Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling
Artículo de investigación científica
- Autores:
-
Ortiz, Claudia
Caviedes Rubio, Diego Ivan
Martínez, Fleming
Delgado, Daniel Ricardo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2024
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- eng
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/57841
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/57841
- Palabra clave:
- 540 - Química y ciencias afines
sulfamerazine
solubility
infections
shake-flask method
thermodynamic properties
van’t Hoff
Yalkowsky–Roseman
binary mixtures
- Rights
- openAccess
- License
- Creative Commons Attribution (CC BY)
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Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
| title |
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
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Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling 540 - Química y ciencias afines sulfamerazine solubility infections shake-flask method thermodynamic properties van’t Hoff Yalkowsky–Roseman binary mixtures |
| title_short |
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
| title_full |
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
| title_fullStr |
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
| title_full_unstemmed |
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
| title_sort |
Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling |
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Ortiz, Claudia Caviedes Rubio, Diego Ivan Martínez, Fleming Delgado, Daniel Ricardo |
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Ortiz, Claudia Caviedes Rubio, Diego Ivan Martínez, Fleming Delgado, Daniel Ricardo |
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Grupo de Investigación de Ingenierías UCC-Neiva |
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540 - Química y ciencias afines |
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540 - Química y ciencias afines sulfamerazine solubility infections shake-flask method thermodynamic properties van’t Hoff Yalkowsky–Roseman binary mixtures |
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sulfamerazine solubility infections shake-flask method thermodynamic properties van’t Hoff Yalkowsky–Roseman binary mixtures |
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Artículo de investigación científica |
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2024 |
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2024-12-10T16:28:01Z |
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2024-11-09 |
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MDPI and ACS Style Ortiz, C.P.; Caviedes-Rubio, D.I.; Martinez, F.; Delgado, D.R. Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules 2024, 29, 5294. https://doi.org/10.3390/molecules29225294 AMA Style Ortiz CP, Caviedes-Rubio DI, Martinez F, Delgado DR. Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules. 2024; 29(22):5294. https://doi.org/10.3390/molecules29225294 Chicago/Turabian Style Ortiz, Claudia Patricia, Diego Ivan Caviedes-Rubio, Fleming Martinez, and Daniel Ricardo Delgado. 2024. "Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling" Molecules 29, no. 22: 5294. https://doi.org/10.3390/molecules29225294 APA Style Ortiz, C. P., Caviedes-Rubio, D. I., Martinez, F., & Delgado, D. R. (2024). Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules, 29(22), 5294. https://doi.org/10.3390/molecules29225294 |
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1420-3049 |
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https://hdl.handle.net/20.500.12494/57841 |
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doi.org/10.3390/molecules29225294 |
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MDPI and ACS Style Ortiz, C.P.; Caviedes-Rubio, D.I.; Martinez, F.; Delgado, D.R. Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules 2024, 29, 5294. https://doi.org/10.3390/molecules29225294 AMA Style Ortiz CP, Caviedes-Rubio DI, Martinez F, Delgado DR. Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules. 2024; 29(22):5294. https://doi.org/10.3390/molecules29225294 Chicago/Turabian Style Ortiz, Claudia Patricia, Diego Ivan Caviedes-Rubio, Fleming Martinez, and Daniel Ricardo Delgado. 2024. "Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling" Molecules 29, no. 22: 5294. https://doi.org/10.3390/molecules29225294 APA Style Ortiz, C. P., Caviedes-Rubio, D. I., Martinez, F., & Delgado, D. R. (2024). Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules, 29(22), 5294. https://doi.org/10.3390/molecules29225294 1420-3049 doi.org/10.3390/molecules29225294 |
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eng |
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eng |
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Molecules |
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Schmidt, L.; Hughes, H.B.; Badger, E.A.; Schmidt, I.G. The toxicity of sulfamerazine and sulfamethazine. J. Pharmacol. Exp. Ther. 1944, 81, 17–42. Donald, G.A.; Oliver, C.S.; Chester, S.K. A clinical evaluation of sulfamerazine. N. Engl. J. Med. 1944, 230, 369–379. Christensen, S.B. Drugs that changed society: History and current status of the early antibiotics: Salvarsan, sulfonamides, and β-lactams. Molecules 2021, 26, 6057. Sköld, O. Sulfonamide resistance: Mechanisms and trends. Drug Resist. Updat. 2000, 3, 155–160 Delgado, D.R. LaTeX Code of the Chemical Structure of Some Drugs; Mendeley Data, Version 1; Universidad Cooperativa de Colombia: Arauca, Colombia, 2024. dos Santos, P.E.; do Amaral, M.S.; Fernando Mazon Cardoso, T.; Kassab, N.M. Development and validation of method for the simultaneous determination of sulfamethazine, trimethoprim and doxycycline in veterinary formulation using high performance liquid chromatography. Biomed. Chromatogr. 2024, 38, e5781. NORMAN Network. Emerging Substances. 2023. Available online: https://www.norman-network.com/nds/susdat/susdatSearchShow.php Sinko, P.J. Martin’s Physical Pharmacy and Pharmaceutical Sciences, 8th ed.; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2011. Yalkowsky, S.H. Solubility and Solubilization in Aqueous Media; American Chemical Society: Washington, DC, USA, 1999. Yaws, C.L.; Narasimhan, P.K.; Lou, H.H.; Pike, R.W. Solubility of Chemicals in Water. In Water Encyclopedia; John Wiley & Sons, Ltd.: Hoboken, NJ, USA, 2005; pp. 555–559. |
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Ortiz, ClaudiaCaviedes Rubio, Diego IvanMartínez, FlemingDelgado, Daniel RicardoGrupo de Investigación de Ingenierías UCC-NeivaMundial2024-12-10T16:28:01Z2024-12-10T16:28:01Z2024-11-09MDPI and ACS Style Ortiz, C.P.; Caviedes-Rubio, D.I.; Martinez, F.; Delgado, D.R. Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules 2024, 29, 5294. https://doi.org/10.3390/molecules29225294 AMA Style Ortiz CP, Caviedes-Rubio DI, Martinez F, Delgado DR. Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules. 2024; 29(22):5294. https://doi.org/10.3390/molecules29225294 Chicago/Turabian Style Ortiz, Claudia Patricia, Diego Ivan Caviedes-Rubio, Fleming Martinez, and Daniel Ricardo Delgado. 2024. "Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling" Molecules 29, no. 22: 5294. https://doi.org/10.3390/molecules29225294 APA Style Ortiz, C. P., Caviedes-Rubio, D. I., Martinez, F., & Delgado, D. R. (2024). Solubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and Modeling. Molecules, 29(22), 5294. https://doi.org/10.3390/molecules292252941420-3049https://hdl.handle.net/20.500.12494/57841doi.org/10.3390/molecules29225294Artículo de investigación científicaSulfamerazine (SMR) is a drug used as an antibacterial agent in the treatment of some pathologies, such as bronchitis, prostatitis and urinary tract infections. Although this drug was developed in 1945 and, due to its toxicity, was partially displaced by penicillin, due to the current problem of bacterial resistance, compounds such as SMR have regained validity. In this context, the thermodynamic study of SMR in cosolvent mixtures of acetonitrile (MeCN) + ethanol (EtOH) at nine temperatures (278.15–318.15 K) is presented. The solubility of SMR was determined by UV–Vis spectrophotometry, following the guidelines of the shake-flask method. The solubility process was endothermic in all cases; thus, the minimum solubility was reached in pure EtOH at 278.15 K, and the maximum solubility was reached in pure MeCN at 318.15 K. Both the solution process and the mixing process were entropy-driven. On the other hand, the solubility data were modeled by using the van’t Hoff–Yalkowsky–Roseman model, obtaining an overall average relative deviation of 3.9%. In general terms, it can be concluded that the solution process of SMR in {MeCN (1) + EtOH (2)} mixtures is thermodependent, favored by the entropy of the solution and mixture; additionally, the van’t Hoff–Yalkowsky–Roseman model allows very good approximations to be obtained and is a simple model that starts from only four experimental data.Universidad Cooperativa de ColombiaEnergías, agua y medio ambiente14 pagapplication/pdfengUniversidad Cooperativa de ColombiaNeivaCreative Commons Attribution (CC BY)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttp://purl.org/coar/access_right/c_abf2https://www.mdpi.com/1420-3049/29/22/5294540 - Química y ciencias afinessulfamerazinesolubilityinfectionsshake-flask methodthermodynamic propertiesvan’t HoffYalkowsky–Rosemanbinary mixturesSolubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures: Thermodynamics and ModelingArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersion1422129MoleculesSchmidt, L.; Hughes, H.B.; Badger, E.A.; Schmidt, I.G. The toxicity of sulfamerazine and sulfamethazine. J. Pharmacol. Exp. Ther. 1944, 81, 17–42.Donald, G.A.; Oliver, C.S.; Chester, S.K. A clinical evaluation of sulfamerazine. N. Engl. J. Med. 1944, 230, 369–379.Christensen, S.B. Drugs that changed society: History and current status of the early antibiotics: Salvarsan, sulfonamides, and β-lactams. Molecules 2021, 26, 6057.Sköld, O. Sulfonamide resistance: Mechanisms and trends. Drug Resist. Updat. 2000, 3, 155–160Delgado, D.R. LaTeX Code of the Chemical Structure of Some Drugs; Mendeley Data, Version 1; Universidad Cooperativa de Colombia: Arauca, Colombia, 2024.dos Santos, P.E.; do Amaral, M.S.; Fernando Mazon Cardoso, T.; Kassab, N.M. Development and validation of method for the simultaneous determination of sulfamethazine, trimethoprim and doxycycline in veterinary formulation using high performance liquid chromatography. Biomed. Chromatogr. 2024, 38, e5781.NORMAN Network. Emerging Substances. 2023. Available online: https://www.norman-network.com/nds/susdat/susdatSearchShow.phpSinko, P.J. Martin’s Physical Pharmacy and Pharmaceutical Sciences, 8th ed.; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2011.Yalkowsky, S.H. Solubility and Solubilization in Aqueous Media; American Chemical Society: Washington, DC, USA, 1999.Yaws, C.L.; Narasimhan, P.K.; Lou, H.H.; Pike, R.W. Solubility of Chemicals in Water. In Water Encyclopedia; John Wiley & Sons, Ltd.: Hoboken, NJ, USA, 2005; pp. 555–559.Industria y comunidad acdémicaPublicationINV3457ANÁLISIS TERMODINÁMICO DE LA SOLUBILIDAD DE ALGUNOS FÁRMACOS EN SISTEMAS COSOLVENTES DE USO INDUSTRIALORIGINALSolubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures- Thermodynamics and Modeling.pdfSolubility of Sulfamerazine in Acetonitrile + Ethanol Cosolvent Mixtures- Thermodynamics and Modeling.pdfapplication/pdf574338https://repository.ucc.edu.co/bitstreams/0ea3db8d-408d-4345-b660-505832d394f7/downloadc4cc75c9581ba019af5a0e2baf06f296MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repository.ucc.edu.co/bitstreams/5a5d515e-f62a-4fe6-969c-109e49913a6b/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; 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