The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp

Antecedentes: El propósito de este estudio fue cuantificar el efecto de las fuerzas de ortodoncia moderadas y severas sobre la expresión del péptido relacionado con el gen de la calcitonina (CGRP) en el ligamento periodontal humano sano (PDL) y su posible relación con la pulpa dental humana. Materia...

Full description

Autores:: Caviedes bucheli, Javier
Moreno, Jaime O.
Aranguren Carrero, Morella
Buitrago Rojas, Sandra
Lopez Matheus, Rossant
Martinez Corredor, Gerson
Dias Barrera, Luis
Muñoz Alvear, Hernán Dario
Gomez Sosa, Jose Francisco
Muñoz, Hugo Roberto

Tipo de recurso:: Article of journal

Fecha de publicación:: 2022

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

id	COOPER2_765d680f63568b97996fbc5d1c98c4dc
oai_identifier_str	oai:repository.ucc.edu.co:20.500.12494/52428
network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
dc.title.none.fl_str_mv	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
title	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
spellingShingle	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp Peptido del gen relacionado con la calcitonina Fuerzas ortodonticas Ligamento periodontal humano Inflamacion neurogenica Calcitonin gene-related peptide orthodontic force human periodontal ligament neurogenic inflammation
title_short	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
title_full	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
title_fullStr	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
title_full_unstemmed	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
title_sort	The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp
dc.creator.fl_str_mv	Caviedes bucheli, Javier Moreno, Jaime O. Aranguren Carrero, Morella Buitrago Rojas, Sandra Lopez Matheus, Rossant Martinez Corredor, Gerson Dias Barrera, Luis Muñoz Alvear, Hernán Dario Gomez Sosa, Jose Francisco Muñoz, Hugo Roberto
dc.contributor.author.none.fl_str_mv	Caviedes bucheli, Javier Moreno, Jaime O. Aranguren Carrero, Morella Buitrago Rojas, Sandra Lopez Matheus, Rossant Martinez Corredor, Gerson Dias Barrera, Luis Muñoz Alvear, Hernán Dario Gomez Sosa, Jose Francisco Muñoz, Hugo Roberto
dc.subject.none.fl_str_mv	Peptido del gen relacionado con la calcitonina Fuerzas ortodonticas Ligamento periodontal humano Inflamacion neurogenica
topic	Peptido del gen relacionado con la calcitonina Fuerzas ortodonticas Ligamento periodontal humano Inflamacion neurogenica Calcitonin gene-related peptide orthodontic force human periodontal ligament neurogenic inflammation
dc.subject.other.none.fl_str_mv	Calcitonin gene-related peptide orthodontic force human periodontal ligament neurogenic inflammation
description	Antecedentes: El propósito de este estudio fue cuantificar el efecto de las fuerzas de ortodoncia moderadas y severas sobre la expresión del péptido relacionado con el gen de la calcitonina (CGRP) en el ligamento periodontal humano sano (PDL) y su posible relación con la pulpa dental humana. Material y Métodos: Se obtuvieron 90 muestras de ligamento periodontal humano de premolares sanos en los que se indicó extracción por motivos de ortodoncia. Antes de la extracción, los dientes se dividieron en 3 grupos de 30 muestras cada uno: I) Grupo de control de dientes no tratados; II) Grupo de fuerza moderada: Se aplicó una fuerza de 56 g en los premolares durante 24 horas; y III) Grupo de fuerza severa: Se aplicó una fuerza de 224 g en los premolares durante 7 días. Se procesaron todas las muestras de ligamento periodontal y se midió el CGRP mediante radioinmunoensayo. Resultados: Se encontró mayor expresión de CGRP en el grupo de fuerza severa, seguido del grupo de fuerza moderada. Los valores más bajos de CGRP fueron para los dientes no tratados. La prueba de Kruskal-Wallis mostró diferencias estadísticamente significativas entre los grupos (p<0,001). Las pruebas post hoc de LSD mostraron diferencias estadísticamente significativas en la expresión de CGRP entre los dientes no tratados y el grupo de fuerzas severas (p<0,001). Las diferencias entre los grupos de fuerza moderada y severa fueron estadísticamente significativas (p<0,001). No hubo diferencias estadísticamente significativas entre los dientes no tratados y el grupo de fuerzas moderadas (p<0,261). Conclusiones: La expresión de CGRP en el ligamento periodontal humano aumenta cuando los dientes se someten a fuerzas ortodóncicas severas. Esta expresión elevada de CGRP, que es proporcional a la fuerza aplicada, puede afectar la forma en que la pulpa dental responde a diferentes estímulos de las fuerzas de ortodoncia.
publishDate	2022
dc.date.issued.none.fl_str_mv	2022-09-13
dc.date.accessioned.none.fl_str_mv	2023-08-14T19:47:12Z
dc.date.available.none.fl_str_mv	2023-08-14T19:47:12Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.issn.none.fl_str_mv	1989-5488
dc.identifier.uri.none.fl_str_mv	10.4317/jced.59975 https://hdl.handle.net/20.500.12494/52428
dc.identifier.bibliographicCitation.none.fl_str_mv	Caviedes-Bucheli J, Moreno JO, Aranguren-Carrero M, Buitrago-Rojas S, Lopez-Matheus R, Martinez-Corredor G, Díaz-Barrera LE, Muñoz- Alvear HD, Gomez-Sosa JF, Munoz HR. The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human peri- odontal ligament and its relationship with the human dental pulp. J Clin Exp Dent. 2022;14(11):e932-7.
identifier_str_mv	1989-5488 10.4317/jced.59975 Caviedes-Bucheli J, Moreno JO, Aranguren-Carrero M, Buitrago-Rojas S, Lopez-Matheus R, Martinez-Corredor G, Díaz-Barrera LE, Muñoz- Alvear HD, Gomez-Sosa JF, Munoz HR. The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human peri- odontal ligament and its relationship with the human dental pulp. J Clin Exp Dent. 2022;14(11):e932-7.
url	https://hdl.handle.net/20.500.12494/52428
dc.relation.isversionof.none.fl_str_mv	https://pubmed.ncbi.nlm.nih.gov/36458031/
dc.relation.ispartofjournal.none.fl_str_mv	Journal of Clinical and Experimental Dentistry
dc.relation.references.none.fl_str_mv	Beertsen Wouter, Mcculloch Christopher AG, Sodek Jaroslav. The periodontal ligament: a unique, multifunctional connective tissue. Pe- riodontol 2000. 1997;13:20-40. McCulloch Christopher AG, Lekic Predrag, McKee Marc D. Role of physical forces in regulating the form and function of the periodon- tal ligament. Periodontol 2000. 2000;24:56-72. Lekic P, Mcculloch CAG. Periodontal Ligament Cell Populations: The Central Role of Fibroblasts in Creating a Unique Tissue. THE ANATOMICAL RECORD. 1996;245:327-41. Rotstein Ilan. Interaction between endodontics and periodontics. Periodontol 2000. 2017;74:11-39. Siqueira JF, Antunes HS, Pérez AR, Alves FRF, Mdala I, Silva EJNL, et al. The Apical Root Canal System of Teeth with Posttreatment Apical Periodontitis: Correlating Microbiologic, Tomographic, and Histopathologic Findings. J Endod. 2020;46:1195-203. Caviedes-Bucheli J, Moreno JO, Ardila-Pinto J, Toro-Carreño HR, Saltarín-Quintero H, Sierra-Tapias CL, et al. The effect of orthodontic forces on calcitonin gene-related peptide expression in human dental pulp. Journal of Endodontics. 2011;37:934-7. Roberts WE, Goodwin WC, Heiner SR. Cellular response to ortho- dontic force. Dental Clinics of North America. 1981;25:3-17. Sandy Jonathan R, Farndale Richard W, Meikle Murray C. Recent advances in understanding mechanically induced bone remodeling and their relevance to orthodontic theory and practice. Am J Orthod Dento- facial Orthop. 1993;103:212-22. Caviedes-Bucheli J, Muñoz HR, Azuero-Holguín MM, Ulate E. Neuropeptides in Dental Pulp: The Silent Protagonists. Journal of En- dodontics. 2008;34:773-88. Price TJ, Flores CM, Cervero F, Hargreaves KM. The RNA bin- ding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Neuroscience. 2006;141:2107-16. Vandevska-Radunovic V. Neural modulation of inflammatory re- actions in dental tissues incident to orthodontic tooth movement. A review of the literature. Eur J Orthod. 1999;21:231-47. Caviedes-Bucheli J, Azuero-Holguin MM, Correa-Ortiz JA, Agui- lar-Mora MV, Pedroza-Flores JD, Ulate E, et al. Effect of experimenta- lly induced occlusal trauma on substance P expression in human dental pulp and periodontal ligament. Journal of Endodontics. 2011;37:627- 30. Krishnan V., Davidovitch Z. On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res. 2009;88:597- 608. Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, et al. Cyclical tensile force on periodontal ligament cells inhibits os- teoclastogenesis through OPG induction. J Dent Res. 2006;85:457-62. Mostafa Yehya A, Iskander Kameel G, El-Mangoury NH. Iatroge- nic pulpal reactions to orthodontic extrusion. Am J Orthod Dentofacial Orthop. 1991;99:30-4. Yijin R, Maltha Jaap C, van ‘t Hof Martin A, Kuijpers-Jagtman AM. Optimum force magnitude for orthodontic tooth movement: A mathematic model. American Journal of Orthodontics and Dentofacial Orthopedics 2004;125:71-7. Caviedes-Bucheli J, Lombana N, Azuero-Holguín MM, Munoz HR. Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp. International Endodontic Journal. 2006;39:394-400. Caviedes-Bucheli J, Correa-Ortiz JA, Ballestero AC, Jimenez M, Munoz A, Rivero C, et al. The effect of dentine-bonding agents on substance P release in human dental pulp. Int Endod J. 2010;43:95- 101. Caviedes-Bucheli J, Ariza-García G, Restrepo-Méndez S, Ríos-Osorio N, Lombana N, Muñoz HR. The effect of tooth blea- ching on substance P expression in human dental pulp. J Endod. 2008;34:1462-5. Caviedes-Bucheli J, Correa-Ortíz JA, García LV, López-Torres R, Lombana N, Muñoz HR. The effect of cavity preparation on substance P expression in human dental pulp. J Endod. 2005;31:857-9. Vandevska-Radunovic V, Kristiansen AB, Heyeraas Karin J, Kvin- nsland S. Changes in blood circulation in teeth and supporting tissues incident to experimental tooth movement. Eur J Orthod. 1994;16:361- 9. Kvinnsland S, Heyeraas K, øfjord ES. Effect of experimental tooth movement on periodontal and pulpal blood flow. Eur J Orthod. 1989;11:200-5. Krishnan V, Jyothindra KK, Orth RCSM, Rcps Mdo, Rcs FDS. Mechanical Properties and Surface Characteristics of Three Archwire Alloys. Angle Orthodontist. 2004;74:825-31. Caviedes-Bucheli J, Rojas P, Escalona M, Estrada A, Sandoval C, Rivero C, et al. The effect of different vasoconstrictors and local anesthetic solutions on substance P expression in human dental pulp. J Endod. 2009;35:631-3. Vandevska-Radunovic V, Kvinnsland S, Kvinnsland IH. Effect of experimental tooth movement on nerve fibres immunoreactive to calcitonin gene-related peptide, protein gene product 9.5, and blood vessel density and distribution in rats. Eur J Orthod. 1997;19:517-29. Yamaguchi M, Kojima T, Kanekawa M, Aihara N, Nogimura A, Kasai K. Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells. Inflamm Res. 2004;53:199-204. Kvinnsland I., Heyeraas KJ. Effect of traumatic occlusion on CGRP and SP immunoreactive nerve fibre morphology in rat molar pulp and periodontium. Histochemistry. 1992;97:111-20. Long A, Loescher AR, Robinson PP. A histological study on the effect of different periods of orthodontic force on the innervation and dimensions of the cat periodontal ligament. Arch Oral Biol. 1996;41:799-808. Cuoghi OA, de FARIA LP, Ervolino E, Barioni SRP, Topolski F, Arana-Chavez VE, et al. Pulp analysis of teeth submitted to different types of forces: a histological study in rats. J Appl Oral Sci. 2018;26. Caviedes-Bucheli J, Lopez-Moncayo LF, Muñoz-Alvear HD, Go- mez-Sosa JF, Diaz-Barrera LE, Curtidor H, et al. Expression of subs- tance P, calcitonin gene-related peptide and vascular endothelial grow- th factor in human dental pulp under different clinical stimuli. BMC Oral Health. 2021;21:152. Owman-Moll P, Kurol J, Lundgren D. Effects of a doubled ortho- dontic force magnitude on tooth movement and root resorptions. An inter-individual study in adolescents. Eur J Orthod. 1996;18:141-50. Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, et al. Calcitonin ge- ne-related peptide promotes angiogenesis via AMP-activated protein kinase. 2010:1485-92. Sabeti M, Tayeed H, Kurtzman G, Mashhadiabbas F, Ardakani MT. Histopathological Investigation of Dental Pulp Reactions Related to Periodontitis. European Endodontic Journal. 2021;6:164-9. Kurol J, Owman-Moll P, Lundgren D. Time-related root resorption after application of a controlled continuous orthodontic force. Am J Orthod Dentofacial Orthop. 1996;110:303-10.
dc.rights.license.none.fl_str_mv	Atribución – No comercial – Compartir igual
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv	http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv	Atribución – No comercial – Compartir igual http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.none.fl_str_mv	5
dc.coverage.temporal.none.fl_str_mv	15
dc.publisher.none.fl_str_mv	José V. Bagán Endodontics Department, Universidad Cooperativa de Colombia, Pasto, Colombia
dc.publisher.program.none.fl_str_mv	Especialización en endodoncia
dc.publisher.place.none.fl_str_mv	Pasto
publisher.none.fl_str_mv	José V. Bagán Endodontics Department, Universidad Cooperativa de Colombia, Pasto, Colombia
institution	Universidad Cooperativa de Colombia
bitstream.url.fl_str_mv	https://repository.ucc.edu.co/bitstreams/415a7b70-0e38-4ff5-810f-596ea09c9d32/download
bitstream.checksum.fl_str_mv	3bce4f7ab09dfc588f126e1e36e98a45
bitstream.checksumAlgorithm.fl_str_mv	MD5
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814246768977641472
spelling	Caviedes bucheli, JavierMoreno, Jaime O.Aranguren Carrero, MorellaBuitrago Rojas, SandraLopez Matheus, RossantMartinez Corredor, GersonDias Barrera, LuisMuñoz Alvear, Hernán DarioGomez Sosa, Jose FranciscoMuñoz, Hugo Roberto152023-08-14T19:47:12Z2023-08-14T19:47:12Z2022-09-131989-548810.4317/jced.59975https://hdl.handle.net/20.500.12494/52428Caviedes-Bucheli J, Moreno JO, Aranguren-Carrero M, Buitrago-Rojas S, Lopez-Matheus R, Martinez-Corredor G, Díaz-Barrera LE, Muñoz- Alvear HD, Gomez-Sosa JF, Munoz HR. The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human peri- odontal ligament and its relationship with the human dental pulp. J Clin Exp Dent. 2022;14(11):e932-7.Antecedentes: El propósito de este estudio fue cuantificar el efecto de las fuerzas de ortodoncia moderadas y severas sobre la expresión del péptido relacionado con el gen de la calcitonina (CGRP) en el ligamento periodontal humano sano (PDL) y su posible relación con la pulpa dental humana. Material y Métodos: Se obtuvieron 90 muestras de ligamento periodontal humano de premolares sanos en los que se indicó extracción por motivos de ortodoncia. Antes de la extracción, los dientes se dividieron en 3 grupos de 30 muestras cada uno: I) Grupo de control de dientes no tratados; II) Grupo de fuerza moderada: Se aplicó una fuerza de 56 g en los premolares durante 24 horas; y III) Grupo de fuerza severa: Se aplicó una fuerza de 224 g en los premolares durante 7 días. Se procesaron todas las muestras de ligamento periodontal y se midió el CGRP mediante radioinmunoensayo. Resultados: Se encontró mayor expresión de CGRP en el grupo de fuerza severa, seguido del grupo de fuerza moderada. Los valores más bajos de CGRP fueron para los dientes no tratados. La prueba de Kruskal-Wallis mostró diferencias estadísticamente significativas entre los grupos (p<0,001). Las pruebas post hoc de LSD mostraron diferencias estadísticamente significativas en la expresión de CGRP entre los dientes no tratados y el grupo de fuerzas severas (p<0,001). Las diferencias entre los grupos de fuerza moderada y severa fueron estadísticamente significativas (p<0,001). No hubo diferencias estadísticamente significativas entre los dientes no tratados y el grupo de fuerzas moderadas (p<0,261). Conclusiones: La expresión de CGRP en el ligamento periodontal humano aumenta cuando los dientes se someten a fuerzas ortodóncicas severas. Esta expresión elevada de CGRP, que es proporcional a la fuerza aplicada, puede afectar la forma en que la pulpa dental responde a diferentes estímulos de las fuerzas de ortodoncia.Background: The purpose of this study was to quantify the effect of moderate and severe orthodontic forces on Cal- citonin gene-related peptide (CGRP) expression in the healthy human periodontal ligament (PDL) and its possible relationship with the human dental pulp. Material and Methods: Ninety human periodontal ligament samples were obtained from healthy premolars where extraction was indicated for orthodontic reasons. Prior to extraction, teeth were divided in 3 groups of 30 samples each: I) Untreated teeth control group; II) Moderate force group: A 56 g force was applied to the premolars for 24 hours; and III) Severe force group: A 224 g force was applied to the premolars for 7 days. All periodontal ligament samples were processed and CGRP was measured by radioimmunoassay. Results: Greater CGRP expression was found in the severe force group, followed by the moderate force group. The lower CGRP values were for the untreated teeth. Kruskal-Wallis test showed statistically significant differences be- tween groups (p<0.001). LSD post hoc tests showed statistically significant differences in CGRP expression between the untreated teeth and the severe forces group (p<0.001). Differences between the moderate and severe force groups were statistically significant (p<0.001). There was no statistically significant differences between the untreated teeth and the moderate forces group (p<0.261). Conclusions: CGRP expression in human periodontal ligament increases when teeth are submitted to severe orthodon- tic forces. This elevated expression of CGRP, which is proportional to the applied force, may affect the way the dental pulp responds to different stimuli from the orthodontic forces.1. Resumen 2. Introducción 3. Materiales y Métodos 4. Resultados 5. Discusión 6. Conclusiónhttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000149405https://orcid.org/my-orcid?orcid=0000-0002-4327-4242https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000002911hernandmunoza@gmail.com5José V. BagánEndodontics Department, Universidad Cooperativa de Colombia, Pasto, ColombiaEspecialización en endodonciaPastohttps://pubmed.ncbi.nlm.nih.gov/36458031/Journal of Clinical and Experimental DentistryBeertsen Wouter, Mcculloch Christopher AG, Sodek Jaroslav. The periodontal ligament: a unique, multifunctional connective tissue. Pe- riodontol 2000. 1997;13:20-40.McCulloch Christopher AG, Lekic Predrag, McKee Marc D. Role of physical forces in regulating the form and function of the periodon- tal ligament. Periodontol 2000. 2000;24:56-72.Lekic P, Mcculloch CAG. Periodontal Ligament Cell Populations: The Central Role of Fibroblasts in Creating a Unique Tissue. THE ANATOMICAL RECORD. 1996;245:327-41.Rotstein Ilan. Interaction between endodontics and periodontics. Periodontol 2000. 2017;74:11-39.Siqueira JF, Antunes HS, Pérez AR, Alves FRF, Mdala I, Silva EJNL, et al. The Apical Root Canal System of Teeth with Posttreatment Apical Periodontitis: Correlating Microbiologic, Tomographic, and Histopathologic Findings. J Endod. 2020;46:1195-203.Caviedes-Bucheli J, Moreno JO, Ardila-Pinto J, Toro-Carreño HR, Saltarín-Quintero H, Sierra-Tapias CL, et al. The effect of orthodontic forces on calcitonin gene-related peptide expression in human dental pulp. Journal of Endodontics. 2011;37:934-7.Roberts WE, Goodwin WC, Heiner SR. Cellular response to ortho- dontic force. Dental Clinics of North America. 1981;25:3-17.Sandy Jonathan R, Farndale Richard W, Meikle Murray C. Recent advances in understanding mechanically induced bone remodeling and their relevance to orthodontic theory and practice. Am J Orthod Dento- facial Orthop. 1993;103:212-22.Caviedes-Bucheli J, Muñoz HR, Azuero-Holguín MM, Ulate E. Neuropeptides in Dental Pulp: The Silent Protagonists. Journal of En- dodontics. 2008;34:773-88.Price TJ, Flores CM, Cervero F, Hargreaves KM. The RNA bin- ding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons. Neuroscience. 2006;141:2107-16.Vandevska-Radunovic V. Neural modulation of inflammatory re- actions in dental tissues incident to orthodontic tooth movement. A review of the literature. Eur J Orthod. 1999;21:231-47.Caviedes-Bucheli J, Azuero-Holguin MM, Correa-Ortiz JA, Agui- lar-Mora MV, Pedroza-Flores JD, Ulate E, et al. Effect of experimenta- lly induced occlusal trauma on substance P expression in human dental pulp and periodontal ligament. Journal of Endodontics. 2011;37:627- 30.Krishnan V., Davidovitch Z. On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res. 2009;88:597- 608.Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, et al. Cyclical tensile force on periodontal ligament cells inhibits os- teoclastogenesis through OPG induction. J Dent Res. 2006;85:457-62.Mostafa Yehya A, Iskander Kameel G, El-Mangoury NH. Iatroge- nic pulpal reactions to orthodontic extrusion. Am J Orthod Dentofacial Orthop. 1991;99:30-4.Yijin R, Maltha Jaap C, van ‘t Hof Martin A, Kuijpers-Jagtman AM. Optimum force magnitude for orthodontic tooth movement: A mathematic model. American Journal of Orthodontics and Dentofacial Orthopedics 2004;125:71-7.Caviedes-Bucheli J, Lombana N, Azuero-Holguín MM, Munoz HR. Quantification of neuropeptides (calcitonin gene-related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp. International Endodontic Journal. 2006;39:394-400.Caviedes-Bucheli J, Correa-Ortiz JA, Ballestero AC, Jimenez M, Munoz A, Rivero C, et al. The effect of dentine-bonding agents on substance P release in human dental pulp. Int Endod J. 2010;43:95- 101.Caviedes-Bucheli J, Ariza-García G, Restrepo-Méndez S, Ríos-Osorio N, Lombana N, Muñoz HR. The effect of tooth blea- ching on substance P expression in human dental pulp. J Endod. 2008;34:1462-5.Caviedes-Bucheli J, Correa-Ortíz JA, García LV, López-Torres R, Lombana N, Muñoz HR. The effect of cavity preparation on substance P expression in human dental pulp. J Endod. 2005;31:857-9.Vandevska-Radunovic V, Kristiansen AB, Heyeraas Karin J, Kvin- nsland S. Changes in blood circulation in teeth and supporting tissues incident to experimental tooth movement. Eur J Orthod. 1994;16:361- 9.Kvinnsland S, Heyeraas K, øfjord ES. Effect of experimental tooth movement on periodontal and pulpal blood flow. Eur J Orthod. 1989;11:200-5.Krishnan V, Jyothindra KK, Orth RCSM, Rcps Mdo, Rcs FDS. Mechanical Properties and Surface Characteristics of Three Archwire Alloys. Angle Orthodontist. 2004;74:825-31.Caviedes-Bucheli J, Rojas P, Escalona M, Estrada A, Sandoval C, Rivero C, et al. The effect of different vasoconstrictors and local anesthetic solutions on substance P expression in human dental pulp. J Endod. 2009;35:631-3.Vandevska-Radunovic V, Kvinnsland S, Kvinnsland IH. Effect of experimental tooth movement on nerve fibres immunoreactive to calcitonin gene-related peptide, protein gene product 9.5, and blood vessel density and distribution in rats. Eur J Orthod. 1997;19:517-29.Yamaguchi M, Kojima T, Kanekawa M, Aihara N, Nogimura A, Kasai K. Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells. Inflamm Res. 2004;53:199-204.Kvinnsland I., Heyeraas KJ. Effect of traumatic occlusion on CGRP and SP immunoreactive nerve fibre morphology in rat molar pulp and periodontium. Histochemistry. 1992;97:111-20.Long A, Loescher AR, Robinson PP. A histological study on the effect of different periods of orthodontic force on the innervation and dimensions of the cat periodontal ligament. Arch Oral Biol. 1996;41:799-808.Cuoghi OA, de FARIA LP, Ervolino E, Barioni SRP, Topolski F, Arana-Chavez VE, et al. Pulp analysis of teeth submitted to different types of forces: a histological study in rats. J Appl Oral Sci. 2018;26.Caviedes-Bucheli J, Lopez-Moncayo LF, Muñoz-Alvear HD, Go- mez-Sosa JF, Diaz-Barrera LE, Curtidor H, et al. Expression of subs- tance P, calcitonin gene-related peptide and vascular endothelial grow- th factor in human dental pulp under different clinical stimuli. BMC Oral Health. 2021;21:152.Owman-Moll P, Kurol J, Lundgren D. Effects of a doubled ortho- dontic force magnitude on tooth movement and root resorptions. An inter-individual study in adolescents. Eur J Orthod. 1996;18:141-50.Zheng S, Li W, Xu M, Bai X, Zhou Z, Han J, et al. Calcitonin ge- ne-related peptide promotes angiogenesis via AMP-activated protein kinase. 2010:1485-92.Sabeti M, Tayeed H, Kurtzman G, Mashhadiabbas F, Ardakani MT. Histopathological Investigation of Dental Pulp Reactions Related to Periodontitis. European Endodontic Journal. 2021;6:164-9.Kurol J, Owman-Moll P, Lundgren D. Time-related root resorption after application of a controlled continuous orthodontic force. Am J Orthod Dentofacial Orthop. 1996;110:303-10.Peptido del gen relacionado con la calcitoninaFuerzas ortodonticasLigamento periodontal humanoInflamacion neurogenicaCalcitonin gene-related peptideorthodontic forcehuman periodontal ligamentneurogenic inflammationThe effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulpArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/415a7b70-0e38-4ff5-810f-596ea09c9d32/download3bce4f7ab09dfc588f126e1e36e98a45MD5120.500.12494/52428oai:repository.ucc.edu.co:20.500.12494/524282024-07-16 13:34:49.027metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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

The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp

Publicaciones similares