Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol

Introduction Anti-platelet therapy, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, beta-blockers and statins are cost-effective in patients with atherosclerotic cardiovascular diseases (ASCVD) for reducing the risk of ASCVD events. Unfortunately, there is abundant evidenc...

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Autores:
Bermon A.
Uribe-Rodríguez A.F.
Pérez-Rivero P.F.
Prieto-Merino D.
Cáceres Rivera, Diana Isabel
Guio E.
Atkins L.
Horne R.
Murray E.
Serrano DÍaz N.C.
Free C.
Perel P.
Casas J.P.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/51042
Acceso en línea:
https://doi.org/10.1136/bmjopen-2018-028017
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076268991&doi=10.1136%2fbmjopen-2018-028017&partnerID=40&md5=8e9eba1ee1ff2bc9a075b0d8436b4d64
https://hdl.handle.net/20.500.12494/51042
Palabra clave:
11 OXOTHROMBOXANE B2
ADULT
ANGIOTENSIN RECEPTOR ANTAGONIST
ARTICLE
ATORVASTATIN
BEHAVIOR CHANGE
BETA ADRENERGIC RECEPTOR BLOCKING AGENT
BLOOD
CARDIOVASCULAR AGENT
CONTROLLED STUDY
CORONARY ARTERY ATHEROSCLEROSIS
DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR
FLUINDOSTATIN
HEART RATE
HUMAN
HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR
LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL
MEDICATION COMPLIANCE
PATIENT COMPLIANCE
PRAVASTATIN
PROGRAM EFFICACY
RANDOMIZED CONTROLLED TRIAL
ROSUVASTATIN
SECONDARY PREVENTION
SELF REPORT
SIMVASTATIN
SINGLE BLIND PROCEDURE
SYSTOLIC BLOOD PRESSURE
TEXT MESSAGING
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_7e47927f34f185909e7f74c7b3f62d35
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/51042
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
title Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
spellingShingle Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
11 OXOTHROMBOXANE B2
ADULT
ANGIOTENSIN RECEPTOR ANTAGONIST
ARTICLE
ATORVASTATIN
BEHAVIOR CHANGE
BETA ADRENERGIC RECEPTOR BLOCKING AGENT
BLOOD
CARDIOVASCULAR AGENT
CONTROLLED STUDY
CORONARY ARTERY ATHEROSCLEROSIS
DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR
FLUINDOSTATIN
HEART RATE
HUMAN
HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR
LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL
MEDICATION COMPLIANCE
PATIENT COMPLIANCE
PRAVASTATIN
PROGRAM EFFICACY
RANDOMIZED CONTROLLED TRIAL
ROSUVASTATIN
SECONDARY PREVENTION
SELF REPORT
SIMVASTATIN
SINGLE BLIND PROCEDURE
SYSTOLIC BLOOD PRESSURE
TEXT MESSAGING
title_short Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
title_full Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
title_fullStr Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
title_full_unstemmed Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
title_sort Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol
dc.creator.fl_str_mv Bermon A.
Uribe-Rodríguez A.F.
Pérez-Rivero P.F.
Prieto-Merino D.
Cáceres Rivera, Diana Isabel
Guio E.
Atkins L.
Horne R.
Murray E.
Serrano DÍaz N.C.
Free C.
Perel P.
Casas J.P.
dc.contributor.author.none.fl_str_mv Bermon A.
Uribe-Rodríguez A.F.
Pérez-Rivero P.F.
Prieto-Merino D.
Cáceres Rivera, Diana Isabel
Guio E.
Atkins L.
Horne R.
Murray E.
Serrano DÍaz N.C.
Free C.
Perel P.
Casas J.P.
dc.subject.spa.fl_str_mv 11 OXOTHROMBOXANE B2
ADULT
ANGIOTENSIN RECEPTOR ANTAGONIST
ARTICLE
ATORVASTATIN
BEHAVIOR CHANGE
BETA ADRENERGIC RECEPTOR BLOCKING AGENT
BLOOD
CARDIOVASCULAR AGENT
CONTROLLED STUDY
CORONARY ARTERY ATHEROSCLEROSIS
DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR
FLUINDOSTATIN
HEART RATE
HUMAN
HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR
LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL
MEDICATION COMPLIANCE
PATIENT COMPLIANCE
PRAVASTATIN
PROGRAM EFFICACY
RANDOMIZED CONTROLLED TRIAL
ROSUVASTATIN
SECONDARY PREVENTION
SELF REPORT
SIMVASTATIN
SINGLE BLIND PROCEDURE
SYSTOLIC BLOOD PRESSURE
TEXT MESSAGING
topic 11 OXOTHROMBOXANE B2
ADULT
ANGIOTENSIN RECEPTOR ANTAGONIST
ARTICLE
ATORVASTATIN
BEHAVIOR CHANGE
BETA ADRENERGIC RECEPTOR BLOCKING AGENT
BLOOD
CARDIOVASCULAR AGENT
CONTROLLED STUDY
CORONARY ARTERY ATHEROSCLEROSIS
DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR
FLUINDOSTATIN
HEART RATE
HUMAN
HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR
LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL
MEDICATION COMPLIANCE
PATIENT COMPLIANCE
PRAVASTATIN
PROGRAM EFFICACY
RANDOMIZED CONTROLLED TRIAL
ROSUVASTATIN
SECONDARY PREVENTION
SELF REPORT
SIMVASTATIN
SINGLE BLIND PROCEDURE
SYSTOLIC BLOOD PRESSURE
TEXT MESSAGING
description Introduction Anti-platelet therapy, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, beta-blockers and statins are cost-effective in patients with atherosclerotic cardiovascular diseases (ASCVD) for reducing the risk of ASCVD events. Unfortunately, there is abundant evidence that adherence to these cardiovascular medications is far from ideal. A recent Cochrane review showed a potential beneficial effect of Short Message Service (SMS) interventions on adherence to medication in ASCVD patients. Methods and analysis The txt2heart study is a pragmatic randomised single-blind controlled trial. The objective is to evaluate the efficacy and safety of an intervention with SMS messages delivered by mobile phones to improve adherence to cardiovascular medications in patients with ASCVD. The intervention consists of behavioural techniques delivered via SMS. The primary outcome is change in blood serum low-density lipoprotein cholesterol levels as an indicator of adherence to statins. Secondary outcomes will include systolic blood pressure as an indicator of adherence to blood-lowering therapies and heart rate as an indicator of adherence to beta-blockers, urine levels of 11-dehydrothromboxane B2, self-reported adherence to cardiovascular medications and rates of cardiovascular death or hospitalisation due to cardiovascular disease. Ethics and dissemination The study will be performed in compliance with the protocol, regulatory requirements, Good Clinical Practice and ethical principles of the Declaration of Helsinki. The Ethics Committee of Fundación Cardiovascular de Colombia evaluated and approved the trial. The txt2heart Colombia trial aims to provide robust evidence to evaluate whether SMS messages delivered through mobile telephones change the behaviour of Colombian patients who have suffered a cardiovascular event. Trial results will be presented to the local health authorities, and if the intervention is effective and safe, we hope this strategy will be implemented quickly because of its low cost and wide-reaching impact on the population. Trial registration number NCT03098186. © Author(s) (or their employer(s)) 2019.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2019
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:32:14Z
dc.date.available.none.fl_str_mv 2023-05-24T16:32:14Z
dc.type.none.fl_str_mv Artículo
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1136/bmjopen-2018-028017
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076268991&doi=10.1136%2fbmjopen-2018-028017&partnerID=40&md5=8e9eba1ee1ff2bc9a075b0d8436b4d64
dc.identifier.issn.spa.fl_str_mv 20446055
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/51042
dc.identifier.bibliographicCitation.spa.fl_str_mv Bermon A.,Uribe-Rodríguez A.F.,Pérez-Rivero P.F.,Prieto-Merino D.,Caceres Rivera Diana,Guio E.,Atkins L.,Horne R.,Murray E.,Serrano DÍaz N.C.,Free C.,Perel P.,Casas J.P..Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol.Bmj Open. 2019. 9. (12): 028017
url https://doi.org/10.1136/bmjopen-2018-028017
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076268991&doi=10.1136%2fbmjopen-2018-028017&partnerID=40&md5=8e9eba1ee1ff2bc9a075b0d8436b4d64
https://hdl.handle.net/20.500.12494/51042
identifier_str_mv 20446055
Bermon A.,Uribe-Rodríguez A.F.,Pérez-Rivero P.F.,Prieto-Merino D.,Caceres Rivera Diana,Guio E.,Atkins L.,Horne R.,Murray E.,Serrano DÍaz N.C.,Free C.,Perel P.,Casas J.P..Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol.Bmj Open. 2019. 9. (12): 028017
dc.relation.ispartofjournal.spa.fl_str_mv Bmj Open
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 028017
dc.publisher.spa.fl_str_mv BMJ Publishing Group
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814246645366259712
spelling Bermon A.Uribe-Rodríguez A.F.Pérez-Rivero P.F.Prieto-Merino D.Cáceres Rivera, Diana IsabelGuio E.Atkins L.Horne R.Murray E.Serrano DÍaz N.C.Free C.Perel P.Casas J.P.2023-05-24T16:32:14Z2023-05-24T16:32:14Z01/01/2019https://doi.org/10.1136/bmjopen-2018-028017https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076268991&doi=10.1136%2fbmjopen-2018-028017&partnerID=40&md5=8e9eba1ee1ff2bc9a075b0d8436b4d6420446055https://hdl.handle.net/20.500.12494/51042Bermon A.,Uribe-Rodríguez A.F.,Pérez-Rivero P.F.,Prieto-Merino D.,Caceres Rivera Diana,Guio E.,Atkins L.,Horne R.,Murray E.,Serrano DÍaz N.C.,Free C.,Perel P.,Casas J.P..Evaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocol.Bmj Open. 2019. 9. (12): 028017Introduction Anti-platelet therapy, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, beta-blockers and statins are cost-effective in patients with atherosclerotic cardiovascular diseases (ASCVD) for reducing the risk of ASCVD events. Unfortunately, there is abundant evidence that adherence to these cardiovascular medications is far from ideal. A recent Cochrane review showed a potential beneficial effect of Short Message Service (SMS) interventions on adherence to medication in ASCVD patients. Methods and analysis The txt2heart study is a pragmatic randomised single-blind controlled trial. The objective is to evaluate the efficacy and safety of an intervention with SMS messages delivered by mobile phones to improve adherence to cardiovascular medications in patients with ASCVD. The intervention consists of behavioural techniques delivered via SMS. The primary outcome is change in blood serum low-density lipoprotein cholesterol levels as an indicator of adherence to statins. Secondary outcomes will include systolic blood pressure as an indicator of adherence to blood-lowering therapies and heart rate as an indicator of adherence to beta-blockers, urine levels of 11-dehydrothromboxane B2, self-reported adherence to cardiovascular medications and rates of cardiovascular death or hospitalisation due to cardiovascular disease. Ethics and dissemination The study will be performed in compliance with the protocol, regulatory requirements, Good Clinical Practice and ethical principles of the Declaration of Helsinki. The Ethics Committee of Fundación Cardiovascular de Colombia evaluated and approved the trial. The txt2heart Colombia trial aims to provide robust evidence to evaluate whether SMS messages delivered through mobile telephones change the behaviour of Colombian patients who have suffered a cardiovascular event. Trial results will be presented to the local health authorities, and if the intervention is effective and safe, we hope this strategy will be implemented quickly because of its low cost and wide-reaching impact on the population. Trial registration number NCT03098186. © Author(s) (or their employer(s)) 2019.028017BMJ Publishing Group11 OXOTHROMBOXANE B2ADULTANGIOTENSIN RECEPTOR ANTAGONISTARTICLEATORVASTATINBEHAVIOR CHANGEBETA ADRENERGIC RECEPTOR BLOCKING AGENTBLOODCARDIOVASCULAR AGENTCONTROLLED STUDYCORONARY ARTERY ATHEROSCLEROSISDIPEPTIDYL CARBOXYPEPTIDASE INHIBITORFLUINDOSTATINHEART RATEHUMANHYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITORLOW DENSITY LIPOPROTEIN CHOLESTEROL LEVELMEDICATION COMPLIANCEPATIENT COMPLIANCEPRAVASTATINPROGRAM EFFICACYRANDOMIZED CONTROLLED TRIALROSUVASTATINSECONDARY PREVENTIONSELF REPORTSIMVASTATINSINGLE BLIND PROCEDURESYSTOLIC BLOOD PRESSURETEXT MESSAGINGEvaluation of the efficacy and safety of text messages targeting adherence to cardiovascular medications in secondary prevention: The txt2heart Colombia randomised controlled trial protocolArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionBmj Openinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/51042oai:repository.ucc.edu.co:20.500.12494/510422024-08-20 16:16:31.212metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com