Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV

El síndrome reproductivo y respiratorio porcino o también conocido por sus siglas en ingles PRRS, es una enfermedad de origen viral que afecta gravemente a las producciones porcícolas causando una gran desmedida en pérdidas económicas y productivas a nivel mundial, esto debido a que el virus cuenta...

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Autores:
Varón Delgado, Angie Daniela
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2022
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/48323
Acceso en línea:
https://hdl.handle.net/20.500.12494/48323
Palabra clave:
PRRS
Vacuna Ingelvac
Lesiones Pulmonares
Porcinos
Base de datos
Histopatología
Patología
Macro
Micro
TG 2022 MVZ 48323
PRRS
Ingelvac Vaccine
Pulmonary Injuries
Swine
Database
Histopathology
Pathology
Micro
Macro
Rights
openAccess
License
Atribución – No comercial – Sin Derivar
id COOPER2_9789b811cc0ef7739148e42c46a42473
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/48323
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
title Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
spellingShingle Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
PRRS
Vacuna Ingelvac
Lesiones Pulmonares
Porcinos
Base de datos
Histopatología
Patología
Macro
Micro
TG 2022 MVZ 48323
PRRS
Ingelvac Vaccine
Pulmonary Injuries
Swine
Database
Histopathology
Pathology
Micro
Macro
title_short Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
title_full Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
title_fullStr Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
title_full_unstemmed Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
title_sort Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV
dc.creator.fl_str_mv Varón Delgado, Angie Daniela
dc.contributor.advisor.none.fl_str_mv Posada Almanza, Iván José
dc.contributor.author.none.fl_str_mv Varón Delgado, Angie Daniela
dc.subject.spa.fl_str_mv PRRS
Vacuna Ingelvac
Lesiones Pulmonares
Porcinos
Base de datos
Histopatología
Patología
Macro
Micro
topic PRRS
Vacuna Ingelvac
Lesiones Pulmonares
Porcinos
Base de datos
Histopatología
Patología
Macro
Micro
TG 2022 MVZ 48323
PRRS
Ingelvac Vaccine
Pulmonary Injuries
Swine
Database
Histopathology
Pathology
Micro
Macro
dc.subject.classification.spa.fl_str_mv TG 2022 MVZ 48323
dc.subject.other.spa.fl_str_mv PRRS
Ingelvac Vaccine
Pulmonary Injuries
Swine
Database
Histopathology
Pathology
Micro
Macro
description El síndrome reproductivo y respiratorio porcino o también conocido por sus siglas en ingles PRRS, es una enfermedad de origen viral que afecta gravemente a las producciones porcícolas causando una gran desmedida en pérdidas económicas y productivas a nivel mundial, esto debido a que el virus cuenta con un genoma de ARN, consecuente a estar en constante mutación presentando así una gran variación genómica que dificultan el control y la erradicación de esta enfermedad, por lo cual se han realizado diversos estudios para poder mitigar el impacto de este enfermedad; Existen varios agentes comerciales que utilizan el virus atenuado y otras el virus inactivado. Entre las más usadas están aquellas que contiene el virus “vivo o atenuado” existiendo muchos laboratorios que venden sus propios prototipos y entre los más conocidos y más antiguos esta la vacuna Ingelvac PRRS® MLV del laboratorio Boehringer Ingelheim que ha tenido muchas controversias al pasar de los años por la eficacia que produce contra la inmunidad hacia el virus del PRRS contra los daños a nivel lobular de los pulmones, por lo cual en el presente trabajo se indagara en artículos que correspondan desde el año 2016 al 2022 sobre la funcionalidad de esta vacuna y sus pros y contras con la protección inmunomediada de este virus.
publishDate 2022
dc.date.issued.none.fl_str_mv 2022-12-22
dc.date.accessioned.none.fl_str_mv 2023-01-12T13:52:03Z
dc.date.available.none.fl_str_mv 2023-01-12T13:52:03Z
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/48323
dc.identifier.bibliographicCitation.spa.fl_str_mv Varón Delgado, A. D. (2022). Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/48323
url https://hdl.handle.net/20.500.12494/48323
identifier_str_mv Varón Delgado, A. D. (2022). Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/48323
dc.relation.references.spa.fl_str_mv Cui W, Yu F, Zhang Y, Han X, Zou R, Tang Y, et al. Discovery of traditional Chinese medicines against porcine reproductive and respiratory syndrome virus. Pharmacol Res - Mod Chinese Med. 2021 Dec 1;1:100003. 2. Li N, Huang K, Chen Y, Huang Z, Zhang Y, Leng CL, et al. MicroRNA ssc-miR-124a exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via suppression of host genes CD163. Vet Microbiol. 2021 Oct 1;261:109216. 3. Prather RS, Wells KD, Whitworth KM, Kerrigan MA, Samuel MS, Mileham A, et al. Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV). Sci Reports 2017 71. 2017 Oct 17;7(1):1–5. 4. Jeong J, Kim S, Park KH, Kang I, Park SJ, Park C, et al. Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol. 2017 Sep 1;208:47–52. 5. Jiang Y, Li G, Yu L, Li L, Zhang Y, Zhou Y, et al. Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China. Front Microbiol. 2020 Apr 24;11:618. 6. Su CM, Rowland RRR, Yoo D. Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines. 2021 Apr 1;9(4). 7. Han G, Yang H, Xu H, Zheng S, Li Y, Liu Z, et al. Broad antiviral peptides against PRRSV based on novel linear epitopes on porcine CD163. Int J Biol Macromol. 2022 May 15;207:635–43. 8. Teresa Fernández Caballero. Caracterización de poblaciones celulares del linaje monocitomacrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv) . [Madrid]: Universidad COMPLUTENSE; 2019. 9. Ye N, Wang B, Feng W, Tang D, Zeng Z. PRRS virus receptors and an alternative pathway for viral invasion. Virus Res. 2022 Oct 15;320:198885. 10. Castillo Espinoza A, Ramírez Velásquez M, Castillo Espinoza A, Ramírez Velásquez M. Síndrome Reproductivo y Respiratorio Porcino: Una revisión del agente etiológico y su influencia en el comportamiento actual de la enfermedad. Rev Investig Vet del Perú. 2021 Feb 23;32(1):19645. 11. Plata García M. Receptores involucrados en la infección y entrada de PRRS a la célula [Internet]. Porcicultura.com. 2018 [cited 2022 Oct 21]. Available from: https://www.porcicultura.com/destacado/Receptores-involucrados-en-la-infección-y-entrada-de-PRRS-a-la-célula 12. Fernández-Caballero T, Álvarez B, Alonso F, Revilla C, Martínez-Lobo J, Prieto C, et al. Interaction of PRRS virus with bone marrow monocyte subsets. Vet Microbiol. 2018 Jun 1;219:123–7. 13. Stoian AMM, Rowland RRR. Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization. Vet Sci. 2019 Mar;6(1). 14. Moura CAA, Philips R, Silva GS, Holtkamp DJ, Linhares DCL. Comparison of virus detection, productivity, and economic performance between lots of growing pigs vaccinated with two doses or one dose of PRRS MLV vaccine, under field conditions. Prev Vet Med. 2022 Jul 1;204:105669. 15. Vu HLX, Pattnaik AK, Osorio FA. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Jul 1;206:29–34. 16. Chae C. Commercial PRRS Modified-Live Virus Vaccines. Vaccines. 2021 Feb 1;9(2):1–16. 17. Kraft C, Hennies R, Dreckmann K, Noguera M, Rathkjen PH, Gassel M, et al. Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity. PLoS One. 2019 Oct 1;14(10). 18. Constance LA, Thissen JB, Jaing CJ, McLoughlin KS, Rowland RRR, Serão NVL, et al. Gut microbiome associations with outcome following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in pigs immunized with a PRRS modified live virus vaccine. Vet Microbiol. 2021 Mar 1;254:109018. 19. Wang A, Chen Q, Wang L, Madson D, Harmon K, Gauger P, et al. Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. Emerg Infect Dis. 2019;25(12):2335. 20. Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021 Apr 1;9(4). 21. Rowland RRR, Doerksen T, Lu A, Sheahan M, Lunney J, Dekkers J, et al. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Res. 2022 Jul 15;316:198809. 22. Carrascosa De Lome L. Estudio comparativo de la seguridad de distintas vacunas vivas atenuadas frente al Síndrome Reproductor y Respiratorio Porcino. [Madrid]: UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA DEPARTAMENTO DE SANIDAD ANIMAL; 2018. 23. Echave RS, López-Úbeda R, Ramis G, Caravaca IH. Control integral del PRRSv mediante el concepto de las 5 fases: revisión crítica. An Vet Murcia. 2021 Nov 26;35:59–78. 24. Carvajal Sánchez JM. El papel del cd163 y otros biomarcadores deinterés en la inmunopatogenia del prrsv-1 a nivel pulmonar - Dialnet. [Córdoba]: Universidad de Córdoba; 2020. 25. Jeong J, Choi K, Kang I, Park C, Chae C. Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea. Vet Microbiol. 2016 Aug 30;192:102–9. 26. Dr. Alejandro Macias. ¿Cómo interpretar un Odds Ratio? - YouTube [Internet]. 2017 [cited 2022 Oct 26]. Available from: https://www.youtube.com/watch?v=WUQlr7lXbvE 27. Nicolas Bevacqua. Interpretación de un meta-análisis. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=z0JwqXlg3M0 28. Ariel Albedaño. Metaanálisis en RevMan. Metanaálisis de Odds Ratio. Epidemiología y Estadística [Internet]. 2021 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=3KDFFxWpRNI&t=2580s 29. Caro DA. Revisiones Sistemáticas de la Literatura. Chile; 2008 May. 30. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 1. DYNA. 2015;82(189):9–12. 31. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 2. DYNA. 2015;82(189):9–12. 32. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 3. DYNA. 2015;82(189):9–12. 33. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 4. DYNA. 2015;82(189):9–12. 34. Kroll J, Piontkowski M, Rathkjen PH, Orveillon FX, Kraft C, Duran OG. Long duration of immunity against a type 1 heterologous PRRS virus challenge in pigs immunised with a novel PRRS MLV vaccine: A randomised controlled study. Porc Heal Manag. 2018 May 16;4(1):1–8. 35. Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, et al. Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs. Vaccine. 2018 Jan 4;36(2):227–36. 36. Sun YF, Zhou L, Bian T, Tian XX, Ren WK, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018 Mar 1;216:176–82. 37. Huang Y, Li Z, Li J, Yibo-Kong, Yang L, Mah CK, et al. Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2019 Feb 1;229:117–23. 38. Chai W, Liu Z, Sun Z, Su L, Zhang C, Huang L. Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge. Vet Microbiol. 2020 Sep 1;248:108805. 39. Madapong A, Saeng-chuto K, Tantituvanont A, Nilubol D. Safety of PRRSV-2 MLV vaccines administrated via the intramuscular or intradermal route and evaluation of PRRSV transmission upon needle-free and needle delivery. Sci Rep. 2021 Dec 1;11(1):23107. 40. Duerlinger S, Knecht C, Sawyer S, Balka G, Zaruba M, Ruemenapf T, et al. Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets. Vaccines. 2022 Jun 1;10(6). 41. Madapong A, Temeeyasen G, Saeng-chuto K, Tripipat T, Navasakuljinda W, Boonsoongnern A, et al. Humoral immune responses and viral shedding following vaccination with modified live porcine reproductive and respiratory syndrome virus vaccines. Arch Virol 2016 1621. 2016 Sep 30;162(1):139–46. 42. Patterson A, Haiwick G, Hermann J, Fergen B, Wakeland K, Chittick W, et al. Efficacy of Ingelvac PRRS ® Modified Live Virus Vaccine against Heterologous Porcine Reproductive and Respiratory Syndrome Virus Challenges. 2019; 43. Balka G, Dreckmann K, Papp G, Kraft C. Vaccination of piglets at 2 and 3 weeks of age with Ingelvac PRRSFLEX® EU provides protection against heterologous field challenge in the face of homologous maternally derived antibodies. Porc Heal Manag. 2016 Aug 14;2(1):1–9. 44. Nicolas Bevacqua. Funnel plot. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=Tx17ly2Z1Vo&t=157s 45. Han J, Zhou L, Ge X, Guo X, Yang H. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Sep 1;209:30–47. 46. Ding Y, Wubshet AK, Ding X, Zhang Z, Li Q, Dai J, et al. Evaluation of four commercial vaccines for the protection of piglets against the highly pathogenic porcine reproductive and respiratory syndrome virus (hp-PRRSV) QH-08 strain. Vaccines. 2021 Sep 1;9(9).
Li N, Huang K, Chen Y, Huang Z, Zhang Y, Leng CL, et al. MicroRNA ssc-miR-124a exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via suppression of host genes CD163. Vet Microbiol. 2021 Oct 1;261:109216.
Prather RS, Wells KD, Whitworth KM, Kerrigan MA, Samuel MS, Mileham A, et al. Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV). Sci Reports 2017 71. 2017 Oct 17;7(1):1–5.
Jeong J, Kim S, Park KH, Kang I, Park SJ, Park C, et al. Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol. 2017 Sep 1;208:47–52.
Su CM, Rowland RRR, Yoo D. Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines. 2021 Apr 1;9(4).
Jiang Y, Li G, Yu L, Li L, Zhang Y, Zhou Y, et al. Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China. Front Microbiol. 2020 Apr 24;11:618.
Han G, Yang H, Xu H, Zheng S, Li Y, Liu Z, et al. Broad antiviral peptides against PRRSV based on novel linear epitopes on porcine CD163. Int J Biol Macromol. 2022 May 15;207:635–43.
Teresa Fernández Caballero. Caracterización de poblaciones celulares del linaje monocitomacrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv) . [Madrid]: Universidad COMPLUTENSE; 2019.
Ye N, Wang B, Feng W, Tang D, Zeng Z. PRRS virus receptors and an alternative pathway for viral invasion. Virus Res. 2022 Oct 15;320:198885.
Castillo Espinoza A, Ramírez Velásquez M, Castillo Espinoza A, Ramírez Velásquez M. Síndrome Reproductivo y Respiratorio Porcino: Una revisión del agente etiológico y su influencia en el comportamiento actual de la enfermedad. Rev Investig Vet del Perú. 2021 Feb 23;32(1):19645.
Plata García M. Receptores involucrados en la infección y entrada de PRRS a la célula [Internet]. Porcicultura.com. 2018 [cited 2022 Oct 21]. Available from: https://www.porcicultura.com/destacado/Receptores-involucrados-en-la-infección-y-entrada-de-PRRS-a-la-célula
Fernández-Caballero T, Álvarez B, Alonso F, Revilla C, Martínez-Lobo J, Prieto C, et al. Interaction of PRRS virus with bone marrow monocyte subsets. Vet Microbiol. 2018 Jun 1;219:123–7.
Stoian AMM, Rowland RRR. Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization. Vet Sci. 2019 Mar;6(1).
Moura CAA, Philips R, Silva GS, Holtkamp DJ, Linhares DCL. Comparison of virus detection, productivity, and economic performance between lots of growing pigs vaccinated with two doses or one dose of PRRS MLV vaccine, under field conditions. Prev Vet Med. 2022 Jul 1;204:105669.
Vu HLX, Pattnaik AK, Osorio FA. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Jul 1;206:29–34.
Chae C. Commercial PRRS Modified-Live Virus Vaccines. Vaccines. 2021 Feb 1;9(2):1–16.
Kraft C, Hennies R, Dreckmann K, Noguera M, Rathkjen PH, Gassel M, et al. Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity. PLoS One. 2019 Oct 1;14(10).
Constance LA, Thissen JB, Jaing CJ, McLoughlin KS, Rowland RRR, Serão NVL, et al. Gut microbiome associations with outcome following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in pigs immunized with a PRRS modified live virus vaccine. Vet Microbiol. 2021 Mar 1;254:109018.
Wang A, Chen Q, Wang L, Madson D, Harmon K, Gauger P, et al. Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. Emerg Infect Dis. 2019;25(12):2335.
Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021 Apr 1;9(4).
Rowland RRR, Doerksen T, Lu A, Sheahan M, Lunney J, Dekkers J, et al. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Res. 2022 Jul 15;316:198809.
Carrascosa De Lome L. Estudio comparativo de la seguridad de distintas vacunas vivas atenuadas frente al Síndrome Reproductor y Respiratorio Porcino. [Madrid]: UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA DEPARTAMENTO DE SANIDAD ANIMAL; 2018.
Echave RS, López-Úbeda R, Ramis G, Caravaca IH. Control integral del PRRSv mediante el concepto de las 5 fases: revisión crítica. An Vet Murcia. 2021 Nov 26;35:59–78.
Carvajal Sánchez JM. El papel del cd163 y otros biomarcadores deinterés en la inmunopatogenia del prrsv-1 a nivel pulmonar - Dialnet. [Córdoba]: Universidad de Córdoba; 2020.
Jeong J, Choi K, Kang I, Park C, Chae C. Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea. Vet Microbiol. 2016 Aug 30;192:102–9.
Dr. Alejandro Macias. ¿Cómo interpretar un Odds Ratio? - YouTube [Internet]. 2017 [cited 2022 Oct 26]. Available from: https://www.youtube.com/watch?v=WUQlr7lXbvE
Nicolas Bevacqua. Interpretación de un meta-análisis. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=z0JwqXlg3M0
Ariel Albedaño. Metaanálisis en RevMan. Metanaálisis de Odds Ratio. Epidemiología y Estadística [Internet]. 2021 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=3KDFFxWpRNI&t=2580s
Caro DA. Revisiones Sistemáticas de la Literatura. Chile; 2008 May.
Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 1. DYNA. 2015;82(189):9–12.
Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 2. DYNA. 2015;82(189):9–12.
Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 3. DYNA. 2015;82(189):9–12.
Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 4. DYNA. 2015;82(189):9–12.
Kroll J, Piontkowski M, Rathkjen PH, Orveillon FX, Kraft C, Duran OG. Long duration of immunity against a type 1 heterologous PRRS virus challenge in pigs immunised with a novel PRRS MLV vaccine: A randomised controlled study. Porc Heal Manag. 2018 May 16;4(1):1–8.
Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, et al. Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs. Vaccine. 2018 Jan 4;36(2):227–36.
Sun YF, Zhou L, Bian T, Tian XX, Ren WK, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018 Mar 1;216:176–82.
Huang Y, Li Z, Li J, Yibo-Kong, Yang L, Mah CK, et al. Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2019 Feb 1;229:117–23.
Chai W, Liu Z, Sun Z, Su L, Zhang C, Huang L. Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge. Vet Microbiol. 2020 Sep 1;248:108805.
Madapong A, Saeng-chuto K, Tantituvanont A, Nilubol D. Safety of PRRSV-2 MLV vaccines administrated via the intramuscular or intradermal route and evaluation of PRRSV transmission upon needle-free and needle delivery. Sci Rep. 2021 Dec 1;11(1):23107.
Duerlinger S, Knecht C, Sawyer S, Balka G, Zaruba M, Ruemenapf T, et al. Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets. Vaccines. 2022 Jun 1;10(6).
Madapong A, Temeeyasen G, Saeng-chuto K, Tripipat T, Navasakuljinda W, Boonsoongnern A, et al. Humoral immune responses and viral shedding following vaccination with modified live porcine reproductive and respiratory syndrome virus vaccines. Arch Virol 2016 1621. 2016 Sep 30;162(1):139–46.
Patterson A, Haiwick G, Hermann J, Fergen B, Wakeland K, Chittick W, et al. Efficacy of Ingelvac PRRS ® Modified Live Virus Vaccine against Heterologous Porcine Reproductive and Respiratory Syndrome Virus Challenges. 2019;
Balka G, Dreckmann K, Papp G, Kraft C. Vaccination of piglets at 2 and 3 weeks of age with Ingelvac PRRSFLEX® EU provides protection against heterologous field challenge in the face of homologous maternally derived antibodies. Porc Heal Manag. 2016 Aug 14;2(1):1–9.
Cui W, Yu F, Zhang Y, Han X, Zou R, Tang Y, et al. Discovery of traditional Chinese medicines against porcine reproductive and respiratory syndrome virus. Pharmacol Res - Mod Chinese Med. 2021 Dec 1;1:100003. 2. Li N, Huang K, Chen Y, Huang Z, Zhang Y, Leng CL, et al. MicroRNA ssc-miR-124a exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via suppression of host genes CD163. Vet Microbiol. 2021 Oct 1;261:109216. 3. Prather RS, Wells KD, Whitworth KM, Kerrigan MA, Samuel MS, Mileham A, et al. Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV). Sci Reports 2017 71. 2017 Oct 17;7(1):1–5. 4. Jeong J, Kim S, Park KH, Kang I, Park SJ, Park C, et al. Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol. 2017 Sep 1;208:47–52. 5. Jiang Y, Li G, Yu L, Li L, Zhang Y, Zhou Y, et al. Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China. Front Microbiol. 2020 Apr 24;11:618. 6. Su CM, Rowland RRR, Yoo D. Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines. 2021 Apr 1;9(4). 7. Han G, Yang H, Xu H, Zheng S, Li Y, Liu Z, et al. Broad antiviral peptides against PRRSV based on novel linear epitopes on porcine CD163. Int J Biol Macromol. 2022 May 15;207:635–43. 8. Teresa Fernández Caballero. Caracterización de poblaciones celulares del linaje monocitomacrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv) . [Madrid]: Universidad COMPLUTENSE; 2019. 9. Ye N, Wang B, Feng W, Tang D, Zeng Z. PRRS virus receptors and an alternative pathway for viral invasion. Virus Res. 2022 Oct 15;320:198885. 10. Castillo Espinoza A, Ramírez Velásquez M, Castillo Espinoza A, Ramírez Velásquez M. Síndrome Reproductivo y Respiratorio Porcino: Una revisión del agente etiológico y su influencia en el comportamiento actual de la enfermedad. Rev Investig Vet del Perú. 2021 Feb 23;32(1):19645. 11. Plata García M. Receptores involucrados en la infección y entrada de PRRS a la célula [Internet]. Porcicultura.com. 2018 [cited 2022 Oct 21]. Available from: https://www.porcicultura.com/destacado/Receptores-involucrados-en-la-infección-y-entrada-de-PRRS-a-la-célula 12. Fernández-Caballero T, Álvarez B, Alonso F, Revilla C, Martínez-Lobo J, Prieto C, et al. Interaction of PRRS virus with bone marrow monocyte subsets. Vet Microbiol. 2018 Jun 1;219:123–7. 13. Stoian AMM, Rowland RRR. Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization. Vet Sci. 2019 Mar;6(1). 14. Moura CAA, Philips R, Silva GS, Holtkamp DJ, Linhares DCL. Comparison of virus detection, productivity, and economic performance between lots of growing pigs vaccinated with two doses or one dose of PRRS MLV vaccine, under field conditions. Prev Vet Med. 2022 Jul 1;204:105669. 15. Vu HLX, Pattnaik AK, Osorio FA. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Jul 1;206:29–34. 16. Chae C. Commercial PRRS Modified-Live Virus Vaccines. Vaccines. 2021 Feb 1;9(2):1–16. 17. Kraft C, Hennies R, Dreckmann K, Noguera M, Rathkjen PH, Gassel M, et al. Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity. PLoS One. 2019 Oct 1;14(10). 18. Constance LA, Thissen JB, Jaing CJ, McLoughlin KS, Rowland RRR, Serão NVL, et al. Gut microbiome associations with outcome following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in pigs immunized with a PRRS modified live virus vaccine. Vet Microbiol. 2021 Mar 1;254:109018. 19. Wang A, Chen Q, Wang L, Madson D, Harmon K, Gauger P, et al. Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. Emerg Infect Dis. 2019;25(12):2335. 20. Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021 Apr 1;9(4). 21. Rowland RRR, Doerksen T, Lu A, Sheahan M, Lunney J, Dekkers J, et al. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Res. 2022 Jul 15;316:198809. 22. Carrascosa De Lome L. Estudio comparativo de la seguridad de distintas vacunas vivas atenuadas frente al Síndrome Reproductor y Respiratorio Porcino. [Madrid]: UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA DEPARTAMENTO DE SANIDAD ANIMAL; 2018. 23. Echave RS, López-Úbeda R, Ramis G, Caravaca IH. Control integral del PRRSv mediante el concepto de las 5 fases: revisión crítica. An Vet Murcia. 2021 Nov 26;35:59–78. 24. Carvajal Sánchez JM. El papel del cd163 y otros biomarcadores deinterés en la inmunopatogenia del prrsv-1 a nivel pulmonar - Dialnet. [Córdoba]: Universidad de Córdoba; 2020. 25. Jeong J, Choi K, Kang I, Park C, Chae C. Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea. Vet Microbiol. 2016 Aug 30;192:102–9. 26. Dr. Alejandro Macias. ¿Cómo interpretar un Odds Ratio? - YouTube [Internet]. 2017 [cited 2022 Oct 26]. Available from: https://www.youtube.com/watch?v=WUQlr7lXbvE 27. Nicolas Bevacqua. Interpretación de un meta-análisis. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=z0JwqXlg3M0 28. Ariel Albedaño. Metaanálisis en RevMan. Metanaálisis de Odds Ratio. Epidemiología y Estadística [Internet]. 2021 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=3KDFFxWpRNI&t=2580s 29. Caro DA. Revisiones Sistemáticas de la Literatura. Chile; 2008 May. 30. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 1. DYNA. 2015;82(189):9–12. 31. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 2. DYNA. 2015;82(189):9–12. 32. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 3. DYNA. 2015;82(189):9–12. 33. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 4. DYNA. 2015;82(189):9–12. 34. Kroll J, Piontkowski M, Rathkjen PH, Orveillon FX, Kraft C, Duran OG. Long duration of immunity against a type 1 heterologous PRRS virus challenge in pigs immunised with a novel PRRS MLV vaccine: A randomised controlled study. Porc Heal Manag. 2018 May 16;4(1):1–8. 35. Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, et al. Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs. Vaccine. 2018 Jan 4;36(2):227–36. 36. Sun YF, Zhou L, Bian T, Tian XX, Ren WK, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018 Mar 1;216:176–82. 37. Huang Y, Li Z, Li J, Yibo-Kong, Yang L, Mah CK, et al. Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2019 Feb 1;229:117–23. 38. Chai W, Liu Z, Sun Z, Su L, Zhang C, Huang L. Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge. Vet Microbiol. 2020 Sep 1;248:108805. 39. Madapong A, Saeng-chuto K, Tantituvanont A, Nilubol D. Safety of PRRSV-2 MLV vaccines administrated via the intramuscular or intradermal route and evaluation of PRRSV transmission upon needle-free and needle delivery. Sci Rep. 2021 Dec 1;11(1):23107. 40. Duerlinger S, Knecht C, Sawyer S, Balka G, Zaruba M, Ruemenapf T, et al. Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets. Vaccines. 2022 Jun 1;10(6). 41. Madapong A, Temeeyasen G, Saeng-chuto K, Tripipat T, Navasakuljinda W, Boonsoongnern A, et al. Humoral immune responses and viral shedding following vaccination with modified live porcine reproductive and respiratory syndrome virus vaccines. Arch Virol 2016 1621. 2016 Sep 30;162(1):139–46. 42. Patterson A, Haiwick G, Hermann J, Fergen B, Wakeland K, Chittick W, et al. Efficacy of Ingelvac PRRS ® Modified Live Virus Vaccine against Heterologous Porcine Reproductive and Respiratory Syndrome Virus Challenges. 2019; 43. Balka G, Dreckmann K, Papp G, Kraft C. Vaccination of piglets at 2 and 3 weeks of age with Ingelvac PRRSFLEX® EU provides protection against heterologous field challenge in the face of homologous maternally derived antibodies. Porc Heal Manag. 2016 Aug 14;2(1):1–9. 44. Nicolas Bevacqua. Funnel plot. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=Tx17ly2Z1Vo&t=157s
Han J, Zhou L, Ge X, Guo X, Yang H. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Sep 1;209:30–47.
Ding Y, Wubshet AK, Ding X, Zhang Z, Li Q, Dai J, et al. Evaluation of four commercial vaccines for the protection of piglets against the highly pathogenic porcine reproductive and respiratory syndrome virus (hp-PRRSV) QH-08 strain. Vaccines. 2021 Sep 1;9(9).
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spelling Posada Almanza, Iván JoséVarón Delgado, Angie Daniela2023-01-12T13:52:03Z2023-01-12T13:52:03Z2022-12-22https://hdl.handle.net/20.500.12494/48323Varón Delgado, A. D. (2022). Síndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLV. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/48323El síndrome reproductivo y respiratorio porcino o también conocido por sus siglas en ingles PRRS, es una enfermedad de origen viral que afecta gravemente a las producciones porcícolas causando una gran desmedida en pérdidas económicas y productivas a nivel mundial, esto debido a que el virus cuenta con un genoma de ARN, consecuente a estar en constante mutación presentando así una gran variación genómica que dificultan el control y la erradicación de esta enfermedad, por lo cual se han realizado diversos estudios para poder mitigar el impacto de este enfermedad; Existen varios agentes comerciales que utilizan el virus atenuado y otras el virus inactivado. Entre las más usadas están aquellas que contiene el virus “vivo o atenuado” existiendo muchos laboratorios que venden sus propios prototipos y entre los más conocidos y más antiguos esta la vacuna Ingelvac PRRS® MLV del laboratorio Boehringer Ingelheim que ha tenido muchas controversias al pasar de los años por la eficacia que produce contra la inmunidad hacia el virus del PRRS contra los daños a nivel lobular de los pulmones, por lo cual en el presente trabajo se indagara en artículos que correspondan desde el año 2016 al 2022 sobre la funcionalidad de esta vacuna y sus pros y contras con la protección inmunomediada de este virus.Porcine reproductive and respiratory syndrome or also known by its acronym in English PRRS, is a disease of viral origin that seriously affects pig production, causing great disproportionate economic and productive losses worldwide, this due to the fact that the virus has an RNA genome, as a result of being in constant mutation, thus presenting a great genomic variation that makes it difficult to control and eradicate this disease, for which various studies have been carried out to mitigate the impact of this disease; There are several commercial agents that use the attenuated virus and others the inactivated virus. Among the most used are those that contain the “live or attenuated” virus, with many laboratories selling their own prototypes, and among the best known and oldest is the Ingelvac PRRS® MLV vaccine from the Boehringer Ingelheim laboratory, which has had many controversies since the years for the effectiveness it produces against immunity to the PRRS virus against damage at the lobular level of the lungs, for which in the present work articles that correspond from 2016 to 2022 on the functionality of this vaccine will be investigated. and its pros and cons with immune-mediated protection from this virus.angie.varond@campusucc.edu.co18 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéPRRSVacuna IngelvacLesiones PulmonaresPorcinosBase de datosHistopatologíaPatologíaMacroMicroTG 2022 MVZ 48323PRRSIngelvac VaccinePulmonary InjuriesSwineDatabaseHistopathologyPathologyMicroMacroSíndrome Reproductivo y Respiratorio Porcino: Revisión de Literatura Sobre la protección contra las lesiones pulmonares mediada por la vacuna viva modifica Ingelvac PRRS® MLVTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cui W, Yu F, Zhang Y, Han X, Zou R, Tang Y, et al. Discovery of traditional Chinese medicines against porcine reproductive and respiratory syndrome virus. Pharmacol Res - Mod Chinese Med. 2021 Dec 1;1:100003. 2. Li N, Huang K, Chen Y, Huang Z, Zhang Y, Leng CL, et al. MicroRNA ssc-miR-124a exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via suppression of host genes CD163. Vet Microbiol. 2021 Oct 1;261:109216. 3. Prather RS, Wells KD, Whitworth KM, Kerrigan MA, Samuel MS, Mileham A, et al. Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV). Sci Reports 2017 71. 2017 Oct 17;7(1):1–5. 4. Jeong J, Kim S, Park KH, Kang I, Park SJ, Park C, et al. Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol. 2017 Sep 1;208:47–52. 5. Jiang Y, Li G, Yu L, Li L, Zhang Y, Zhou Y, et al. Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China. Front Microbiol. 2020 Apr 24;11:618. 6. Su CM, Rowland RRR, Yoo D. Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines. 2021 Apr 1;9(4). 7. Han G, Yang H, Xu H, Zheng S, Li Y, Liu Z, et al. Broad antiviral peptides against PRRSV based on novel linear epitopes on porcine CD163. Int J Biol Macromol. 2022 May 15;207:635–43. 8. Teresa Fernández Caballero. Caracterización de poblaciones celulares del linaje monocitomacrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv) . [Madrid]: Universidad COMPLUTENSE; 2019. 9. Ye N, Wang B, Feng W, Tang D, Zeng Z. PRRS virus receptors and an alternative pathway for viral invasion. Virus Res. 2022 Oct 15;320:198885. 10. Castillo Espinoza A, Ramírez Velásquez M, Castillo Espinoza A, Ramírez Velásquez M. Síndrome Reproductivo y Respiratorio Porcino: Una revisión del agente etiológico y su influencia en el comportamiento actual de la enfermedad. Rev Investig Vet del Perú. 2021 Feb 23;32(1):19645. 11. Plata García M. Receptores involucrados en la infección y entrada de PRRS a la célula [Internet]. Porcicultura.com. 2018 [cited 2022 Oct 21]. Available from: https://www.porcicultura.com/destacado/Receptores-involucrados-en-la-infección-y-entrada-de-PRRS-a-la-célula 12. Fernández-Caballero T, Álvarez B, Alonso F, Revilla C, Martínez-Lobo J, Prieto C, et al. Interaction of PRRS virus with bone marrow monocyte subsets. Vet Microbiol. 2018 Jun 1;219:123–7. 13. Stoian AMM, Rowland RRR. Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization. Vet Sci. 2019 Mar;6(1). 14. Moura CAA, Philips R, Silva GS, Holtkamp DJ, Linhares DCL. Comparison of virus detection, productivity, and economic performance between lots of growing pigs vaccinated with two doses or one dose of PRRS MLV vaccine, under field conditions. Prev Vet Med. 2022 Jul 1;204:105669. 15. Vu HLX, Pattnaik AK, Osorio FA. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Jul 1;206:29–34. 16. Chae C. Commercial PRRS Modified-Live Virus Vaccines. Vaccines. 2021 Feb 1;9(2):1–16. 17. Kraft C, Hennies R, Dreckmann K, Noguera M, Rathkjen PH, Gassel M, et al. Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity. PLoS One. 2019 Oct 1;14(10). 18. Constance LA, Thissen JB, Jaing CJ, McLoughlin KS, Rowland RRR, Serão NVL, et al. Gut microbiome associations with outcome following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in pigs immunized with a PRRS modified live virus vaccine. Vet Microbiol. 2021 Mar 1;254:109018. 19. Wang A, Chen Q, Wang L, Madson D, Harmon K, Gauger P, et al. Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. Emerg Infect Dis. 2019;25(12):2335. 20. Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021 Apr 1;9(4). 21. Rowland RRR, Doerksen T, Lu A, Sheahan M, Lunney J, Dekkers J, et al. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Res. 2022 Jul 15;316:198809. 22. Carrascosa De Lome L. Estudio comparativo de la seguridad de distintas vacunas vivas atenuadas frente al Síndrome Reproductor y Respiratorio Porcino. [Madrid]: UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA DEPARTAMENTO DE SANIDAD ANIMAL; 2018. 23. Echave RS, López-Úbeda R, Ramis G, Caravaca IH. Control integral del PRRSv mediante el concepto de las 5 fases: revisión crítica. An Vet Murcia. 2021 Nov 26;35:59–78. 24. Carvajal Sánchez JM. El papel del cd163 y otros biomarcadores deinterés en la inmunopatogenia del prrsv-1 a nivel pulmonar - Dialnet. [Córdoba]: Universidad de Córdoba; 2020. 25. Jeong J, Choi K, Kang I, Park C, Chae C. Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea. Vet Microbiol. 2016 Aug 30;192:102–9. 26. Dr. Alejandro Macias. ¿Cómo interpretar un Odds Ratio? - YouTube [Internet]. 2017 [cited 2022 Oct 26]. Available from: https://www.youtube.com/watch?v=WUQlr7lXbvE 27. Nicolas Bevacqua. Interpretación de un meta-análisis. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=z0JwqXlg3M0 28. Ariel Albedaño. Metaanálisis en RevMan. Metanaálisis de Odds Ratio. Epidemiología y Estadística [Internet]. 2021 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=3KDFFxWpRNI&t=2580s 29. Caro DA. Revisiones Sistemáticas de la Literatura. Chile; 2008 May. 30. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 1. DYNA. 2015;82(189):9–12. 31. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 2. DYNA. 2015;82(189):9–12. 32. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 3. DYNA. 2015;82(189):9–12. 33. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 4. DYNA. 2015;82(189):9–12. 34. Kroll J, Piontkowski M, Rathkjen PH, Orveillon FX, Kraft C, Duran OG. Long duration of immunity against a type 1 heterologous PRRS virus challenge in pigs immunised with a novel PRRS MLV vaccine: A randomised controlled study. Porc Heal Manag. 2018 May 16;4(1):1–8. 35. Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, et al. Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs. Vaccine. 2018 Jan 4;36(2):227–36. 36. Sun YF, Zhou L, Bian T, Tian XX, Ren WK, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018 Mar 1;216:176–82. 37. Huang Y, Li Z, Li J, Yibo-Kong, Yang L, Mah CK, et al. Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2019 Feb 1;229:117–23. 38. Chai W, Liu Z, Sun Z, Su L, Zhang C, Huang L. Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge. Vet Microbiol. 2020 Sep 1;248:108805. 39. Madapong A, Saeng-chuto K, Tantituvanont A, Nilubol D. Safety of PRRSV-2 MLV vaccines administrated via the intramuscular or intradermal route and evaluation of PRRSV transmission upon needle-free and needle delivery. Sci Rep. 2021 Dec 1;11(1):23107. 40. Duerlinger S, Knecht C, Sawyer S, Balka G, Zaruba M, Ruemenapf T, et al. Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets. Vaccines. 2022 Jun 1;10(6). 41. Madapong A, Temeeyasen G, Saeng-chuto K, Tripipat T, Navasakuljinda W, Boonsoongnern A, et al. Humoral immune responses and viral shedding following vaccination with modified live porcine reproductive and respiratory syndrome virus vaccines. Arch Virol 2016 1621. 2016 Sep 30;162(1):139–46. 42. Patterson A, Haiwick G, Hermann J, Fergen B, Wakeland K, Chittick W, et al. Efficacy of Ingelvac PRRS ® Modified Live Virus Vaccine against Heterologous Porcine Reproductive and Respiratory Syndrome Virus Challenges. 2019; 43. Balka G, Dreckmann K, Papp G, Kraft C. Vaccination of piglets at 2 and 3 weeks of age with Ingelvac PRRSFLEX® EU provides protection against heterologous field challenge in the face of homologous maternally derived antibodies. Porc Heal Manag. 2016 Aug 14;2(1):1–9. 44. Nicolas Bevacqua. Funnel plot. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=Tx17ly2Z1Vo&t=157s 45. Han J, Zhou L, Ge X, Guo X, Yang H. 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Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol. 2017 Sep 1;208:47–52.Su CM, Rowland RRR, Yoo D. Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines. 2021 Apr 1;9(4).Jiang Y, Li G, Yu L, Li L, Zhang Y, Zhou Y, et al. Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China. Front Microbiol. 2020 Apr 24;11:618.Han G, Yang H, Xu H, Zheng S, Li Y, Liu Z, et al. Broad antiviral peptides against PRRSV based on novel linear epitopes on porcine CD163. Int J Biol Macromol. 2022 May 15;207:635–43.Teresa Fernández Caballero. Caracterización de poblaciones celulares del linaje monocitomacrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv) . [Madrid]: Universidad COMPLUTENSE; 2019.Ye N, Wang B, Feng W, Tang D, Zeng Z. PRRS virus receptors and an alternative pathway for viral invasion. Virus Res. 2022 Oct 15;320:198885.Castillo Espinoza A, Ramírez Velásquez M, Castillo Espinoza A, Ramírez Velásquez M. Síndrome Reproductivo y Respiratorio Porcino: Una revisión del agente etiológico y su influencia en el comportamiento actual de la enfermedad. Rev Investig Vet del Perú. 2021 Feb 23;32(1):19645.Plata García M. Receptores involucrados en la infección y entrada de PRRS a la célula [Internet]. Porcicultura.com. 2018 [cited 2022 Oct 21]. Available from: https://www.porcicultura.com/destacado/Receptores-involucrados-en-la-infección-y-entrada-de-PRRS-a-la-célulaFernández-Caballero T, Álvarez B, Alonso F, Revilla C, Martínez-Lobo J, Prieto C, et al. Interaction of PRRS virus with bone marrow monocyte subsets. Vet Microbiol. 2018 Jun 1;219:123–7.Stoian AMM, Rowland RRR. Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization. Vet Sci. 2019 Mar;6(1).Moura CAA, Philips R, Silva GS, Holtkamp DJ, Linhares DCL. Comparison of virus detection, productivity, and economic performance between lots of growing pigs vaccinated with two doses or one dose of PRRS MLV vaccine, under field conditions. Prev Vet Med. 2022 Jul 1;204:105669.Vu HLX, Pattnaik AK, Osorio FA. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Jul 1;206:29–34.Chae C. Commercial PRRS Modified-Live Virus Vaccines. Vaccines. 2021 Feb 1;9(2):1–16.Kraft C, Hennies R, Dreckmann K, Noguera M, Rathkjen PH, Gassel M, et al. Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity. PLoS One. 2019 Oct 1;14(10).Constance LA, Thissen JB, Jaing CJ, McLoughlin KS, Rowland RRR, Serão NVL, et al. Gut microbiome associations with outcome following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in pigs immunized with a PRRS modified live virus vaccine. Vet Microbiol. 2021 Mar 1;254:109018.Wang A, Chen Q, Wang L, Madson D, Harmon K, Gauger P, et al. Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. Emerg Infect Dis. 2019;25(12):2335.Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021 Apr 1;9(4).Rowland RRR, Doerksen T, Lu A, Sheahan M, Lunney J, Dekkers J, et al. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Res. 2022 Jul 15;316:198809.Carrascosa De Lome L. Estudio comparativo de la seguridad de distintas vacunas vivas atenuadas frente al Síndrome Reproductor y Respiratorio Porcino. [Madrid]: UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA DEPARTAMENTO DE SANIDAD ANIMAL; 2018.Echave RS, López-Úbeda R, Ramis G, Caravaca IH. Control integral del PRRSv mediante el concepto de las 5 fases: revisión crítica. An Vet Murcia. 2021 Nov 26;35:59–78.Carvajal Sánchez JM. El papel del cd163 y otros biomarcadores deinterés en la inmunopatogenia del prrsv-1 a nivel pulmonar - Dialnet. [Córdoba]: Universidad de Córdoba; 2020.Jeong J, Choi K, Kang I, Park C, Chae C. Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea. Vet Microbiol. 2016 Aug 30;192:102–9.Dr. Alejandro Macias. ¿Cómo interpretar un Odds Ratio? - YouTube [Internet]. 2017 [cited 2022 Oct 26]. Available from: https://www.youtube.com/watch?v=WUQlr7lXbvENicolas Bevacqua. Interpretación de un meta-análisis. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=z0JwqXlg3M0Ariel Albedaño. Metaanálisis en RevMan. Metanaálisis de Odds Ratio. Epidemiología y Estadística [Internet]. 2021 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=3KDFFxWpRNI&t=2580sCaro DA. Revisiones Sistemáticas de la Literatura. Chile; 2008 May.Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 1. DYNA. 2015;82(189):9–12.Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 2. DYNA. 2015;82(189):9–12.Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 3. DYNA. 2015;82(189):9–12.Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 4. DYNA. 2015;82(189):9–12.Kroll J, Piontkowski M, Rathkjen PH, Orveillon FX, Kraft C, Duran OG. Long duration of immunity against a type 1 heterologous PRRS virus challenge in pigs immunised with a novel PRRS MLV vaccine: A randomised controlled study. Porc Heal Manag. 2018 May 16;4(1):1–8.Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, et al. Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs. Vaccine. 2018 Jan 4;36(2):227–36.Sun YF, Zhou L, Bian T, Tian XX, Ren WK, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018 Mar 1;216:176–82.Huang Y, Li Z, Li J, Yibo-Kong, Yang L, Mah CK, et al. Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2019 Feb 1;229:117–23.Chai W, Liu Z, Sun Z, Su L, Zhang C, Huang L. Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge. Vet Microbiol. 2020 Sep 1;248:108805.Madapong A, Saeng-chuto K, Tantituvanont A, Nilubol D. Safety of PRRSV-2 MLV vaccines administrated via the intramuscular or intradermal route and evaluation of PRRSV transmission upon needle-free and needle delivery. Sci Rep. 2021 Dec 1;11(1):23107.Duerlinger S, Knecht C, Sawyer S, Balka G, Zaruba M, Ruemenapf T, et al. Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets. Vaccines. 2022 Jun 1;10(6).Madapong A, Temeeyasen G, Saeng-chuto K, Tripipat T, Navasakuljinda W, Boonsoongnern A, et al. Humoral immune responses and viral shedding following vaccination with modified live porcine reproductive and respiratory syndrome virus vaccines. Arch Virol 2016 1621. 2016 Sep 30;162(1):139–46.Patterson A, Haiwick G, Hermann J, Fergen B, Wakeland K, Chittick W, et al. Efficacy of Ingelvac PRRS ® Modified Live Virus Vaccine against Heterologous Porcine Reproductive and Respiratory Syndrome Virus Challenges. 2019;Balka G, Dreckmann K, Papp G, Kraft C. Vaccination of piglets at 2 and 3 weeks of age with Ingelvac PRRSFLEX® EU provides protection against heterologous field challenge in the face of homologous maternally derived antibodies. Porc Heal Manag. 2016 Aug 14;2(1):1–9.Cui W, Yu F, Zhang Y, Han X, Zou R, Tang Y, et al. Discovery of traditional Chinese medicines against porcine reproductive and respiratory syndrome virus. Pharmacol Res - Mod Chinese Med. 2021 Dec 1;1:100003. 2. Li N, Huang K, Chen Y, Huang Z, Zhang Y, Leng CL, et al. MicroRNA ssc-miR-124a exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via suppression of host genes CD163. Vet Microbiol. 2021 Oct 1;261:109216. 3. Prather RS, Wells KD, Whitworth KM, Kerrigan MA, Samuel MS, Mileham A, et al. Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV). Sci Reports 2017 71. 2017 Oct 17;7(1):1–5. 4. Jeong J, Kim S, Park KH, Kang I, Park SJ, Park C, et al. Evaluation of the effect of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine on sow reproductive performance in endemic PRRS farms. Vet Microbiol. 2017 Sep 1;208:47–52. 5. Jiang Y, Li G, Yu L, Li L, Zhang Y, Zhou Y, et al. Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China. Front Microbiol. 2020 Apr 24;11:618. 6. Su CM, Rowland RRR, Yoo D. Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines. 2021 Apr 1;9(4). 7. Han G, Yang H, Xu H, Zheng S, Li Y, Liu Z, et al. Broad antiviral peptides against PRRSV based on novel linear epitopes on porcine CD163. Int J Biol Macromol. 2022 May 15;207:635–43. 8. Teresa Fernández Caballero. Caracterización de poblaciones celulares del linaje monocitomacrófago en órganos linfoides porcinos y su permisividad a la infección por el virus del síndrome respiratorio y reproductivo porcino (PRRSv) . [Madrid]: Universidad COMPLUTENSE; 2019. 9. Ye N, Wang B, Feng W, Tang D, Zeng Z. PRRS virus receptors and an alternative pathway for viral invasion. Virus Res. 2022 Oct 15;320:198885. 10. Castillo Espinoza A, Ramírez Velásquez M, Castillo Espinoza A, Ramírez Velásquez M. Síndrome Reproductivo y Respiratorio Porcino: Una revisión del agente etiológico y su influencia en el comportamiento actual de la enfermedad. Rev Investig Vet del Perú. 2021 Feb 23;32(1):19645. 11. Plata García M. Receptores involucrados en la infección y entrada de PRRS a la célula [Internet]. Porcicultura.com. 2018 [cited 2022 Oct 21]. Available from: https://www.porcicultura.com/destacado/Receptores-involucrados-en-la-infección-y-entrada-de-PRRS-a-la-célula 12. Fernández-Caballero T, Álvarez B, Alonso F, Revilla C, Martínez-Lobo J, Prieto C, et al. Interaction of PRRS virus with bone marrow monocyte subsets. Vet Microbiol. 2018 Jun 1;219:123–7. 13. Stoian AMM, Rowland RRR. Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus Neutralization. Vet Sci. 2019 Mar;6(1). 14. Moura CAA, Philips R, Silva GS, Holtkamp DJ, Linhares DCL. Comparison of virus detection, productivity, and economic performance between lots of growing pigs vaccinated with two doses or one dose of PRRS MLV vaccine, under field conditions. Prev Vet Med. 2022 Jul 1;204:105669. 15. Vu HLX, Pattnaik AK, Osorio FA. Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Jul 1;206:29–34. 16. Chae C. Commercial PRRS Modified-Live Virus Vaccines. Vaccines. 2021 Feb 1;9(2):1–16. 17. Kraft C, Hennies R, Dreckmann K, Noguera M, Rathkjen PH, Gassel M, et al. Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity. PLoS One. 2019 Oct 1;14(10). 18. Constance LA, Thissen JB, Jaing CJ, McLoughlin KS, Rowland RRR, Serão NVL, et al. Gut microbiome associations with outcome following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) in pigs immunized with a PRRS modified live virus vaccine. Vet Microbiol. 2021 Mar 1;254:109018. 19. Wang A, Chen Q, Wang L, Madson D, Harmon K, Gauger P, et al. Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. Emerg Infect Dis. 2019;25(12):2335. 20. Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines. 2021 Apr 1;9(4). 21. Rowland RRR, Doerksen T, Lu A, Sheahan M, Lunney J, Dekkers J, et al. Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. Virus Res. 2022 Jul 15;316:198809. 22. Carrascosa De Lome L. Estudio comparativo de la seguridad de distintas vacunas vivas atenuadas frente al Síndrome Reproductor y Respiratorio Porcino. [Madrid]: UNIVERSIDAD COMPLUTENSE DE MADRID FACULTAD DE VETERINARIA DEPARTAMENTO DE SANIDAD ANIMAL; 2018. 23. Echave RS, López-Úbeda R, Ramis G, Caravaca IH. Control integral del PRRSv mediante el concepto de las 5 fases: revisión crítica. An Vet Murcia. 2021 Nov 26;35:59–78. 24. Carvajal Sánchez JM. El papel del cd163 y otros biomarcadores deinterés en la inmunopatogenia del prrsv-1 a nivel pulmonar - Dialnet. [Córdoba]: Universidad de Córdoba; 2020. 25. Jeong J, Choi K, Kang I, Park C, Chae C. Evaluation of a 20 year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea. Vet Microbiol. 2016 Aug 30;192:102–9. 26. Dr. Alejandro Macias. ¿Cómo interpretar un Odds Ratio? - YouTube [Internet]. 2017 [cited 2022 Oct 26]. Available from: https://www.youtube.com/watch?v=WUQlr7lXbvE 27. Nicolas Bevacqua. Interpretación de un meta-análisis. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=z0JwqXlg3M0 28. Ariel Albedaño. Metaanálisis en RevMan. Metanaálisis de Odds Ratio. Epidemiología y Estadística [Internet]. 2021 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=3KDFFxWpRNI&t=2580s 29. Caro DA. Revisiones Sistemáticas de la Literatura. Chile; 2008 May. 30. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 1. DYNA. 2015;82(189):9–12. 31. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 2. DYNA. 2015;82(189):9–12. 32. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 3. DYNA. 2015;82(189):9–12. 33. Velásquez JD. Una guía corta para escribir revisiones sistemáticas de literatura parte 4. DYNA. 2015;82(189):9–12. 34. Kroll J, Piontkowski M, Rathkjen PH, Orveillon FX, Kraft C, Duran OG. Long duration of immunity against a type 1 heterologous PRRS virus challenge in pigs immunised with a novel PRRS MLV vaccine: A randomised controlled study. Porc Heal Manag. 2018 May 16;4(1):1–8. 35. Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, et al. Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs. Vaccine. 2018 Jan 4;36(2):227–36. 36. Sun YF, Zhou L, Bian T, Tian XX, Ren WK, Lu C, et al. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2018 Mar 1;216:176–82. 37. Huang Y, Li Z, Li J, Yibo-Kong, Yang L, Mah CK, et al. Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2019 Feb 1;229:117–23. 38. Chai W, Liu Z, Sun Z, Su L, Zhang C, Huang L. Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge. Vet Microbiol. 2020 Sep 1;248:108805. 39. Madapong A, Saeng-chuto K, Tantituvanont A, Nilubol D. Safety of PRRSV-2 MLV vaccines administrated via the intramuscular or intradermal route and evaluation of PRRSV transmission upon needle-free and needle delivery. Sci Rep. 2021 Dec 1;11(1):23107. 40. Duerlinger S, Knecht C, Sawyer S, Balka G, Zaruba M, Ruemenapf T, et al. Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets. Vaccines. 2022 Jun 1;10(6). 41. Madapong A, Temeeyasen G, Saeng-chuto K, Tripipat T, Navasakuljinda W, Boonsoongnern A, et al. Humoral immune responses and viral shedding following vaccination with modified live porcine reproductive and respiratory syndrome virus vaccines. Arch Virol 2016 1621. 2016 Sep 30;162(1):139–46. 42. Patterson A, Haiwick G, Hermann J, Fergen B, Wakeland K, Chittick W, et al. Efficacy of Ingelvac PRRS ® Modified Live Virus Vaccine against Heterologous Porcine Reproductive and Respiratory Syndrome Virus Challenges. 2019; 43. Balka G, Dreckmann K, Papp G, Kraft C. Vaccination of piglets at 2 and 3 weeks of age with Ingelvac PRRSFLEX® EU provides protection against heterologous field challenge in the face of homologous maternally derived antibodies. Porc Heal Manag. 2016 Aug 14;2(1):1–9. 44. Nicolas Bevacqua. Funnel plot. [Internet]. 2020 [cited 2022 Oct 28]. Available from: https://www.youtube.com/watch?v=Tx17ly2Z1Vo&t=157sHan J, Zhou L, Ge X, Guo X, Yang H. Pathogenesis and control of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Microbiol. 2017 Sep 1;209:30–47.Ding Y, Wubshet AK, Ding X, Zhang Z, Li Q, Dai J, et al. Evaluation of four commercial vaccines for the protection of piglets against the highly pathogenic porcine reproductive and respiratory syndrome virus (hp-PRRSV) QH-08 strain. 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