Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection
PlosOne, 2015; 10(3): e0119844.
- Autores:
-
Hernández López, Juan Carlos
Giraldo, Diana Marcela
Paul, Stephane
Urcuqui Inchima, Silvio
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/970
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/970
- Palabra clave:
- Neutrophils
HIV-1
- Rights
- openAccess
- License
- Licencia CC
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Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| title |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| spellingShingle |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection Neutrophils HIV-1 |
| title_short |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| title_full |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| title_fullStr |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| title_full_unstemmed |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| title_sort |
Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protection |
| dc.creator.fl_str_mv |
Hernández López, Juan Carlos Giraldo, Diana Marcela Paul, Stephane Urcuqui Inchima, Silvio |
| dc.contributor.author.none.fl_str_mv |
Hernández López, Juan Carlos Giraldo, Diana Marcela Paul, Stephane Urcuqui Inchima, Silvio |
| dc.subject.spa.fl_str_mv |
Neutrophils HIV-1 |
| topic |
Neutrophils HIV-1 |
| description |
PlosOne, 2015; 10(3): e0119844. |
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2015 |
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2015-03 |
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2017-08-09T01:10:01Z |
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2017-08-09T01:10:01Z |
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Hernández, J. C., Giraldo, D. M., Paul, S. & Urcuqui Inchima, S. (2015). Involvement of neutrophil hyporesponse and the role of Toll-like receptors in HIV-1 protection. PlosOne, 10(3). Recuperado de https://doi.org/10.1371/journal.pone.0119844 |
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https://hdl.handle.net/20.500.12494/970 |
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Hernández, J. C., Giraldo, D. M., Paul, S. & Urcuqui Inchima, S. (2015). Involvement of neutrophil hyporesponse and the role of Toll-like receptors in HIV-1 protection. PlosOne, 10(3). Recuperado de https://doi.org/10.1371/journal.pone.0119844 |
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119844 |
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Licencia CC |
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Licencia CC http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000 |
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Medicina |
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Medellín |
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Universidad Cooperativa de Colombia |
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Hernández López, Juan CarlosGiraldo, Diana MarcelaPaul, StephaneUrcuqui Inchima, Silvio2017-08-09T01:10:01Z2017-08-09T01:10:01Z2015-03https://hdl.handle.net/20.500.12494/970Hernández, J. C., Giraldo, D. M., Paul, S. & Urcuqui Inchima, S. (2015). Involvement of neutrophil hyporesponse and the role of Toll-like receptors in HIV-1 protection. PlosOne, 10(3). Recuperado de https://doi.org/10.1371/journal.pone.0119844PlosOne, 2015; 10(3): e0119844.Objectives Neutrophils contribute to pathogen clearance through pattern recognition receptors (PRRs) activation. However, the role of PRRs in neutrophils in both HIV-1-infected [HIV-1(+)] and HIV-1-exposed seronegative individuals (HESN) is unknown. Here, a study was carried out to evaluate the level of PRR mRNAs and cytokines produced after activation of neutrophils from HIV-1(+), HESN and healthy donors. Methods The neutrophils were stimulated with specific agonists for TLR2, TLR4 and TLR9 in the presence of HIV-1 particles. Pro-inflammatory cytokine production, expression of neutrophil activation markers and reactive oxygen species (ROS) production were analyzed in neutrophils from HESN, HIV-1(+) and healthy donors (controls). Results We found that neutrophils from HESN presented reduced expression of PRR mRNAs (TLR4, TLR9, NOD1, NOD2, NLRC4 and RIG-I) and reduced expression of cytokine mRNAs (IL-1β, IL-6, IL-18, TNF-α and TGF-β). Moreover, neutrophils from HESN were less sensitive to stimulation through TLR4. Furthermore, neutrophils from HESN challenged with HIV-1 and stimulated with TLR2 and TLR4 agonists, produced significantly lower levels of reactive oxygen species, versus HIV-1(+). Conclusions A differential pattern of PRR expression and release of innate immune factors in neutrophils from HESN is evident. Our results suggest that lower neutrophil activation can be involved in protection against HIV-1 infection.juanc.hernandezl@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000MedicinaMedellínhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119844NeutrophilsHIV-1Involvement of neutrophil hyporesponse and the role of Toll-Like receptors in human immunodeficiency virus 1 protectionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/81fccac2-8aad-4c83-97fa-bd204c57ac4b/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTPlosOne HESN Neu.pdf.txtPlosOne HESN Neu.pdf.txtExtracted texttext/plain51026https://repository.ucc.edu.co/bitstreams/69f0e5de-291a-4881-8dbc-efadf1414c38/download1588b40bc2807a27642f22b9139ba3b4MD53THUMBNAILPlosOne HESN Neu.pdf.jpgPlosOne HESN Neu.pdf.jpgIM Thumbnailimage/jpeg20586https://repository.ucc.edu.co/bitstreams/26bef074-7415-433c-85a8-3228603c0bb7/download86ab534d61edbced8778ba4065430d9dMD54ORIGINALPlosOne HESN Neu.pdfPlosOne HESN Neu.pdfapplication/pdf1471634https://repository.ucc.edu.co/bitstreams/1eee8a8c-0694-4539-97cc-65f4358f6f99/download71fe4c3da4885380d5f187385a320c39MD5120.500.12494/970oai:repository.ucc.edu.co:20.500.12494/9702024-08-10 22:46:20.678open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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 |