Assessment of endocrine disruptor effects of levonorgestrel and its photoproducts: Environmental implications of released fractions after their photocatalytic removal

The presence of levonorgestrel (LNG) in water bodies via direct discharge and human excretion has been reported worldwide, but its effects on the reproduction of aquatic species and humans are still unknown. Owing to its recalcitrant properties, LNG is not completely removed during wastewater treatment plants, and many species may be exposed to low traces of this compound from discharged effluents. Thus, in this study, a photocatalytic process for removing LNG along with screening of endocrine disruptor effects for risk assessment was applied. Although the removal rate of LNG by ultraviolet C (UV-C) radiation was >90%, reproductive toxicity testing using the BeWo cell line exposed to LNG and its degraded fraction showed the reduced production of basal human chorionic gonadotropin hormone (ß-hCG) by more than 73%, from 8.90 mIU mL-1 to <2.39 mIU mL-1, with both LNG and the degraded fraction. ß-hCG hormone has been implicated in the viability of trophoblastic cells during the first trimester of pregnancy; therefore, degraded fractions and waterborne LNG may affect reproduction in some aquatic species and humans with low level of exposure. © 2019

• Autores: Narváez J.F.; Grant H.; Gil V.C.; Porras J.; Bueno Sanchez J.C.; Ocampo Duque L.F.; Sossa R.R.; Quintana Castillo, Juan Carlos
• Tipo de recurso: Article of journal
• Fecha de publicación: 2019
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41489
• Acceso en línea: https://doi.org/10.1016/j.rcp.2016.04.002; https://hdl.handle.net/20.500.12494/41489
• Palabra clave: Cell culture; Effluents; Wastewater treatment; Cell lines; Endocrine disruptor; Levonorgestrel; Photo catalytic degradation; Photo-catalytic removal; Risk assessment; chorionic gonadotropin beta subunit; endocrine disruptor; levonorgestrel; assessment method; catalysis; cell component; chemical compound; degradation; effluent; endocrine disruptor; excretion; hormone; pollutant removal; pregnancy; reproduction; risk assessment; toxicity; wastewater; wastewater treatment plant; aquatic species; Article; BeWo cell line; cell proliferation; cell viability; controlled study; effluent; hormone synthesis; mineralization; photocatalysis; photodegradation; photolysis; reproductive toxicity; risk assessment; sunlight; trophoblast; ultraviolet C radiation; waste water management
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb