Tumor venéreo transmisible, actualidad y prospectiva de tratamiento

El TVT, es una de las neoplasias más comunes en caninos, la cual se puede presentar tanto genital como extragenital en lugares como fosa nasal, mucosa ocular, mucosa oral, entre otras. Según varios estudios, hay países endémicos, y se relaciona con la cantidad de perros callejeros, ya que estos actú...

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Autores:: Arias Huertas, Daniel Fernando

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2020

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

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dc.title.spa.fl_str_mv	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
title	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
spellingShingle	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento Vincristina TVT Inmunosupresion TG 2020 MVZ 20349 vincristine TVT Immunosuppression
title_short	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
title_full	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
title_fullStr	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
title_full_unstemmed	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
title_sort	Tumor venéreo transmisible, actualidad y prospectiva de tratamiento
dc.creator.fl_str_mv	Arias Huertas, Daniel Fernando
dc.contributor.advisor.none.fl_str_mv	Trujillo Piso, Dunia Yisela
dc.contributor.author.none.fl_str_mv	Arias Huertas, Daniel Fernando
dc.subject.spa.fl_str_mv	Vincristina TVT Inmunosupresion
topic	Vincristina TVT Inmunosupresion TG 2020 MVZ 20349 vincristine TVT Immunosuppression
dc.subject.classification.spa.fl_str_mv	TG 2020 MVZ 20349
dc.subject.other.spa.fl_str_mv	vincristine TVT Immunosuppression
description	El TVT, es una de las neoplasias más comunes en caninos, la cual se puede presentar tanto genital como extragenital en lugares como fosa nasal, mucosa ocular, mucosa oral, entre otras. Según varios estudios, hay países endémicos, y se relaciona con la cantidad de perros callejeros, ya que estos actúan como reservorio. Este tumor crea inmunosupresión en el paciente, y pasa por diversas fases de desarrollo, para lo cual, el mejor tratamiento hasta el momento es el sulfato de vincristina, y la doxorrubicina, sin embargo, se estudian muchas alternativas como el uso de virus oncolíticos, metabolitos secundarios de frutas como la guanábana, y demás. El objetivo de esta revisión de literatura, es recoger información actual del TVT y su tratamiento actual y a futuro.
publishDate	2020
dc.date.accessioned.none.fl_str_mv	2020-10-06T18:32:52Z
dc.date.available.none.fl_str_mv	2020-10-06T18:32:52Z
dc.date.issued.none.fl_str_mv	2020-09-29
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
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dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/20349
dc.identifier.bibliographicCitation.spa.fl_str_mv	Arias Huertas, D. F. (2020). Tumor venéreo transmisible, actualidad y prospectiva de tratamiento. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/20349
url	https://hdl.handle.net/20.500.12494/20349
identifier_str_mv	Arias Huertas, D. F. (2020). Tumor venéreo transmisible, actualidad y prospectiva de tratamiento. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/20349
dc.relation.references.spa.fl_str_mv	Amber, E. I., Henderson, R. A., Adeyanju, J. B., & Gyang, E. O. (1990). Single‐Drug Chemotherapy of Canine Transmissible Venereal Tumor With Cyclophosphamide, Methotrexate, or Vincristine. Journal of Veterinary Internal Medicine, 4(3), 144–147. https://doi.org/10.1111/j.1939-1676.1990.tb00887.x Pai, C. C., Kuo, T. F., Mao, S. J. T., Chuang, T. F., Lin, C. S., & Chu, R. M. (2011). Immunopathogenic behaviors of canine transmissible venereal tumor in dogs following an immunotherapy using dendritic/tumor cell hybrid. Veterinary Immunology and Immunopathology, 139(2–4), 187–199. https://doi.org/10.1016/j.vetimm.2010.10.013 Araujo, D. C. C., Antonioli, T., Costa, T. S., De Carvalho, J. R. G., Laguna, A. G. V., Ramadinha, R. H. R., & Fernandes, J. I. (2016). Occurrence and location of transmissible venereal tumors in dogs seen at the universidade federal rural do Rio de Janeiro Veterinary Hospital: Oncology Sector between 2010 and 2014. Revista Brasileira de Medicina Veterinaria, 38(3), 277–280. Correal Suárez, M. L., Bortolotti Vièra, R., & Camplesi, A. C. (2017). Terapia metronómica en el manejo del paciente veterinario con cáncer. CES Medicina Veterinaria y Zootecnia, 12(3), 195–210. https://doi.org/10.21615/cesmvz.12.3.3 Crossley, R., & Ramírez, J. A. (2017). Tumor venéreo transmisible canino de presentación atípica. Revista de La Facultad de Medicina Veterinaria y de Zootecnia, 64(3), 14. https://doi.org/10.15446/rfmvz.v64n3.68695 Cruz, A. P. S. (2013). Tumor venéreo transmisible (TVT). Journal of Chemical Information and Modeling, 53(9), 1689–1699. https://doi.org/10.1017/CBO9781107415324.004 Filgueira, K. D., Peixoto, G., Souza, Z., & Correia, A. (2013). Tumor venéreo transmissível canino com múltiplas localizações extragenitais Canine Transmissible Venereal Tumor with Multiple Extragenital Locations. Acta Scientiae Veterinariae, 41, 7. Ayala-Díaz, S., Jiménez-Lima, R., Ramírez-Alcántara, K. M., Lizano, M., Castro-Muñoz, L. J., Reyes-Hernández, D. O., … Manzo-Merino, J. (2019). Presence of Papillomavirus DNA sequences in the canine transmissible venereal tumor (CTVT). PeerJ, 2019(10), 1–15. https://doi.org/10.7717/peerj.7962 Duarte, R., Niero, R., Doretto, J. S., Manzan, R. M., & Kogika, M. M. (2006). Eritrocitose associada a tumor venéreo transmissível em cão: Relato de caso. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 58(6), 1018–1023. https://doi.org/10.1590/S0102-09352006000600007 Feghiu, A., Crînganu, D., Dumitrescu, F., Pascal, M., Vasilescu, F., & Militaru, M. (2015). Nasal transmissible venereal tumor in a Jack Russel Terrier bitch. Acta Veterinaria, 65(1), 143–148. https://doi.org/10.1515/acve-2015-0012 Filgueira, D. (2010). Tumor venéreo transmissível canino com localização primária e única em cavidade oral Canine transmissible venereal tumor with primary and unique site in the oral cavity. Acta Scientiae Veterinariae, 38(1), 91–94. Frampton, D., Schwenzer, H., Marino, G., Butcher, L. M., Pollara, G., Kriston-Vizi, J., … Fassati, A. (2018). Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor. Cancer Cell, 33(4), 620-633.e6. https://doi.org/10.1016/j.ccell.2018.03.003 Gaviria Calle, M. M., Posada Arias, S., & Mira Hernández, J. (2018). Acetogeninas, alternativa en el tratamiento de cáncer en caninos. CES Medicina Veterinaria y Zootecnia, 13(2), 157–172. https://doi.org/10.21615/cesmvz.13.2.5 Bhat, A. H., Ganguly, B., Tiwari, A. K., & Das, A. K. (2017). Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor. Scientific Reports, 7(1), 1–7. https://doi.org/10.1038/s41598-017-15734-6 Javanbakht, J., Pedram, B., Taheriyan, M. R., Khadivar, F., Hosseini, S. H., Abdi, F. S., … Emrani Bidi, R. (2014). Canine transmissible venereal tumor and seminoma: A cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy. Tumor Biology, 35(6), 5493–5500. https://doi.org/10.1007/s13277-014-1723-5 Kanca, H., Tez, G., Bal, K., Ozen, D., Alcigir, E., & Atalay Vural, S. (2018). Intratumoral recombinant human interferon alpha-2a and vincristine combination therapy in canine transmissible venereal tumour. Veterinary Medicine and Science, 4(4), 364–372. https://doi.org/10.1002/vms3.119 Khan, L. A., Khante, G. S., Raut, B. M., Bodkhe, A. M., Chavan, M. S., Pagrut, N. S., & Bobde, S. P. (2009). Incidence of venereal granuloma and its medicinal treatment in stray dogs of Nagpur City. Veterinary World, 2(1), 13–14. https://doi.org/10.5455/vetworld.2009.13-14 Moro, J. V., Tinucci-Costa, M., Silveira, A. C. T., Gerardi, D. G., & Alessi, A. C. (2010). Reactivity of p53 protein in canine transmissible venereal tumor. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 62(2), 318–323. https://doi.org/10.1590/s0102-09352010000200011 Landi, U. N., Borges, T. B., Quessada, A. M., Borges, J. L., de Oliveira, D. H., Zaniolo, M. M., … Lima Ribeiro, R. de C. (2017). Acute Urethral Obstruction Due to Transmissible Venereal Tumor in a Dog. Acta Scientiae Veterinariae, 45(S), 5. Liu, C. C., Wang, Y. S., Lin, C. Y., Chuang, T. F., Liao, K. W., Chi, K. H., … Chu, R. M. (2008). Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor. Cancer Immunology, Immunotherapy, 57(4), 479–491. https://doi.org/10.1007/s00262-007-0386-0 Mascarenhas, M. B., Peixoto, P. V., Ramadinha, R. R., Yamasaki, E. M., Costa, S. Z. R., Driemeier, D., … França, T. N. (2014). Immunohistochemical study of genital and extragenital forms of canine transmissible venereal tumor in Brazil. Pesquisa Veterinaria Brasileira, 34(3), 250–254. https://doi.org/10.1590/S0100-736X2014000300009 Ballut, J. C. (2002). Informe De Caso Tumor Venéreo Transmisible ( Tvt ) De Localización Extragenital. MVZ-CÓRDOBA, (1), 168–170. Mendez, N., Alarcón, P., Millán, C., Burgos, R. A., Morera, F. J., & Ojeda, J. (2020). Vincristine, carboplatin and cisplatin increase oxidative burst induced by PAF in canine neutrophils. Veterinary Immunology and Immunopathology, 221(December 2019), 110011. https://doi.org/10.1016/j.vetimm.2020.110011 Montoya Flórez, L., Ballestero Fêo, H., & Sousa Rocha, N. (2014). Canine transmissible venereal tumor: expression of MDR-1, and TP53 and BCL-2 family genes and its implications in biological and therapeutic behavior. Revista CES Medicina Veterinaria y Zootecnia, 9(2), 281–294. https://doi.org/10.21615/3181 Murgia, C., Pritchard, J. K., Kim, S. Y., Fassati, A., & Weiss, R. A. (2006). Clonal Origin and Evolution of a Transmissible Cancer. Cell, 126(3), 477–487. https://doi.org/10.1016/j.cell.2006.05.051 Murphy y Jirtle, 2003; Chamary y Hurst, 2009). CITADOS POR: Fonseca L, Mota L, Colodel M, Ferreira I, Brandao C, Rocha N. Spontaneous canine transmissible venereal tumor: association between different phenotypes and the insertion LINE-1/c-myc¤. Rev Colomb Cienc Pecu; 2012. Ojeda, J., Alfaro, A., Moroni, M., Camacho, V., Martínez, J., & Noro, M. (2016). Tumor venéreo transmisible diseminado sobre piel, párpados y pene en un perro. Reporte de caso. Archivos de Medicina Veterinaria, 48(1), 119–123. https://doi.org/10.4067/S0301-732X2016000100015 Pinczowski, P., Gimeno, M., Aceña, C., Villegas, A., De Martino, A., & Luján, L. (2015). Brain metastasis in a case of canine transmissible venereal tumor after a supposed successful treatment with vincristine sulfate. Acta Veterinaria, 65(1), 137–142. https://doi.org/10.1515/acve-2015-0011 Santos, F. G. A., Moro, L., Cassali, G. D., Paixão, T. A., Campos, P. P., Silva, S. S., & Vasconcelos, A. C. (2011). Cell proliferation markers in the transplanted canine transmissible venereal tumor. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 63(6), 1345–1352. https://doi.org/10.1590/S0102-09352011000600010 Champour, M., Ojrati, N., Nikrou, A., Rahimian, H., & Tehrani-Sharif, M. (2015). First report of diffuse cutaneous canine transmissible venereal tumor in Iran. Comparative Clinical Pathology, 24(4), 741–744. https://doi.org/10.1007/s00580-014-1973-z Romero, R. R., Ciércoles, J. A. G. de J., Garza, A. M. N., & Tovar, L. E. R. (2010). Tumor venéreo transmisible con metástasis a un hemangioma esplénico en una perra. Veterinaria Mexico, 41(4), 305–310. Scarpelli, K. C., Valladão, M. L., & Metze, K. (2010). Predictive factors for the regression of canine transmissible venereal tumor during vincristine therapy. Veterinary Journal, 183(3), 362–363. https://doi.org/10.1016/j.tvjl.2008.11.009 Spugnini, E. P., Dotsinsky, I., Mudrov, N., Citro, G., D’Avino, A., & Baldi, A. (2008). Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma. Journal of Experimental and Clinical Cancer Research, 27(1), 7–10. https://doi.org/10.1186/1756-9966-27-58 Strakova, A., & Murchison, E. P. (2014). The changing global distribution and prevalence of canine transmissible venereal tumour. BMC Veterinary Research, 10(1), 1–10. https://doi.org/10.1186/s12917-014-0168-9 Sudjaidee, P., Theewasutrakul, P., Techarungchaikul, S., Ponglowhapan, S., & Chatdarong, K. (2012). Treatment of canine transmissible venereal tumor using vincristine sulfate combined with L-asparaginase in clinical vincristine-resistant cases: A case report. Thai Journal of Veterinary Medicine, 42(1), 117–122. Sudjaidee, P., Ponglowhapan, S., Tummaruk, P., & Chatdarong, K. (2015). Factors affecting treatment outcome of canine transmissible venereal tumor: A retrospective study. Thai Journal of Veterinary Medicine, 45(4), 535–541. Valladão, M. L., Scarpelli, K. C., & Metze, K. (2010). Clinical utility of a life quality score in dogs with canine transmissible venereal tumor treated by vincristine chemotherapy. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 62(5), 1086–1093. https://doi.org/10.1590/s0102-09352010000500010 Arcila-Villa, A., Dussán-Lubert, C., & Pedraza-Ordoñez, F. (2018). Distribution and prevalence of transmissible venereal tumor in the Colombian canine population. Revista Colombiana de Ciencias Pecuarias, 31(3), 180–187. https://doi.org/10.17533/udea.rccp.v31n3a02
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spelling	Trujillo Piso, Dunia YiselaArias Huertas, Daniel Fernando2020-10-06T18:32:52Z2020-10-06T18:32:52Z2020-09-29https://hdl.handle.net/20.500.12494/20349Arias Huertas, D. F. (2020). Tumor venéreo transmisible, actualidad y prospectiva de tratamiento. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/20349El TVT, es una de las neoplasias más comunes en caninos, la cual se puede presentar tanto genital como extragenital en lugares como fosa nasal, mucosa ocular, mucosa oral, entre otras. Según varios estudios, hay países endémicos, y se relaciona con la cantidad de perros callejeros, ya que estos actúan como reservorio. Este tumor crea inmunosupresión en el paciente, y pasa por diversas fases de desarrollo, para lo cual, el mejor tratamiento hasta el momento es el sulfato de vincristina, y la doxorrubicina, sin embargo, se estudian muchas alternativas como el uso de virus oncolíticos, metabolitos secundarios de frutas como la guanábana, y demás. El objetivo de esta revisión de literatura, es recoger información actual del TVT y su tratamiento actual y a futuro.TVT is one of the most common neoplasms in canines, which can occur both genital and extragenital in places such as the nostril, ocular mucosa, oral mucosa, among others. According to several studies, there are endemic countries, and it is related to the number of stray dogs, since they act as a reservoir. This tumor creates immunosuppression in the patient, and goes through various stages of development, for which the best treatment so far is vincristine sulfate, and doxorubicin, however, many alternatives such as the use of oncolytic viruses are being studied, secondary metabolites of fruits such as soursop, and others. The objective of this literature review is to collect current information on TVT and its current and future treatment.daniel.ariash@campusucc.edu.co12 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéVincristinaTVTInmunosupresionTG 2020 MVZ 20349vincristineTVTImmunosuppressionTumor venéreo transmisible, actualidad y prospectiva de tratamientoTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Amber, E. I., Henderson, R. A., Adeyanju, J. B., & Gyang, E. O. (1990). Single‐Drug Chemotherapy of Canine Transmissible Venereal Tumor With Cyclophosphamide, Methotrexate, or Vincristine. Journal of Veterinary Internal Medicine, 4(3), 144–147. https://doi.org/10.1111/j.1939-1676.1990.tb00887.xPai, C. C., Kuo, T. F., Mao, S. J. T., Chuang, T. F., Lin, C. S., & Chu, R. M. (2011). Immunopathogenic behaviors of canine transmissible venereal tumor in dogs following an immunotherapy using dendritic/tumor cell hybrid. Veterinary Immunology and Immunopathology, 139(2–4), 187–199. https://doi.org/10.1016/j.vetimm.2010.10.013Araujo, D. C. C., Antonioli, T., Costa, T. S., De Carvalho, J. R. G., Laguna, A. G. V., Ramadinha, R. H. R., & Fernandes, J. I. (2016). Occurrence and location of transmissible venereal tumors in dogs seen at the universidade federal rural do Rio de Janeiro Veterinary Hospital: Oncology Sector between 2010 and 2014. Revista Brasileira de Medicina Veterinaria, 38(3), 277–280.Correal Suárez, M. L., Bortolotti Vièra, R., & Camplesi, A. C. (2017). Terapia metronómica en el manejo del paciente veterinario con cáncer. CES Medicina Veterinaria y Zootecnia, 12(3), 195–210. https://doi.org/10.21615/cesmvz.12.3.3Crossley, R., & Ramírez, J. A. (2017). Tumor venéreo transmisible canino de presentación atípica. Revista de La Facultad de Medicina Veterinaria y de Zootecnia, 64(3), 14. https://doi.org/10.15446/rfmvz.v64n3.68695Cruz, A. P. S. (2013). Tumor venéreo transmisible (TVT). Journal of Chemical Information and Modeling, 53(9), 1689–1699. https://doi.org/10.1017/CBO9781107415324.004Filgueira, K. D., Peixoto, G., Souza, Z., & Correia, A. (2013). Tumor venéreo transmissível canino com múltiplas localizações extragenitais Canine Transmissible Venereal Tumor with Multiple Extragenital Locations. Acta Scientiae Veterinariae, 41, 7.Ayala-Díaz, S., Jiménez-Lima, R., Ramírez-Alcántara, K. M., Lizano, M., Castro-Muñoz, L. J., Reyes-Hernández, D. O., … Manzo-Merino, J. (2019). Presence of Papillomavirus DNA sequences in the canine transmissible venereal tumor (CTVT). PeerJ, 2019(10), 1–15. https://doi.org/10.7717/peerj.7962Duarte, R., Niero, R., Doretto, J. S., Manzan, R. M., & Kogika, M. M. (2006). Eritrocitose associada a tumor venéreo transmissível em cão: Relato de caso. Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, 58(6), 1018–1023. https://doi.org/10.1590/S0102-09352006000600007Feghiu, A., Crînganu, D., Dumitrescu, F., Pascal, M., Vasilescu, F., & Militaru, M. (2015). Nasal transmissible venereal tumor in a Jack Russel Terrier bitch. Acta Veterinaria, 65(1), 143–148. https://doi.org/10.1515/acve-2015-0012Filgueira, D. (2010). Tumor venéreo transmissível canino com localização primária e única em cavidade oral Canine transmissible venereal tumor with primary and unique site in the oral cavity. Acta Scientiae Veterinariae, 38(1), 91–94.Frampton, D., Schwenzer, H., Marino, G., Butcher, L. M., Pollara, G., Kriston-Vizi, J., … Fassati, A. (2018). Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor. Cancer Cell, 33(4), 620-633.e6. https://doi.org/10.1016/j.ccell.2018.03.003Gaviria Calle, M. M., Posada Arias, S., & Mira Hernández, J. (2018). Acetogeninas, alternativa en el tratamiento de cáncer en caninos. CES Medicina Veterinaria y Zootecnia, 13(2), 157–172. https://doi.org/10.21615/cesmvz.13.2.5Bhat, A. H., Ganguly, B., Tiwari, A. K., & Das, A. K. (2017). Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor. Scientific Reports, 7(1), 1–7. https://doi.org/10.1038/s41598-017-15734-6Javanbakht, J., Pedram, B., Taheriyan, M. R., Khadivar, F., Hosseini, S. H., Abdi, F. S., … Emrani Bidi, R. (2014). Canine transmissible venereal tumor and seminoma: A cytohistopathology and chemotherapy study of tumors in the growth phase and during regression after chemotherapy. Tumor Biology, 35(6), 5493–5500. https://doi.org/10.1007/s13277-014-1723-5Kanca, H., Tez, G., Bal, K., Ozen, D., Alcigir, E., & Atalay Vural, S. (2018). 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