Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer

Introduction and objective Follicular gastritis is associated with Helicobacter pylori infection, but little is known of its relation to bacterial genotypes. Our aim was to establish the relation between follicular gastritis and different H. pylori strains. Materials and methods An analytic case-con...

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Autores:: Carlosama Rosero, Yeison Harvey
Bolaños Bravo, Harold
Sierra Torres, Carlos

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2019

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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network_name_str	Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
title	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
spellingShingle	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer Helicobacter pylori Gastritis Mucosa-associated limphoid tissue Genotype Lynfoma Helicobacter pylori Gastritis Mucosa-associated lymphoid tissue Genotype Lymphoma
title_short	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
title_full	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
title_fullStr	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
title_full_unstemmed	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
title_sort	Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer
dc.creator.fl_str_mv	Carlosama Rosero, Yeison Harvey Bolaños Bravo, Harold Sierra Torres, Carlos
dc.contributor.author.none.fl_str_mv	Carlosama Rosero, Yeison Harvey Bolaños Bravo, Harold Sierra Torres, Carlos
dc.subject.spa.fl_str_mv	Helicobacter pylori Gastritis Mucosa-associated limphoid tissue Genotype Lynfoma
topic	Helicobacter pylori Gastritis Mucosa-associated limphoid tissue Genotype Lynfoma Helicobacter pylori Gastritis Mucosa-associated lymphoid tissue Genotype Lymphoma
dc.subject.other.spa.fl_str_mv	Helicobacter pylori Gastritis Mucosa-associated lymphoid tissue Genotype Lymphoma
description	Introduction and objective Follicular gastritis is associated with Helicobacter pylori infection, but little is known of its relation to bacterial genotypes. Our aim was to establish the relation between follicular gastritis and different H. pylori strains. Materials and methods An analytic case-control study was conducted that included 36 patients with follicular gastritis (cases) and 83 with nonatrophic gastritis (controls). The sociodemographic information was obtained through a questionnaire. Biopsies were evaluated according to the Sydney System and the Wotherspoon scoring system. Helicobacter pylori genotyping was performed using the polymerase chain reaction technique. The quantitative variables were presented as mean and standard deviation and the qualitative variables as proportions and absolute frequency. The effect of each variable on outcome (follicular gastritis) was evaluated through the odds ratio and its 95% confidence interval. Statistical significance was set at a p < 0.05. Results Follicular gastritis was associated with Helicobacter pylori infection (OR: 13.41, CI: 1.7-103, p = 0.01). The CagA+ genotype was present in 56.5% of the cases and 58% of the controls. The cytotoxic VacAs1m1strain was present in 82% of the isolates in both groups. IceA1 frequency was 34.8% in the cases and 26% in the controls and the difference was not statistically significant. Conclusions The population studied had elevated frequencies of cytotoxic Helicobacter pylori strains and the iceA1 genotype was more frequent in follicular gastritis.
publishDate	2019
dc.date.issued.none.fl_str_mv	2019-04-01
dc.date.accessioned.none.fl_str_mv	2021-04-15T15:18:08Z
dc.date.available.none.fl_str_mv	2021-04-15T15:18:08Z
dc.type.none.fl_str_mv	Artículos Científicos
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dc.identifier.issn.spa.fl_str_mv	2255-534X
dc.identifier.uri.spa.fl_str_mv	https://doi.org/10.1016/j.rgmxen.2018.03.012
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dc.identifier.bibliographicCitation.spa.fl_str_mv	Carlosama-Rosero, Y. H., Bolaños-Bravo, H., Sierra-Tórres, C. H., & Rosero, E. A. (2019). Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer. Revista de Gastroenterología de México (English Edition), 84(2), 158–164. https://doi.org/10.1016/j.rgmxen.2018.03.012
identifier_str_mv	2255-534X Carlosama-Rosero, Y. H., Bolaños-Bravo, H., Sierra-Tórres, C. H., & Rosero, E. A. (2019). Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer. Revista de Gastroenterología de México (English Edition), 84(2), 158–164. https://doi.org/10.1016/j.rgmxen.2018.03.012
url	https://doi.org/10.1016/j.rgmxen.2018.03.012 https://hdl.handle.net/20.500.12494/33883
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dc.relation.ispartofjournal.spa.fl_str_mv	Revista de Gastroenterologìa de Mèxico. English Edition
dc.relation.references.spa.fl_str_mv	R.M. Genta, H.W. Hamner, D.Y. Graham Gastric lymphoid follicles in Helicobacter pylori infection: Frequency, distribution, and response to triple therapy Human Pathol, 24 (1993), pp. 577-583 C. De Giacomo, R. Fiocca, L. Villani, et al. Helicobacter pylori infection and chronic gastritis: Clinical, serological, and histologic correlations in children treated with amoxicillin and colloidal bismuth subcitrate Z. Ma, T. Tanizawa, Z. Nihei, et al. Follicular gastritis associated with Helicobacter pylori J Med Dental Sci, 47 (2000), pp. 39-47 S.D. Ladas, T. Rokkas, S. Georgopoulos, et al. Predictive factors and prevalence of follicular gastritis in adults with peptic ulcer and nonulcer dyspepsia F. Zerbib, G. Vialette, R. Cayla, et al. Follicular gastritis in adults Relations with Helicobacter pylori, histological and endoscopic aspects. Gastroenterologie clinique et biologique, 17 (1993), pp. 529-534 S. Eidt, M. Stolte Prevalence of lymphoid follicles and aggregates in Helicobacter pylori gastritis in antral and body mucosa R.M. Genta, H.W. Hamner The significance of lymphoid follicles in the interpretation of gastric biopsy specimens Arch Pathol Lab Med, 118 (1994), pp. 740-743 X. Chen, W. Liu, Y. Shi, et al. Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa J Clin Pathol, 55 (2002), pp. 133-137 J.D.M. Marín, S.C.H. Riveros Hiperplasia linfoide folicular gástrica e infección por Helicobacter pylori en adultos colombianos Rev Colomb Gastroenterol, 24 (2009), pp. 148-156 A. Zullo, C. Hassan, L. Ridola, et al. Gastric MALT lymphoma: Old and new insights Ann Gastroenterol, 27 (2014), pp. 27-33 M.G.S. Bahú, T.R. da Silveira, I. Maguilnick, et al. Endoscopic nodular gastritis: An endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori J Pediatr Gastroenterol Nutr, 36 (2003), pp. 217-222 A. Morgner, N. Lehn, L.P. Andersen, et al. Helicobacter heilmannii–associated primary gastric low-grade MALT lymphoma: Complete remission after curing the infection Gastroenterology, 118 (2000), pp. 821-828 C. Thiede, A. Morgner, B. Alpen, et al. What role does Helicobacter pylori eradication play in gastric MALT and gastric MALT lymphoma? Gastroenterology, 113 (1997), pp. 61-64 M.J. Blaser Science, medicine, and the future: Helicobacter pylori and gastric diseases Br Med J, 316 (1998), pp. 1507-1510 C. Pardo Ramos, R. Cendales Duarte Incidencia estimada y mortalidad por cáncer en Colombia 2002-2006. Incidencia estimada y mortalidad por cáncer en Colombia 2002-2006 143, Instituto Nacional de Cancerología (2010), pp. lil-lil668548 A. Wotherspoon, C. Doglioni, P. Isaacson Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): A multifocal disease Histopathology, 20 (1992), pp. 29-34 J. Raymond, M. Bergeret, P. Benhamou, et al. A 2-year study of Helicobacter pylori in children J Clin Microbiol, 32 (1994), pp. 461-463 J.D. Martínez, S.C. Henao, C. Granados The corporal atrophic chronic gastritis and the age Rev Colomb Gastroenterol, 22 (2007), pp. 17-22 A. Zaitoun The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer dyspepsia J Clin Pathol, 48 (1995), pp. 325-329 I.K. Önal, C. Sökmensüer, E.D. Önal, et al. Clinical and pathological features of nodular gastritis in adults Turkish J Med Sci, 39 (2009), pp. 719-723 I. Lee, H. Lee, M. Kim, et al. Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male-and antrum-predominant acute foveolitis in comparison with American gastritis World J Gastroenterol, 11 (2005), pp. 94-98 N. Kodaman, A. Pazos, B.G. Schneider, et al. Human and Helicobacter pylori coevolution shapes the risk of gastric disease Proceed Nat Acad Sci, 111 (2014), pp. 1455-1460 I. Segal, R. Ally, F. Sitas, et al. Helicobacter pylori: The African enigma Gut, 43 (1998), pp. 300-301 M.Y. Yakoob, A.S. Hussainy Chronic gastritis and Helicobacter pylori: A histopathological study of gastric mucosal biopsies J Coll Phys Surg Pakistan, 20 (2010), pp. 773-775 L.E. Bravo, J.C. Bravo, J.L. Realpe, et al. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori Colombia Médica, 39 (2008), pp. 58-65 C. Mejia, C. Vera, L. Huiza-Espinoza Association between follicular gastritis and Helicobacter pylori in children seen at a public hospital in Peru Rev Gastroenterol México (English ed), 81 (2016), pp. 80-85 A. Wotherspoon, C. Ortiz Hidalgo, M. Falzon, et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma The Lancet, 338 (1991), pp. 1175-1176 C. Koehler, M. Mues, H. Dienes, et al. Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues Molecular Pathol, 56 (2003), pp. 36-42 M. Eck, B. Schmausser, R. Haas, et al. MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA protein Gastroenterology, 112 (1997), pp. 1482-1486 H. Ye, H. Liu, A. Attygalle, et al. Variable frequencies of t (11; 18)(q21; q21) in MALT lymphomas of different sites: Significant association with CagA strains of H pylori in gastric MALT lymphoma Blood, 102 (2003), pp. 1012-1018 A. Soltermann, S. Koetzer, F. Eigenmann, et al. Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age Modern Pathol, 20 (2007), pp. 878-883 Y. Yamaoka, T. Kodama, O. Gutierrez, et al. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: Studies in four different countries J Clin Microbiol, 37 (1999), pp. 2274-2279 C.A. Brito, L. Silva, N. Jucá, et al. Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori-associated gastroduodenal diseases in Recife, Pernambuco, Brazil Memorias do Instituto Oswaldo Cruz, 98 (2003), pp. 817-821 G.L. Paniagua, E. Monroy, R. Rodriguez, et al. Frequency of vacA, cagA and babA2 virulence markers in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis Annals Clin Microbiol Antimicrob, 8 (2009), p. 14 E. Trujillo, T. Martínez, M.M. Bravo Genotyping of Helicobacter pylori virulence factors vacA and cagA in individuals from two regions in Colombia with opposing risk for gastric cancer Biomédica, 34 (2014), pp. 567-573 D. Cittelly, M. Huertas, J. Martinez, et al. Helicobacter pylori genotypes in non atrophic gastritis are different of the found in peptic ulcer, premalignant lesions and gastric cancer in Colombia Rev Med Chile, 130 (2002), pp. 143-151 P. Correa Human gastric carcinogenesis: A multistep and multifactorial process–first American Cancer Society award lecture on cancer epidemiology and prevention Cancer Res, 52 (1992), pp. 6735-6740 A.J. Quiroga, C. Diana Marcela, M.M. Bravo BabA2, oipA and cagE Helicobacter pylori genotypes in Colombian patients with gastroduodenal diseases Biomédica, 25 (2005), pp. 325-334 V. Caner, M. Yilmaz, N. Yonetci, et al. H pylori iceA alleles are disease-specific virulence factors World J Gastroenterol, 13 (2007), pp. 2581-2585 M. Höcker, P. Hohenberger Helicobacter pylori virulence factors–one part of a big picture The Lancet, 362 (2003), pp. 1231-1233
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spelling	Carlosama Rosero, Yeison HarveyBolaños Bravo, HaroldSierra Torres, CarlosVolumen 84 Numero 2.2021-04-15T15:18:08Z2021-04-15T15:18:08Z2019-04-012255-534Xhttps://doi.org/10.1016/j.rgmxen.2018.03.012https://hdl.handle.net/20.500.12494/33883Carlosama-Rosero, Y. H., Bolaños-Bravo, H., Sierra-Tórres, C. H., & Rosero, E. A. (2019). Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer. Revista de Gastroenterología de México (English Edition), 84(2), 158–164. https://doi.org/10.1016/j.rgmxen.2018.03.012Introduction and objective Follicular gastritis is associated with Helicobacter pylori infection, but little is known of its relation to bacterial genotypes. Our aim was to establish the relation between follicular gastritis and different H. pylori strains. Materials and methods An analytic case-control study was conducted that included 36 patients with follicular gastritis (cases) and 83 with nonatrophic gastritis (controls). The sociodemographic information was obtained through a questionnaire. Biopsies were evaluated according to the Sydney System and the Wotherspoon scoring system. Helicobacter pylori genotyping was performed using the polymerase chain reaction technique. The quantitative variables were presented as mean and standard deviation and the qualitative variables as proportions and absolute frequency. The effect of each variable on outcome (follicular gastritis) was evaluated through the odds ratio and its 95% confidence interval. Statistical significance was set at a p < 0.05. Results Follicular gastritis was associated with Helicobacter pylori infection (OR: 13.41, CI: 1.7-103, p = 0.01). The CagA+ genotype was present in 56.5% of the cases and 58% of the controls. The cytotoxic VacAs1m1strain was present in 82% of the isolates in both groups. IceA1 frequency was 34.8% in the cases and 26% in the controls and the difference was not statistically significant. Conclusions The population studied had elevated frequencies of cytotoxic Helicobacter pylori strains and the iceA1 genotype was more frequent in follicular gastritis.Introduction and objective Follicular gastritis is associated with Helicobacter pylori infection, but little is known of its relation to bacterial genotypes. Our aim was to establish the relation between follicular gastritis and different H. pylori strains. Materials and methods An analytic case-control study was conducted that included 36 patients with follicular gastritis (cases) and 83 with nonatrophic gastritis (controls). The sociodemographic information was obtained through a questionnaire. Biopsies were evaluated according to the Sydney System and the Wotherspoon scoring system. Helicobacter pylori genotyping was performed using the polymerase chain reaction technique. The quantitative variables were presented as mean and standard deviation and the qualitative variables as proportions and absolute frequency. The effect of each variable on outcome (follicular gastritis) was evaluated through the odds ratio and its 95% confidence interval. Statistical significance was set at a p < 0.05. Results Follicular gastritis was associated with Helicobacter pylori infection (OR: 13.41, CI: 1.7-103, p = 0.01). The CagA+ genotype was present in 56.5% of the cases and 58% of the controls. The cytotoxic VacAs1m1strain was present in 82% of the isolates in both groups. IceA1 frequency was 34.8% in the cases and 26% in the controls and the difference was not statistically significant. Conclusions The population studied had elevated frequencies of cytotoxic Helicobacter pylori strains and the iceA1 genotype was more frequent in follicular gastritis.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001444110https://orcid.org/0000-0002-6529-9758https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000002788yeharca@hotmail.comyeison.carlosama@campusucc.edu.cohttps://scholar.google.es/citations?user=Enxjag0AAAAJ&hl=es158-164Pelaez-Luna MarioUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, PastoMedicinaPastohttps://www.sciencedirect.com/science/article/pii/S2255534X18301099Revista de Gastroenterologìa de Mèxico. English EditionR.M. Genta, H.W. Hamner, D.Y. Graham Gastric lymphoid follicles in Helicobacter pylori infection: Frequency, distribution, and response to triple therapy Human Pathol, 24 (1993), pp. 577-583C. De Giacomo, R. Fiocca, L. Villani, et al. Helicobacter pylori infection and chronic gastritis: Clinical, serological, and histologic correlations in children treated with amoxicillin and colloidal bismuth subcitrateZ. Ma, T. Tanizawa, Z. Nihei, et al. Follicular gastritis associated with Helicobacter pylori J Med Dental Sci, 47 (2000), pp. 39-47S.D. Ladas, T. Rokkas, S. Georgopoulos, et al. Predictive factors and prevalence of follicular gastritis in adults with peptic ulcer and nonulcer dyspepsiaF. Zerbib, G. Vialette, R. Cayla, et al. Follicular gastritis in adults Relations with Helicobacter pylori, histological and endoscopic aspects. Gastroenterologie clinique et biologique, 17 (1993), pp. 529-534S. Eidt, M. Stolte Prevalence of lymphoid follicles and aggregates in Helicobacter pylori gastritis in antral and body mucosaR.M. Genta, H.W. Hamner The significance of lymphoid follicles in the interpretation of gastric biopsy specimens Arch Pathol Lab Med, 118 (1994), pp. 740-743X. Chen, W. Liu, Y. Shi, et al. Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa J Clin Pathol, 55 (2002), pp. 133-137J.D.M. Marín, S.C.H. Riveros Hiperplasia linfoide folicular gástrica e infección por Helicobacter pylori en adultos colombianos Rev Colomb Gastroenterol, 24 (2009), pp. 148-156A. Zullo, C. Hassan, L. Ridola, et al. Gastric MALT lymphoma: Old and new insights Ann Gastroenterol, 27 (2014), pp. 27-33M.G.S. Bahú, T.R. da Silveira, I. Maguilnick, et al. Endoscopic nodular gastritis: An endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori J Pediatr Gastroenterol Nutr, 36 (2003), pp. 217-222A. Morgner, N. Lehn, L.P. Andersen, et al. Helicobacter heilmannii–associated primary gastric low-grade MALT lymphoma: Complete remission after curing the infection Gastroenterology, 118 (2000), pp. 821-828C. Thiede, A. Morgner, B. Alpen, et al. What role does Helicobacter pylori eradication play in gastric MALT and gastric MALT lymphoma? Gastroenterology, 113 (1997), pp. 61-64M.J. Blaser Science, medicine, and the future: Helicobacter pylori and gastric diseases Br Med J, 316 (1998), pp. 1507-1510C. Pardo Ramos, R. Cendales Duarte Incidencia estimada y mortalidad por cáncer en Colombia 2002-2006. Incidencia estimada y mortalidad por cáncer en Colombia 2002-2006 143, Instituto Nacional de Cancerología (2010), pp. lil-lil668548A. Wotherspoon, C. Doglioni, P. Isaacson Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): A multifocal disease Histopathology, 20 (1992), pp. 29-34J. Raymond, M. Bergeret, P. Benhamou, et al. A 2-year study of Helicobacter pylori in children J Clin Microbiol, 32 (1994), pp. 461-463J.D. Martínez, S.C. Henao, C. Granados The corporal atrophic chronic gastritis and the age Rev Colomb Gastroenterol, 22 (2007), pp. 17-22A. Zaitoun The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer dyspepsia J Clin Pathol, 48 (1995), pp. 325-329I.K. Önal, C. Sökmensüer, E.D. Önal, et al. Clinical and pathological features of nodular gastritis in adults Turkish J Med Sci, 39 (2009), pp. 719-723I. Lee, H. Lee, M. Kim, et al. Ethnic difference of Helicobacter pylori gastritis: Korean and Japanese gastritis is characterized by male-and antrum-predominant acute foveolitis in comparison with American gastritis World J Gastroenterol, 11 (2005), pp. 94-98N. Kodaman, A. Pazos, B.G. Schneider, et al. Human and Helicobacter pylori coevolution shapes the risk of gastric disease Proceed Nat Acad Sci, 111 (2014), pp. 1455-1460I. Segal, R. Ally, F. Sitas, et al. Helicobacter pylori: The African enigma Gut, 43 (1998), pp. 300-301M.Y. Yakoob, A.S. Hussainy Chronic gastritis and Helicobacter pylori: A histopathological study of gastric mucosal biopsies J Coll Phys Surg Pakistan, 20 (2010), pp. 773-775L.E. Bravo, J.C. Bravo, J.L. Realpe, et al. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori Colombia Médica, 39 (2008), pp. 58-65C. Mejia, C. Vera, L. Huiza-Espinoza Association between follicular gastritis and Helicobacter pylori in children seen at a public hospital in Peru Rev Gastroenterol México (English ed), 81 (2016), pp. 80-85A. Wotherspoon, C. Ortiz Hidalgo, M. Falzon, et al. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma The Lancet, 338 (1991), pp. 1175-1176C. Koehler, M. Mues, H. Dienes, et al. Helicobacter pylori genotyping in gastric adenocarcinoma and MALT lymphoma by multiplex PCR analyses of paraffin wax embedded tissues Molecular Pathol, 56 (2003), pp. 36-42M. Eck, B. Schmausser, R. Haas, et al. MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA protein Gastroenterology, 112 (1997), pp. 1482-1486H. Ye, H. Liu, A. Attygalle, et al. Variable frequencies of t (11; 18)(q21; q21) in MALT lymphomas of different sites: Significant association with CagA strains of H pylori in gastric MALT lymphoma Blood, 102 (2003), pp. 1012-1018A. Soltermann, S. Koetzer, F. Eigenmann, et al. Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age Modern Pathol, 20 (2007), pp. 878-883Y. Yamaoka, T. Kodama, O. Gutierrez, et al. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: Studies in four different countries J Clin Microbiol, 37 (1999), pp. 2274-2279C.A. Brito, L. Silva, N. Jucá, et al. Prevalence of cagA and vacA genes in isolates from patients with Helicobacter pylori-associated gastroduodenal diseases in Recife, Pernambuco, Brazil Memorias do Instituto Oswaldo Cruz, 98 (2003), pp. 817-821G.L. Paniagua, E. Monroy, R. Rodriguez, et al. Frequency of vacA, cagA and babA2 virulence markers in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis Annals Clin Microbiol Antimicrob, 8 (2009), p. 14E. Trujillo, T. Martínez, M.M. Bravo Genotyping of Helicobacter pylori virulence factors vacA and cagA in individuals from two regions in Colombia with opposing risk for gastric cancer Biomédica, 34 (2014), pp. 567-573D. Cittelly, M. Huertas, J. Martinez, et al. Helicobacter pylori genotypes in non atrophic gastritis are different of the found in peptic ulcer, premalignant lesions and gastric cancer in Colombia Rev Med Chile, 130 (2002), pp. 143-151P. Correa Human gastric carcinogenesis: A multistep and multifactorial process–first American Cancer Society award lecture on cancer epidemiology and prevention Cancer Res, 52 (1992), pp. 6735-6740A.J. Quiroga, C. Diana Marcela, M.M. Bravo BabA2, oipA and cagE Helicobacter pylori genotypes in Colombian patients with gastroduodenal diseases Biomédica, 25 (2005), pp. 325-334V. Caner, M. Yilmaz, N. Yonetci, et al. H pylori iceA alleles are disease-specific virulence factors World J Gastroenterol, 13 (2007), pp. 2581-2585M. Höcker, P. Hohenberger Helicobacter pylori virulence factors–one part of a big picture The Lancet, 362 (2003), pp. 1231-1233Helicobacter pyloriGastritisMucosa-associated limphoid tissueGenotypeLynfomaHelicobacter pyloriGastritisMucosa-associated lymphoid tissueGenotypeLymphomaAssociation of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancerArtículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINALAssociation of the Helicobacter pylori.pdfAssociation of the Helicobacter pylori.pdfArtículoapplication/pdf868834https://repository.ucc.edu.co/bitstreams/c5bdc024-c01d-45c2-9311-8c0de2866358/downloadf85d0495d875ce3d83a745ce6fc17924MD51LICENSElicense.txtlicense.txttext/plain; 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Association of the Helicobacter pylori cagA, vacA, and iceA genotypes with chronic follicular gastritis in a Colombian population at high risk for gastric cancer

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