CHILD
CHILD, PRESCHOOL
DENGUE
DENGUE VIRUS
ENVELOPE GENE
FEMALE
GENE SEQUENCE
GENETIC VARIABILITY
GENETIC VARIATION
GENETICS
GENOTYPE
GEOGRAPHY
HIGH THROUGHPUT SEQUENCING
HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING
HUMAN
HUMANS
MALE
MIDDLE AGED
NONHUMAN
NUCLEOTIDE SEQUENCE
PHYLOGENY
PRESCHOOL CHILD
RETROSPECTIVE STUDIES
RETROSPECTIVE STUDY
RNA, VIRAL
SEROGROUP
SEROTYPE
SEVERE DENGUE
VIRAL ENVELOPE PROTEINS
VIROLOGY
VIRUS CHARACTERIZATION
VIRUS ENVELOPE PROTEIN
VIRUS GENE
VIRUS ISOLATION
VIRUS RNA
YOUNG ADULT
title_short Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_full Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_fullStr Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_full_unstemmed Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
title_sort Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
dc.creator.fl_str_mv Laiton-Donato K.
Alvarez D.A.
Peláez-Carvajal D.
Mercado M.
Ajami N.J.
Bosch I.
Usme Ciro, José Aldemar
dc.contributor.author.none.fl_str_mv Laiton-Donato K.
Alvarez D.A.
Peláez-Carvajal D.
Mercado M.
Ajami N.J.
Bosch I.
Usme Ciro, José Aldemar
dc.subject.spa.fl_str_mv ADOLESCENT
ADULT
ARTICLE
BIOBANK
BIOLOGICAL SPECIMEN BANKS
BLOOD
CLINICAL ARTICLE
COLOMBIA
CHILD
CHILD, PRESCHOOL
DENGUE
DENGUE VIRUS
ENVELOPE GENE
FEMALE
GENE SEQUENCE
GENETIC VARIABILITY
GENETIC VARIATION
GENETICS
GENOTYPE
GEOGRAPHY
HIGH THROUGHPUT SEQUENCING
HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING
HUMAN
HUMANS
MALE
MIDDLE AGED
NONHUMAN
NUCLEOTIDE SEQUENCE
PHYLOGENY
PRESCHOOL CHILD
RETROSPECTIVE STUDIES
RETROSPECTIVE STUDY
RNA, VIRAL
SEROGROUP
SEROTYPE
SEVERE DENGUE
VIRAL ENVELOPE PROTEINS
VIROLOGY
VIRUS CHARACTERIZATION
VIRUS ENVELOPE PROTEIN
VIRUS GENE
VIRUS ISOLATION
VIRUS RNA
YOUNG ADULT
topic ADOLESCENT
ADULT
ARTICLE
BIOBANK
BIOLOGICAL SPECIMEN BANKS
BLOOD
CLINICAL ARTICLE
COLOMBIA
CHILD
CHILD, PRESCHOOL
DENGUE
DENGUE VIRUS
ENVELOPE GENE
FEMALE
GENE SEQUENCE
GENETIC VARIABILITY
GENETIC VARIATION
GENETICS
GENOTYPE
GEOGRAPHY
HIGH THROUGHPUT SEQUENCING
HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING
HUMAN
HUMANS
MALE
MIDDLE AGED
NONHUMAN
NUCLEOTIDE SEQUENCE
PHYLOGENY
PRESCHOOL CHILD
RETROSPECTIVE STUDIES
RETROSPECTIVE STUDY
RNA, VIRAL
SEROGROUP
SEROTYPE
SEVERE DENGUE
VIRAL ENVELOPE PROTEINS
VIROLOGY
VIRUS CHARACTERIZATION
VIRUS ENVELOPE PROTEIN
VIRUS GENE
VIRUS ISOLATION
VIRUS RNA
YOUNG ADULT
description Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013-2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. © 2019 The Author(s).
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2019
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:30:12Z
dc.date.available.none.fl_str_mv 2023-05-24T16:30:12Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1186/s12985-019-1170-4
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065464529&doi=10.1186%2fs12985-019-1170-4&partnerID=40&md5=84ab110d9fc2b3160f206ea924d62679
dc.identifier.issn.spa.fl_str_mv 1743422X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/50888
dc.identifier.bibliographicCitation.spa.fl_str_mv Laiton-Donato K.,Alvarez D.A.,Peláez-Carvajal D.,Mercado M.,Ajami N.J.,Bosch I.,Usme Ciro Jose aldemar.Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia.VIROL J. 2019. 16. (1): 62
url https://doi.org/10.1186/s12985-019-1170-4
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065464529&doi=10.1186%2fs12985-019-1170-4&partnerID=40&md5=84ab110d9fc2b3160f206ea924d62679
https://hdl.handle.net/20.500.12494/50888
identifier_str_mv 1743422X
Laiton-Donato K.,Alvarez D.A.,Peláez-Carvajal D.,Mercado M.,Ajami N.J.,Bosch I.,Usme Ciro Jose aldemar.Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia.VIROL J. 2019. 16. (1): 62
dc.relation.ispartofjournal.spa.fl_str_mv VIROL J
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 62
dc.publisher.spa.fl_str_mv BioMed Central
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247134833147904

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