Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance,...
- Autores:
-
Velasquez-Agudelo V.
Cardona Arias, Jaiberth antonio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/49524
- Acceso en línea:
- https://doi.org/10.1186/s12879-017-2258-3
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013487370&doi=10.1186%2fs12879-017-2258-3&partnerID=40&md5=50fe93faf4342a789d25df3b0880f6d3
https://hdl.handle.net/20.500.12494/49524
- Palabra clave:
- DIAGNOSIS
META-ANALYSIS AS TOPIC
ONYCHOMYCOSIS
TEST VALIDITY
VALIDATION STUDIES
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
id |
COOPER2_85ed958cb3612d0ecb8e58901ef96c1e |
---|---|
oai_identifier_str |
oai:repository.ucc.edu.co:20.500.12494/49524 |
network_acronym_str |
COOPER2 |
network_name_str |
Repositorio UCC |
repository_id_str |
|
spelling |
Velasquez-Agudelo V.Cardona Arias, Jaiberth antonio2023-05-24T16:21:29Z2023-05-24T16:21:29Z22/02/2017https://doi.org/10.1186/s12879-017-2258-3https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013487370&doi=10.1186%2fs12879-017-2258-3&partnerID=40&md5=50fe93faf4342a789d25df3b0880f6d314712334https://hdl.handle.net/20.500.12494/49524Velasquez-Agudelo V.,Cardona Arias Jaiberth antonio.Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis.BMC Infectious Diseases. 2017. 17. (1): 166Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests. © 2017 The Author(s).jaiberth.cardona@campusucc.edu.co166BioMed Central Ltd.DIAGNOSISMETA-ANALYSIS AS TOPICONYCHOMYCOSISTEST VALIDITYVALIDATION STUDIESMeta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionBMC Infectious Diseasesinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49524oai:repository.ucc.edu.co:20.500.12494/495242024-08-20 16:21:25.914metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
spellingShingle |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis DIAGNOSIS META-ANALYSIS AS TOPIC ONYCHOMYCOSIS TEST VALIDITY VALIDATION STUDIES |
title_short |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_full |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_fullStr |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_full_unstemmed |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
title_sort |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis |
dc.creator.fl_str_mv |
Velasquez-Agudelo V. Cardona Arias, Jaiberth antonio |
dc.contributor.author.none.fl_str_mv |
Velasquez-Agudelo V. Cardona Arias, Jaiberth antonio |
dc.subject.spa.fl_str_mv |
DIAGNOSIS META-ANALYSIS AS TOPIC ONYCHOMYCOSIS TEST VALIDITY VALIDATION STUDIES |
topic |
DIAGNOSIS META-ANALYSIS AS TOPIC ONYCHOMYCOSIS TEST VALIDITY VALIDATION STUDIES |
description |
Background: Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. Methods: A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and Epidat using a random effects model. Results: The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. Conclusion: The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests. © 2017 The Author(s). |
publishDate |
2023 |
dc.date.accessioned.none.fl_str_mv |
2023-05-24T16:21:29Z |
dc.date.available.none.fl_str_mv |
2023-05-24T16:21:29Z |
dc.date.issued.none.fl_str_mv |
22/02/2017 |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://doi.org/10.1186/s12879-017-2258-3 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013487370&doi=10.1186%2fs12879-017-2258-3&partnerID=40&md5=50fe93faf4342a789d25df3b0880f6d3 |
dc.identifier.issn.spa.fl_str_mv |
14712334 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/49524 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Velasquez-Agudelo V.,Cardona Arias Jaiberth antonio.Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis.BMC Infectious Diseases. 2017. 17. (1): 166 |
url |
https://doi.org/10.1186/s12879-017-2258-3 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013487370&doi=10.1186%2fs12879-017-2258-3&partnerID=40&md5=50fe93faf4342a789d25df3b0880f6d3 https://hdl.handle.net/20.500.12494/49524 |
identifier_str_mv |
14712334 Velasquez-Agudelo V.,Cardona Arias Jaiberth antonio.Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis.BMC Infectious Diseases. 2017. 17. (1): 166 |
dc.relation.ispartofjournal.spa.fl_str_mv |
BMC Infectious Diseases |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
166 |
dc.publisher.spa.fl_str_mv |
BioMed Central Ltd. |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814247150767308800 |