Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population
Artículo científico
- Autores:
-
Guauque Olarte, Sandra Milena
Rivera, Ana Lucia
Cifuentes Cardona, Laura Fernanda
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1317
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1317
- Palabra clave:
- Cancer
CHEK2
Latinoamérica
Mutaciones
- Rights
- openAccess
- License
- Licencia CC
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Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| title |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| spellingShingle |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population Cancer CHEK2 Latinoamérica Mutaciones |
| title_short |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| title_full |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| title_fullStr |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| title_full_unstemmed |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| title_sort |
Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population |
| dc.creator.fl_str_mv |
Guauque Olarte, Sandra Milena Rivera, Ana Lucia Cifuentes Cardona, Laura Fernanda |
| dc.contributor.author.none.fl_str_mv |
Guauque Olarte, Sandra Milena Rivera, Ana Lucia Cifuentes Cardona, Laura Fernanda |
| dc.subject.spa.fl_str_mv |
Cancer CHEK2 Latinoamérica Mutaciones |
| topic |
Cancer CHEK2 Latinoamérica Mutaciones |
| description |
Artículo científico |
| publishDate |
2016 |
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2016-11-29 |
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2017-08-23T20:19:41Z |
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2017-08-23T20:19:41Z |
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Guauque Olarte, S., Rivera Herrera, A. L., & Cifuentes C, L. (2016). Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population [version 1; referees: 3 approved with reservations]. F1000Research, 5(2791). https://doi.org/10.12688/f1000research.9932.1 |
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Guauque Olarte, S., Rivera Herrera, A. L., & Cifuentes C, L. (2016). Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population [version 1; referees: 3 approved with reservations]. F1000Research, 5(2791). https://doi.org/10.12688/f1000research.9932.1 |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Odontología, Pasto, Colombia, 00000 |
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Odontología |
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Guauque Olarte, Sandra Milena Rivera, Ana LuciaCifuentes Cardona, Laura Fernanda2017-08-23T20:19:41Z2017-08-23T20:19:41Z2016-11-29https://hdl.handle.net/20.500.12494/1317Guauque Olarte, S., Rivera Herrera, A. L., & Cifuentes C, L. (2016). Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population [version 1; referees: 3 approved with reservations]. F1000Research, 5(2791). https://doi.org/10.12688/f1000research.9932.1Artículo científicoCHEK2 (Checkpoint Kinase 2) encodes CHK2, a serine/threonine kinase involved in maintaining the G1/S and G2/M checkpoints and repair of double-strand DNA breaks via homologous recombination. Functions of CHK2 include the prevention of damaged cells from going through the cell cycle or proliferating and the maintenance of chromosomal stability. CHEK2 mutations have been reported in a variety of cancers including glioblastoma, ovarian, prostate, colorectal, gastric, thyroid, and lung cancer in studies performed mainly in White populations. The most studied mutation in CHEK2 is c.1100delC, which was associated with increased risk of breast cancer. The objective of this study was to compile mutations in CHEK2 identified in cancer genomics studies in different populations and especially in Latin American individualsIntroduction. -- Search of cancer genomics data repositories and the GWAS catalog. -- Literature review of Latin American studies. -- Results. -- CHEK2 mutations in the data genomics repositories. -- CHEK2 mutations in Latinos reported in the literature. -- Discussion.sandra.guauque@campusucc.edu.coanaluciarivera@hotmail.comlaura.cifuentesc@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Odontología, Pasto, Colombia, 00000OdontologíaPastohttps://f1000research.com/articles/5-2791/v1CancerCHEK2LatinoaméricaMutacionesMutations of the CHEK2 gene in patients with cancer and their presence in the Latin American 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