Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura

La Neosporosis bovina es una patológica reproductiva generada por N. caninum, la cual se encuentra distribuida a nivel mundial. Sus estadios parasitarios son taquizoíto, bradizoíto y esporozoíto. El hospedador intermediario es el perro, el cual elimina al patógeno en sus heces. El signo más importan...

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Autores:
Garcia Ocampo, Daniel
Morad Quintero, Felipe
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2022
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/46889
Acceso en línea:
https://hdl.handle.net/20.500.12494/46889
Palabra clave:
Neosporosis
N. Caninum
Aborto
Ooquistes
TG 2022 MVZ 46889
Neosporosis
N. Caninum
Abortion
Oocysts
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openAccess
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Atribución – No comercial – Compartir igual
id COOPER2_7eca5a84d22b4f7788fd7cb0a7e5c02a
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/46889
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
title Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
spellingShingle Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
Neosporosis
N. Caninum
Aborto
Ooquistes
TG 2022 MVZ 46889
Neosporosis
N. Caninum
Abortion
Oocysts
title_short Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
title_full Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
title_fullStr Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
title_full_unstemmed Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
title_sort Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura
dc.creator.fl_str_mv Garcia Ocampo, Daniel
Morad Quintero, Felipe
dc.contributor.advisor.none.fl_str_mv Bonilla León, Lilian
dc.contributor.author.none.fl_str_mv Garcia Ocampo, Daniel
Morad Quintero, Felipe
dc.subject.spa.fl_str_mv Neosporosis
N. Caninum
Aborto
Ooquistes
topic Neosporosis
N. Caninum
Aborto
Ooquistes
TG 2022 MVZ 46889
Neosporosis
N. Caninum
Abortion
Oocysts
dc.subject.classification.spa.fl_str_mv TG 2022 MVZ 46889
dc.subject.other.spa.fl_str_mv Neosporosis
N. Caninum
Abortion
Oocysts
description La Neosporosis bovina es una patológica reproductiva generada por N. caninum, la cual se encuentra distribuida a nivel mundial. Sus estadios parasitarios son taquizoíto, bradizoíto y esporozoíto. El hospedador intermediario es el perro, el cual elimina al patógeno en sus heces. El signo más importante y en ocasiones el único es el aborto, el cual se presenta en el tercio medio de la gestación, por medio de diversos mecanismos. La infección se puede determinar con pruebas inmunodiagnósticas, moleculares, histopatológicas y de aislamiento. Por el momento no se conoce un tratamiento específico, pero si medidas preventivas, razón por la cual la prevalencia incrementa.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-10-25T19:51:07Z
dc.date.available.none.fl_str_mv 2022-10-25T19:51:07Z
dc.date.issued.none.fl_str_mv 2022-10-25
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/46889
dc.identifier.bibliographicCitation.spa.fl_str_mv García Ocampo, D. y Morad Quintero, F. (2022). Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/46889
url https://hdl.handle.net/20.500.12494/46889
identifier_str_mv García Ocampo, D. y Morad Quintero, F. (2022). Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/46889
dc.relation.references.spa.fl_str_mv Alaeddine, F., Keller, N., Leepin, A., & Hemphill, A. (2005). REDUCED INFECTION AND PROTECTION FROM CLINICAL SIGNS OF CEREBRAL NEOSPOROSIS IN C57BL / 6 MICE VACCINATED WITH RECOMBINANT MICRONEME ANTIGEN NCMIC1 NEOSPOROSIS IN C57BL / 6 MICE VACCINATED WITH RECOMBINANT MICRONEME ANTIGEN NCMIC1. American Society of Parasitologists DOI:, 91(3), 657–665.
Almería, S., & López-Gatius, F. (2013). Bovine neosporosis: Clinical and practical aspects. Research in Veterinary Science, 95(2), 303–309. https://doi.org/10.1016/j.rvsc.2013.04.008
Álvarez, D. (2016). Neospora caninum y sus alteraciones sobre la salud reproductiva bovina. Journal of Chemical Information and Modeling, 53(9), 1689–1699.
Anderson, M., Andrianarivo, A., & Conrad, P. (2000). Neosporosis in cattle. Veterinary Clinics of North America - Food Animal Practice, 21(2 SPEC. ISS.), 473–483. https://doi.org/10.1016/j.cvfa.2005.03.004
Andrianarivo, A. G., Anderson, M. L., Rowe, J. D., Gardner, I. A., Reynolds, J. P., Choromanski, L., & Conrad, P. A. (2005). Immune responses during pregnancy in heifers naturally infected with Neospora caninum with and without immunization. Parasitology Research, 96(1), 24–31. https://doi.org/10.1007/s00436-005-1313-
Baillargeon, P., Fecteau, G., Paré, J., Lamothe, P., & Sauvé, R. (2001). Evaluation of the embryo transfer procedure proposed by the International Embryo Transfer Society as a method of controlling vertical transmission of Neospora caninum in cattle. 218(11), 6–9.
Barr, B. C., Rowe, J. D., Sverlow, K. W., BonDurant, R. H., Ardans, A. A., Oliver, M. N., & Conrad, P. A. (1994). Experimental reproduction of bovine fetal Neospora infection and death with a bovine Neospora isolate. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 6(2), 207–215. https://doi.org/10.1177/104063879400600212
Buxton, D., & Mcallister, M. M. (2002). Review Neospora. TRENDSin Parasitology, 18(12), 546–552. http://parasites.trends.com1471-4922/02/$-seefrontmatter
Campero, C. M., Moore, D. P., Lagomarsino, H., Odeón, A. C., Castro, M., & Visca, H. (2003). 13 NEOSPOROSIS BOVINA Serological Status and Abortion Rate in Progeny Obtained by Natural Service or Embryo Transfer from Neospora caninum-Seropositive Cows. Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health, 50(9), 458–460. https://doi.org/10.1046/j.0931-1793.2003.00698.x
Conrad, P. A., Anderson, M. L., & Barr, B. C. (1995). Neosporosis: a newly recognized cause of abortion in dairy cattle. 2Nd western large herd dairy management conference, 61–68.
Conrad, P. A., Barr, B. C., Sverlow, K. W., Anderson, M., Daft, B., Kinde, H., & Dubey, J. P. (1993). In vitro isolation and characterization of a Neospora sp. from aborted bovine foetuses. Parasitology, 106(3), 239–249. https://doi.org/10.1017/S0031182000075065
Dijkstra, T., Barkema, H. W., Björkman, C., & Wouda, W. (2002). A high rate of seroconversion for Neospora caninum in a dairy herd without an obvious increased incidence of abortions. Veterinary Parasitology, 109(3–4), 203–211. https://doi.org/10.1016/S0304- 4017(02)00303-5
Dubey, J. P. (1999). Recent advances in Neospora and neosporosis. Veterinary Parasitology, 84(3–4), 349–367. https://doi.org/10.1016/S0304-4017(99)00044-8
Dubey, J. P. (2003). Review of Neospora caninum and neosporosis in animals. The Korean Journal of Parasitology, 41(1), 1–16. https://doi.org/10.3347/kjp.2003.41.1.1
Dubey, J. P., Barr, B. C., Barta, J. R., Bjerkås, I., Björkman, C., Blagburn, B. L., Bowman, D. D., Buxton, D., Ellis, J. T., Gottstein, B., Hemphill, A., Hill, D. E., Howe, D. K., Jenkins, M. C., Kobayashi, Y., Koudela, B., Marsh, A. E., Mattsson, J. G., McAllister, M. M., … Lindsay, D. S. (2002). Redescription of Neospora caninum and its differentiation from related coccidia. International Journal for Parasitology, 32(8), 929–946. https://doi.org/10.1016/S0020-7519(02)00094-2
Dubey, J. P., Buxton, D., & Wouda, W. (2006). Pathogenesis of Bovine Neosporosis. Journal of Comparative Pathology, 134(4), 267–289. https://doi.org/10.1016/j.jcpa.2005.11.004
Dubey, J. P., & Lindsay, D. S. (1996). A review of Neospora caninum and neosporosis. Veterinary Parasitology, 67(1–2), 1–59. https://doi.org/10.1016/S0304-4017(96)01035-7
Dubey, J. P., & Schares, G. (2011). Neosporosis in animals-The last five years. Veterinary Parasitology, 180(1–2), 90–108. https://doi.org/10.1016/j.vetpar.2011.05.031
Dubey, J. P., Schares, G., & Ortega-Mora, L. M. (2007). Epidemiology and control of neosporosis and Neospora caninum. Clinical Microbiology Reviews, 20(2), 323–367. https://doi.org/10.1128/CMR.00031-06
Echaide, I. (2000). La neosporosis bovina Volver a: Enfermedades de la reproducción. INTA, 6. www.produccion-animal.com.ar
Engeland, I. V., Waldeland, H., Kindahl, H., Ropstad, E., & Andresen, Ø. (1996). Effect of Toxoplasma gondii infection on the development of pregnancy and on endocrine foetalplacental function in the goat. Veterinary Parasitology, 67(1–2), 61–74. https://doi.org/10.1016/S0304-4017(96)01025-4
Fort, M. (2003). Neospora caninum : Estudio seroepidemiológico en bovinos de la provincia de La Pampa.
Garcia, J., Moreno, G., & Cruz, A. (2014). Prevalencia de Neospora caninum y DVB en una fina con problemas reproductivos en Sopó (Cundinamarca). Ciencia y Agricultura, 11, 9–16.
Goodswen, S. J., Kennedy, P. J., & Ellis, J. T. (2013). A review of the infection, genetics, and evolution of Neospora caninum: From the past to the present. Infection, Genetics and Evolution, 13(1), 133–150. https://doi.org/10.1016/j.meegid.2012.08.012
Gottstein, B., Eperon, S., Dai, W. J., Cannas, A., Hemphill, A., & Greif, G. (2001). Efficacy of toltrazuril and ponazuril against experimental Neospora caninum infection in mice. Parasitology Research, 87(1), 43–48. https://doi.org/10.1007/s004360000306
Hemphill, A., Vonlaufen, N., Naguleswaran, A., Keller, N., Riesen, M., Guetg, N., Srinivasan, S., & Alaeddine, F. (2004). M icroscopy M icroanalysis Tissue Culture and Explant Approaches to Studying and Visualizing Neospora caninum and Its Interactions with the Host Cell. University of Berne, 602–620.
Innes, E. A. (2007). The host-parasite relationship in pregnant cattle infected with Neospora caninum. Parasitology, 134(13), 1903–1910. https://doi.org/10.1017/S0031182007000194
Innes, E. A., Andrianarivo, A. G., Björkman, C., Williams, D. J. L., & Conrad, P. A. (2002). Immune responses to Neospora caninum and prospects for vaccination. Trends in Parasitology, 18(11), 497–504. https://doi.org/10.1016/S1471-4922(02)02372-3
Innes, E. A., Wright, S., Bartley, P., Maley, S., Macaldowie, C., Esteban-Redondo, I., & Buxton, D. (2005). The host-parasite relationship in bovine neosporosis. Veterinary Immunology and Immunopathology, 108(1-2 SPEC. ISS.), 29–36. https://doi.org/10.1016/j.vetimm.2005.07.004
Jenny Chaparro, G., Martha Olivera, A., Nicolás Ramírez, V., David Villar, A., Jorge Fernandez, S., Julián Londoño, P., & Luis Palacio, B. (2016). Estudio serológico de Neospora caninum en ganado de leche del altiplano Norte de Antioquia, Colombia. Revista MVZ Cordoba, 21(3), 5577–5583. https://doi.org/10.21897/rmvz.832
López-Gatius, F., Pabón, M., & Almería, S. (2004). Neospora caninum infection does not affect early pregnancy in dairy cattle. Theriogenology, 62(3–4), 606–613. https://doi.org/10.1016/j.theriogenology.2003.11.002
Macaldowie, C., Maley, S. W., Wright, S., Bartley, P., Esteban-Redondo, I., Buxton, D., & Innes, E. A. (2004). Placental pathology associated with fetal death in cattle inoculated with Neospora caninum by two different routes in early pregnancy. Journal of Comparative Pathology, 131(2–3), 142–156. https://doi.org/10.1016/j.jcpa.2004.02.005
Mainato, M. (2019). Universidad de Cuenca Facultad de Ciencias Agropecuarias Escuela de Medicina Veterinaria y Zootecnia. Laminitis Bovina, 73. http://dspace.utb.edu.ec/handle/49000/6879%0Ahttps://dspace.ucuenca.edu.ec/bitstream/123 456789/3051/1/mv168.pdf
Maley, S. W., Buxton, D., Rae, A. G., Wright, S. E., Schock, A., Bartley, P. M., EstebanRedondo, I., Swales, C., Hamilton, C. M., Sales, J., & Innes, E. A. (2003). The pathogenesis of neosporosis in pregnant cattle: Inoculation at mid-gestation. Journal of Comparative Pathology, 129(2–3), 186–195. https://doi.org/10.1016/S0021-9975(03)00032-X
Martínez, J., A, F. S., Urrutia, N., & Remehue, C. I. (2018). Neosporosis bovina: signos clínicos, diagnóstico, prevención y control. Instituto de Investigaciones Agropecuarias INIA REMEHUE, 20(Imagen 2), 1–2.
McAllister, M. M. (2016). Diagnosis and Control of Bovine Neosporosis. Veterinary Clinics of North America - Food Animal Practice, 32(2), 443–463. https://doi.org/10.1016/j.cvfa.2016.01.012
McAllister, M. M., Dubey, J. P., Lindsay, D. S., Jolley, W. R., Wills, R. A., & McGuire, A. M. (1998). Dogs are definitive hosts of Neospora caninum. International Journal for Parasitology, 28(9), 1473–1479. https://doi.org/10.1016/S0020-7519(98)00138-6
Moore, D. P., Odeón, A. C., Venturini, M. C., & Campero, C. M. (2005a). Neosporosis bovina: Conceptos generales, inmunidad y perspectivas para la vacunación. Revista Argentina de Microbiologia, 37(4), 217–228.
Moore, D. P., Odeón, A. C., Venturini, M. C., & Campero, C. M. (2005b). Neosporosis bovina: Conceptos generales, inmunidad y perspectivas para la vacunación. Revista Argentina de Microbiologia, 37(4), 217–228.
Morales Salinas, E. (2016). Neosporosis Bovina : Control Y Prevención. Sitio Argentino de Producción Animal, 1–5. jairoserrano.com;
Nishikawa, Y., Tragoolpua, K., Makala, L., Nagasawa, H., & Otsuka, H. (2001). In the Absence of Endogenous Gamma Interferon , Mice Acutely Infected with Neospora caninum Succumb to a Lethal Immune Response Characterized by Inactivation of Peritoneal Macrophages In the Absence of Endogenous Gamma Interferon , Mice Acutely Infected w. Clin. Diagn. Lab. Immunol. 2001, 8. https://doi.org/10.1128/CDLI.8.4.811
Ortega-Mora, L. M., Fernández-García, A., & Gómez-Bautista, M. (2006). Diagnosis of bovine neosporosis: Recent advances and perspectives. Acta Parasitologica, 51(1), 1–14. https://doi.org/10.2478/s11686-006-0001-0
Oscar, R., & Murcia, J. (2015). Neosporosis bovina como causa de falla reproductiva en hatos del cordon lechero de UBATÉ y Chiquinquira. Universidad de La Salle, 1–66.
Parrado, S. (2016). Prevención de la Neosporosis Bovina en Colombia.pdf
Pérez-Zaballos, F. J., Ortega-Mora, L. M., Álvarez-García, G., Collantes-Fernández, E., Navarro-Lozano, V., García-Villada, L., & Costas, E. (2005). Adaptation of Neospora caninum isolates to cell-culture changes: An argument in favor of its clonal population structure. Journal of Parasitology, 91(3), 507–510. https://doi.org/10.1645/GE-381R1
Pérez, D. C., & Rojas, O. J. (2021). Neosporosis en caninos y bovinos. Revista Veterinaria, 32(2), 238. https://doi.org/10.30972/vet.3225751
Rondón, I., & Bragagnini, H. (2006). Aspectos inmunopatológicos de la neosporosis bovina Immunopathologic aspects of bovine neosporosis. 1, 52–58.
Santana, O. I., Cruz-Vázquez, C., Medina-Esparza, L., Parra, M. R., Morales, C. C., & Gallardo, D. Q. (2010). Neospora caninum: DNA detection in blood during first gestation of naturally infected heifers | Neospora caninum: Detección de ADN en sangre durante la primera gestación de vaquillas infectadas naturalmente. Veterinaria Mexico, 41(2), 131–137.
Thurmond, M. C., Hietala, S. K., & Blanchard, P. C. (1997). Herd-based diagnosis of Neospora caninum-induced endemic and epidemic abortion in cows and evidence for congenital and postnatal transmission. Journal of Veterinary Diagnostic Investigation, 9(1), 44–49. https://doi.org/10.1177/104063879700900108
Uchida, Y., Ike, K., Kurotaki, T., Ito, A., & Imai, S. (2004). Monoclonal antibodies preventing invasion of Neospora caninum tachyzoites into host cells. Journal of Veterinary Medical Science, 66(11), 1355–1358. https://doi.org/10.1292/jvms.66.1355
W. Wouda, A. R. M. and Y. H. S. ’. (1998). ABORTION RISK IN PROGENY OF COWS AFTER A Neospora caninum EPIDEMIC. Animal Health Service, 98, 3–8.
Zambrano J, Cotrino V, Jiménez C, Romero M, Guerrero B. Evaluación serológica de Neospora caninum en bovinos en Colombia. Revista Acovez; 2001.
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spelling Bonilla León, LilianGarcia Ocampo, DanielMorad Quintero, Felipe2022-10-25T19:51:07Z2022-10-25T19:51:07Z2022-10-25https://hdl.handle.net/20.500.12494/46889García Ocampo, D. y Morad Quintero, F. (2022). Consideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literatura. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/46889La Neosporosis bovina es una patológica reproductiva generada por N. caninum, la cual se encuentra distribuida a nivel mundial. Sus estadios parasitarios son taquizoíto, bradizoíto y esporozoíto. El hospedador intermediario es el perro, el cual elimina al patógeno en sus heces. El signo más importante y en ocasiones el único es el aborto, el cual se presenta en el tercio medio de la gestación, por medio de diversos mecanismos. La infección se puede determinar con pruebas inmunodiagnósticas, moleculares, histopatológicas y de aislamiento. Por el momento no se conoce un tratamiento específico, pero si medidas preventivas, razón por la cual la prevalencia incrementa.Bovine Neosporosis is a reproductive pathology generated by N. caninum, which is distributed worldwide. Its parasitic stages are tachyzoite, bradyzoite, and sporozoite. The intermediate host is the dog, which eliminates the pathogen in its feces. The most important sign and sometimes the only one is abortion, which occurs in the middle third of pregnancy, through various mechanisms. Infection can be determined with immunodiagnostic, molecular, histopathological, and isolation tests. At the moment a specific treatment is not known, but preventive measures are known, which is why the prevalence increases.daniel.garciaca@campusucc.edu.cofelipe.morad@campusucc.edu.co16 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaria y Zootecnia; IbagueMedicina veterinaria y zootecniaIbaguéNeosporosisN. CaninumAbortoOoquistesTG 2022 MVZ 46889NeosporosisN. CaninumAbortionOocystsConsideraciones generales & mecanismo de aborto de la neosporosis bovina: revisión de literaturaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Alaeddine, F., Keller, N., Leepin, A., & Hemphill, A. (2005). REDUCED INFECTION AND PROTECTION FROM CLINICAL SIGNS OF CEREBRAL NEOSPOROSIS IN C57BL / 6 MICE VACCINATED WITH RECOMBINANT MICRONEME ANTIGEN NCMIC1 NEOSPOROSIS IN C57BL / 6 MICE VACCINATED WITH RECOMBINANT MICRONEME ANTIGEN NCMIC1. American Society of Parasitologists DOI:, 91(3), 657–665.Almería, S., & López-Gatius, F. (2013). Bovine neosporosis: Clinical and practical aspects. Research in Veterinary Science, 95(2), 303–309. https://doi.org/10.1016/j.rvsc.2013.04.008Álvarez, D. (2016). Neospora caninum y sus alteraciones sobre la salud reproductiva bovina. Journal of Chemical Information and Modeling, 53(9), 1689–1699.Anderson, M., Andrianarivo, A., & Conrad, P. (2000). Neosporosis in cattle. Veterinary Clinics of North America - Food Animal Practice, 21(2 SPEC. ISS.), 473–483. https://doi.org/10.1016/j.cvfa.2005.03.004Andrianarivo, A. G., Anderson, M. L., Rowe, J. D., Gardner, I. A., Reynolds, J. P., Choromanski, L., & Conrad, P. A. (2005). Immune responses during pregnancy in heifers naturally infected with Neospora caninum with and without immunization. Parasitology Research, 96(1), 24–31. https://doi.org/10.1007/s00436-005-1313-Baillargeon, P., Fecteau, G., Paré, J., Lamothe, P., & Sauvé, R. (2001). Evaluation of the embryo transfer procedure proposed by the International Embryo Transfer Society as a method of controlling vertical transmission of Neospora caninum in cattle. 218(11), 6–9.Barr, B. C., Rowe, J. D., Sverlow, K. W., BonDurant, R. H., Ardans, A. A., Oliver, M. N., & Conrad, P. A. (1994). Experimental reproduction of bovine fetal Neospora infection and death with a bovine Neospora isolate. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 6(2), 207–215. https://doi.org/10.1177/104063879400600212Buxton, D., & Mcallister, M. M. (2002). Review Neospora. TRENDSin Parasitology, 18(12), 546–552. http://parasites.trends.com1471-4922/02/$-seefrontmatterCampero, C. M., Moore, D. P., Lagomarsino, H., Odeón, A. C., Castro, M., & Visca, H. (2003). 13 NEOSPOROSIS BOVINA Serological Status and Abortion Rate in Progeny Obtained by Natural Service or Embryo Transfer from Neospora caninum-Seropositive Cows. Journal of Veterinary Medicine Series B: Infectious Diseases and Veterinary Public Health, 50(9), 458–460. https://doi.org/10.1046/j.0931-1793.2003.00698.xConrad, P. A., Anderson, M. L., & Barr, B. C. (1995). Neosporosis: a newly recognized cause of abortion in dairy cattle. 2Nd western large herd dairy management conference, 61–68.Conrad, P. A., Barr, B. C., Sverlow, K. W., Anderson, M., Daft, B., Kinde, H., & Dubey, J. P. (1993). In vitro isolation and characterization of a Neospora sp. from aborted bovine foetuses. Parasitology, 106(3), 239–249. https://doi.org/10.1017/S0031182000075065Dijkstra, T., Barkema, H. W., Björkman, C., & Wouda, W. (2002). A high rate of seroconversion for Neospora caninum in a dairy herd without an obvious increased incidence of abortions. Veterinary Parasitology, 109(3–4), 203–211. https://doi.org/10.1016/S0304- 4017(02)00303-5Dubey, J. P. (1999). Recent advances in Neospora and neosporosis. Veterinary Parasitology, 84(3–4), 349–367. https://doi.org/10.1016/S0304-4017(99)00044-8Dubey, J. P. (2003). Review of Neospora caninum and neosporosis in animals. The Korean Journal of Parasitology, 41(1), 1–16. https://doi.org/10.3347/kjp.2003.41.1.1Dubey, J. P., Barr, B. C., Barta, J. R., Bjerkås, I., Björkman, C., Blagburn, B. L., Bowman, D. D., Buxton, D., Ellis, J. T., Gottstein, B., Hemphill, A., Hill, D. E., Howe, D. K., Jenkins, M. C., Kobayashi, Y., Koudela, B., Marsh, A. E., Mattsson, J. G., McAllister, M. M., … Lindsay, D. S. (2002). Redescription of Neospora caninum and its differentiation from related coccidia. International Journal for Parasitology, 32(8), 929–946. https://doi.org/10.1016/S0020-7519(02)00094-2Dubey, J. P., Buxton, D., & Wouda, W. (2006). Pathogenesis of Bovine Neosporosis. Journal of Comparative Pathology, 134(4), 267–289. https://doi.org/10.1016/j.jcpa.2005.11.004Dubey, J. P., & Lindsay, D. S. (1996). A review of Neospora caninum and neosporosis. Veterinary Parasitology, 67(1–2), 1–59. https://doi.org/10.1016/S0304-4017(96)01035-7Dubey, J. P., & Schares, G. (2011). Neosporosis in animals-The last five years. Veterinary Parasitology, 180(1–2), 90–108. https://doi.org/10.1016/j.vetpar.2011.05.031Dubey, J. P., Schares, G., & Ortega-Mora, L. M. (2007). Epidemiology and control of neosporosis and Neospora caninum. Clinical Microbiology Reviews, 20(2), 323–367. https://doi.org/10.1128/CMR.00031-06Echaide, I. (2000). La neosporosis bovina Volver a: Enfermedades de la reproducción. INTA, 6. www.produccion-animal.com.arEngeland, I. V., Waldeland, H., Kindahl, H., Ropstad, E., & Andresen, Ø. (1996). Effect of Toxoplasma gondii infection on the development of pregnancy and on endocrine foetalplacental function in the goat. Veterinary Parasitology, 67(1–2), 61–74. https://doi.org/10.1016/S0304-4017(96)01025-4Fort, M. (2003). Neospora caninum : Estudio seroepidemiológico en bovinos de la provincia de La Pampa.Garcia, J., Moreno, G., & Cruz, A. (2014). Prevalencia de Neospora caninum y DVB en una fina con problemas reproductivos en Sopó (Cundinamarca). Ciencia y Agricultura, 11, 9–16.Goodswen, S. J., Kennedy, P. J., & Ellis, J. T. (2013). A review of the infection, genetics, and evolution of Neospora caninum: From the past to the present. Infection, Genetics and Evolution, 13(1), 133–150. https://doi.org/10.1016/j.meegid.2012.08.012Gottstein, B., Eperon, S., Dai, W. J., Cannas, A., Hemphill, A., & Greif, G. (2001). Efficacy of toltrazuril and ponazuril against experimental Neospora caninum infection in mice. Parasitology Research, 87(1), 43–48. https://doi.org/10.1007/s004360000306Hemphill, A., Vonlaufen, N., Naguleswaran, A., Keller, N., Riesen, M., Guetg, N., Srinivasan, S., & Alaeddine, F. (2004). M icroscopy M icroanalysis Tissue Culture and Explant Approaches to Studying and Visualizing Neospora caninum and Its Interactions with the Host Cell. University of Berne, 602–620.Innes, E. A. (2007). The host-parasite relationship in pregnant cattle infected with Neospora caninum. Parasitology, 134(13), 1903–1910. https://doi.org/10.1017/S0031182007000194Innes, E. A., Andrianarivo, A. G., Björkman, C., Williams, D. J. L., & Conrad, P. A. (2002). Immune responses to Neospora caninum and prospects for vaccination. Trends in Parasitology, 18(11), 497–504. https://doi.org/10.1016/S1471-4922(02)02372-3Innes, E. A., Wright, S., Bartley, P., Maley, S., Macaldowie, C., Esteban-Redondo, I., & Buxton, D. (2005). The host-parasite relationship in bovine neosporosis. Veterinary Immunology and Immunopathology, 108(1-2 SPEC. ISS.), 29–36. https://doi.org/10.1016/j.vetimm.2005.07.004Jenny Chaparro, G., Martha Olivera, A., Nicolás Ramírez, V., David Villar, A., Jorge Fernandez, S., Julián Londoño, P., & Luis Palacio, B. (2016). Estudio serológico de Neospora caninum en ganado de leche del altiplano Norte de Antioquia, Colombia. Revista MVZ Cordoba, 21(3), 5577–5583. https://doi.org/10.21897/rmvz.832López-Gatius, F., Pabón, M., & Almería, S. (2004). Neospora caninum infection does not affect early pregnancy in dairy cattle. Theriogenology, 62(3–4), 606–613. https://doi.org/10.1016/j.theriogenology.2003.11.002Macaldowie, C., Maley, S. W., Wright, S., Bartley, P., Esteban-Redondo, I., Buxton, D., & Innes, E. A. (2004). Placental pathology associated with fetal death in cattle inoculated with Neospora caninum by two different routes in early pregnancy. Journal of Comparative Pathology, 131(2–3), 142–156. https://doi.org/10.1016/j.jcpa.2004.02.005Mainato, M. (2019). Universidad de Cuenca Facultad de Ciencias Agropecuarias Escuela de Medicina Veterinaria y Zootecnia. Laminitis Bovina, 73. http://dspace.utb.edu.ec/handle/49000/6879%0Ahttps://dspace.ucuenca.edu.ec/bitstream/123 456789/3051/1/mv168.pdfMaley, S. W., Buxton, D., Rae, A. G., Wright, S. E., Schock, A., Bartley, P. M., EstebanRedondo, I., Swales, C., Hamilton, C. M., Sales, J., & Innes, E. A. (2003). The pathogenesis of neosporosis in pregnant cattle: Inoculation at mid-gestation. Journal of Comparative Pathology, 129(2–3), 186–195. https://doi.org/10.1016/S0021-9975(03)00032-XMartínez, J., A, F. S., Urrutia, N., & Remehue, C. I. (2018). Neosporosis bovina: signos clínicos, diagnóstico, prevención y control. Instituto de Investigaciones Agropecuarias INIA REMEHUE, 20(Imagen 2), 1–2.McAllister, M. M. (2016). Diagnosis and Control of Bovine Neosporosis. Veterinary Clinics of North America - Food Animal Practice, 32(2), 443–463. https://doi.org/10.1016/j.cvfa.2016.01.012McAllister, M. M., Dubey, J. P., Lindsay, D. S., Jolley, W. R., Wills, R. A., & McGuire, A. M. (1998). Dogs are definitive hosts of Neospora caninum. International Journal for Parasitology, 28(9), 1473–1479. https://doi.org/10.1016/S0020-7519(98)00138-6Moore, D. P., Odeón, A. C., Venturini, M. C., & Campero, C. M. (2005a). Neosporosis bovina: Conceptos generales, inmunidad y perspectivas para la vacunación. Revista Argentina de Microbiologia, 37(4), 217–228.Moore, D. P., Odeón, A. C., Venturini, M. C., & Campero, C. M. (2005b). Neosporosis bovina: Conceptos generales, inmunidad y perspectivas para la vacunación. Revista Argentina de Microbiologia, 37(4), 217–228.Morales Salinas, E. (2016). Neosporosis Bovina : Control Y Prevención. Sitio Argentino de Producción Animal, 1–5. jairoserrano.com;Nishikawa, Y., Tragoolpua, K., Makala, L., Nagasawa, H., & Otsuka, H. (2001). In the Absence of Endogenous Gamma Interferon , Mice Acutely Infected with Neospora caninum Succumb to a Lethal Immune Response Characterized by Inactivation of Peritoneal Macrophages In the Absence of Endogenous Gamma Interferon , Mice Acutely Infected w. Clin. Diagn. Lab. Immunol. 2001, 8. https://doi.org/10.1128/CDLI.8.4.811Ortega-Mora, L. M., Fernández-García, A., & Gómez-Bautista, M. (2006). Diagnosis of bovine neosporosis: Recent advances and perspectives. Acta Parasitologica, 51(1), 1–14. https://doi.org/10.2478/s11686-006-0001-0Oscar, R., & Murcia, J. (2015). Neosporosis bovina como causa de falla reproductiva en hatos del cordon lechero de UBATÉ y Chiquinquira. Universidad de La Salle, 1–66.Parrado, S. (2016). Prevención de la Neosporosis Bovina en Colombia.pdfPérez-Zaballos, F. J., Ortega-Mora, L. M., Álvarez-García, G., Collantes-Fernández, E., Navarro-Lozano, V., García-Villada, L., & Costas, E. (2005). Adaptation of Neospora caninum isolates to cell-culture changes: An argument in favor of its clonal population structure. Journal of Parasitology, 91(3), 507–510. https://doi.org/10.1645/GE-381R1Pérez, D. C., & Rojas, O. J. (2021). Neosporosis en caninos y bovinos. Revista Veterinaria, 32(2), 238. https://doi.org/10.30972/vet.3225751Rondón, I., & Bragagnini, H. (2006). Aspectos inmunopatológicos de la neosporosis bovina Immunopathologic aspects of bovine neosporosis. 1, 52–58.Santana, O. I., Cruz-Vázquez, C., Medina-Esparza, L., Parra, M. R., Morales, C. C., & Gallardo, D. Q. (2010). Neospora caninum: DNA detection in blood during first gestation of naturally infected heifers | Neospora caninum: Detección de ADN en sangre durante la primera gestación de vaquillas infectadas naturalmente. Veterinaria Mexico, 41(2), 131–137.Thurmond, M. C., Hietala, S. K., & Blanchard, P. C. (1997). Herd-based diagnosis of Neospora caninum-induced endemic and epidemic abortion in cows and evidence for congenital and postnatal transmission. Journal of Veterinary Diagnostic Investigation, 9(1), 44–49. https://doi.org/10.1177/104063879700900108Uchida, Y., Ike, K., Kurotaki, T., Ito, A., & Imai, S. (2004). Monoclonal antibodies preventing invasion of Neospora caninum tachyzoites into host cells. Journal of Veterinary Medical Science, 66(11), 1355–1358. https://doi.org/10.1292/jvms.66.1355W. Wouda, A. R. M. and Y. H. S. ’. (1998). ABORTION RISK IN PROGENY OF COWS AFTER A Neospora caninum EPIDEMIC. Animal Health Service, 98, 3–8.Zambrano J, Cotrino V, Jiménez C, Romero M, Guerrero B. Evaluación serológica de Neospora caninum en bovinos en Colombia. 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