Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina

Se recopiló información científica y actualizada de los factores de virulencia de B. bronchiseptica, con el objetivo de plantear cómo actúa cada uno de estos en la fisiopatología de la traqueobronquitis infecciosa canina, conociendo de manera precisa la interacción de la bacteria con el huésped en e...

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Autores:
Moreno Garzon, Yiseth Katherine
Marín Rincón, Jeimmy Viviana
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2021
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/34678
Acceso en línea:
https://hdl.handle.net/20.500.12494/34678
Palabra clave:
Adenilato ciclasa
Citotoxina traqueal
Hemaglutinina filamentosa
Lipopolisacárido
Pertactina
Toxina dermonecrótica
TG 2021 MVZ 34678
Adenylate cyclase
Tracheal cytotoxin
Filamentous hemagglutinin
Lipopolysaccharide
Pertactin
Dermonecrotic toxin
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openAccess
License
Atribución
id COOPER2_6f833f73a85ee0efaca596bd47589a83
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/34678
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
title Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
spellingShingle Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
Adenilato ciclasa
Citotoxina traqueal
Hemaglutinina filamentosa
Lipopolisacárido
Pertactina
Toxina dermonecrótica
TG 2021 MVZ 34678
Adenylate cyclase
Tracheal cytotoxin
Filamentous hemagglutinin
Lipopolysaccharide
Pertactin
Dermonecrotic toxin
title_short Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
title_full Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
title_fullStr Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
title_full_unstemmed Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
title_sort Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina
dc.creator.fl_str_mv Moreno Garzon, Yiseth Katherine
Marín Rincón, Jeimmy Viviana
dc.contributor.advisor.none.fl_str_mv Sánchez Bonilla, María del Pilar
dc.contributor.author.none.fl_str_mv Moreno Garzon, Yiseth Katherine
Marín Rincón, Jeimmy Viviana
dc.subject.spa.fl_str_mv Adenilato ciclasa
Citotoxina traqueal
Hemaglutinina filamentosa
Lipopolisacárido
Pertactina
Toxina dermonecrótica
topic Adenilato ciclasa
Citotoxina traqueal
Hemaglutinina filamentosa
Lipopolisacárido
Pertactina
Toxina dermonecrótica
TG 2021 MVZ 34678
Adenylate cyclase
Tracheal cytotoxin
Filamentous hemagglutinin
Lipopolysaccharide
Pertactin
Dermonecrotic toxin
dc.subject.classification.spa.fl_str_mv TG 2021 MVZ 34678
dc.subject.other.spa.fl_str_mv Adenylate cyclase
Tracheal cytotoxin
Filamentous hemagglutinin
Lipopolysaccharide
Pertactin
Dermonecrotic toxin
description Se recopiló información científica y actualizada de los factores de virulencia de B. bronchiseptica, con el objetivo de plantear cómo actúa cada uno de estos en la fisiopatología de la traqueobronquitis infecciosa canina, conociendo de manera precisa la interacción de la bacteria con el huésped en este caso el canino. Se seleccionaron artículos indexados originales, realizados y publicados durante el año de 1977-1980 en caso de la historia y los años 2015 y 2021 sobre los factores de virulencia. Dentro de los criterios de inclusión, se tuvieron en cuenta estudios de idiomas diferentes al español, como el inglés y que se encontrarán dentro del tiempo de fecha de publicación. De 3.220 artículos revisados de bases de datos se seleccionaron 70 que cumplieron con los criterios de inclusión, los cuales determinaron, traqueobronquitis infecciosa, B. bronchiseptica, hemaglutinina filamentosa, pertactina, fimbrias, adenilato ciclasa, citotoxina traqueal y toxina dermonecrótica. En conclusión, la revisión sistemática permitió establecer que B. bronchiseptica, coloniza las células ciliadas del tracto respiratorio, debido a la presencia de adhesinas fimbriales y no fimbriales, como la hemaglutinina filamentosa y pertactina, ubicadas principalmente en la membrana externa de la bacteria, así como la participación del bacteriófago Bordetella el cuál expresa genes de fácil mutación para receptores adaptando a la bacteria. De igual manera, la expresión de endotoxinas y exotoxinas, dentro de estas últimas adenilato ciclasa, toxina dermonecrótica y citotoxina traqueal, las cuales, participan en la fisiopatología de la traqueobronquitis infecciosa canina, afectando así las células ciliadas, inhibiendo la respuesta de las células fagocíticas, suprimiendo la respuesta inmune, asociándose finalmente con los signos clínicos característicos en perros con traqueobronquitis infecciosa.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-06-21T16:39:02Z
dc.date.available.none.fl_str_mv 2021-06-21T16:39:02Z
dc.date.issued.none.fl_str_mv 2021-06-18
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/34678
dc.identifier.bibliographicCitation.spa.fl_str_mv Moreno Garzon, Y. K. y Marin Rincon, J. V. (2021). Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/34678
url https://hdl.handle.net/20.500.12494/34678
identifier_str_mv Moreno Garzon, Y. K. y Marin Rincon, J. V. (2021). Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/34678
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spelling Sánchez Bonilla, María del PilarMoreno Garzon, Yiseth KatherineMarín Rincón, Jeimmy Viviana2021-06-21T16:39:02Z2021-06-21T16:39:02Z2021-06-18https://hdl.handle.net/20.500.12494/34678Moreno Garzon, Y. K. y Marin Rincon, J. V. (2021). Factores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa canina. [tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. http://hdl.handle.net/20.500.12494/34678Se recopiló información científica y actualizada de los factores de virulencia de B. bronchiseptica, con el objetivo de plantear cómo actúa cada uno de estos en la fisiopatología de la traqueobronquitis infecciosa canina, conociendo de manera precisa la interacción de la bacteria con el huésped en este caso el canino. Se seleccionaron artículos indexados originales, realizados y publicados durante el año de 1977-1980 en caso de la historia y los años 2015 y 2021 sobre los factores de virulencia. Dentro de los criterios de inclusión, se tuvieron en cuenta estudios de idiomas diferentes al español, como el inglés y que se encontrarán dentro del tiempo de fecha de publicación. De 3.220 artículos revisados de bases de datos se seleccionaron 70 que cumplieron con los criterios de inclusión, los cuales determinaron, traqueobronquitis infecciosa, B. bronchiseptica, hemaglutinina filamentosa, pertactina, fimbrias, adenilato ciclasa, citotoxina traqueal y toxina dermonecrótica. En conclusión, la revisión sistemática permitió establecer que B. bronchiseptica, coloniza las células ciliadas del tracto respiratorio, debido a la presencia de adhesinas fimbriales y no fimbriales, como la hemaglutinina filamentosa y pertactina, ubicadas principalmente en la membrana externa de la bacteria, así como la participación del bacteriófago Bordetella el cuál expresa genes de fácil mutación para receptores adaptando a la bacteria. De igual manera, la expresión de endotoxinas y exotoxinas, dentro de estas últimas adenilato ciclasa, toxina dermonecrótica y citotoxina traqueal, las cuales, participan en la fisiopatología de la traqueobronquitis infecciosa canina, afectando así las células ciliadas, inhibiendo la respuesta de las células fagocíticas, suprimiendo la respuesta inmune, asociándose finalmente con los signos clínicos característicos en perros con traqueobronquitis infecciosa.Scientific and updated information was collected on the virulence factors of B. bronchiseptica, with the aim of establishing how each of these acts in the pathophysiology of canine infectious tracheobronchitis, knowing precisely the interaction of the bacteria with the host in this case the canine. Original indexed articles, made and published during the year 1977-1980 were selected in the case of history and the years 2015 and 2021 on virulence factors. Within the inclusion criteria, studies of languages other than Spanish were taken into account, such as English, which will be found within the time of publication date. Of 3.220 articles reviewed from databases, 70 were selected that met the inclusion criteria, witch determined infectious tracheobronchitis, B. bronchiseptica, filamentous hemagglutinin, pertactin, fimbriae, adenylate cyclase, tracheal cytotoxina and dermonecrotic toxin. In conclusion, the systematic review will establish that B. bronchiseptica colonizes the ciliated cells of the respiratory tract, due to the presence of fimbrial and not fimbrial adhesins, such as filamentous hemagglutinin and pertactin, located mainly in the outer membrane of the bacterium, thus such as the participation of the Bordetella Bacteriophage which expresses easily mutated genes for receptors adapting to the bacteria. Similarly, the expression of endotoxins and exotoxins, within the latter, adenylate cyclase, dermonecrotic toxin and tracheal cytotoxin, which participate in the pathophysiology of canine infectious tracheobronchitis, affecting hair cells, inhibiting the responde of phagocytic cells, suppressing the immune response, finally associating with the characteristic clinical signs seen in dogs with infectious tracheobronchitis.yiseth.morenog@campusucc.edu.cojeimmy.marinr@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéAdenilato ciclasaCitotoxina traquealHemaglutinina filamentosaLipopolisacáridoPertactinaToxina dermonecróticaTG 2021 MVZ 34678Adenylate cyclaseTracheal cytotoxinFilamentous hemagglutininLipopolysaccharidePertactinDermonecrotic toxinFactores de virulencia de bordetella bronchiseptica y su acción en la fisiopatologia de la traqueobronquitis infecciosa caninaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Bhardwaj M, Singh BR, Vadhana P. 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Development of a Pertactin-Coated Beads Approach for Screening of Functional Monoclonal Antibodies. J Pharm Sci [Internet]. 2020;109(2):1002–7. Available from: https://doi.org/10.1016/j.xphs.2019.10.001Hovingh ES, Mariman R, Solans L, Hijdra D, Hamstra HJ, Jongerius I, et al. Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor article. Emerg Microbes Infect [Internet]. 2018;7(1):1–13. Available from: https://doi.org/10.1038/s41426-018-0039-8Wehmann E, Khayer B, Magyar T. Heterogeneity of Bordetella bronchiseptica adenylate cyclase (cyaA) RTX domain. Arch Microbiol [Internet]. 2015;197(1):105–12. Available from: https://link.springer.com/article/10.1007/s00203-014-1068-xScheller E V., Cotter PA. Bordetella filamentous hemagglutinin and fimbriae: critical adhesins with unrealized vaccine potential. Pathog Dis [Internet]. 2015;73(8):1–9. Available from: https://academic.oup.com/femspd/article/73/8/ftv079/2467727Scheller E V., Melvin JA, Sheets AJ, Cotter PA. Cooperative roles for fimbria and filamentous hemagglutinin in Bordetella adherence and immune modulation. MBio. 2015;6(3):1–11.Chen Y, Yang L, Sun E, Song J, Wu B. Characterisation of a newly detected bacteriophage infecting Bordetella bronchiseptica in swine. Arch Virol [Internet]. 2019;164(1):33–40. Available from: https://doi.org/10.1007/s00705-018-4034-0Park GY, Yu HJ, Son JS, Park SJ, Cha HJ, Song KS. Specific bacteriophage of Bordetella bronchiseptica regulates B. bronchiseptica-induced microRNA expression profiles to decrease inflammation in swine nasal turbinate cells. Genes and Genomics [Internet]. 2020;42(4):441–7. Available from: https://doi.org/10.1007/s13258-019-00906-7Szymczak M, Grygorcewicz B, Karczewska-Golec J, Decewicz P, Pankowski JA, Országh-Szturo H, et al. 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Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells. Sci Rep [Internet]. 2015;5:1–17. Available from: http://dx.doi.org/10.1038/srep13774Aya Fukui-Miyazaki, a Hirono Toshima, a Yukihiro Hiramatsu, a Keisuke Okada, a Keiji Nakamura A, Keisuke Ishigaki A, Naoaki Shinzawa, a Hiroyuki Abe A, Horiguchia Y. The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis. MBio [Internet]. 2018;9(4):1–15. Available from: https://doi.org/ 10.1128/mBio.00628-18Bouchez V, Douché T, Dazas M, Delaplane S, Matondo M, Chamot-Rooke J, et al. Characterization of post-translational modifications and cytotoxic properties of the adenylate-cyclase hemolysin produced by various Bordetella pertussis and Bordetella parapertussis isolates. Toxins (Basel) [Internet]. 2017;9(10):1–13. Available from: https://pubmed.ncbi.nlm.nih.gov/28954396/Brandenburg K, Schromm AB, Weindl G, Heinbockel L, Correa W, Mauss K, et al. An update on endotoxin neutralization strategies in Gram-negative bacterial infections. Expert Rev Anti Infect Ther [Internet]. 2020;00(00):1–23. Available from: https://doi.org/10.1080/14787210.2021.1834847Ucieklak K, Koj S, Niedziela T. Conserved structural features of core oligosaccharides among the lipopolysaccharides of respiratory pathogens from the genus bordetella analyzed exclusively by nmr spectroscopy. Int J Mol Sci [Internet]. 2021;22(3):1–15. Available from: https://doi.org/10.3390/ijms22031029Ucieklak K, Koj S, Niedziela T. Bordetella holmesii lipopolysaccharide hide and seek game with pertussis: Structural analysis of the o-specific polysaccharide and the core oligosaccharide of the type strain ATCC 51541. Int J Mol Sci [Internet]. 2020;21(17):1–17. 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Available from: http://dx.doi.org/10.4172/2168-9652.1000168%0ALaura A. Gonyar A, Mary C. Gray, a Gregory J. Christianson, b Borna Mehrad C, Hewletta EL. Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin. Infect inmunity [Internet]. 2017;85(6):1–19. Available from: http://iai.asm.org/Ryan LK, Wu J, Schwartz K, Yim S, Diamond G. Β-Defensins Coordinate in Vivo To Inhibit Bacterial Infections of the Trachea. Vaccines [Internet]. 2018;6(3):1–15. Available from: https://doi.org/10.3390/vaccines6030057Belhart K, Gutierrez MDLP, Zacca F, Ambrosis N, Gestal MC, Taylor D, et al. Bordetella bronchiseptica diguanylate cyclase bdca regulates motility and is important for the establishment of respiratory infection in mice. J Bacteriol [Internet]. 2019;201(17):1–13. Available from: https://doi.org/10.1128/JB .00011-19Ambrosis N, Boyd CD, O’Toole GA, Fernández J, Sisti F. 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