Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. © 2016 Institut Pasteur

• Autores: Aguilar-Jimenez W.; Zapata Builes, Wildeman; Rugeles M.T.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2016
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41506
• Acceso en línea: https://doi.org/10.1016/j.vetpar.2011.11.011; https://hdl.handle.net/20.500.12494/41506
• Palabra clave: alpha defensin; apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 3G; beta actin; cathelicidin; cholestanetriol 26 monooxygenase; colecalciferol 24 hydroxylase; cytochrome P450; cytochrome P450 27B1; human alpha defensin 4; messenger RNA; phosphoglycerate kinase 1; ribonuclease; RNase 7; secretory leukocyte proteinase inhibitor; tiprelestat; toll like receptor 2; toll like receptor 4; tripartite motif protein 5; unclassified drug; vitamin D; immunologic factor; vitamin D; adult; Article; cohort analysis; Colombia; controlled study; correlation analysis; cross-sectional study; female; gene expression; human; human cell; Human immunodeficiency virus 1; Human immunodeficiency virus 1 infection; human tissue; immunomodulation; infection resistance; major clinical study; male; mouth mucosa; nonhuman; peripheral blood mononuclear cell; priority journal; protein expression; vagina mucosa; environmental exposure; gene expression profiling; genetics; Human immunodeficiency vir
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb