Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino

En el mundo de la terapia regenerativa, las plaquetas están siendo una elección exitosa para los médicos dedicados a equinos y para muchos microbiólogos, microscopistas e investigadores, un tema controversial y novedoso. Esta Revisión de Literaria Sistemática tiene como fin profundizar en el conocim...

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Autores:
García Nuñez, Maira Alejandra
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/53065
Acceso en línea:
https://hdl.handle.net/20.500.12494/53065
Palabra clave:
Equinos
Lesiones
PRP
Recuperación
Tratamiento
TG 2023 MVZ 53065
Equine
Injury
PRP
Recovery
Treatment
Rights
openAccess
License
Atribución
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network_name_str Repositorio UCC
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dc.title.none.fl_str_mv Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
title Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
spellingShingle Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
Equinos
Lesiones
PRP
Recuperación
Tratamiento
TG 2023 MVZ 53065
Equine
Injury
PRP
Recovery
Treatment
title_short Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
title_full Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
title_fullStr Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
title_full_unstemmed Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
title_sort Plasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equino
dc.creator.fl_str_mv García Nuñez, Maira Alejandra
dc.contributor.advisor.none.fl_str_mv Sánchez Bonilla, María del Pilar
dc.contributor.author.none.fl_str_mv García Nuñez, Maira Alejandra
dc.subject.none.fl_str_mv Equinos
Lesiones
PRP
Recuperación
Tratamiento
topic Equinos
Lesiones
PRP
Recuperación
Tratamiento
TG 2023 MVZ 53065
Equine
Injury
PRP
Recovery
Treatment
dc.subject.classification.none.fl_str_mv TG 2023 MVZ 53065
dc.subject.other.none.fl_str_mv Equine
Injury
PRP
Recovery
Treatment
description En el mundo de la terapia regenerativa, las plaquetas están siendo una elección exitosa para los médicos dedicados a equinos y para muchos microbiólogos, microscopistas e investigadores, un tema controversial y novedoso. Esta Revisión de Literaria Sistemática tiene como fin profundizar en el conocimiento de las plaquetas, cómo funciona el Plasma Rico en Plaquetas (PRP), en que medidas terapéuticas utilizarlo y los beneficios que atrae emplearlo
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-10-18T21:21:02Z
dc.date.available.none.fl_str_mv 2023-10-18T21:21:02Z
dc.date.issued.none.fl_str_mv 2023-10-18
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/53065
dc.identifier.bibliographicCitation.none.fl_str_mv Garcia Nuñez, M. A. (2023). Plasma Rico en Plaquetas (PRP) como Alternativa Terapéutica en Lesiones del Equino [ Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/53065
url https://hdl.handle.net/20.500.12494/53065
identifier_str_mv Garcia Nuñez, M. A. (2023). Plasma Rico en Plaquetas (PRP) como Alternativa Terapéutica en Lesiones del Equino [ Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/53065
dc.relation.references.none.fl_str_mv Panuganti S, Schlinker AC, Lindholm PF, Papoutsakis ET, Miller WM. Three-stage Ex vivo Expansion of High-ploidy Megakaryocytic Cells: Toward Large-scale Platelet Production. Tissue Eng Part A. 2013 Apr 1;19(7–8):998–1014.
Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, et al. Signal-dependent Splicing of Tissue Factor Pre-mRNA Modulates the Thrombogenecity of Human Platelets. Journal of Experimental Medicine. 2006 Oct;203(11):2433–40.
Shi DS, Smith MCP, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, et al. Proteasome Function is Required for Platelet Production. Journal of Clinical Investigation. 2014 Sep 2;124(9):3757–66
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Rossi R, Oliveira A, Mello G, Frazílio F, Leal C, Facco G, et al. Effects of Platelet-rich Plasma Gel on Skin Healing in Surgical Wound in Horses. Acta Cirúrgica Brasileira . 2009;24
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Carrrasco J, Bonete D, Gomar F. Plasma Rico en Plaquetas vs Plasma Rico en Factores de Crecimiento. Revista Española de Cirugía Osteoarticular . 2009;46
Norma Fernández-Delgado, Porfirio Hernández-Ramírez, Forrellat-Barrios M. Espectro Funcional de las Plaquetas: de la Hemostasia a la Medicina Regenerativa Platelet Functional Spectrum: from Hemostasis to Regenerative Medicine. Revista Cubana de Hematología, Inmunología y Hemoterapia [Internet]. 2012;28(3):200–16. Available from: http://scielo.sld.cu200
Romero, Barrachina, Ranera, Remacha, Moreno, de Blas, et al. Comparison of Autologous Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells, and Platelet Rich Plasma, for Treating Surgically Induced Lesions of the Equine Superficial Digital Flexor Tendon. Veterinary Journal. 2017 Jun 1;224:76–84
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Tuemmers C, Saldivia A. Terapias Regenerativas Alternativas: Versatilidad de Uso, Alcances y Utilidad en Tendinopatias en la Practica Clinica Equina. Sustainability, Agri, Food and Environmental Research. 2015;4
Rodríguez Flores J, Palomar Gallego MA, Torres García-Denche J. Plasma rico en Plaquetas: Fundamentos Biológicos y Aplicaciones en Cirugía Maxilofacial y Estética Facial. Revista Espanola de Cirugia Oral y Maxilofacial. 2012 Jan;34(1):8–17
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White, Schuren, Wardlaw, Diamandopoulos, Anderson. Biomechanical Assessment of Gait in Below-knee Walking Casts. Prosthet Orthot Int. 1999;23:142–51
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Abellanet I. La Terapia de Lesiones de Tejidos Blandos y Articulaciones con Plasma Rico en Plaquetas en Caballos de Deporte: Evidencias Clínicas y Bioquímicas que Validad su Utilización. [Barcelona ]: Universitat Autònoma de Barcelona; 2009
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Bosch G, Van Schie HTM, De Groot MW, Cadby JA, Van De Lest CHA, Barneveld A, et al. Effects of Platelet-rich Plasma on the Quality of Repair of Mechanically Induced core Lesions in Equine Superficial Digital Flexor Tendons: A Placebo-controlled Experimental Study. Journal of Orthopaedic Research. 2010 Feb;28(2):211–7
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Fernandes Filgueira FG, Minto BW, Chung DG, Prada TC, Rosa-Ballaben NM, Nogueira Campos MG. Platelet-rich plasma, Bone Marrow and Chitosan in Minimally Invasive Plate Osteosynthesis of Canine Tibia Fractures – A Randomized Study. Vet Med (Praha). 2019;64(7):309–16
López S, Vilar JM, Sopena JJ, Damià E, Chicharro D, Carrillo JM, et al. Assessment of the Efficacy of Platelet-rich Plasma in the Treatment of Traumatic Canine Fractures. Int J Mol Sci. 2019 Mar 1;20(5)
Yin N, Wang Y, Ding L, Yuan J, Du L, Zhu Z, et al. Platelet-rich plasma Enhances the Repair Capacity of Muscle-derived Mesenchymal Stem cells to Large Humeral Bone Defect in Rabbits. Sci Rep. 2020 Dec 1;10(1)
Norma Fernández-Delgado D, Porfirio Hernández-Ramírez C, Forrellat-Barrios M. Espectro Funcional de las Plaquetas: de la Hemostasia a la Medicina Regenerativa Platelet Functional Spectrum: From Hemostasis to Regenerative Medicine. Revista Cubana de Hematología, Inmunología y Hemoterapia [Internet]. 2012;28(3):200–16. Available from: http://scielo.sld.cu200
Piso D, Barreto MYP, Bonilla M del PS, Rincón AC, Páez OLA, Rengifo CA, et al. Effects of platelet-rich Plasma on Corneal Re-epithelization and Metalloproteinase Expression in the Cornea of Sheep with Experimentally-induced Infectious Keratoconjunctivitis. Vet World. 2023 Apr;16:799–810
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Maia L, de Souza MV, Ribeiro Júnior JI, de Oliveira AC, Alves GES, dos Anjos Benjamin L, et al. Platelet-Rich Plasma in the Treatment of Induced Tendinopathy in Horses: Histologic Evaluation. J Equine Vet Sci. 2009;29(8):618–26
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spelling Sánchez Bonilla, María del PilarGarcía Nuñez, Maira Alejandra2023-10-18T21:21:02Z2023-10-18T21:21:02Z2023-10-18https://hdl.handle.net/20.500.12494/53065Garcia Nuñez, M. A. (2023). Plasma Rico en Plaquetas (PRP) como Alternativa Terapéutica en Lesiones del Equino [ Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/53065En el mundo de la terapia regenerativa, las plaquetas están siendo una elección exitosa para los médicos dedicados a equinos y para muchos microbiólogos, microscopistas e investigadores, un tema controversial y novedoso. Esta Revisión de Literaria Sistemática tiene como fin profundizar en el conocimiento de las plaquetas, cómo funciona el Plasma Rico en Plaquetas (PRP), en que medidas terapéuticas utilizarlo y los beneficios que atrae emplearloIn the world of regenerative therapy, platelets are being a successful choice for equine doctors and for many microbiologists, microscopists and researchers, a controversial and novel topic. This Systematic Literature Review aims to deepen the knowledge of platelets, how Platelet Rich Plasma (PRP) works, in what therapeutic measures to use it and the benefits of using it.maira.garcian@campusucc.edu.co31 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéEquinosLesionesPRPRecuperaciónTratamientoTG 2023 MVZ 53065EquineInjuryPRPRecoveryTreatmentPlasma rico en plaquetas (PRP) como alternativa terapéutica en lesiones del equinoTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Panuganti S, Schlinker AC, Lindholm PF, Papoutsakis ET, Miller WM. Three-stage Ex vivo Expansion of High-ploidy Megakaryocytic Cells: Toward Large-scale Platelet Production. Tissue Eng Part A. 2013 Apr 1;19(7–8):998–1014.Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, et al. Signal-dependent Splicing of Tissue Factor Pre-mRNA Modulates the Thrombogenecity of Human Platelets. Journal of Experimental Medicine. 2006 Oct;203(11):2433–40.Shi DS, Smith MCP, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, et al. Proteasome Function is Required for Platelet Production. Journal of Clinical Investigation. 2014 Sep 2;124(9):3757–66Garraud O, Cognasse F. Are Platelets Cells? And If yes, are they Immune Cells? Vol. 6, Frontiers in Immunology. Frontiers Media S.A.; 2015.Varki A, Gagneux P. Multifarious Roles of Sialic Acids in Immunity. Ann N Y Acad Sci. 2012;1253(1):16–36.Nguyen KA, Hamzeh-Cognasse H, Palle S, Anselme-Bertrand I, Arthaud CA, Chavarin P, et al. Role of Siglec-7 in Apoptosis in Human Platelets. PLoS One. 2014 Sep 17;9(9).Reddy EC, Rand ML. Procoagulant Phosphatidylserine-exposing Plateletsinvitro and Invivo. Vol. 7, Frontiers in Cardiovascular Medicine. Frontiers Media S.A.; 2020Leytin V. Apoptosis in the Anucleate Platelet. Blood Rev. 2012 Mar;26(2):51–63Nurden AT. Platelets, Inflammation and Tissue Regeneration. Thrombosis and Haemostasis suplement. 2011;105(SUPPL. 1):13–33Garraud O, Cognasse H, Pozzetto B, Cavaillon J, Cognasse F. Bench to Bedside Review: Platelets and Active Inmune Functions- New Clues for Immnunopathology. Biomed Central. 2013;17Klinger MHF, Jelkmann W. Role of Blood Platelets in Infection and Inflammation. Vol. 22, JOURNAL OF INTERFERON & CYTOKINE RESEARCH. 2002Brandt E, Ludwig A, Petersen F, Flad HD. Immunological Reviews Platelet-derived CXC Chemokines: old Players in New Games. Immunol Rev. 2000;177:204–16Verschoor A, Langer HF. Crosstalk Between Platelets and the Complement System in Immune Protection and Disease. Vol. 110, Thrombosis and Haemostasis. 2013. p. 910–9Wagner DD. New links Between Inflammation and Thrombosis. Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1321–4Long MW, Williams N, Ebbe S. Immature Megakaryocytes in the Mouse: Physical Characteristics, Cell Cycle Status, and In Vitro Responsiveness to Thrombopoietic Stimulatory Factor. Blood [Internet]. 1982;59(3). Available from: http://ashpublications.org/blood/article-pdf/59/3/569/586704/569.pdfPlatelets - Google Books [Internet]. [cited 2023 Oct 15]. Available from: https://books.google.com.co/books?hl=en&lr=&id=gj-MDwAAQBAJ&oi=fnd&pg=PP1&ots=syeuaxmSgu&sig=OgCNVJUvFi1VaynlzU-CIJsXMZo&redir_esc=y#v=onepage&q&f=falseGeddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic Megakaryocytes that form a Bipolar Spindle Exhibit Cleavage Furrow Ingression Followed by Furrow Regression. Vol. 6, Cell Cycle. Taylor and Francis Inc.; 2007. p. 455–60Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, et al. Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release. Journal of Cell Biology. 2010 Nov 15;191(4):861–74Tablin F, Castro M, Levenf RM. Blood Platelet Formation in vitro. The Role of the Cytoskeleton in Megakaryocyte Fragmentation. J Cell Sci. 1990;97Hartwig JH, Italiano JE. Cytoskeletal Mechanisms for Platelet Production. Blood Cells Mol Dis. 2006 Mar;36(2):99–103Lecine P, Italiano JE, Kim SW, Villeval JL, Shivdasani RA. Hematopoietic-specific 1 Tubulin Participates in a Pathway of Platelet Biogenesis Dependent on the Transcription Factor NF-E2. The American Society of Hematology [Internet]. 2000;96. Available from: http://ashpublications.org/blood/article-pdf/96/4/1366/1666807/1366.pdfRosenfeld A, Arvanitis D, Junt T, Schulze H, Chen Z, Massberg S, et al. Dynamic Visualization of Thrombopoiesis Within Bone Marrow. Science [Internet]. 2007;317:3172. Available from: www.sciencemag.org/cgi/content/full/1146067/DC1Clavi M, Adams G, Weibrecht W, Weber J, Olson D, Knight M, et al. Osteoblastic Cells Regulate the Haematopoietic Stem Cell Niche. Nature Publishing Group. 2003 Oct 23;425(6960):836–41Malara A, Abbonante V, Di Buduo CA, Tozzi L, Currao M, Balduini A. The Secret life of a Megakaryocyte: Emerging roles in Bone Marrow Homeostasis Control. Vol. 72, Cellular and Molecular Life Sciences. Birkhauser Verlag AG; 2015. p. 1517–36Rossi R, Oliveira A, Mello G, Frazílio F, Leal C, Facco G, et al. Effects of Platelet-rich Plasma Gel on Skin Healing in Surgical Wound in Horses. Acta Cirúrgica Brasileira . 2009;24Bonfá AF, Nomura RHC, Prado AMB do, Silveira AB da, Dornbusch LPTC, Dornbusch PT. Efeito do Gel de Plasma Rico em Plaquetas na Cicatrização de Enxertos Cutâneos em Equinos. Ciência Animal Brasileira. 2017 Aug 21;18(0)Carrrasco J, Bonete D, Gomar F. Plasma Rico en Plaquetas vs Plasma Rico en Factores de Crecimiento. Revista Española de Cirugía Osteoarticular . 2009;46Norma Fernández-Delgado, Porfirio Hernández-Ramírez, Forrellat-Barrios M. Espectro Funcional de las Plaquetas: de la Hemostasia a la Medicina Regenerativa Platelet Functional Spectrum: from Hemostasis to Regenerative Medicine. Revista Cubana de Hematología, Inmunología y Hemoterapia [Internet]. 2012;28(3):200–16. Available from: http://scielo.sld.cu200Romero, Barrachina, Ranera, Remacha, Moreno, de Blas, et al. Comparison of Autologous Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells, and Platelet Rich Plasma, for Treating Surgically Induced Lesions of the Equine Superficial Digital Flexor Tendon. Veterinary Journal. 2017 Jun 1;224:76–84Theoret C, Schumacher J. Equine Wound Management. Vol. 3. 2017Lenín D, Mejía E, Sánchez España A. Evaluación de un Nuevo Protocolo para Concentrar Plaquetas Equinas, en el Laboratorio Clínico. 2013;4(1):15–21Tuemmers C, Saldivia A. Terapias Regenerativas Alternativas: Versatilidad de Uso, Alcances y Utilidad en Tendinopatias en la Practica Clinica Equina. Sustainability, Agri, Food and Environmental Research. 2015;4Rodríguez Flores J, Palomar Gallego MA, Torres García-Denche J. Plasma rico en Plaquetas: Fundamentos Biológicos y Aplicaciones en Cirugía Maxilofacial y Estética Facial. Revista Espanola de Cirugia Oral y Maxilofacial. 2012 Jan;34(1):8–17Quintana C. Manejo de Heridas en Equinos [Internet]. Bogotá ; 2015. Available from: https://ciencia.lasalle.edu.co/medicina_veterinariaCWhite, Schuren, Wardlaw, Diamandopoulos, Anderson. Biomechanical Assessment of Gait in Below-knee Walking Casts. Prosthet Orthot Int. 1999;23:142–51Marquez G. Manejo Clínico de las Heridas en Equinos. 1993Brossi PM, Moreira JJ, Machado TSL, Baccarin RYA. Platelet-rich Plasma in Orthopedic Therapy: A Comparative Systematic Review of Clinical and Experimental Data in Equine and Human Musculoskeletal Lesions. BMC Vet Res. 2015 Apr 22;11(1)Abellanet I. La Terapia de Lesiones de Tejidos Blandos y Articulaciones con Plasma Rico en Plaquetas en Caballos de Deporte: Evidencias Clínicas y Bioquímicas que Validad su Utilización. [Barcelona ]: Universitat Autònoma de Barcelona; 2009Eppley BL, Woodell JE, Higgins J. Platelet Quantification and Growth Factor Analysis from Platelet-rich Plasma: Implications for Wound Healing. Plast Reconstr Surg. 2004 Nov;114(6):1502–8Vasconcelos A, Leme P, Alves G. Ativação de Plaquetas de Eqüinos com Laminite Induzida e Tratados com Ketoprofeno, Fenilbutazona e Flunixin Meglumina. Arq Bras Med Vet Zootec. 2006;58:149–57Anitua E. Plasma Rich in Growth Factors: Preliminary Results of Use in the Preparation of Future Sities for Implants. Int J Oral Maxillofac Implants. 1999;14:529–35Álvarez M, López C, Giraldo C, Samudio I, Carmona J. In Vitro Bactericidal Activity of Equine Platelet Concentrates, Platelet Poor Plasma, and Plasma Against Methicillin-resistant Staphylococcus aureus. Arch Med Vet [Internet]. 2011;43:155–61. Available from: www.dssresearch.com/toolkit/spcalc/power_p2.aspKastelic, Galeski, Baer Ohio. The Multicomposite Structure of Tendon. Cowwctioe Tissue Research. 1978;6(6):11–23Thorpe, Clegg, Birch. A Review of Tendon Injury: Why is the Equine Superficial Digital Flexor Tendon Most at Risk? Equine Vet J. 2010 Mar;42(2):174–80Goodship A, Birch H, Wilson A. The Pathoniology and Repair of Tendon and Ligament Injury. Vet Clin North Am Equine Pract. 1994;10(2):323–49Crevier-Denoix N, Collobert C, Bernard N, Bousseau. Mechanical Properties of Pathological Equine Superficial Digital Flexor Tendons. Equine Vet J Suppl. 1997;23(23):23–6Dowling, Dart, Hodgson, Smith. Superficial Digital Flexor Tendonitis in the Horse. Equine Vet J. 2000;32(5):369–78Smith R, Schramme M. Tendon Injury in the Horse: Current Theories and Therapies. In Pract. 2003;25(9):529–39Denoix J. Functional Anatomy of Tendons and Ligaments in the Distal Limbs (manus and pes). Vet Clin North Am Equine Pract. 1994;10(2):273–322Anderson, McIlwraith, Douay. The Role of Conformation in Musculoskeletal Problems in the Racing Thoroughbred. Equine Vet J. 2004;36(7):571–5Pool R, Meagher D. Pathologic Findings and Pathogenesis of Racetrack Injuries. Vet Clin North Am Equine Pract. 1990;6(1):1–30Kobayashi A, Sugisaka M, Takehana K, Yamaguchi M, Abe M. Morphological and Histochemical Analysis of a Case of Superficial Digital Flexor Tendon Injury in the Horse. Vol. 120, J. Comp. Path. 1999Dahlgren L, Van Der Meulen M, Bertram ’ J, Starrak G, Nixon A. Insulin-like Growth Factor-I Improves Cellular and Molecular Aspects of Healing in a Collagenase-induced Model of Flexor Tendinitis [Internet]. Vol. 20, Journal or Orthopaedic Research. 2002. Available from: www.ekevier.com/locate/orthresBirch H, Wilson A, Goodship A. Physical activity: Does Long-term, High-intensity Exercise in Horses Result in Tendon Degeneration? J Appl Physiol [Internet]. 2008;105:1927–33Carmona, Prades, Argüelles. Concentrados Autólogos de Plaquetas como Tratamiento de Lesiones de Tejidos Blandos del Aparato Locomotor en Caballos. Archivos de Medicina Veterinaria . 2009;41Dyson S, Arthur R, Palmer S, Richardson D. Suspensory Ligament Desmitis. Vet Clin North Am Equine Pract. 1995;11(2):177–215Dyson S, Genovese R. The Suspensory Apparatus. In: Diagnosis and Management of Lameness in the Horse. Elsevier Inc.; 2003. p. 654–72Gaujoux-Viala, Dougados, Gossec. Efficacy and Safety of Steroid Injections for Shoulder and Elbow Tendonitis: A meta-analysis of Randomised Controlled Trials. Ann Rheum Dis. 2009 Dec;68(12):1843–9Dyson. Medical Management of Superficial Digital Flexor tendonitis: A Comparative Study in 219 Horses (1992-2000). Equine Vet J. 2004;36(5):415–9Kaneps A. Surgical Options for Treating Tendon and Ligament Injuries. Clinical Techniques in Equine Practice. 2007 Sep;6(3):209–16Araghi-Sooreh A, Navidi M, Razi M. The Effects of High and Low Altitudes on Conjunctival Flora in Sport and Work Horses: A Field Study in the Northeast Anatolia Region of Turkey (Kars and Iğdır). Kafkas Univ Vet Fak Derg. 2014;20(4):625–7Ferreira AR de A, Santana AF, de Almeida AC da VR, Sousa RF, Perecmanis S, Galera PD. Cultura e Sensibilidade Bacteriana da Conjuntiva Ocular de Equinos. Ciencia Rural Santa Maria . 2017;47(6)Ribeiro MVMR, de Melo VF, Barbosa MEFC, Tozzi MU de F, Ramos MSB, Gaia NMSRS, et al. The use of platelet Rich-plasma in Ophthalmology: A Literature Review. Rev Bras Oftalmol. 2017 Nov 1;76(6):319–24Tambella AM, Attili AR, Dupré G, Cantalamessa A, Martin S, Cuteri V, et al. Platelet-rich Plasma to Treat Experimentally-induced Skin Wounds in Animals: A Systematic Review and Meta-analysis. PLoS One. 2018 Jan 1;13(1)Alsousou, Ali, Willett, Harrison. The Role of Platelet-rich Plasma in Tissue Regeneration. Platelets. 2013;24(3):173–82Rushton, Kammergruber, Tichy, Egerbacher, Nell, Gabner. Effects of Three Blood Derived Products on Equine Corneal Cells, an in Vitro Study. Equine Vet J. 2018 May 1;50(3):356–62Bosch G, Van Schie HTM, De Groot MW, Cadby JA, Van De Lest CHA, Barneveld A, et al. Effects of Platelet-rich Plasma on the Quality of Repair of Mechanically Induced core Lesions in Equine Superficial Digital Flexor Tendons: A Placebo-controlled Experimental Study. Journal of Orthopaedic Research. 2010 Feb;28(2):211–7Sutter A, Kaneps, Alicia, Bertone. Comparison of Hematologic Values and Transforming Growth Factor-β and Insulin-like Growth Factor Concentrations in Platelet Concentrates Obtained by use of Buffy Coat and Apheresis Aethods from Equine Blood. 2004;65Zhang F, Liu H, Stile F, Lei MP, Pang Y, Oswald TM, et al. Effect of Vascular Endothelial Growth Factor on Rat Achilles Tendon Healing. Plast Reconstr Surg. 2003 Nov;112(6):1613–9Fernandes Filgueira FG, Minto BW, Chung DG, Prada TC, Rosa-Ballaben NM, Nogueira Campos MG. Platelet-rich plasma, Bone Marrow and Chitosan in Minimally Invasive Plate Osteosynthesis of Canine Tibia Fractures – A Randomized Study. Vet Med (Praha). 2019;64(7):309–16López S, Vilar JM, Sopena JJ, Damià E, Chicharro D, Carrillo JM, et al. Assessment of the Efficacy of Platelet-rich Plasma in the Treatment of Traumatic Canine Fractures. Int J Mol Sci. 2019 Mar 1;20(5)Yin N, Wang Y, Ding L, Yuan J, Du L, Zhu Z, et al. Platelet-rich plasma Enhances the Repair Capacity of Muscle-derived Mesenchymal Stem cells to Large Humeral Bone Defect in Rabbits. Sci Rep. 2020 Dec 1;10(1)Norma Fernández-Delgado D, Porfirio Hernández-Ramírez C, Forrellat-Barrios M. Espectro Funcional de las Plaquetas: de la Hemostasia a la Medicina Regenerativa Platelet Functional Spectrum: From Hemostasis to Regenerative Medicine. Revista Cubana de Hematología, Inmunología y Hemoterapia [Internet]. 2012;28(3):200–16. Available from: http://scielo.sld.cu200Piso D, Barreto MYP, Bonilla M del PS, Rincón AC, Páez OLA, Rengifo CA, et al. Effects of platelet-rich Plasma on Corneal Re-epithelization and Metalloproteinase Expression in the Cornea of Sheep with Experimentally-induced Infectious Keratoconjunctivitis. Vet World. 2023 Apr;16:799–810Abellanet I, Prades M. Intraarticular Platelet Rich Plasma (PRP) Therapy: Evaluation in Horses With Oa. Brasil; 2009Maia L, de Souza MV, Ribeiro Júnior JI, de Oliveira AC, Alves GES, dos Anjos Benjamin L, et al. Platelet-Rich Plasma in the Treatment of Induced Tendinopathy in Horses: Histologic Evaluation. J Equine Vet Sci. 2009;29(8):618–26Hernandez H. Tendinitis Equina: Revisión de Casos Clínicos Tratados con Plasma Rico en Plaquetas. [Argentina ]: Universidad de Buenos Aires ; 2012Quintana A. Manejo de Heridas en Equinos [Internet]. [Bogotá]: Universidad de la Salle; 2015. 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