Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mR...

Full description

Autores:
Aguilar-Jimenez W.
Zapata Builes, Wildeman
Rugeles M.T.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49556
Acceso en línea:
https://doi.org/10.1016/j.micinf.2016.03.015
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971641019&doi=10.1016%2fj.micinf.2016.03.015&partnerID=40&md5=fb11ef071878cee3e4a51c3756e200fb
https://hdl.handle.net/20.500.12494/49556
Palabra clave:
ADULT
ALPHA DEFENSIN
APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G
ARTICLE
BETA ACTIN
CATHELICIDIN
COHORT ANALYSIS
COLECALCIFEROL 24 HYDROXYLASE
COLOMBIA
CONTROLLED STUDY
CORRELATION ANALYSIS
CROSS-SECTIONAL STUDY
CYTOCHROME P450
CYTOCHROME P450 27B1
CHOLESTANETRIOL 26 MONOOXYGENASE
ENVIRONMENTAL EXPOSURE
FEMALE
GENE EXPRESSION
GENE EXPRESSION PROFILING
GENETICS
HUMAN
HUMAN ALPHA DEFENSIN 4
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIR
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN TISSUE
IMMUNOLOGIC FACTOR
IMMUNOMODULATION
INFECTION RESISTANCE
MAJOR CLINICAL STUDY
MALE
MESSENGER RNA
MOUTH MUCOSA
NONHUMAN
PERIPHERAL BLOOD MONONUCLEAR CELL
PHOSPHOGLYCERATE KINASE 1
PRIORITY JOURNAL
PROTEIN EXPRESSION
RIBONUCLEASE
RNASE 7
SECRETORY LEUKOCYTE PROTEINASE INHIBITOR
TIPRELESTAT
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TRIPARTITE MOTIF PROTEIN 5
UNCLASSIFIED DRUG
VAGINA MUCOSA
VITAMIN D
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_7b7897a6964d2ca4419364862c36b241
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49556
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Aguilar-Jimenez W.Zapata Builes, WildemanRugeles M.T.2023-05-24T16:21:31Z2023-05-24T16:21:31Z12/04/2016https://doi.org/10.1016/j.micinf.2016.03.015https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971641019&doi=10.1016%2fj.micinf.2016.03.015&partnerID=40&md5=fb11ef071878cee3e4a51c3756e200fb12864579https://hdl.handle.net/20.500.12494/49556Aguilar-Jimenez W.,Zapata Builes Wildeman,Rugeles M.T..Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection.MICROBES AND INFECTION. 2016. 18. (7-8):p. 510-516The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. © 2016 Institut Pasteur0000-0002-7351-8738wildeman.zapatab@campusucc.edu.co510-516Elsevier Masson SASADULTALPHA DEFENSINAPOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3GARTICLEBETA ACTINCATHELICIDINCOHORT ANALYSISCOLECALCIFEROL 24 HYDROXYLASECOLOMBIACONTROLLED STUDYCORRELATION ANALYSISCROSS-SECTIONAL STUDYCYTOCHROME P450CYTOCHROME P450 27B1CHOLESTANETRIOL 26 MONOOXYGENASEENVIRONMENTAL EXPOSUREFEMALEGENE EXPRESSIONGENE EXPRESSION PROFILINGGENETICSHUMANHUMAN ALPHA DEFENSIN 4HUMAN CELLHUMAN IMMUNODEFICIENCY VIRHUMAN IMMUNODEFICIENCY VIRUS 1HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTIONHUMAN TISSUEIMMUNOLOGIC FACTORIMMUNOMODULATIONINFECTION RESISTANCEMAJOR CLINICAL STUDYMALEMESSENGER RNAMOUTH MUCOSANONHUMANPERIPHERAL BLOOD MONONUCLEAR CELLPHOSPHOGLYCERATE KINASE 1PRIORITY JOURNALPROTEIN EXPRESSIONRIBONUCLEASERNASE 7SECRETORY LEUKOCYTE PROTEINASE INHIBITORTIPRELESTATTOLL LIKE RECEPTOR 2TOLL LIKE RECEPTOR 4TRIPARTITE MOTIF PROTEIN 5UNCLASSIFIED DRUGVAGINA MUCOSAVITAMIN DAntiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infectionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionMICROBES AND INFECTIONinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49556oai:repository.ucc.edu.co:20.500.12494/495562024-08-20 16:20:24.685metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
spellingShingle Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
ADULT
ALPHA DEFENSIN
APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G
ARTICLE
BETA ACTIN
CATHELICIDIN
COHORT ANALYSIS
COLECALCIFEROL 24 HYDROXYLASE
COLOMBIA
CONTROLLED STUDY
CORRELATION ANALYSIS
CROSS-SECTIONAL STUDY
CYTOCHROME P450
CYTOCHROME P450 27B1
CHOLESTANETRIOL 26 MONOOXYGENASE
ENVIRONMENTAL EXPOSURE
FEMALE
GENE EXPRESSION
GENE EXPRESSION PROFILING
GENETICS
HUMAN
HUMAN ALPHA DEFENSIN 4
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIR
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN TISSUE
IMMUNOLOGIC FACTOR
IMMUNOMODULATION
INFECTION RESISTANCE
MAJOR CLINICAL STUDY
MALE
MESSENGER RNA
MOUTH MUCOSA
NONHUMAN
PERIPHERAL BLOOD MONONUCLEAR CELL
PHOSPHOGLYCERATE KINASE 1
PRIORITY JOURNAL
PROTEIN EXPRESSION
RIBONUCLEASE
RNASE 7
SECRETORY LEUKOCYTE PROTEINASE INHIBITOR
TIPRELESTAT
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TRIPARTITE MOTIF PROTEIN 5
UNCLASSIFIED DRUG
VAGINA MUCOSA
VITAMIN D
title_short Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_full Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_fullStr Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_full_unstemmed Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_sort Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
dc.creator.fl_str_mv Aguilar-Jimenez W.
Zapata Builes, Wildeman
Rugeles M.T.
dc.contributor.author.none.fl_str_mv Aguilar-Jimenez W.
Zapata Builes, Wildeman
Rugeles M.T.
dc.subject.spa.fl_str_mv ADULT
ALPHA DEFENSIN
APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G
ARTICLE
BETA ACTIN
CATHELICIDIN
COHORT ANALYSIS
COLECALCIFEROL 24 HYDROXYLASE
COLOMBIA
CONTROLLED STUDY
CORRELATION ANALYSIS
CROSS-SECTIONAL STUDY
CYTOCHROME P450
CYTOCHROME P450 27B1
CHOLESTANETRIOL 26 MONOOXYGENASE
ENVIRONMENTAL EXPOSURE
FEMALE
GENE EXPRESSION
GENE EXPRESSION PROFILING
GENETICS
HUMAN
HUMAN ALPHA DEFENSIN 4
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIR
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN TISSUE
IMMUNOLOGIC FACTOR
IMMUNOMODULATION
INFECTION RESISTANCE
MAJOR CLINICAL STUDY
MALE
MESSENGER RNA
MOUTH MUCOSA
NONHUMAN
PERIPHERAL BLOOD MONONUCLEAR CELL
PHOSPHOGLYCERATE KINASE 1
PRIORITY JOURNAL
PROTEIN EXPRESSION
RIBONUCLEASE
RNASE 7
SECRETORY LEUKOCYTE PROTEINASE INHIBITOR
TIPRELESTAT
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TRIPARTITE MOTIF PROTEIN 5
UNCLASSIFIED DRUG
VAGINA MUCOSA
VITAMIN D
topic ADULT
ALPHA DEFENSIN
APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G
ARTICLE
BETA ACTIN
CATHELICIDIN
COHORT ANALYSIS
COLECALCIFEROL 24 HYDROXYLASE
COLOMBIA
CONTROLLED STUDY
CORRELATION ANALYSIS
CROSS-SECTIONAL STUDY
CYTOCHROME P450
CYTOCHROME P450 27B1
CHOLESTANETRIOL 26 MONOOXYGENASE
ENVIRONMENTAL EXPOSURE
FEMALE
GENE EXPRESSION
GENE EXPRESSION PROFILING
GENETICS
HUMAN
HUMAN ALPHA DEFENSIN 4
HUMAN CELL
HUMAN IMMUNODEFICIENCY VIR
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN TISSUE
IMMUNOLOGIC FACTOR
IMMUNOMODULATION
INFECTION RESISTANCE
MAJOR CLINICAL STUDY
MALE
MESSENGER RNA
MOUTH MUCOSA
NONHUMAN
PERIPHERAL BLOOD MONONUCLEAR CELL
PHOSPHOGLYCERATE KINASE 1
PRIORITY JOURNAL
PROTEIN EXPRESSION
RIBONUCLEASE
RNASE 7
SECRETORY LEUKOCYTE PROTEINASE INHIBITOR
TIPRELESTAT
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TRIPARTITE MOTIF PROTEIN 5
UNCLASSIFIED DRUG
VAGINA MUCOSA
VITAMIN D
description The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. © 2016 Institut Pasteur
publishDate 2023
dc.date.issued.none.fl_str_mv 12/04/2016
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:31Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:31Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.micinf.2016.03.015
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971641019&doi=10.1016%2fj.micinf.2016.03.015&partnerID=40&md5=fb11ef071878cee3e4a51c3756e200fb
dc.identifier.issn.spa.fl_str_mv 12864579
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49556
dc.identifier.bibliographicCitation.spa.fl_str_mv Aguilar-Jimenez W.,Zapata Builes Wildeman,Rugeles M.T..Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection.MICROBES AND INFECTION. 2016. 18. (7-8):p. 510-516
url https://doi.org/10.1016/j.micinf.2016.03.015
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971641019&doi=10.1016%2fj.micinf.2016.03.015&partnerID=40&md5=fb11ef071878cee3e4a51c3756e200fb
https://hdl.handle.net/20.500.12494/49556
identifier_str_mv 12864579
Aguilar-Jimenez W.,Zapata Builes Wildeman,Rugeles M.T..Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection.MICROBES AND INFECTION. 2016. 18. (7-8):p. 510-516
dc.relation.ispartofjournal.spa.fl_str_mv MICROBES AND INFECTION
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 510-516
dc.publisher.spa.fl_str_mv Elsevier Masson SAS
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247058170707968

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