Sulfasalazine as an Immunomodulator of the Inflammatory Process during HIV-1 Infection.

HIV-1 induces an uncontrolled inflammatory response of several immune components, such as inflammasomes. These molecular complexes, associated with Toll-like receptor (TLR) activity, induce the maturation and release of IL-1 and IL-18 and eventually induce pyroptosis. It has been previously demonstrated that HIV induces inflammasome activation, which is significantly lower in the gastrointestinal tissue and blood from people living with HIV-1 with spontaneous control of viral replication. Therefore, immunomodulatory agents could be useful in improving HIV prognosis.

• Autores: Feria-Garzón, Manuel G; Rugeles, María T; Hernández López, Juan Carlos; Lujan, Jorge A; Taborda, Natalia A
• Tipo de recurso: Article of journal
• Fecha de publicación: 2019
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/42850
• Acceso en línea: https://doi.org/10.5944/rppc.vol.21.num.3.2016.15711; https://www.scielo.br/scielo.php?pid=S0103-84782012000400017&script=sci_abstract; https://hdl.handle.net/20.500.12494/42850
• Palabra clave: HIV; inflammasomes; inflammation; sulfasalazine; toll-like receptors
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb