Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures

Artículo de Investigación

Autores:
Delgado, Daniel Ricardo
Peña, María A.
Martínez, Fleming
Jouyban, Abolghasem
Acree Jr, William Eugene
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/1011
Acceso en línea:
https://hdl.handle.net/20.500.12494/1011
Palabra clave:
-Sulfapyridine -Ethanol + water mixtures -Jouyban-Acree model -Preferential solvation
Rights
openAccess
License
Licencia CC
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repository_id_str
dc.title.spa.fl_str_mv Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
title Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
spellingShingle Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
-Sulfapyridine -Ethanol + water mixtures -Jouyban-Acree model -Preferential solvation
title_short Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
title_full Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
title_fullStr Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
title_full_unstemmed Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
title_sort Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures
dc.creator.fl_str_mv Delgado, Daniel Ricardo
Peña, María A.
Martínez, Fleming
Jouyban, Abolghasem
Acree Jr, William Eugene
dc.contributor.advisor.none.fl_str_mv Delgado, Daniel Ricardo
dc.contributor.author.none.fl_str_mv Delgado, Daniel Ricardo
Peña, María A.
Martínez, Fleming
Jouyban, Abolghasem
Acree Jr, William Eugene
dc.subject.spa.fl_str_mv -Sulfapyridine -Ethanol + water mixtures -Jouyban-Acree model -Preferential solvation
topic -Sulfapyridine -Ethanol + water mixtures -Jouyban-Acree model -Preferential solvation
description Artículo de Investigación
publishDate 2016
dc.date.issued.none.fl_str_mv 2016-04-23
dc.date.accessioned.none.fl_str_mv 2017-08-10T20:29:25Z
dc.date.available.none.fl_str_mv 2017-08-10T20:29:25Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/1011
dc.identifier.bibliographicCitation.spa.fl_str_mv Daniel R. Delgado, María Á. Peña, Fleming Martínez, Abolghasem Jouyban, William E. Acree Jr. Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures. Pharmaceutical Sciences. 22, 143-152 (2016)
url https://hdl.handle.net/20.500.12494/1011
identifier_str_mv Daniel R. Delgado, María Á. Peña, Fleming Martínez, Abolghasem Jouyban, William E. Acree Jr. Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures. Pharmaceutical Sciences. 22, 143-152 (2016)
dc.relation.isversionof.spa.fl_str_mv http://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_4039_20160308164718
dc.rights.cc.none.fl_str_mv Licencia CC
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Licencia CC
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000
dc.publisher.program.spa.fl_str_mv Ingeniería Industrial
dc.publisher.place.spa.fl_str_mv Neiva
institution Universidad Cooperativa de Colombia
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spelling Delgado, Daniel RicardoDelgado, Daniel RicardoPeña, María A.Martínez, FlemingJouyban, AbolghasemAcree Jr, William Eugene2017-08-10T20:29:25Z2017-08-10T20:29:25Z2016-04-23https://hdl.handle.net/20.500.12494/1011Daniel R. Delgado, María Á. Peña, Fleming Martínez, Abolghasem Jouyban, William E. Acree Jr. Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures. Pharmaceutical Sciences. 22, 143-152 (2016)Artículo de InvestigaciónBackground: Dissolution thermodynamic quantities of sulfapyridine (SP) have been reported in the literature for aqueous alcoholic mixtures. Nevertheless, no attempts to evaluate the preferential solvation of this drug in this binary system, have been reported. In this way, the inverse Kirkwood-Buff integrals (IKBI) were used to evaluate this behavior in solution. Methods: Solubility data for SP dissolved in binary ethanol (EtOH) + water mixtures at various temperatures were mathematically represented using the Jouyban-Acree (J-A) model. The preferential solvation parameters of SP by EtOH (δx1,3) in EtOH + water mixtures were obtained from some thermodynamic properties of the mixtures by means of the IKBI method. Results: Solubility of SP in EtOH + water mixtures is adequately described by the J-A model in second order. Moreover, SP is sensitive to specific solvation effects, so the δx1,3 values are negative in water-rich and EtOH-rich mixtures indicating preferential solvation by water in these mixtures. By contrary, δx1,3 values are positive in the range 0.24 < x1 < 0.53 indicating preferential solvation by EtOH in these mixtures. Conclusion: It can be assumed that in water-rich mixtures the hydrophobic hydration around the aromatic rings plays a relevant role in the solvation. The higher drug solvation by EtOH in mixtures of similar solvent proportions could be due to polarity effects. Moreover, in EtOH + water mixtures SP could be acting as a Lewis acid with the EtOH molecules and in EtOH-rich mixtures the drug could be acting as a Lewis base with water molecules.1. Introduction, 2. Results and Discussion, 2.2 Jouyban-Acree model, 3. Preferential solvation, 4. Conclusions, 5.Conflict of interests, 6. References.danielr.delgado@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000Ingeniería IndustrialNeivahttp://journals.tbzmed.ac.ir/PHARM/Abstract/PHARM_4039_20160308164718-Sulfapyridine -Ethanol + water mixtures -Jouyban-Acree model -Preferential solvationFurther Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water MixturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINAL2016_Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water Mixtures.pdf2016_Further Numerical Analyses on the Solubility of Sulfapyridine in Ethanol + Water 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