Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells
Artículo original
- Autores:
-
Gómez, Diana M.
Urcuqui Inchima, Silvio
Hernández López, Juan Carlos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2017
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/4276
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/4276
- Palabra clave:
- Silica nanoparticles
Immunomodulation
NLRP3 inflammasome
Pro-inflammatory cytokines
- Rights
- openAccess
- License
- Licencia CC
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| dc.title.spa.fl_str_mv |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| title |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| spellingShingle |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells Silica nanoparticles Immunomodulation NLRP3 inflammasome Pro-inflammatory cytokines |
| title_short |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| title_full |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| title_fullStr |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| title_full_unstemmed |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| title_sort |
Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells |
| dc.creator.fl_str_mv |
Gómez, Diana M. Urcuqui Inchima, Silvio Hernández López, Juan Carlos |
| dc.contributor.author.none.fl_str_mv |
Gómez, Diana M. Urcuqui Inchima, Silvio Hernández López, Juan Carlos |
| dc.subject.spa.fl_str_mv |
Silica nanoparticles Immunomodulation NLRP3 inflammasome Pro-inflammatory cytokines |
| topic |
Silica nanoparticles Immunomodulation NLRP3 inflammasome Pro-inflammatory cytokines |
| description |
Artículo original |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017 |
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2018-06-12T17:00:26Z |
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2018-06-12T17:00:26Z |
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Gómez, D. M., Urcuqui Inchima, S., & Hernandez, J. C. (2017). Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells. Innate immunity, 23(8), 697-708. doi: 10.1177/1753425917738331 |
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Gómez, D. M., Urcuqui Inchima, S., & Hernandez, J. C. (2017). Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells. Innate immunity, 23(8), 697-708. doi: 10.1177/1753425917738331 |
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http://journals.sagepub.com/doi/abs/10.1177/1753425917738331 |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y Envigado |
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Medicina |
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Medellín |
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Gómez, Diana M.Urcuqui Inchima, SilvioHernández López, Juan Carlos2018-06-12T17:00:26Z2018-06-12T17:00:26Z2017https://hdl.handle.net/20.500.12494/4276Gómez, D. M., Urcuqui Inchima, S., & Hernandez, J. C. (2017). Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells. Innate immunity, 23(8), 697-708. doi: 10.1177/1753425917738331Artículo originalIn recent years, the potential use of silica nanoparticles (SiNPs) among different biomedical fields has grown. A deep understanding of the physicochemical properties of nanoparticles (NPs) and their regulation of specific biological responses is crucial for the successful application of NPs. Exposure to NP physicochemical properties (size, shape,porosity, etc.) could result in deleterious effects on cellular functions, including a pro-inflammatory response mediated via activation of the NLRP3 inflammasome. The aim of this study was to evaluate the potential in vitro immunomodulatory effect of 12-nm and 200-nm SiNPs on the expression of pro-inflammatory cytokines and NLRP3 inflammasome components in human primary neutrophils and PBMCs. This study demonstrates that regardless of the size of the nanoparticles, SiNPs induce the production of pro-inflammatory cytokines in a dose-dependent manner. Induced IL-1b production after exposure to SiNPs suggests the involvement of NLRP3 inflammasome components participation in this process. In conclusion, SiNPs induce the production of pro-inflammatory cytokines in a dose-dependent manner. Furthermore, our data suggest that the production and release of IL-1b possibly occurs through the formation of the NLRP3 inflammasome.diana.gomezga@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Medellín y EnvigadoMedicinaMedellínhttp://journals.sagepub.com/doi/abs/10.1177/1753425917738331Silica nanoparticlesImmunomodulationNLRP3 inflammasomePro-inflammatory cytokinesSilica nanoparticles induce NLRP3 inflammasome activation in human primary immune cellsArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf20000-0003-3433-7288PublicationORIGINALSilica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells.pdfSilica nanoparticles induce NLRP3 inflammasome activation in human 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