Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mR...

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Autores:: Aguilar-Jimenez W.
Zapata Builes, Wildeman
Rugeles M.T.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2016

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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repository_id_str
spelling	Aguilar-Jimenez W.Zapata Builes, WildemanRugeles M.T.2021-12-16T22:15:34Z2021-12-16T22:15:34Z2016https://doi.org/10.1016/j.vetpar.2011.11.01112864579https://hdl.handle.net/20.500.12494/41506Aguilar W,Zapata W,Rugeles MT. Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. MICROBES AND INFECTION. 2016. 18. (7-8):p. 510-516. .The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. © 2016 Institut Pasteur0000-0002-7351-8738wildeman.zapatab@campusucc.edu.co516-510Elsevier Masson SASalpha defensinapolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3Gbeta actincathelicidincholestanetriol 26 monooxygenasecolecalciferol 24 hydroxylasecytochrome P450cytochrome P450 27B1human alpha defensin 4messenger RNAphosphoglycerate kinase 1ribonucleaseRNase 7secretory leukocyte proteinase inhibitortiprelestattoll like receptor 2toll like receptor 4tripartite motif protein 5unclassified drugvitamin Dimmunologic factorvitamin DadultArticlecohort analysisColombiacontrolled studycorrelation analysiscross-sectional studyfemalegene expressionhumanhuman cellHuman immunodeficiency virus 1Human immunodeficiency virus 1 infectionhuman tissueimmunomodulationinfection resistancemajor clinical studymalemouth mucosanonhumanperipheral blood mononuclear cellpriority journalprotein expressionvagina mucosaenvironmental exposuregene expression profilinggeneticsHuman immunodeficiency virAntiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infectionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionMICROBES AND INFECTIONinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41506oai:repository.ucc.edu.co:20.500.12494/415062024-08-20 16:18:47.823metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
spellingShingle	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection alpha defensin apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G beta actin cathelicidin cholestanetriol 26 monooxygenase colecalciferol 24 hydroxylase cytochrome P450 cytochrome P450 27B1 human alpha defensin 4 messenger RNA phosphoglycerate kinase 1 ribonuclease RNase 7 secretory leukocyte proteinase inhibitor tiprelestat toll like receptor 2 toll like receptor 4 tripartite motif protein 5 unclassified drug vitamin D immunologic factor vitamin D adult Article cohort analysis Colombia controlled study correlation analysis cross-sectional study female gene expression human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection human tissue immunomodulation infection resistance major clinical study male mouth mucosa nonhuman peripheral blood mononuclear cell priority journal protein expression vagina mucosa environmental exposure gene expression profiling genetics Human immunodeficiency vir
title_short	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_full	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_fullStr	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_full_unstemmed	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_sort	Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
dc.creator.fl_str_mv	Aguilar-Jimenez W. Zapata Builes, Wildeman Rugeles M.T.
dc.contributor.author.none.fl_str_mv	Aguilar-Jimenez W. Zapata Builes, Wildeman Rugeles M.T.
dc.subject.spa.fl_str_mv	alpha defensin apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G beta actin cathelicidin cholestanetriol 26 monooxygenase colecalciferol 24 hydroxylase cytochrome P450 cytochrome P450 27B1 human alpha defensin 4 messenger RNA phosphoglycerate kinase 1 ribonuclease RNase 7 secretory leukocyte proteinase inhibitor tiprelestat toll like receptor 2 toll like receptor 4 tripartite motif protein 5 unclassified drug vitamin D immunologic factor vitamin D adult Article cohort analysis Colombia controlled study correlation analysis cross-sectional study female gene expression human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection human tissue immunomodulation infection resistance major clinical study male mouth mucosa nonhuman peripheral blood mononuclear cell priority journal protein expression vagina mucosa environmental exposure gene expression profiling genetics Human immunodeficiency vir
topic	alpha defensin apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G beta actin cathelicidin cholestanetriol 26 monooxygenase colecalciferol 24 hydroxylase cytochrome P450 cytochrome P450 27B1 human alpha defensin 4 messenger RNA phosphoglycerate kinase 1 ribonuclease RNase 7 secretory leukocyte proteinase inhibitor tiprelestat toll like receptor 2 toll like receptor 4 tripartite motif protein 5 unclassified drug vitamin D immunologic factor vitamin D adult Article cohort analysis Colombia controlled study correlation analysis cross-sectional study female gene expression human human cell Human immunodeficiency virus 1 Human immunodeficiency virus 1 infection human tissue immunomodulation infection resistance major clinical study male mouth mucosa nonhuman peripheral blood mononuclear cell priority journal protein expression vagina mucosa environmental exposure gene expression profiling genetics Human immunodeficiency vir
description	The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. © 2016 Institut Pasteur
publishDate	2016
dc.date.issued.none.fl_str_mv	2016
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:15:34Z
dc.date.available.none.fl_str_mv	2021-12-16T22:15:34Z
dc.type.none.fl_str_mv	Artículo
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dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
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dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv	https://doi.org/10.1016/j.vetpar.2011.11.011
dc.identifier.issn.spa.fl_str_mv	12864579
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41506
dc.identifier.bibliographicCitation.spa.fl_str_mv	Aguilar W,Zapata W,Rugeles MT. Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. MICROBES AND INFECTION. 2016. 18. (7-8):p. 510-516. .
url	https://doi.org/10.1016/j.vetpar.2011.11.011 https://hdl.handle.net/20.500.12494/41506
identifier_str_mv	12864579 Aguilar W,Zapata W,Rugeles MT. Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. MICROBES AND INFECTION. 2016. 18. (7-8):p. 510-516. .
dc.relation.ispartofjournal.spa.fl_str_mv	MICROBES AND INFECTION
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
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rights_invalid_str_mv	http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv	516-510
dc.publisher.spa.fl_str_mv	Elsevier Masson SAS
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
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Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

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