Manejo de la dermatitis atópica canina, un desafío para el médico veterinario

La dermatitis atópica es una enfermedad cutánea alérgica que genera cuadros pruriginosos y que posee características asociadas a la reacción de la Inmunoglobulina E ante alergenos ambientales. Esta es una patología común en la casuística dermatológica de la clínica veterinaria y su manejo se ha conv...

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Autores:: Rueda, Maria del Rosario

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2015

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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dc.title.spa.fl_str_mv	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
title	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
spellingShingle	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario Prurito Estrato Corneo Inmunoglobulina E Alergeno TG 2021 MVZ 33959 Pruritus Stratum Corneum Immunoglobulin E Allergen
title_short	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
title_full	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
title_fullStr	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
title_full_unstemmed	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
title_sort	Manejo de la dermatitis atópica canina, un desafío para el médico veterinario
dc.creator.fl_str_mv	Rueda, Maria del Rosario
dc.contributor.advisor.none.fl_str_mv	Trujillo Piso, Dunia Yisela
dc.contributor.author.none.fl_str_mv	Rueda, Maria del Rosario
dc.subject.spa.fl_str_mv	Prurito Estrato Corneo Inmunoglobulina E Alergeno
topic	Prurito Estrato Corneo Inmunoglobulina E Alergeno TG 2021 MVZ 33959 Pruritus Stratum Corneum Immunoglobulin E Allergen
dc.subject.classification.spa.fl_str_mv	TG 2021 MVZ 33959
dc.subject.other.spa.fl_str_mv	Pruritus Stratum Corneum Immunoglobulin E Allergen
description	La dermatitis atópica es una enfermedad cutánea alérgica que genera cuadros pruriginosos y que posee características asociadas a la reacción de la Inmunoglobulina E ante alergenos ambientales. Esta es una patología común en la casuística dermatológica de la clínica veterinaria y su manejo se ha convertido en un reto para el médico veterinario ya que puede confundirse con otras dermatopatías. Los factores que se han relacionado con la enfermedad son la disfunción de la barrera epidérmica, infecciones cutáneas bacterianas o por levaduras, factores psicógenos y enfermedades concurrentes de la piel. El diagnóstico de esta enfermedad está basado en los hallazgos clínicos y puede complementarse con pruebas de alergia. Una vez se ha llegado al diagnóstico, el tratamiento debe ir enfocado a controlar las infecciones asociadas, al manejo del prurito y la inflamación, así como a la creación de estrategias que disminuyan el riesgo de recurrencia de las lesiones en estos pacientes. Gran variedad de fármacos tópicos o sistémicos se involucran en la terapia y la selección de ellos se realiza de acuerdo a las características de cada canino; dentro de ellos están los corticoides, inmunomoduladores, antihistamínicos, antibióticos y antimicóticos. Sin embargo, es la inmunoterapia con alergenos hasta el momento la alternativa más eficaz y segura para pacientes con dermatitis atópica. El objetivo de la presente revisión es recopilar información importante y actualizada de aspectos tales como la fisiopatología, diagnóstico y tratamiento de la enfermedad, que permitan una mayor comprensión de la dermatitis atópica canina.
publishDate	2015
dc.date.available.none.fl_str_mv	2015-12-15 2021-04-22T14:29:57Z
dc.date.accessioned.none.fl_str_mv	2021-04-22T14:29:57Z
dc.date.issued.none.fl_str_mv	2021-04-22
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
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dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/33959
dc.identifier.bibliographicCitation.spa.fl_str_mv	Rueda, M. R. (2021). Manejo de la dermatitis atópica canina, un desafío para el médico veterinario. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/33959
url	https://hdl.handle.net/20.500.12494/33959
identifier_str_mv	Rueda, M. R. (2021). Manejo de la dermatitis atópica canina, un desafío para el médico veterinario. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/33959
dc.relation.references.spa.fl_str_mv	Halliwell R. Revised nomenclature for veterinary allergy. Vet Immunol Immunopathol. 2006;114(3–4):207–8. Wittich FW. Spontaneous allergy (atopy( in the lower animal - seasonal hay fever (fall type) in a dog. J Allergy. 1941;247–51 Wittich FW. Animal Allergy. Iowa State Coll Vet. 1951;13(3). Haiwell R. Atopic disease in the dog. Vet Rec. 1971;89(8):209–14 Butterfield ME, Hill SE, Lord CG. Mangy mutt or furry friend? Anthropomorphism promotes animal welfare. J Exp Soc Psychol. 2012;48(4):957–60. Favrot C, Steffan J, Seewald W, Picco F. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol. 2010;21(January 2009):23–31 Santoro D, Hoffmann AR. Canine and Human Atopic Dermatitis : Two Faces of the Same Host-Microbe Interaction. J Invest Dermatol. 2015;136(6):1087–9. Wollina U. Atopic dermatitis and the metabolic syndrome. Clin Dermatol. 2018;36(1):62–6. Cabanillas B, Novak N. Atopic dermatitis and filaggrin. Curr Opin Immunol. 2016;42:1–8 Olivry T. Is the skin barrier abnormal in dogs with atopic dermatitis ? Vet Immunol Immunopathol. 2011;144(1–2):11–6. Hillier A, Grif CE. The ACVD task force on canine atopic dermatitis ( I ): incidence and prevalence. Vet Immunol Immunopathol. 2001;81:147–51. Pereira DT, Schmidt C, Magnus T, Krause A. Sensitization study of dogs with atopic dermatitis in the central region of Rio Grande do Sul. Arq Bras Med Veterinária e Zootec. 2015;67(6):1533–8. Elias PM. Stratum Corneum Defensive Functions : An Integrated View. J Invest Dermatol. 2005;125(2):183–200. Elias P, Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol. 2009;9(5):437–46. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. Vet J. 2016;207:29–37. Santoro D, Marsella R, Pucheu-haston CM, Eisenschenk MNC, Bizikova P. Review : Pathogenesis of canine atopic dermatitis : skin barrier and host – micro-organism interaction. Vet Dermatol. 2015;1–12. Pucheu-Haston C, Jackson HA, Olivry T. Epicutaneous sensitization with Dermatophagoides farinae induces generalized allergic dermatitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis Clinical and Experimental Allergy. Clin Exp Allergy. 2008;38:667–79. Olivry T, Wofford J, Paps JS, Dunston SM. Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs. Vet Dermatol. 2010;22(September):188–96. Popa I, Remoue N, Thuy L, Portoukalian J. Atopic dermatitis in dogs is associated with a high heterogeneity in the distribution of protein-bound lipids within the stratum corneum. Arch Dermatol Res. 2011;303:433–40. Yoon J, Nishifuji K, Sasaki A, Ide K, Ishikawa J, Yoshihara T. Alteration of stratum corneum ceramide profiles in spontaneous canine model of atopic dermatitis. Exp Dermatol. 2011;20:732–6. Bäumer W, Roßbach K, Mischke R, Reines I, Langbein-Detsch I, Lüth A, et al. Decreased Concentration and Enhanced Metabolism of Sphingosine-1-Phosphate in Lesional Skin of Dogs with Atopic Dermatitis : Disturbed Sphingosine-1-Phosphate Homeostasis in Atopic Dermatitis. J Investig Dermatology (. 2011;131:266–8. Marsella R, Samuelson D, Harrington L. Immunohistochemical evaluation of filaggrin polyclonal antibody in atopic and normal beagles. Vet Dermatol. 2009;20:547–54. Wood SH, Ollier WE, Nuttall T, Mcewan NA, Carter SD. Despite identifying some shared gene associations with human atopic dermatitis the use of multiple dog breeds from various locations limits detection of gene associations in canine atopic dermatitis. Vet Immunol Immunopathol. 2010;138(3):193–7. Roque JB, Leary CAO, Duffy DL, Kyaw-tanner M, Gharahkhani P, Vogelnest L, et al. Atopic dermatitis in West Highland white terriers is associated with a 1 . 3-Mb region on CFA 17. Inmunogenetics. 2012;64:209–17. Hoffmann AR, Patterson AP, Diesel A, Lawhon SD, Ly HJ, Steiner M, et al. The Skin Microbiome in Healthy and Allergic Dogs. PLoS One. 2014;9(1). Weese JS. The canine and feline skin microbiome in health and disease. Vet Dermatol. 2013;24(1):137–46. Fazakerley J, Williams N, Mcewan N, Nuttall T. Heterogeneity of Staphylococcus pseudintermedius isolates from atopic and healthy dogs. Vet Dermatol. 2010;21(February):578–85. Fazakerley J, Nuttall T, Schmidt V, Carter SD, Hart CA, Mcewan NA. Staphylococcal colonization of mucosal and lesional skin sites in atopic and healthy dogs. Vet Dermatol. 2009;20:179–84. mou C, Thoday KL, Forsythe PJ, Hill PB. Adherence of Staphylococcus intermedius to corneocytes of healthy and atopic dogs : effect of pyoderma , pruritus score , treatment and gender. Vet Dermatol. 2005;16:385–91. Hill PB, Olivry T. The ACVD task force on canine atopic dermatitis ( V ): biology and role of in ¯ ammatory cells in cutaneous allergic reactions. Vet Immunol Immunopathol. 2001;81:187–98. Kobayashi T, Kano R, Nagata M, Hasegawa A, Kamata H. Genotyping of Malassezia pachydermatis isolates from canine healthy skin and atopic dermatitis by internal spacer 1 ( IGS1 ) region analysis. Vet Dermatol. 2011;1(January):401–5. Kobayashi T, Kano R, Nagata M, Hasegawa A, Kamata H. Genotyping of Malassezia pachydermatis isolates from canine healthy skin and atopic dermatitis by internal spacer 1 ( IGS1 ) region analysis. Vet Dermatol. 2011;1(January):401–5. Mueller RS. Immunopathology of Atopic Dermatitis. In: World Small Animal Veterinary Association World Congress Proceedings [Internet]. Sidney, Australia; 2007. Available from: https://www.vin.com/apputil/content/defaultadv1.aspx?pId=11242&meta=generic&catId=31918&id=3860701&ind=163&objTypeID=17 Teresiak-Mikołajczak E, Czarnecka-Operacz M, Jenerowicz D, Silny W. Neurogenic markers of the inflammatory process in atopic dermatitis: Relation to the severity and pruritus. Postep Dermatologii i Alergol. 2013;30(5):286–92 Deboer DJ, Hillier A. The ACVD task force on canine atopic dermatitis ( XV ): fundamental concepts in clinical diagnosis. Vet Immunol Immunopathol. 2001;81:271–6. Bensignor E, Grillon M, Mueller R. Can atopic dermatitis be diagnosed in case of atypical clinical signs ? About four clinical cases. Prat medicale Chir l’animal Cie. 2012;47(1):1–6. Hensel P, Santoro D, Favrot C, Hill P, Griffin C. Canine atopic dermatitis : detailed guidelines for diagnosis and allergen identification. BMC Vet Res. 2015;11(196):1–13. Ka D, Marignac G, Desquilbet L, Freyburger L, Hubert B, Garelik D, et al. Association between passive smoking and atopic dermatitis in dogs. Food Chem Toxicol. 2014;66:329–33 Olivry T. New diagnostic criteria for canine atopic dermatitis. Letter to Editor. Vet Dermatol. 2010;21(1):123–6. Willemse T, Education B, Commissioned C. Atopic skin disease: a review and a reconsideration of diagnostic criteria. J Small Anim Pr [Internet]. 1986;27:771–8. Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Atopic+skin+disease+:+a+review+and+a+reconsideration+of+diagnostic+criteria#0 Williams HC, Jburney PG, Hay RJ, Archer CB, Shipley MJ, Ahunter JJ, et al. The U.K. Working Party’s Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol. 1994;131(3):383–96. WILLIAMS HC, JBURNEY PG, STRACHAN D, HAY RJ. The U.K. Working Party’s Diagnostic Criteria for Atopic Dermatitis II. Observer variation of clinical diagnosis and signs of atopic dermatitis. Br J Dermatol. 1994;131(3):397–405. Williams HC, Burney PGJ, Pembrokef AC, Hay RJ. The U . K . Working Party â€TM s Diagnostic Criteria for Atopic Dermatitis . III . Independent hospital validation. Br J Dermatol. 1994;406–16 Prelaud P, Guaguere E, Alhaidari Z, Faivre N. Reevaluation of diagnostic criteria of canine atopic dermatitis. Rev Med Vet (Toulouse). 1998;149:1057–64. Olivry T, Deboer DJ, Jackson HA, Mueller RS, Nuttall T, Pre P. Treatment of canine atopic dermatitis : 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. Vet Dermatol. 2011;21:233–48. Hill PB, Deboer DJ. The ACVD task force on canine atopic dermatitis ( IV ): environmental allergens. Vet Immunol Immunopathol. 2001;81(3–4):169–86. Deboer DJ, Hillier A. The ACVD task force on canine atopic dermatitis ( XVI ): laboratory evaluation of dogs with atopic dermatitis with serum-based `` allergy tests. Vet Immunol Immunopathol. 2001;81:277–87. Chanthick C, Anaman S, Buathet K. The prevalence of positive intradermal allergy tests in 114 dogs with atopic dermatitis in the Bangkok metropolis , Thailand. Vet Immunol Immunopathol. 2008;126:256–62. Griot-Wenk ME, Busato A, Welle M, Racine BP, Weilenmann R, Tschudi P, et al. Total serum IgE and IgA antibody levels in healthy dogs of different breeds and exposed to different environments. Res Vet Sci. 1999;67(3):239–43 Hammerberg B. Canine Immunoglobulin E. Vet Allergy. 2013;132:8–15. Olivry T, Deboer DJ, Favrot C, Jackson HA, Mueller RS, Nuttall T, et al. Treatment of canine atopic dermatitis : 2015 updated guidelines from the International Committee on Allergic Diseases of Animals ( ICADA ). BMC Vet Res. 2015;11(210):1–15. Olivry T, Dunston SM, Favrot C, Pr P. The novel high molecular weight Dermatophagoides farinae protein Zen-1 is a major allergen in North American and European mite allergic dogs with atopic dermatitis. Vet Dermatol. 2016;1:1–8. Herrmann I, Einhorn L, Panakova L. Gender aspects in allergies of pets – A secondary publication and update. World Allergy Organ J. 2017;10(42):1–5. Zur G, Elad D, Sterenzy-Agiv N. Increased resistance of Staphylococcus pseudintermedius to the commonly used antibiotics in canine dermatology. Isr J Vet Med. 2011;66(4):143–50. Youn JH, Yoon JW, Koo HC, Lim SK, Park YH. Prevalence and antimicrogram of Staphylococcus intermedius group isolates from veterinary staff, companion animals, and the environment in veterinary hospitals in Korea. J Vet Diagnostic Investig. 2011;23(2):268–74 Yoon JW, Lee KJ, Lee SY, Chae MJ, Park JK, Yoo JH, et al. Antibiotic resistance profiles of Staphylococcus pseudintermedius isolates from canine patients in Korea. J Microbiol Biotechnol. 2010;20(12):1764–8. Vigo GB, Giacoboni GI, Gagetti PS, Pasterán FG, Corso AC. Resistencia antimicrobiana y epidemiología molecular de aislamientos de Staphylococcus pseudintermedius de muestras clínicas de caninos. Rev Argent Microbiol [Internet]. 2015;47(3):206–11. Available from: http://dx.doi.org/10.1016/j.ram.2015.06.002 Westermeyer R, Roy A, Mitchell M, Merchant S. In vitro comparison of Staphylococcus pseudintermedius susceptibility to common cephalosporins used in dogs. Vet Ther. 2010;11(3):1–9. Frosini SM, Bond R, Loeffler A, Larner J. Opportunities for topical antimicrobial therapy: Permeation of canine skin by fusidic acid. BMC Vet Res. 2017;13(1):1–8. Virbac. Allermyl ® Shampoo [Internet]. [cited 2018 Jan 13]. p. 1–2. Available from: https://nz.virbac.com/files/live/sites/nz-public/files/pdf/product-info/Allermyl.pdf Olivry T, Mueller RS. Critically appraised topic on adverse food reactions of companion animals ( 3 ): prevalence of cutaneous adverse food reactions in dogs and cats. BMC Vet Res. 2017;13(51):13–6. Mueller RS, Olivry T, Prélaud P. Critically appraised topic on adverse food reactions of companion animals ( 2 ): common food allergen sources in dogs and cats. BMC Vet Res. 2016;12(9):10–3. Dryden MW, Canfield MS, Kalosy K, Smith A, Crevoiserat L, Mcgrady JC, et al. Evaluation of fluralaner and afoxolaner treatments to control flea populations , reduce pruritus and minimize dermatologic lesions in naturally infested dogs in private residences in west central Florida USA. Parasit Vectors. 2016;9(365):1–11.
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spelling	Trujillo Piso, Dunia Yisela Rueda, Maria del Rosario2021-04-22T14:29:57Z2015-12-152021-04-22T14:29:57Z2021-04-22https://hdl.handle.net/20.500.12494/33959Rueda, M. R. (2021). Manejo de la dermatitis atópica canina, un desafío para el médico veterinario. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/33959La dermatitis atópica es una enfermedad cutánea alérgica que genera cuadros pruriginosos y que posee características asociadas a la reacción de la Inmunoglobulina E ante alergenos ambientales. Esta es una patología común en la casuística dermatológica de la clínica veterinaria y su manejo se ha convertido en un reto para el médico veterinario ya que puede confundirse con otras dermatopatías. Los factores que se han relacionado con la enfermedad son la disfunción de la barrera epidérmica, infecciones cutáneas bacterianas o por levaduras, factores psicógenos y enfermedades concurrentes de la piel. El diagnóstico de esta enfermedad está basado en los hallazgos clínicos y puede complementarse con pruebas de alergia. Una vez se ha llegado al diagnóstico, el tratamiento debe ir enfocado a controlar las infecciones asociadas, al manejo del prurito y la inflamación, así como a la creación de estrategias que disminuyan el riesgo de recurrencia de las lesiones en estos pacientes. Gran variedad de fármacos tópicos o sistémicos se involucran en la terapia y la selección de ellos se realiza de acuerdo a las características de cada canino; dentro de ellos están los corticoides, inmunomoduladores, antihistamínicos, antibióticos y antimicóticos. Sin embargo, es la inmunoterapia con alergenos hasta el momento la alternativa más eficaz y segura para pacientes con dermatitis atópica. El objetivo de la presente revisión es recopilar información importante y actualizada de aspectos tales como la fisiopatología, diagnóstico y tratamiento de la enfermedad, que permitan una mayor comprensión de la dermatitis atópica canina.Atopic dermatitis is an allergic skin disease that causes pruritic disease and has characteristics associated with the reaction of immunoglobulin E against environmental allergens. This is a common pathology in the dermatological casuistry of the veterinary clinic and its management has become a challenge for the veterinarian since it can be confused with other dermatopathies. The factors that have been related to the disease are epidermal barrier dysfunction, bacterial or yeast skin infections, psychogenic factors and concurrent skin diseases. The diagnosis of this disease is based on clinical findings and can be complemented with allergy tests. Once the diagnosis has been reached, treatment should be focused on controlling associated infections, the management of itching and inflammation, as well as the creation of strategies that reduce the risk of recurrence of lesions in these patients. A great variety of topical or systemic drugs are involved in the therapy and the selection of them is carried out according to the characteristics of each canine; Within them are corticosteroids, immunomodulators, antihistamines, antibiotics and antifungals. However, immunotherapy with allergens is the most effective and safe alternative for patients with atopic dermatitis. The objective of this review is to collect important and up-to-date information on aspects such as the pathophysiology, diagnosis and treatment of the disease, which will allow a better understanding of canine atopic dermatitis.maria.ruedaar@campusucc.edu.co27 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéPruritoEstratoCorneoInmunoglobulina EAlergenoTG 2021 MVZ 33959PruritusStratumCorneumImmunoglobulin EAllergenManejo de la dermatitis atópica canina, un desafío para el médico veterinarioTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Halliwell R. Revised nomenclature for veterinary allergy. Vet Immunol Immunopathol. 2006;114(3–4):207–8.Wittich FW. Spontaneous allergy (atopy( in the lower animal - seasonal hay fever (fall type) in a dog. J Allergy. 1941;247–51Wittich FW. Animal Allergy. Iowa State Coll Vet. 1951;13(3).Haiwell R. Atopic disease in the dog. Vet Rec. 1971;89(8):209–14Butterfield ME, Hill SE, Lord CG. Mangy mutt or furry friend? Anthropomorphism promotes animal welfare. J Exp Soc Psychol. 2012;48(4):957–60.Favrot C, Steffan J, Seewald W, Picco F. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Vet Dermatol. 2010;21(January 2009):23–31Santoro D, Hoffmann AR. Canine and Human Atopic Dermatitis : Two Faces of the Same Host-Microbe Interaction. J Invest Dermatol. 2015;136(6):1087–9.Wollina U. Atopic dermatitis and the metabolic syndrome. Clin Dermatol. 2018;36(1):62–6.Cabanillas B, Novak N. Atopic dermatitis and filaggrin. Curr Opin Immunol. 2016;42:1–8Olivry T. Is the skin barrier abnormal in dogs with atopic dermatitis ? Vet Immunol Immunopathol. 2011;144(1–2):11–6.Hillier A, Grif CE. The ACVD task force on canine atopic dermatitis ( I ): incidence and prevalence. Vet Immunol Immunopathol. 2001;81:147–51.Pereira DT, Schmidt C, Magnus T, Krause A. Sensitization study of dogs with atopic dermatitis in the central region of Rio Grande do Sul. Arq Bras Med Veterinária e Zootec. 2015;67(6):1533–8.Elias PM. Stratum Corneum Defensive Functions : An Integrated View. J Invest Dermatol. 2005;125(2):183–200.Elias P, Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr Opin Allergy Clin Immunol. 2009;9(5):437–46.Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. Vet J. 2016;207:29–37.Santoro D, Marsella R, Pucheu-haston CM, Eisenschenk MNC, Bizikova P. Review : Pathogenesis of canine atopic dermatitis : skin barrier and host – micro-organism interaction. Vet Dermatol. 2015;1–12.Pucheu-Haston C, Jackson HA, Olivry T. 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12:57:05.517open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de 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