Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. © 2016 Institut Pasteur

• Autores: Aguilar-Jimenez W.; Zapata Builes, Wildeman; Rugeles M.T.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/49556
• Acceso en línea: https://doi.org/10.1016/j.micinf.2016.03.015; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84971641019&doi=10.1016%2fj.micinf.2016.03.015&partnerID=40&md5=fb11ef071878cee3e4a51c3756e200fb; https://hdl.handle.net/20.500.12494/49556
• Palabra clave: ADULT; ALPHA DEFENSIN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; ARTICLE; BETA ACTIN; CATHELICIDIN; COHORT ANALYSIS; COLECALCIFEROL 24 HYDROXYLASE; COLOMBIA; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; CYTOCHROME P450; CYTOCHROME P450 27B1; CHOLESTANETRIOL 26 MONOOXYGENASE; ENVIRONMENTAL EXPOSURE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; HUMAN; HUMAN ALPHA DEFENSIN 4; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIR; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IMMUNOLOGIC FACTOR; IMMUNOMODULATION; INFECTION RESISTANCE; MAJOR CLINICAL STUDY; MALE; MESSENGER RNA; MOUTH MUCOSA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHOSPHOGLYCERATE KINASE 1; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBONUCLEASE; RNASE 7; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; TIPRELESTAT; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRIPARTITE MOTIF PROTEIN 5; UNCLASSIFIED DRUG; VAGINA MUCOSA; VITAMIN D
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2