Structured model and parameter estimation in plant cell cultures of Thevetia peruviana
This is an article about the modelling, simulation and optimization in biotechnological processes
- Autores:
-
Villegas Quiceno, Adriana Patricia
Arias Echeverry, Juan Pablo
Aragón Mena, Daira
Ochoa Cáceres, Silvia
Arias Zabala, Mario
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/4489
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/4489
- Palabra clave:
- Thevetia peruviana
Plant cell cultures
Modelling
Parameter estimation
Identifiability analysis
- Rights
- closedAccess
- License
- Licencia CC
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Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| title |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| spellingShingle |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana Thevetia peruviana Plant cell cultures Modelling Parameter estimation Identifiability analysis |
| title_short |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| title_full |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| title_fullStr |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| title_full_unstemmed |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| title_sort |
Structured model and parameter estimation in plant cell cultures of Thevetia peruviana |
| dc.creator.fl_str_mv |
Villegas Quiceno, Adriana Patricia Arias Echeverry, Juan Pablo Aragón Mena, Daira Ochoa Cáceres, Silvia Arias Zabala, Mario |
| dc.contributor.author.none.fl_str_mv |
Villegas Quiceno, Adriana Patricia Arias Echeverry, Juan Pablo Aragón Mena, Daira Ochoa Cáceres, Silvia Arias Zabala, Mario |
| dc.subject.spa.fl_str_mv |
Thevetia peruviana Plant cell cultures Modelling Parameter estimation Identifiability analysis |
| topic |
Thevetia peruviana Plant cell cultures Modelling Parameter estimation Identifiability analysis |
| description |
This is an article about the modelling, simulation and optimization in biotechnological processes |
| publishDate |
2016 |
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2016-12-16 |
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2018-06-25T15:25:06Z |
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2018-06-25T15:25:06Z |
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Villegas Quiceno, A. P., Arias Echeverry, J. P., Aragón Mena, D., Ochoa Càceres, S., y Arias Zabala, M. (2016). Structured model and parameter estimation in plant cell cultures of Thevetia peruviana. Bioprocess Biosyst Eng 40: 573. https://doi.org/10.1007/s00449-016-1722-6 |
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https://hdl.handle.net/20.500.12494/4489 |
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Villegas Quiceno, A. P., Arias Echeverry, J. P., Aragón Mena, D., Ochoa Càceres, S., y Arias Zabala, M. (2016). Structured model and parameter estimation in plant cell cultures of Thevetia peruviana. Bioprocess Biosyst Eng 40: 573. https://doi.org/10.1007/s00449-016-1722-6 |
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https://link.springer.com/article/10.1007%2Fs00449-016-1722-6 |
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Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, Medellín y Envigado |
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Ingeniería Civil |
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Medellín |
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Universidad Cooperativa de Colombia |
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Villegas Quiceno, Adriana PatriciaArias Echeverry, Juan PabloAragón Mena, DairaOchoa Cáceres, SilviaArias Zabala, Mario2018-06-25T15:25:06Z2018-06-25T15:25:06Z2016-12-16https://hdl.handle.net/20.500.12494/4489Villegas Quiceno, A. P., Arias Echeverry, J. P., Aragón Mena, D., Ochoa Càceres, S., y Arias Zabala, M. (2016). Structured model and parameter estimation in plant cell cultures of Thevetia peruviana. Bioprocess Biosyst Eng 40: 573. https://doi.org/10.1007/s00449-016-1722-6This is an article about the modelling, simulation and optimization in biotechnological processesIn this work, a mechanistic model for predicting the dynamic behavior of extracellular and intracellular nutrients, biomass production, and the main metabolites involved in the central carbon metabolism in plant cell cultures of Thevetia peruviana is presented. The proposed model is the first mechanistic model implemented for plant cell cultures of this species, and includes 28 metabolites, 33 metabolic reactions, and 61 parameters. Given the overparametrization of the model, its nonlinear nature and the strong correlation among the effects of the parameters, a parameter estimation routine based on identifiability analysis was implemented. This routine reduces the parameter’s search space by selecting the most sensitive and linearly independent parameters. Results have shown that only 19 parameters are identifiable. Finally, the model was used for analyzing the fluxes distribution in plant cell cultures of T. peruviana. This analysis shows high uptake of phosphates and parallel uptake of glucose and fructose. Furthermore, it has pointed out the main central carbon metabolism routes for promoting biomass production in this cell culture.adriana.villegas@ucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, Medellín y EnvigadoIngeniería CivilMedellínhttps://link.springer.com/article/10.1007%2Fs00449-016-1722-6Thevetia peruvianaPlant cell culturesModellingParameter estimationIdentifiability analysisStructured model and parameter estimation in plant cell cultures of Thevetia peruvianaArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cb0000-0001-9697-8297PublicationTEXTVillegas_2017_Structured model and parameter estimation TH.pdf.txtVillegas_2017_Structured model and parameter estimation TH.pdf.txtExtracted 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