Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures
Articulo de investigación
- Autores:
-
Caviedes Rubio, Diego Iván
Delgado, Daniel Ricardo
Rodríguez Rodríguez, Gerson Andrés
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1024
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1024
- Palabra clave:
- naproxen; solubility; thermodynamic of solutions; 2-propanol
- Rights
- openAccess
- License
- Licencia CC
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| dc.title.spa.fl_str_mv |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| title |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| spellingShingle |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures naproxen; solubility; thermodynamic of solutions; 2-propanol |
| title_short |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| title_full |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| title_fullStr |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| title_full_unstemmed |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| title_sort |
Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures |
| dc.creator.fl_str_mv |
Caviedes Rubio, Diego Iván Delgado, Daniel Ricardo Rodríguez Rodríguez, Gerson Andrés |
| dc.contributor.advisor.none.fl_str_mv |
Delgado, Daniel Ricardo |
| dc.contributor.author.none.fl_str_mv |
Caviedes Rubio, Diego Iván Delgado, Daniel Ricardo Rodríguez Rodríguez, Gerson Andrés |
| dc.subject.spa.fl_str_mv |
naproxen; solubility; thermodynamic of solutions; 2-propanol |
| topic |
naproxen; solubility; thermodynamic of solutions; 2-propanol |
| description |
Articulo de investigación |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016-03-14 |
| dc.date.accessioned.none.fl_str_mv |
2017-08-10T20:41:14Z |
| dc.date.available.none.fl_str_mv |
2017-08-10T20:41:14Z |
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Artículo |
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https://hdl.handle.net/20.500.12494/1024 |
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Diego Iván Caviedes Rubio, Gerson Andrés Rodríguez Rodríguez, Daniel Ricardo Delgado. Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures. Revista Facultad de Ciencias Básicas. 12(1), 48-55-2016 |
| url |
https://hdl.handle.net/20.500.12494/1024 |
| identifier_str_mv |
Diego Iván Caviedes Rubio, Gerson Andrés Rodríguez Rodríguez, Daniel Ricardo Delgado. Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures. Revista Facultad de Ciencias Básicas. 12(1), 48-55-2016 |
| dc.relation.isversionof.spa.fl_str_mv |
https://revistas.unimilitar.edu.co/index.php/rfcb/article/view/1853/1493 |
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Licencia CC |
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info:eu-repo/semantics/openAccess |
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Licencia CC http://purl.org/coar/access_right/c_abf2 |
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openAccess |
| dc.publisher.spa.fl_str_mv |
Universidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000 |
| dc.publisher.program.spa.fl_str_mv |
Ingeniería Industrial |
| dc.publisher.place.spa.fl_str_mv |
Neiva |
| institution |
Universidad Cooperativa de Colombia |
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Delgado, Daniel RicardoCaviedes Rubio, Diego IvánDelgado, Daniel RicardoRodríguez Rodríguez, Gerson Andrés2017-08-10T20:41:14Z2017-08-10T20:41:14Z2016-03-14https://hdl.handle.net/20.500.12494/1024Diego Iván Caviedes Rubio, Gerson Andrés Rodríguez Rodríguez, Daniel Ricardo Delgado. Thermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water Mixtures. Revista Facultad de Ciencias Básicas. 12(1), 48-55-2016Articulo de investigaciónThe equilibrium solubilities of the anti-inflammatory drug naproxen (NPX) in 2-propanol + water mixtures were determined at several temperatures from 298.15 to 313.15 K. The Gibbs energy, enthalpy, and entropy of solution and of mixing were obtained from these solubility data. The solubility was maximal in φ1 = 0.90 and very low in pure water at all the temperatures studied. A non-linear plot of ∆solnH° vs. ∆solnG° with negative slope from pure water up to 0.20 in volume fraction of 2-propanol and positive beyond this composition up pure 2-propanol was obtained at the mean temperature, 305.55 K. Accordingly, the driving mechanism for NPX solubility in the water-rich mixtures was the entropy, probably due to water-structure loss around non-polar moieties of the drug and for the 2-propanol-rich mixtures it was the enthalpy, probably due to its better solvation of the drug.INTRODUCTION, RESULTS AND DISCUSSION, CONCLUSIONS, REFERENCESdanielr.delgado@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000Ingeniería IndustrialNeivahttps://revistas.unimilitar.edu.co/index.php/rfcb/article/view/1853/1493naproxen; solubility; thermodynamic of solutions; 2-propanolThermodynamic Study of the Solubility of Naproxen in Some 2-Propanol + Water MixturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia 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