Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures

Este artículo presenta el análisis termodinámico de la solubilidad de gatifloxacinaen el sistema cosolvente de N,N-Dimetilformamida (DMF) + metanol (MeOH) a 10 temperaturas. A partir de los datos de solubilidad se calculan las funciones termodinámicas de solución, mezcla y transferencia. Para el aná...

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Autores:: Rojas-Motta, Mónica
Rojas-Motta, Jhon Edinson
Diaz-Jimenez, Jorge Luis
Bahos-Narváez, Fabio Andrés
Blanco Márquez, Joaquín H

Tipo de recurso:: Article of journal

Fecha de publicación:: 2020

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
spellingShingle	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures Gatifloxacina Solubilidad N,N-dimetilformamida IKBI Solvatación preferencial Gatifloxacin Solubility N,N-dimethylformamide IKBI Preferential solvation
title_short	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_full	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_fullStr	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_full_unstemmed	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
title_sort	Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures
dc.creator.fl_str_mv	Rojas-Motta, Mónica Rojas-Motta, Jhon Edinson Diaz-Jimenez, Jorge Luis Bahos-Narváez, Fabio Andrés Blanco Márquez, Joaquín H
dc.contributor.author.none.fl_str_mv	Rojas-Motta, Mónica Rojas-Motta, Jhon Edinson Diaz-Jimenez, Jorge Luis Bahos-Narváez, Fabio Andrés Blanco Márquez, Joaquín H
dc.subject.spa.fl_str_mv	Gatifloxacina Solubilidad N,N-dimetilformamida IKBI Solvatación preferencial
topic	Gatifloxacina Solubilidad N,N-dimetilformamida IKBI Solvatación preferencial Gatifloxacin Solubility N,N-dimethylformamide IKBI Preferential solvation
dc.subject.other.spa.fl_str_mv	Gatifloxacin Solubility N,N-dimethylformamide IKBI Preferential solvation
description	Este artículo presenta el análisis termodinámico de la solubilidad de gatifloxacinaen el sistema cosolvente de N,N-Dimetilformamida (DMF) + metanol (MeOH) a 10 temperaturas. A partir de los datos de solubilidad se calculan las funciones termodinámicas de solución, mezcla y transferencia. Para el análisis además se utiliza el método gráfico Perlovich. Por otro lado, serealiza un análisis de compensación entalpía-entropía y se calculan los parámetros de solvatación preferencial utilizando el método de las integrales inversas de Kirkwood-Buff (IIKB). Los resultados del análisis termodinámico indican que el proceso de solución de gatifloxacina es endotérmicacon favorecimiento entrópico, donde la adición de DMF tiene un efecto cosolvente positivo en todos los casos. En cuanto a la solvatación preferencial, los resultados no son del todo concluyentes, debido a que en todos los casos los valores del parámetro de solvatación preferencial son menores a 0,01 indicando una solvatación insignificante
publishDate	2020
dc.date.accessioned.none.fl_str_mv	2020-11-20T17:20:00Z
dc.date.available.none.fl_str_mv	2020-11-20T17:20:00Z
dc.date.issued.none.fl_str_mv	2020-11-01
dc.type.none.fl_str_mv	Artículo
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dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
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dc.identifier.issn.spa.fl_str_mv	19096356
dc.identifier.uri.spa.fl_str_mv	https://doi.org/10.15446/rcciquifa.v49n3.91337
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/28233
dc.identifier.bibliographicCitation.spa.fl_str_mv	Rojas-Motta, M., Rojas-Motta, J. E. ., Diaz-Jimenez, J. L. ., Bahos-Narváez, F. A., Blanco-Márquez, J. H. ., Ortiz, C. P., & Delgado, D. R. . (2020). Análisis termodinámico y solvatación preferencial de gatifloxacina en mezclas cosolventes DMF + metanol. Revista Colombiana De Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91337
identifier_str_mv	19096356 Rojas-Motta, M., Rojas-Motta, J. E. ., Diaz-Jimenez, J. L. ., Bahos-Narváez, F. A., Blanco-Márquez, J. H. ., Ortiz, C. P., & Delgado, D. R. . (2020). Análisis termodinámico y solvatación preferencial de gatifloxacina en mezclas cosolventes DMF + metanol. Revista Colombiana De Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91337
url	https://doi.org/10.15446/rcciquifa.v49n3.91337 https://hdl.handle.net/20.500.12494/28233
dc.relation.isversionof.spa.fl_str_mv	https://revistas.unal.edu.co/index.php/rccquifa/article/view/91337
dc.relation.ispartofjournal.spa.fl_str_mv	Revista Colombiana de Ciencias Químico-Farmacéuticas
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Mol. Liq., 293, 111507 (2019). J.H. Blanco-Márquez, D.I. Caviedes Rubio, C.P. Ortiz, N.E. Cerquera, F. Martínez, D.R. Delgado, Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures, Fluid Phase Equilib., 505, 112361 (2020). S.H. Yalkowsky, M. Wu, Estimation of the ideal solubility (crystal-liquid fugacity ratio) of organic compounds, J. Pharm. Sci., 99, 1100-1106 (2010). A.M. Romero-Nieto, D.I. Caviedes-Rubio, J. Polania-Orozco, N.E. Cerquera, D.R. Delgado, Temperature and cosolvent composition effects in the solubility of methylparaben in acetonitrile + water mixtures, Phys. Chem. Liq. Forthcomming 2020, doi: 10.1080/00319104.2019.1636379. M. Mirmehrabi, S. Rohani, L. Perry, Thermodynamic modeling of activity coefficient and prediction of solubility: Part 1 predictive models, J. Pharm. Sci., 95, 790-797 (2006). D.R. Delgado, A. Jouyban, F. Martínez, Solubility and preferential solvation of meloxicam in methanol+ water mixtures at 298.15 K, J. Mol. Liq., 197, 368-376 (2014). D.R. Delgado, F. Martínez, Solution thermodynamics of sulfadiazine in ethanol + water mixtures, J. Mol. Liq., 187, 99-105 (2013). R.R. Krug, W.G. Hunter, R.A. Grieger, Enthalpy-entropy compensation. 1. Some fundamental statistical problems associated with the analysis of van’t Hoff and arrhenius data, J. Phys. Chem., 80, 2335-2341 (1976). R.R. Krug, W.G. Hunter, R.A. Grieger, Enthalpy-entropy compensation. 2. Separation of the chemical from the statistical effect, J. Phys. Chem., 80, 2341-2351 (1976). D.R. Delgado, A. Romdhani, F. Martínez, Solubility of sulfamethizole in some propylene glycol+water mixtures at several temperatures, Fluid Phase Equilib., 322,-113-119 (2012). D.R. Delgado, G.A. Rodríguez, F. Martínez, Thermodynamic study of the solubility of sulfapyridine in some ethanol + water mixtures, J. Mol. Liq., 177, 156-161 (2013). G.L. Perlovich, A.M. Ryzhakov, N.N. Strakhova, V.P. Kazachenko, K.-J. Schaper, O.A. Raevsky, Thermodynamic aspects of solubility and partitioning processes of some sulfonamides in the solvents modeling biological media, J.Chem. Thermodyn., 69, 56-65 (2014). G.L. Perlovich, N.N. Strakhova, V.P. Kazachenko, T.V. Volkova, V.V. Tkachev, K.-J. Schaper, O.A. Raevsky, Sulfonamides as a subject to study molecular interactions in crystals and solutions: Sublimation, solubility, solvation, distribution and crystal structure, Int. J. Pharm., 349, 300-313 (2008). A.R. Holguín, D.R. Delgado, F. Martínez, Thermodynamic study of the solubility of triclocarban in ethanol + propylene glycol mixtures, Quim. Nova, 35, 280-285 (2012). G.L. Perlovich, V.V. Tkachev, N.N. Strakhova, V.P. Kazachenko, T.V. Volkova, O.V. Surov, K.J. Schaper, O.A. Raevsky, Thermodynamic and structural aspects of sulfonamide crystals and solutions, J. Pharm. Sci., 98, 4738-4755 (2009). D.R. Delgado, E.M. Mogollon-Waltero, C.P. 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spelling	Rojas-Motta, MónicaRojas-Motta, Jhon EdinsonDiaz-Jimenez, Jorge LuisBahos-Narváez, Fabio AndrésBlanco Márquez, Joaquín H492020-11-20T17:20:00Z2020-11-20T17:20:00Z2020-11-0119096356https://doi.org/10.15446/rcciquifa.v49n3.91337https://hdl.handle.net/20.500.12494/28233Rojas-Motta, M., Rojas-Motta, J. E. ., Diaz-Jimenez, J. L. ., Bahos-Narváez, F. A., Blanco-Márquez, J. H. ., Ortiz, C. P., & Delgado, D. R. . (2020). Análisis termodinámico y solvatación preferencial de gatifloxacina en mezclas cosolventes DMF + metanol. Revista Colombiana De Ciencias Químico-Farmacéuticas, 49(3). https://doi.org/10.15446/rcciquifa.v49n3.91337Este artículo presenta el análisis termodinámico de la solubilidad de gatifloxacinaen el sistema cosolvente de N,N-Dimetilformamida (DMF) + metanol (MeOH) a 10 temperaturas. A partir de los datos de solubilidad se calculan las funciones termodinámicas de solución, mezcla y transferencia. Para el análisis además se utiliza el método gráfico Perlovich. Por otro lado, serealiza un análisis de compensación entalpía-entropía y se calculan los parámetros de solvatación preferencial utilizando el método de las integrales inversas de Kirkwood-Buff (IIKB). Los resultados del análisis termodinámico indican que el proceso de solución de gatifloxacina es endotérmicacon favorecimiento entrópico, donde la adición de DMF tiene un efecto cosolvente positivo en todos los casos. En cuanto a la solvatación preferencial, los resultados no son del todo concluyentes, debido a que en todos los casos los valores del parámetro de solvatación preferencial son menores a 0,01 indicando una solvatación insignificanteThis paper presents the thermodynamic analysis of solubility of gatifloxacin in the N,N-Dimethylformamide (DMF) + methanol (MeOH) cosolvent system at 10 temperatures. From the solubility data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy-entropy compensation analysis is performed and the preferential solvation parameters are calculated using the inverse Kirkwood-Buff integral (IKBI) method. The result of the performed calculations indicates that the gatifloxacin solution process is endothermic with entropic favor, where the addition of DMF has a positive cosolvent effect in all cases. Regarding preferential solvation, the results are not entirely conclusive, since in all cases the values of the preferential solvation parameter are less than 0.01, so that, negligible preferential solvation takes place.http://scienti.colciencias.gov.co:8081/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116https://orcid.org/0000-0002-4835-9739https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000004151danielr.delgado@campusucc.edu.cohttps://scholar.google.es/citations?user=OW0mejcAAAAJ&hl=esp. 1-24Universidad Nacional de ColombiaUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Industrial, NeivaIngeniería IndustrialNeivahttps://revistas.unal.edu.co/index.php/rccquifa/article/view/91337Revista Colombiana de Ciencias Químico-FarmacéuticasC. Schultz, gatifloxacin ophthalmic solution for treatment of bacterial conjunctivitis: Safety, efficacy and patient perspective, Ophthalmol. Eye Dis., 4, 65-70 (2012).D. Deshpande, J.G. 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B, 118, 7594-7608 (2014).GatifloxacinaSolubilidadN,N-dimetilformamidaIKBISolvatación preferencialGatifloxacinSolubilityN,N-dimethylformamideIKBIPreferential solvationThermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixturesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINAL2020_Thermodynamic_solvation_gatifloxacin.pdf2020_Thermodynamic_solvation_gatifloxacin.pdfArtículo científico Capplication/pdf649399https://repository.ucc.edu.co/bitstreams/25bd5fde-cda8-43d8-a5b5-65c2d03c27d8/downloadc0f762a57f2fb1e90d9acd443b6baa42MD51LICENSElicense.txtlicense.txttext/plain; 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Thermodynamic analysis and preferential solvation of gatifloxacin in DMF+ methanol cosolvent mixtures

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