Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures

Este artículo presenta el análisis termodinámico de la solubilidad de gatifloxacinaen el sistema cosolvente de N,N-Dimetilformamida (DMF) + metanol (MeOH) a 10 temperaturas. A partir de los datos de solubilidad se calculan las funciones termodinámicas de solución, mezcla y transferencia. Para el aná...

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Autores:
Rojas-Motta, Mónica
Rojas-Motta, Jhon Edinson
Diaz-Jimenez, Jorge Luis
Bahos-Narváez, Fabio Andrés
Blanco Márquez, Joaquín H
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/28233
Acceso en línea:
https://doi.org/10.15446/rcciquifa.v49n3.91337
https://hdl.handle.net/20.500.12494/28233
Palabra clave:
Gatifloxacina
Solubilidad
N,N-dimetilformamida
IKBI
Solvatación preferencial
Gatifloxacin
Solubility
N,N-dimethylformamide
IKBI
Preferential solvation
Rights
openAccess
License
Atribución
id COOPER2_6c84db5baaa9b6d954554287e9990323
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/28233
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
spellingShingle Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
Gatifloxacina
Solubilidad
N,N-dimetilformamida
IKBI
Solvatación preferencial
Gatifloxacin
Solubility
N,N-dimethylformamide
IKBI
Preferential solvation
title_short Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_full Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_fullStr Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_full_unstemmed Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_sort Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
dc.creator.fl_str_mv Rojas-Motta, Mónica
Rojas-Motta, Jhon Edinson
Diaz-Jimenez, Jorge Luis
Bahos-Narváez, Fabio Andrés
Blanco Márquez, Joaquín H
dc.contributor.author.none.fl_str_mv Rojas-Motta, Mónica
Rojas-Motta, Jhon Edinson
Diaz-Jimenez, Jorge Luis
Bahos-Narváez, Fabio Andrés
Blanco Márquez, Joaquín H
dc.subject.spa.fl_str_mv Gatifloxacina
Solubilidad
N,N-dimetilformamida
IKBI
Solvatación preferencial
topic Gatifloxacina
Solubilidad
N,N-dimetilformamida
IKBI
Solvatación preferencial
Gatifloxacin
Solubility
N,N-dimethylformamide
IKBI
Preferential solvation
dc.subject.other.spa.fl_str_mv Gatifloxacin
Solubility
N,N-dimethylformamide
IKBI
Preferential solvation
description Este artículo presenta el análisis termodinámico de la solubilidad de gatifloxacinaen el sistema cosolvente de N,N-Dimetilformamida (DMF) + metanol (MeOH) a 10 temperaturas. A partir de los datos de solubilidad se calculan las funciones termodinámicas de solución, mezcla y transferencia. Para el análisis además se utiliza el método gráfico Perlovich. Por otro lado, serealiza un análisis de compensación entalpía-entropía y se calculan los parámetros de solvatación preferencial utilizando el método de las integrales inversas de Kirkwood-Buff (IIKB). Los resultados del análisis termodinámico indican que el proceso de solución de gatifloxacina es endotérmicacon favorecimiento entrópico, donde la adición de DMF tiene un efecto cosolvente positivo en todos los casos. En cuanto a la solvatación preferencial, los resultados no son del todo concluyentes, debido a que en todos los casos los valores del parámetro de solvatación preferencial son menores a 0,01 indicando una solvatación insignificante
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-11-20T17:20:00Z
dc.date.available.none.fl_str_mv 2020-11-20T17:20:00Z
dc.date.issued.none.fl_str_mv 2020-11-01
dc.type.none.fl_str_mv Artículo
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dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.spa.fl_str_mv 19096356
dc.identifier.uri.spa.fl_str_mv https://doi.org/10.15446/rcciquifa.v49n3.91337
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/28233
dc.identifier.bibliographicCitation.spa.fl_str_mv Rojas-Motta, M., Rojas-Motta, J. E. ., Diaz-Jimenez, J. L. ., Bahos-Narváez, F. A., Blanco-Márquez, J. H. ., Ortiz, C. P., & Delgado, D. R. . (2020). Análisis termodinámico y solvatación preferencial de gatifloxacina en mezclas cosolventes DMF + metanol. Revista Colombiana De Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91337
identifier_str_mv 19096356
Rojas-Motta, M., Rojas-Motta, J. E. ., Diaz-Jimenez, J. L. ., Bahos-Narváez, F. A., Blanco-Márquez, J. H. ., Ortiz, C. P., & Delgado, D. R. . (2020). Análisis termodinámico y solvatación preferencial de gatifloxacina en mezclas cosolventes DMF + metanol. Revista Colombiana De Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91337
url https://doi.org/10.15446/rcciquifa.v49n3.91337
https://hdl.handle.net/20.500.12494/28233
dc.relation.isversionof.spa.fl_str_mv https://revistas.unal.edu.co/index.php/rccquifa/article/view/91337
dc.relation.ispartofjournal.spa.fl_str_mv Revista Colombiana de Ciencias Químico-Farmacéuticas
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spelling Rojas-Motta, MónicaRojas-Motta, Jhon EdinsonDiaz-Jimenez, Jorge LuisBahos-Narváez, Fabio AndrésBlanco Márquez, Joaquín H492020-11-20T17:20:00Z2020-11-20T17:20:00Z2020-11-0119096356https://doi.org/10.15446/rcciquifa.v49n3.91337https://hdl.handle.net/20.500.12494/28233Rojas-Motta, M., Rojas-Motta, J. E. ., Diaz-Jimenez, J. L. ., Bahos-Narváez, F. A., Blanco-Márquez, J. H. ., Ortiz, C. P., & Delgado, D. R. . (2020). Análisis termodinámico y solvatación preferencial de gatifloxacina en mezclas cosolventes DMF + metanol. Revista Colombiana De Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91337Este artículo presenta el análisis termodinámico de la solubilidad de gatifloxacinaen el sistema cosolvente de N,N-Dimetilformamida (DMF) + metanol (MeOH) a 10 temperaturas. A partir de los datos de solubilidad se calculan las funciones termodinámicas de solución, mezcla y transferencia. Para el análisis además se utiliza el método gráfico Perlovich. Por otro lado, serealiza un análisis de compensación entalpía-entropía y se calculan los parámetros de solvatación preferencial utilizando el método de las integrales inversas de Kirkwood-Buff (IIKB). Los resultados del análisis termodinámico indican que el proceso de solución de gatifloxacina es endotérmicacon favorecimiento entrópico, donde la adición de DMF tiene un efecto cosolvente positivo en todos los casos. En cuanto a la solvatación preferencial, los resultados no son del todo concluyentes, debido a que en todos los casos los valores del parámetro de solvatación preferencial son menores a 0,01 indicando una solvatación insignificanteThis paper presents the thermodynamic analysis of solubility of gatifloxacin in the N,N-Dimethylformamide (DMF) + methanol (MeOH) cosolvent system at 10 temperatures. From the solubility data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy-entropy compensation analysis is performed and the preferential solvation parameters are calculated using the inverse Kirkwood-Buff integral (IKBI) method. The result of the performed calculations indicates that the gatifloxacin solution process is endothermic with entropic favor, where the addition of DMF has a positive cosolvent effect in all cases. Regarding preferential solvation, the results are not entirely conclusive, since in all cases the values of the preferential solvation parameter are less than 0.01, so that, negligible preferential solvation takes place.http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116https://orcid.org/0000-0002-4835-9739https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000004151danielr.delgado@campusucc.edu.cohttps://scholar.google.es/citations?user=OW0mejcAAAAJ&hl=esp. 1-24Universidad Nacional de ColombiaUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Industrial, NeivaIngeniería IndustrialNeivahttps://revistas.unal.edu.co/index.php/rccquifa/article/view/91337Revista Colombiana de Ciencias Químico-FarmacéuticasC. Schultz, gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis: Safety, efficacy and patient perspective, Ophthalmol. Eye Dis., 4, 65-70 (2012).D. Deshpande, J.G. 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B, 118, 7594-7608 (2014).GatifloxacinaSolubilidadN,N-dimetilformamidaIKBISolvatación preferencialGatifloxacinSolubilityN,N-dimethylformamideIKBIPreferential solvationThermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINAL2020_Thermodynamic_solvation_gatifloxacin.pdf2020_Thermodynamic_solvation_gatifloxacin.pdfArtículo científico Capplication/pdf649399https://repository.ucc.edu.co/bitstreams/25bd5fde-cda8-43d8-a5b5-65c2d03c27d8/downloadc0f762a57f2fb1e90d9acd443b6baa42MD51LICENSElicense.txtlicense.txttext/plain; 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