Extended Hildebrand solubility approach applied to some structurally related sulfonamides in ethanol + water mixtures
Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculatio...
- Autores:
-
Delgado, Daniel ricardo
Peña M.Á.
Martínez F.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/49593
- Acceso en línea:
- https://doi.org/10.15446/rev.colomb.quim.v45n1.57201
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989227689&doi=10.15446%2frev.colomb.quim.v45n1.57201&partnerID=40&md5=346cdf0f60acbdb9530be669fbe1ae25
https://hdl.handle.net/20.500.12494/49593
- Palabra clave:
- BINARY MIXTURES
ETHANOL
EXTENDED HILDEBRAND SOLUBILITY APPROACH
HILDEBRAND SOLUBILITY PARAMETER
SULFONAMIDES
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
Summary: | Extended Hildebrand Solubility Approach (EHSA) was applied to evaluate the solubility of sulfadiazine, sulfamerazine, and sulfamethazine in some ethanol + water mixtures at 298.15 K. Reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations. In particular, a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order four correlating the interaction parameter W with the Hildebrand solubility parameter of solvent mixtures without drug. The predictive character of EHSA was the same as that obtained by direct correlation of drug solubilities with the same descriptor of polarity of the cosolvent mixtures. © 2016, Universidad Nacional de Colombia. All rights reserved. |
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