Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review
Resumen Antecedentes: El tratamiento actual de los dientes permanentes necróticos inmaduros con lesión periapical es la endodoncia regenerativa, la cual se basa en la ingeniería de tejidos bajo la tríada de células madre, andamios y moléculas bioactivas. Objetivos: esta revisión general tuvo como ob...
- Autores:
-
Muñoz Alvear, Hernán Dario
López Moncayo, Luis Fernando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2022
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/46689
- Palabra clave:
- dientes necróticos inmaduros
lesión periapical
materiales regenerativos
andamios
immature necrotic teeth
periapical lesion
regenerative materials
scaffolds
- Rights
- openAccess
- License
- Atribución – No comercial – Compartir igual
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| dc.title.spa.fl_str_mv |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| title |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| spellingShingle |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review dientes necróticos inmaduros lesión periapical materiales regenerativos andamios immature necrotic teeth periapical lesion regenerative materials scaffolds |
| title_short |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| title_full |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| title_fullStr |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| title_full_unstemmed |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| title_sort |
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review |
| dc.creator.fl_str_mv |
Muñoz Alvear, Hernán Dario López Moncayo, Luis Fernando |
| dc.contributor.author.none.fl_str_mv |
Muñoz Alvear, Hernán Dario López Moncayo, Luis Fernando |
| dc.subject.spa.fl_str_mv |
dientes necróticos inmaduros lesión periapical materiales regenerativos andamios |
| topic |
dientes necróticos inmaduros lesión periapical materiales regenerativos andamios immature necrotic teeth periapical lesion regenerative materials scaffolds |
| dc.subject.other.spa.fl_str_mv |
immature necrotic teeth periapical lesion regenerative materials scaffolds |
| description |
Resumen Antecedentes: El tratamiento actual de los dientes permanentes necróticos inmaduros con lesión periapical es la endodoncia regenerativa, la cual se basa en la ingeniería de tejidos bajo la tríada de células madre, andamios y moléculas bioactivas. Objetivos: esta revisión general tuvo como objetivo evaluar el éxito de los materiales de andamiaje y regenerativos utilizados para el tratamiento de estos dientes, en términos de cierre apical, aumento de la longitud del diente, ensanchamiento de las paredes del conducto radicular, vitalidad del tejido y reparación de lesiones periapicales. Métodos: Se llevó a cabo una extensa investigación bibliográfica en las bases de datos Medline, ISI Web of Science y Scopus para revisiones sistemáticas relevantes que coincidieran con la estrategia de búsqueda de palabras clave. Según los criterios de inclusión y exclusión, los revisores calificaron de forma independiente la calidad de cada estudio para determinar su nivel de evidencia. La evaluación de la calidad metodológica de cada artículo se obtuvo mediante la herramienta A Measurement Tool to Assess Systematic Reviews (AMSTAR)-2, y el riesgo de sesgo se evaluó con la herramienta Risk of Bias in Systematic Reviews (ROBIS). Resultados: Después de eliminar los duplicados, se encontraron 155 artículos; de los cuales 133 fueron excluidos por no ser relevantes y otros 15 por criterios de exclusión. Uno más fue descartado luego de la evaluación de la calidad metodológica, para un total de seis artículos restantes. El andamio más utilizado fue el coágulo de sangre, otros utilizados fueron el ácido poliláctico-co-glicólico y la matriz de fibrina rica en plaquetas. El material de regeneración más utilizado fue el agregado de trióxido mineral (MTA), seguido de Biodentine. En todos los estudios seleccionados se informó un aumento en la longitud de los dientes y un ensanchamiento de las paredes del conducto radicular en diferentes proporciones, así como reparación de lesiones periapicales. El análisis ROBIS mostró que solo un artículo tenía un sesgo bajo, dos se clasificaron como sesgo poco claro, mientras que los tres restantes tenían un alto riesgo de sesgo. Discusión: Se realizó una búsqueda bibliográfica exhaustiva aplicando filtros de idioma, revistas indexadas de alta calidad, año de publicación, lo que asegura que se incluyeron artículos de la mejor calidad. El coágulo de sangre fue el andamio más utilizado, ya que es el más fácil de colocar dentro del canal y no requiere extraer sangre del paciente. El uso de MTA y Biodentine como materiales de sellado se ha asociado con el engrosamiento de las paredes del canal, el cierre apical y la reducción de los signos y síntomas de la periodontitis apical. Sin embargo, la mayoría de las revisiones incluidas evaluadas fueron informes de casos y solo en algunas de ellas se incluyeron ensayos clínicos. También hay una falta de análisis del riesgo de sesgo en la mayoría de las revisiones. Conclusión: El coágulo de sangre es el armazón más común utilizado para inducir la regeneración durante el tratamiento de dientes necróticos inmaduros. El aumento de la longitud de los dientes y el ensanchamiento de las paredes del conducto radicular son los criterios más comunes utilizados en los estudios como indicadores de éxito. MTA y Biodentine no mostraron diferencias en los resultados analizados. La evaluación de la calidad y la evaluación del riesgo de sesgo mostraron que es necesario diseñar mejores estudios con una metodología rigurosa para recomendar un protocolo confiable y predecible para el tratamiento de dientes permanentes necróticos inmaduros con lesiones periapicales. |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-10-11T23:14:13Z |
| dc.date.available.none.fl_str_mv |
2022-10-11T23:14:13Z |
| dc.date.issued.none.fl_str_mv |
2022-10 |
| dc.type.none.fl_str_mv |
Artículos Científicos |
| dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.issn.spa.fl_str_mv |
1365-2591 |
| dc.identifier.uri.spa.fl_str_mv |
https://doi.org/10.1111/iej.13799 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/46689 |
| dc.identifier.bibliographicCitation.spa.fl_str_mv |
Caviedes-Bucheli, J., Muñoz-Alvear, H. D., Lopez-Moncayo, L. F., Narvaez-Hidalgo, A., Zambrano-Guerrero, L., Gaviño-Orduña, J. F., Portigliatti, R., Gomez-Sosa, J. F., & Munoz, H. R. (2022). Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review. International endodontic journal, 55(10), 967–988.https://repository.ucc.edu.co/handle/20.500.12494/46689 |
| identifier_str_mv |
1365-2591 Caviedes-Bucheli, J., Muñoz-Alvear, H. D., Lopez-Moncayo, L. F., Narvaez-Hidalgo, A., Zambrano-Guerrero, L., Gaviño-Orduña, J. F., Portigliatti, R., Gomez-Sosa, J. F., & Munoz, H. R. (2022). Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review. International endodontic journal, 55(10), 967–988.https://repository.ucc.edu.co/handle/20.500.12494/46689 |
| url |
https://doi.org/10.1111/iej.13799 https://hdl.handle.net/20.500.12494/46689 |
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https://onlinelibrary.wiley.com/doi/10.1111/iej.13799 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
INTERNATIONAL ENDODONTIC JOURNAL |
| dc.relation.references.spa.fl_str_mv |
Adnan, S. & Ullah, R. (2018) Top-cited articles in regenerative end- odontics: a bibliometric analysis. Journal of Endodontics, 44, 1650–1664. Alghamdi, F.T. & Alqurashi, A.E. (2020) Regenerative endodontic therapy in the management of immature necrotic permanent dentition: a systematic review. The Scientific World Journal, 2020, 7954357. Ali, M.R.W., Mustafa, M., Bårdsen, A. & Bletsa, A. (2019) Tricalcium silicate cements: osteogenic and angiogenic responses of human bone marrow stem cells. European Journal of Oral Sciences, 127, 261–268. Andreasen, J.O., Farik, B. & Munksgaard, E.C. (2002) Long-term cal- cium hydroxide as a root canal dressing may increase risk of root fracture. Dental Traumatology, 18, 134–137. Antunes, L.S., Salles, A.G., Gomes, C.C., Andrade, T.B., Delmindo, M.P. & Antunes, L.A. (2016) The effectiveness of pulp revascularization in root formation of necrotic immature permanent teeth: a system- atic review. Acta Odontologica Scandinavica, 74, 161–169. Aromataris, E., Fernandez, R., Godfrey, C.M., Holly, C., Khalil, H. & Tungpunkom, P. (2015) Summarizing systematic reviews: methodological development, conduct and reporting of an um- brella review approach. International Journal of Evidence-based Healthcare, 13, 132–140. Balshem, H., Helfand, M., Schünemann, H.J., Oxman, A.D., Kunz, R., Brozek, J. et al. (2011) GRADE guidelines: 3. Rating the qual- ity of evidence. Journal of Clinical Epidemiology, 64, 401–406. Banchs, F. & Trope, M. (2004) Revascularization of immature per- manent teeth with apical periodontitis: new treatment proto- col? Journal of Endodontics, 30, 196–200. Bezgin, T., Yilmaz, A.D., Celik, B.N., Kolsuz, M.E. & Sonmez, H. (2015) Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. Journal of Endodontics, 41, 36–44. Brozek, J.L., Akl, E.A., Alonso-Coello, P., Lang, D., Jaeschke, R., Williams, J.W. et al. (2009) Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy, 64, 669–677. Bucchi, C., Valdivia-Gandur, I., Sánchez-Bizjak, R., Tallón-Walton, V. & Manzanares-Céspedes, C. (2017) Regenerative endodontic therapy: a systematic review of clinical protocols. International Journal of Clinical and Experimental Medicine, 10, 2006–2015. Chala, S., Abouqal, R. & Rida, S. (2011) Apexification of immature teeth with calcium hydroxide or mineral trioxide aggregate: sys- tematic review and meta-analysis. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 112, e36–e42. Chisini, L.A., Grazioli, G., Francia, A., San Martin, A.S., Demarco, F.F. & Muniz Conde, M.C. (2018) Revascularization versus api- cal barrier technique with mineral trioxide aggregate plug: a systematic review. Giornale Italiano di Endodonzia, 32, 9–16. Cvek, M. (1992) Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha: a retrospective clinical study. Endodontic Dental Traumatology, 8, 45–55. Digka, A., Sakka, D. & Lyroudia, K. (2020) Histological assessment of human regenerative endodontic procedures (REP) of im- mature permanent teeth with necrotic pulp/apical periodon- titis: a systematic review. Australian Endodontic Journal, 46, 140–153. Diogenes, A. & Ruparel, N.B. (2017) Regenerative endodontic pro- cedures: clinical outcomes. Dental Clinics of North America, 61, 111–125. do Couto, A.M., Espaladori, M.C., Leite, A., Martins, C.C., de Aguiar, M. & Abreu, L.G. (2019) A systematic review of pulp revascu- larization using a triple antibiotic paste. Pediatric Dentistry, 41, 341–353. Dos Reis, S., Cruz, V.M., Hungaro Duarte, M.A., da Silveira Bueno, C.E., Vivan, R.R., Pelegrine, R.A. et al. (2020) Volumetric anal- ysis of irrigant extrusion in immature teeth after different final agitation techniques. Journal of Endodontics, 46, 682–687. ElSheshtawy, A.S., Nazzal, H., El Shahawy, O.I., El Baz, A.A., Ismail, S.M., Kang, J. et al. (2020) The effect of platelet-rich plasma as a scaffold in regeneration/revitalization endodontics of im- mature permanent teeth assessed using 2-dimensional radio- graphs and cone beam computed tomography: a randomized controlled trial. International Endodontic Journal, 53, 905–921. Eramo, S., Natali, A., Pinna, R. & Milia, E. (2018) Dental pulp re- generation via cell homing. International Endodontic Journal, 51, 405–419. Fahmy, S.H., Hassanien, E.E.S., Nagy, M.M., El Batouty, K.M., Mekhemar, M., Fawzy El Sayed, K. et al. (2017) Investigation of the regenerative potential of necrotic mature teeth following different revascularisation protocols. Australian Endodontic, 43, 73–82. Galler, K.M., Krastl, G., Simon, S., Van Gorp, G., Meschi, N., Vahedi, B. et al. (2016) European Society of Endodontology position statement: revitalization procedures. International Endodontic Journal, 49, 717–723. Glynis, A., Foschi, F., Kefalou, I., Koletsi, D. & Tzanetakis, G.N. (2021) Regenerative endodontic procedures for the treatment of necrotic mature teeth with apical periodontitis: a system- atic review and meta-analysis of randomized controlled trials. Journal of Endodontics, 47, 873–882. Gates, A., Gates, M., Duarte, G., Cary, M., Becker, M., Prediger, B. et al. (2018) Evaluation of the reliability, usability, and applica- bility of AMSTAR, AMSTAR 2, and ROBIS: protocol for a de- scriptive analytic study. Systematic Reviews, 7, 85. Gomes-Filho, J.E., Duarte, P.C., de Oliveira, C.B., Watanabe, S., Lodi, C.S., Cintra, L.T. et al. (2012) Tissue reaction to a trian- tibiotic paste used for endodontic tissue self-regeneration of nonvital immature permanent teeth. Journal of Endodontics, 38, 91–94. Guyatt, G.H., Oxman, A.D., Schünemann, H.J., Tugwell, P. & Knottnerus, A. (2011) GRADE guidelines: a new series of arti- cles in the Journal of Clinical Epidemiology. Journal of Clinical Epidemiology, 64, 380–382. Hargreaves, K.M., Giesler, T., Henry, M. & Wang, Y. (2008) Regeneration potential of the young permanent tooth: what does the future hold? Journal of Endodontics, 34, S51–S56. Hargreaves, K.M., Diogenes, A. & Teixeira, F.B. (2013) Treatment op- tions: biological basis of regenerative endodontic procedures. Journal of Endodontics, 39(3 Suppl), S30–S43. He, L., Zhong, J., Gong, Q., Kim, S.G., Zeichner, S.J., Xiang, L. et al. (2017) Treatment of necrotic teeth by apical revascularization: meta-analysis. Scientific Reports, 7, 13941. Jacobs, J.C., Troxel, A., Ehrlich, Y., Spolnik, K., Bringas, J.S., Gregory, R.L. et al. (2017) Antibacterial effects of antimicrobials used in regenerative endodontics against biofilm bacteria obtained from mature and immature teeth with necrotic pulps. Journal of Endodontics, 43, 575–579. Jakovljevic, A., Duncan, H.F., Nagendrababu, V., Jacimovic, J., Milasin, J. & Dummer, P. (2020) Association between cardio- vascular diseases and apical periodontitis: an umbrella review. International Endodontic Journal, 53, 1374–1386. Jitaru, S., Hodisan, I., Timis, L., Lucian, A. & Bud, M. (2016) The use of bioceramics in endodontics - literature review. Clujul Medical, 89, 470–473. Kahler, B., Chugal, N. & Lin, L.M. (2017) Alkaline materials and re- generative endodontics: a review. Materials, 10, 1389. Kahler, B., Rossi-Fedele, G., Chugal, N. & Lin, L.M. (2017) An evidence-based review of the efficacy of treatment approaches for immature permanent teeth with pulp necrosis. Journal of Endodontics, 43, 1052–1057. Kim, S.G., Malek, M., Sigurdsson, A., Lin, L.M. & Kahler, B. (2018) Regenerative endodontics: a comprehensive review. International Endodontic Journal, 51, 1367–1388. Koç, S. & Del Fabbro, M. (2020) Does the etiology of pulp necrosis affect regenerative endodontic treatment outcomes? A system- atic review and meta-analyses. The Journal of Evidence-based Dental Practice, 20, 101400. Kontakiotis, E.G., Filippatos, C.G., Tzanetakis, G.N. & Agrafioti, A. (2015) Regenerative endodontic therapy: a data analysis of clin- ical protocols. Journal of Endodontics, 41, 146–154. Lin, J.C., Lu, J.X., Zeng, Q., Zhao, W., Li, W.Q. & Ling, J.Q. (2016) Comparison of mineral trioxide aggregate and calcium hydrox- ide for apexification of immature permanent teeth: a system- atic review and meta-analysis. Journal of the Formosan Medical Association, 115, 523–530. Lolato, A., Bucchi, C., Taschieri, S., Kabbaney, A.E. & Fabbro, M.D. (2016) Platelet concentrates for revitalization of immature ne- crotic teeth: a systematic review of the clinical studies. Platelets, 27, 383–392. Lopes, L.B., Neves, J.A., Botelho, J., Machado, V. & Mendes, J.J. (2021) Regenerative endodontic procedures: an umbrella re- view. International Journal of Environmental Research and Public Health, 18, 754. Metlerska, J., Fagogeni, I. & Nowicka, A. (2019) Efficacy of au- tologous platelet concentrates in regenerative endodontic treatment: a systematic review of human studies. Journal of Endodontics, 45, 20–30. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G. & PRISMA Group. (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. British Medical Journal, 339, b2535. Murray, P.E. (2018) Platelet-rich plasma and platelet-rich fibrin can induce apical closure more frequently than blood-clot revascu- larization for the regeneration of immature permanent teeth: a meta-analysis of clinical efficacy. Frontiers in Bioengineering and Biotechnology, 6, 139. Nagendrababu, V., Segura-Egea, J.J., Fouad, A.F., Pulikkotil, S.J. & Dummer, P. (2020) Association between diabetes and the out- come of root canal treatment in adults: an umbrella review. International Endodontic Journal, 53, 455–466. Nicoloso, G.F., Pötter, I.G., Rocha, R.O., Montagner, F. & Casagrande, L. (2017) A comparative evaluation of endodontic treatments for immature necrotic permanent teeth based on clinical and radiographic outcomes: a systematic review and meta-analysis. International Journal of Paediatric Dentistry, 27, 217–227. Nicoloso, G.F., Goldenfum, G.M., Pizzol, T.D.S.D., Scarparo, R.K., Montagner, F., de Almeida Rodrigues, J. et al. (2019) Pulp revas- cularization or apexification for the treatment of immature ne- crotic permanent teeth: systematic review and meta-analysis. The Journal of Clinical Pediatric Dentistry, 43, 305–313. Nosrat, A., Kolahdouzan, A., Khatibi, A.H., Verma, P., Jamshidi, D., Nevins, A.J. et al. (2019) Clinical, radiographic, and histo- logic outcome of regenerative endodontic treatment in human teeth using a novel collagen-hydroxyapatite scaffold. Journal of Endodontics, 45, 136–143. Ong, T.K., Lim, G.S., Singh, M. & Fial, A.V. (2020) Quantitative as- sessment of root development following regenerative endodon- tic therapy: a systematic review and meta-analysis. Journal of Endodontics, 46, 1856–1866. Pace, R., Giuliani, V., Nieri, M., Di Nasso, L. & Pagavino, G. (2014) Mineral trioxide aggregate as apical plug in teeth with necrotic pulp and immature apices: a 10-year case series. Journal of Endodontics, 40, 1250–1254. Panda, S., Mishra, L., Arbildo-Vega, H.I., Lapinska, B., Lukomska- Szymanska, M., Khijmatgar, S. et al. (2020) Effectiveness of autologous platelet concentrates in management of young immature necrotic permanent teeth-a systematic review and meta-analysis. Cells, 9, 2241. European Society of Endodontology, Patel, S., Durack, C., Abella, F., Roig, M., Shemesh, H. et al. (2014) European Society of Endodontology position statement: the use of CBCT in end- odontics. International Endodontic Journal, 47, 502–504. Patel, S., Durack, C., Abella, F., Shemesh, H., Roig, M. & Lemberg, K. (2015) Cone beam computed tomography in endodontics – a review. International Endodontic Journal, 48, 3–15. Peng, C., Zhao, Y., Wang, W., Yang, Y., Qin, M. & Ge, L. (2017) Histologic findings of a human immature revascularized/re- generated tooth with symptomatic irreversible pulpitis. Journal of endodontics, 43, 905–909. Reynolds, K., Johnson, J.D. & Cohenca, N. (2009) Pulp revascular- ization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discolouration: a case report. International Endodontic Journal, 42, 84–92. Rossi-Fedele, G., Kahler, B. & Venkateshbabu, N. (2019) Limited evidence suggests benefits of single visit revascularization endodontic procedures – a systematic review. Brazilian Dental Journal, 30, 527–535. Sabour, S. & Vahid-Dastjerdi, E. (2013) Letter to the editor: validity of the bolton index using cone-beam computed tomography (CBCT); methodological mistake. Medicina Oral, Patologia Oral y Cirugia Bucal, 18, e822–e823. Sanz, J.L., Forner, L., Almudéver, A., Guerrero-Gironés, J. & Llena, C. (2020) Viability and stimulation of human stem cells from the apical papilla (hSCAPs) induced by silicate-based materials for their potential use in regenerative endodontics: a systematic review. Materials, 13, 974. Shaik, I., Tulli, M., Unnam, P., Karunakaran, S., Vaddi, D.S., Jabeen, R. et al. (2021) Regenerative endodontic therapy in the man- agement of nonvital immature permanent teeth: a systematic review and meta-analysis. Journal of Pharmacy & Bioallied Sciences, 13, S36–S42. Shamszadeh, S., Asgary, S. & Nosrat, A. (2019) Regenerative end- odontics: A scientometric and bibliometric analysis. Journal of Endodontics, 45, 272–280. Shea, B.J., Reeves, B.C., Wells, G.A., Thuku, M., Hamel, C., Moran, J. et al. (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. British Medical Journal, 358, j4008. Taweewattanapaisan, P., Jantarat, J., Ounjai, P. & Janebodin, K. (2019) The effects of EDTA on blood clot in regenerative end- odontic procedures. Journal of Endodontics, 45, 281–286. Thomson, K., Bambra, C., McNamara, C., Huijts, T. & Todd, A. (2016) The effects of public health policies on population health and health inequalities in European welfare states: protocol for an umbrella review. Systematic Reviews, 5, 57. Torabinejad, M., Nosrat, A., Verma, P. & Udochukwu, O. (2017) Regenerative endodontic treatment or mineral trioxide aggre- gate apical plug in teeth with necrotic pulps and open apices: a systematic review and meta-analysis. Journal of Endodontics, 43, 1806–1820. Torabinejad, M., Parirokh, M. & Dummer, P. (2018) Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part II: other clinical applications and complica- tions. International Endodontic Journal, 51, 284–317. Vandenbroucke, J.P. (2001) In defense of case reports and case se- ries. Annals of Internal Medicine, 134, 330–334. Vidovic Zdrilic, I., de Azevedo Queiroz, I.O., Matthews, B.G., Gomes- Filho, J.E., Mina, M. & Kalajzic, I. (2017) Mineral trioxide ag- gregate improves healing response of periodontal tissue to in- jury in mice. Journal of Periodontal Research, 52, 1058–1067. Whiting, P., Savovic, J., Higgins, J.P., Caldwell, D.M., Reeves, B.C., Shea, B. et al. (2016) ROBIS: a new tool to assess risk of bias in systematic reviews was developed. Journal of Clinical Epidemiology, 69, 225–234. Wigler, R., Kaufman, A.Y., Lin, S., Steinbock, N., Hazan-Molina, H. & Torneck, C.D. (2013) Revascularization: a treatment for per- manent teeth with necrotic pulp and incomplete root develop- ment. Journal of Endodontics, 39, 319–326. Xie, Y., Lu, F., Hong, Y., He, J. & Lin, Y. (2021) Revascularisation versus apexification for treatment of immature teeth based on periapical healing and root development: a systematic review and meta-analysis. European Journal of Paediatric Dentistry, 22, 207–214. |
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Atribución – No comercial – Compartir igual |
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HAL DUNCAN Universidad Cooperativa de Colombia, Posgrado, Especialización en Endodoncia, Pasto |
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Especialización en endodoncia |
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Muñoz Alvear, Hernán DarioLópez Moncayo, Luis Fernando552022-10-11T23:14:13Z2022-10-11T23:14:13Z2022-101365-2591https://doi.org/10.1111/iej.13799https://hdl.handle.net/20.500.12494/46689Caviedes-Bucheli, J., Muñoz-Alvear, H. D., Lopez-Moncayo, L. F., Narvaez-Hidalgo, A., Zambrano-Guerrero, L., Gaviño-Orduña, J. F., Portigliatti, R., Gomez-Sosa, J. F., & Munoz, H. R. (2022). Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review. International endodontic journal, 55(10), 967–988.https://repository.ucc.edu.co/handle/20.500.12494/46689Resumen Antecedentes: El tratamiento actual de los dientes permanentes necróticos inmaduros con lesión periapical es la endodoncia regenerativa, la cual se basa en la ingeniería de tejidos bajo la tríada de células madre, andamios y moléculas bioactivas. Objetivos: esta revisión general tuvo como objetivo evaluar el éxito de los materiales de andamiaje y regenerativos utilizados para el tratamiento de estos dientes, en términos de cierre apical, aumento de la longitud del diente, ensanchamiento de las paredes del conducto radicular, vitalidad del tejido y reparación de lesiones periapicales. Métodos: Se llevó a cabo una extensa investigación bibliográfica en las bases de datos Medline, ISI Web of Science y Scopus para revisiones sistemáticas relevantes que coincidieran con la estrategia de búsqueda de palabras clave. Según los criterios de inclusión y exclusión, los revisores calificaron de forma independiente la calidad de cada estudio para determinar su nivel de evidencia. La evaluación de la calidad metodológica de cada artículo se obtuvo mediante la herramienta A Measurement Tool to Assess Systematic Reviews (AMSTAR)-2, y el riesgo de sesgo se evaluó con la herramienta Risk of Bias in Systematic Reviews (ROBIS). Resultados: Después de eliminar los duplicados, se encontraron 155 artículos; de los cuales 133 fueron excluidos por no ser relevantes y otros 15 por criterios de exclusión. Uno más fue descartado luego de la evaluación de la calidad metodológica, para un total de seis artículos restantes. El andamio más utilizado fue el coágulo de sangre, otros utilizados fueron el ácido poliláctico-co-glicólico y la matriz de fibrina rica en plaquetas. El material de regeneración más utilizado fue el agregado de trióxido mineral (MTA), seguido de Biodentine. En todos los estudios seleccionados se informó un aumento en la longitud de los dientes y un ensanchamiento de las paredes del conducto radicular en diferentes proporciones, así como reparación de lesiones periapicales. El análisis ROBIS mostró que solo un artículo tenía un sesgo bajo, dos se clasificaron como sesgo poco claro, mientras que los tres restantes tenían un alto riesgo de sesgo. Discusión: Se realizó una búsqueda bibliográfica exhaustiva aplicando filtros de idioma, revistas indexadas de alta calidad, año de publicación, lo que asegura que se incluyeron artículos de la mejor calidad. El coágulo de sangre fue el andamio más utilizado, ya que es el más fácil de colocar dentro del canal y no requiere extraer sangre del paciente. El uso de MTA y Biodentine como materiales de sellado se ha asociado con el engrosamiento de las paredes del canal, el cierre apical y la reducción de los signos y síntomas de la periodontitis apical. Sin embargo, la mayoría de las revisiones incluidas evaluadas fueron informes de casos y solo en algunas de ellas se incluyeron ensayos clínicos. También hay una falta de análisis del riesgo de sesgo en la mayoría de las revisiones. Conclusión: El coágulo de sangre es el armazón más común utilizado para inducir la regeneración durante el tratamiento de dientes necróticos inmaduros. El aumento de la longitud de los dientes y el ensanchamiento de las paredes del conducto radicular son los criterios más comunes utilizados en los estudios como indicadores de éxito. MTA y Biodentine no mostraron diferencias en los resultados analizados. La evaluación de la calidad y la evaluación del riesgo de sesgo mostraron que es necesario diseñar mejores estudios con una metodología rigurosa para recomendar un protocolo confiable y predecible para el tratamiento de dientes permanentes necróticos inmaduros con lesiones periapicales.Abstract Background: Current treatment of immature necrotic permanent teeth with a peri- apical lesion is regenerative endodontics, which is based on tissue engineering under the triade of stem cells, scaffolds and bioactive molecules. Objectives: This Umbrella Review was aimed to evaluate the success of scaffold and regenerative materials used for the treatment of these teeth, in terms of apical closure, tooth length increase, widening of root canal walls, tissue vitality and peri- apical lesion repair. Methods: An extensive literature research was carried out in the Medline, ISI Web of Science, and Scopus databases for relevant systematic reviews matching the keyword search strategy. Based on inclusion and exclusion criteria, reviewers independently rated the quality of each study to determine their level of evidence. Methodological quality assessment of each article was obtained using A Measurement Tool to Assess Systematic Reviews (AMSTAR)-2 tool, and risk of bias was assessed with the Risk of Bias in Systematic Reviews (ROBIS) tool. Results: After removing duplicates, 155 articles were found; from which 133 were excluded for being non-relevant and 15 other due to exclusion criteria. One more was discarded after methodological quality evaluation, for a total of six articles re- maining. The most common scaffold used was the blood clot, others used were poly lactic-co-glycolic acid and platelet-rich fibrin matrix. The most common regenera- tion material used was Mineral Trioxide Aggregate (MTA), followed by Biodentine. An increase in tooth length and widening of root canal walls were reported in all selected studies with different proportions, as well as periapical lesion repair. ROBIS analysis showed that only one article had low bias, two were classified as unclear bias, while the remaining three had high risk of bias. Discussion: An exhaustive literature search was carried out applying language filters, high-quality indexed journals, year of publication, which ensures the best quality arti- cles were included. Blood clot was the most used scaffold as is the most easy to place inside the canal and does not require to extract blood from the patient. The use of MTA and Biodentine as sealing materials has been associated with thickening of canal walls, apical closure and reduced signs and symptoms of apical periodontitis. However, most of the included reviews assessed were case reports and only in a few of them were clini- cal trials included. There is also a lack of risk of bias analysis in most reviews. Conclusion: The blood clot is the most common scaffold used for inducing regen- eration during the treatment of immature necrotic teeth. Tooth length increase and widening of root canal walls are the most common criteria used in the studies as suc- cess indicators. MTA and Biodentine did not show differences in the results analysed. Quality assessment and bias risk evaluation showed that it is necessary to design bet- ter studies with rigorous methodology to recommend a trustable and predictable pro- tocol for the treatment of immature necrotic permanent teeth with periapical lesions.Introducción. -- Materiales y Métodos. -- Registro. -- Formulación PICO. -- Estrategia de Búsqueda. -- Estudios de Selección. -- Extracción de datos. -- Evaluación de Calidad usando AMSTAR 2. -- Evaluación de Riesgo de de Sesgo de Estudios Individuales. -- Resultados. -- Artículos Obtenidos en la búsqueda de literatura. -- Características Generales de los estudios seleccionados. -- Hallazgos de Materiales y Métodos. -- Resultados Observados. -- Evaluación de Calidad. -- Evaluación de riesgo de sesgo. -- Discusión. -- Necesidad de Umbrella Review. -- Hallazgos y posibles explicaciones. -- Andamios. -- Materiales de selle. -- Métodos de evaluación clinica y radiografica. -- resultados observados. -- Evaluación de calidad. -- Evaluación de riesgo de sesgo. -- Fortalezas Limitaciones. -- Recomendaciones. -- Conclusion. --https://scienti.minciencias.gov.co/cvlac/EnRecursoHumano/query.dohttps://orcid.org/my-orcid?orcid=0000-0002-4327-4242https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000002911hernan.munoz@campusucc.edu.co22HAL DUNCANUniversidad Cooperativa de Colombia, Posgrado, Especialización en Endodoncia, PastoEspecialización en endodonciaPastohttps://onlinelibrary.wiley.com/doi/10.1111/iej.13799INTERNATIONAL ENDODONTIC JOURNALAdnan, S. & Ullah, R. (2018) Top-cited articles in regenerative end- odontics: a bibliometric analysis. Journal of Endodontics, 44, 1650–1664.Alghamdi, F.T. & Alqurashi, A.E. (2020) Regenerative endodontic therapy in the management of immature necrotic permanent dentition: a systematic review. The Scientific World Journal, 2020, 7954357.Ali, M.R.W., Mustafa, M., Bårdsen, A. & Bletsa, A. (2019) Tricalcium silicate cements: osteogenic and angiogenic responses of human bone marrow stem cells. European Journal of Oral Sciences, 127, 261–268.Andreasen, J.O., Farik, B. & Munksgaard, E.C. (2002) Long-term cal- cium hydroxide as a root canal dressing may increase risk of root fracture. Dental Traumatology, 18, 134–137.Antunes, L.S., Salles, A.G., Gomes, C.C., Andrade, T.B., Delmindo, M.P. & Antunes, L.A. (2016) The effectiveness of pulp revascularization in root formation of necrotic immature permanent teeth: a system- atic review. Acta Odontologica Scandinavica, 74, 161–169.Aromataris, E., Fernandez, R., Godfrey, C.M., Holly, C., Khalil, H. & Tungpunkom, P. (2015) Summarizing systematic reviews: methodological development, conduct and reporting of an um- brella review approach. International Journal of Evidence-based Healthcare, 13, 132–140.Balshem, H., Helfand, M., Schünemann, H.J., Oxman, A.D., Kunz, R., Brozek, J. et al. (2011) GRADE guidelines: 3. Rating the qual- ity of evidence. Journal of Clinical Epidemiology, 64, 401–406.Banchs, F. & Trope, M. (2004) Revascularization of immature per- manent teeth with apical periodontitis: new treatment proto- col? Journal of Endodontics, 30, 196–200.Bezgin, T., Yilmaz, A.D., Celik, B.N., Kolsuz, M.E. & Sonmez, H. (2015) Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. Journal of Endodontics, 41, 36–44.Brozek, J.L., Akl, E.A., Alonso-Coello, P., Lang, D., Jaeschke, R., Williams, J.W. et al. (2009) Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy, 64, 669–677.Bucchi, C., Valdivia-Gandur, I., Sánchez-Bizjak, R., Tallón-Walton, V. & Manzanares-Céspedes, C. (2017) Regenerative endodontic therapy: a systematic review of clinical protocols. International Journal of Clinical and Experimental Medicine, 10, 2006–2015.Chala, S., Abouqal, R. & Rida, S. (2011) Apexification of immature teeth with calcium hydroxide or mineral trioxide aggregate: sys- tematic review and meta-analysis. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 112, e36–e42.Chisini, L.A., Grazioli, G., Francia, A., San Martin, A.S., Demarco, F.F. & Muniz Conde, M.C. (2018) Revascularization versus api- cal barrier technique with mineral trioxide aggregate plug: a systematic review. Giornale Italiano di Endodonzia, 32, 9–16.Cvek, M. (1992) Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha: a retrospective clinical study. Endodontic Dental Traumatology, 8, 45–55.Digka, A., Sakka, D. & Lyroudia, K. (2020) Histological assessment of human regenerative endodontic procedures (REP) of im- mature permanent teeth with necrotic pulp/apical periodon- titis: a systematic review. Australian Endodontic Journal, 46, 140–153.Diogenes, A. & Ruparel, N.B. (2017) Regenerative endodontic pro- cedures: clinical outcomes. Dental Clinics of North America, 61, 111–125.do Couto, A.M., Espaladori, M.C., Leite, A., Martins, C.C., de Aguiar, M. & Abreu, L.G. (2019) A systematic review of pulp revascu- larization using a triple antibiotic paste. Pediatric Dentistry, 41, 341–353.Dos Reis, S., Cruz, V.M., Hungaro Duarte, M.A., da Silveira Bueno, C.E., Vivan, R.R., Pelegrine, R.A. et al. (2020) Volumetric anal- ysis of irrigant extrusion in immature teeth after different final agitation techniques. Journal of Endodontics, 46, 682–687.ElSheshtawy, A.S., Nazzal, H., El Shahawy, O.I., El Baz, A.A., Ismail, S.M., Kang, J. et al. (2020) The effect of platelet-rich plasma as a scaffold in regeneration/revitalization endodontics of im- mature permanent teeth assessed using 2-dimensional radio- graphs and cone beam computed tomography: a randomized controlled trial. International Endodontic Journal, 53, 905–921.Eramo, S., Natali, A., Pinna, R. & Milia, E. (2018) Dental pulp re- generation via cell homing. International Endodontic Journal, 51, 405–419.Fahmy, S.H., Hassanien, E.E.S., Nagy, M.M., El Batouty, K.M., Mekhemar, M., Fawzy El Sayed, K. et al. (2017) Investigation of the regenerative potential of necrotic mature teeth following different revascularisation protocols. Australian Endodontic, 43, 73–82.Galler, K.M., Krastl, G., Simon, S., Van Gorp, G., Meschi, N., Vahedi, B. et al. (2016) European Society of Endodontology position statement: revitalization procedures. International Endodontic Journal, 49, 717–723.Glynis, A., Foschi, F., Kefalou, I., Koletsi, D. & Tzanetakis, G.N. (2021) Regenerative endodontic procedures for the treatment of necrotic mature teeth with apical periodontitis: a system- atic review and meta-analysis of randomized controlled trials. Journal of Endodontics, 47, 873–882.Gates, A., Gates, M., Duarte, G., Cary, M., Becker, M., Prediger, B. et al. (2018) Evaluation of the reliability, usability, and applica- bility of AMSTAR, AMSTAR 2, and ROBIS: protocol for a de- scriptive analytic study. Systematic Reviews, 7, 85.Gomes-Filho, J.E., Duarte, P.C., de Oliveira, C.B., Watanabe, S., Lodi, C.S., Cintra, L.T. et al. (2012) Tissue reaction to a trian- tibiotic paste used for endodontic tissue self-regeneration of nonvital immature permanent teeth. Journal of Endodontics, 38, 91–94.Guyatt, G.H., Oxman, A.D., Schünemann, H.J., Tugwell, P. & Knottnerus, A. (2011) GRADE guidelines: a new series of arti- cles in the Journal of Clinical Epidemiology. Journal of Clinical Epidemiology, 64, 380–382.Hargreaves, K.M., Giesler, T., Henry, M. & Wang, Y. (2008) Regeneration potential of the young permanent tooth: what does the future hold? Journal of Endodontics, 34, S51–S56.Hargreaves, K.M., Diogenes, A. & Teixeira, F.B. (2013) Treatment op- tions: biological basis of regenerative endodontic procedures. Journal of Endodontics, 39(3 Suppl), S30–S43.He, L., Zhong, J., Gong, Q., Kim, S.G., Zeichner, S.J., Xiang, L. et al. (2017) Treatment of necrotic teeth by apical revascularization: meta-analysis. Scientific Reports, 7, 13941.Jacobs, J.C., Troxel, A., Ehrlich, Y., Spolnik, K., Bringas, J.S., Gregory, R.L. et al. (2017) Antibacterial effects of antimicrobials used in regenerative endodontics against biofilm bacteria obtained from mature and immature teeth with necrotic pulps. Journal of Endodontics, 43, 575–579.Jakovljevic, A., Duncan, H.F., Nagendrababu, V., Jacimovic, J., Milasin, J. & Dummer, P. (2020) Association between cardio- vascular diseases and apical periodontitis: an umbrella review. International Endodontic Journal, 53, 1374–1386.Jitaru, S., Hodisan, I., Timis, L., Lucian, A. & Bud, M. (2016) The use of bioceramics in endodontics - literature review. Clujul Medical, 89, 470–473.Kahler, B., Chugal, N. & Lin, L.M. (2017) Alkaline materials and re- generative endodontics: a review. Materials, 10, 1389.Kahler, B., Rossi-Fedele, G., Chugal, N. & Lin, L.M. (2017) An evidence-based review of the efficacy of treatment approaches for immature permanent teeth with pulp necrosis. Journal of Endodontics, 43, 1052–1057.Kim, S.G., Malek, M., Sigurdsson, A., Lin, L.M. & Kahler, B. (2018) Regenerative endodontics: a comprehensive review. International Endodontic Journal, 51, 1367–1388.Koç, S. & Del Fabbro, M. (2020) Does the etiology of pulp necrosis affect regenerative endodontic treatment outcomes? A system- atic review and meta-analyses. The Journal of Evidence-based Dental Practice, 20, 101400.Kontakiotis, E.G., Filippatos, C.G., Tzanetakis, G.N. & Agrafioti, A. (2015) Regenerative endodontic therapy: a data analysis of clin- ical protocols. Journal of Endodontics, 41, 146–154.Lin, J.C., Lu, J.X., Zeng, Q., Zhao, W., Li, W.Q. & Ling, J.Q. (2016) Comparison of mineral trioxide aggregate and calcium hydrox- ide for apexification of immature permanent teeth: a system- atic review and meta-analysis. Journal of the Formosan Medical Association, 115, 523–530.Lolato, A., Bucchi, C., Taschieri, S., Kabbaney, A.E. & Fabbro, M.D. (2016) Platelet concentrates for revitalization of immature ne- crotic teeth: a systematic review of the clinical studies. Platelets, 27, 383–392.Lopes, L.B., Neves, J.A., Botelho, J., Machado, V. & Mendes, J.J. (2021) Regenerative endodontic procedures: an umbrella re- view. International Journal of Environmental Research and Public Health, 18, 754.Metlerska, J., Fagogeni, I. & Nowicka, A. (2019) Efficacy of au- tologous platelet concentrates in regenerative endodontic treatment: a systematic review of human studies. Journal of Endodontics, 45, 20–30.Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G. & PRISMA Group. (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. British Medical Journal, 339, b2535.Murray, P.E. (2018) Platelet-rich plasma and platelet-rich fibrin can induce apical closure more frequently than blood-clot revascu- larization for the regeneration of immature permanent teeth: a meta-analysis of clinical efficacy. Frontiers in Bioengineering and Biotechnology, 6, 139.Nagendrababu, V., Segura-Egea, J.J., Fouad, A.F., Pulikkotil, S.J. & Dummer, P. (2020) Association between diabetes and the out- come of root canal treatment in adults: an umbrella review. International Endodontic Journal, 53, 455–466.Nicoloso, G.F., Pötter, I.G., Rocha, R.O., Montagner, F. & Casagrande, L. (2017) A comparative evaluation of endodontic treatments for immature necrotic permanent teeth based on clinical and radiographic outcomes: a systematic review and meta-analysis. International Journal of Paediatric Dentistry, 27, 217–227.Nicoloso, G.F., Goldenfum, G.M., Pizzol, T.D.S.D., Scarparo, R.K., Montagner, F., de Almeida Rodrigues, J. et al. (2019) Pulp revas- cularization or apexification for the treatment of immature ne- crotic permanent teeth: systematic review and meta-analysis. The Journal of Clinical Pediatric Dentistry, 43, 305–313.Nosrat, A., Kolahdouzan, A., Khatibi, A.H., Verma, P., Jamshidi, D., Nevins, A.J. et al. (2019) Clinical, radiographic, and histo- logic outcome of regenerative endodontic treatment in human teeth using a novel collagen-hydroxyapatite scaffold. Journal of Endodontics, 45, 136–143.Ong, T.K., Lim, G.S., Singh, M. & Fial, A.V. (2020) Quantitative as- sessment of root development following regenerative endodon- tic therapy: a systematic review and meta-analysis. Journal of Endodontics, 46, 1856–1866.Pace, R., Giuliani, V., Nieri, M., Di Nasso, L. & Pagavino, G. (2014) Mineral trioxide aggregate as apical plug in teeth with necrotic pulp and immature apices: a 10-year case series. Journal of Endodontics, 40, 1250–1254.Panda, S., Mishra, L., Arbildo-Vega, H.I., Lapinska, B., Lukomska- Szymanska, M., Khijmatgar, S. et al. (2020) Effectiveness of autologous platelet concentrates in management of young immature necrotic permanent teeth-a systematic review and meta-analysis. Cells, 9, 2241.European Society of Endodontology, Patel, S., Durack, C., Abella, F., Roig, M., Shemesh, H. et al. (2014) European Society of Endodontology position statement: the use of CBCT in end- odontics. International Endodontic Journal, 47, 502–504.Patel, S., Durack, C., Abella, F., Shemesh, H., Roig, M. & Lemberg, K. (2015) Cone beam computed tomography in endodontics – a review. International Endodontic Journal, 48, 3–15.Peng, C., Zhao, Y., Wang, W., Yang, Y., Qin, M. & Ge, L. (2017) Histologic findings of a human immature revascularized/re- generated tooth with symptomatic irreversible pulpitis. Journal of endodontics, 43, 905–909.Reynolds, K., Johnson, J.D. & Cohenca, N. (2009) Pulp revascular- ization of necrotic bilateral bicuspids using a modified novel technique to eliminate potential coronal discolouration: a case report. International Endodontic Journal, 42, 84–92.Rossi-Fedele, G., Kahler, B. & Venkateshbabu, N. (2019) Limited evidence suggests benefits of single visit revascularization endodontic procedures – a systematic review. Brazilian Dental Journal, 30, 527–535.Sabour, S. & Vahid-Dastjerdi, E. (2013) Letter to the editor: validity of the bolton index using cone-beam computed tomography (CBCT); methodological mistake. Medicina Oral, Patologia Oral y Cirugia Bucal, 18, e822–e823.Sanz, J.L., Forner, L., Almudéver, A., Guerrero-Gironés, J. & Llena, C. (2020) Viability and stimulation of human stem cells from the apical papilla (hSCAPs) induced by silicate-based materials for their potential use in regenerative endodontics: a systematic review. Materials, 13, 974.Shaik, I., Tulli, M., Unnam, P., Karunakaran, S., Vaddi, D.S., Jabeen, R. et al. (2021) Regenerative endodontic therapy in the man- agement of nonvital immature permanent teeth: a systematic review and meta-analysis. Journal of Pharmacy & Bioallied Sciences, 13, S36–S42.Shamszadeh, S., Asgary, S. & Nosrat, A. (2019) Regenerative end- odontics: A scientometric and bibliometric analysis. Journal of Endodontics, 45, 272–280.Shea, B.J., Reeves, B.C., Wells, G.A., Thuku, M., Hamel, C., Moran, J. et al. (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. British Medical Journal, 358, j4008.Taweewattanapaisan, P., Jantarat, J., Ounjai, P. & Janebodin, K. (2019) The effects of EDTA on blood clot in regenerative end- odontic procedures. Journal of Endodontics, 45, 281–286.Thomson, K., Bambra, C., McNamara, C., Huijts, T. & Todd, A. (2016) The effects of public health policies on population health and health inequalities in European welfare states: protocol for an umbrella review. Systematic Reviews, 5, 57.Torabinejad, M., Nosrat, A., Verma, P. & Udochukwu, O. (2017) Regenerative endodontic treatment or mineral trioxide aggre- gate apical plug in teeth with necrotic pulps and open apices: a systematic review and meta-analysis. Journal of Endodontics, 43, 1806–1820.Torabinejad, M., Parirokh, M. & Dummer, P. (2018) Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part II: other clinical applications and complica- tions. International Endodontic Journal, 51, 284–317.Vandenbroucke, J.P. (2001) In defense of case reports and case se- ries. Annals of Internal Medicine, 134, 330–334.Vidovic Zdrilic, I., de Azevedo Queiroz, I.O., Matthews, B.G., Gomes- Filho, J.E., Mina, M. & Kalajzic, I. (2017) Mineral trioxide ag- gregate improves healing response of periodontal tissue to in- jury in mice. Journal of Periodontal Research, 52, 1058–1067.Whiting, P., Savovic, J., Higgins, J.P., Caldwell, D.M., Reeves, B.C., Shea, B. et al. (2016) ROBIS: a new tool to assess risk of bias in systematic reviews was developed. Journal of Clinical Epidemiology, 69, 225–234.Wigler, R., Kaufman, A.Y., Lin, S., Steinbock, N., Hazan-Molina, H. & Torneck, C.D. (2013) Revascularization: a treatment for per- manent teeth with necrotic pulp and incomplete root develop- ment. Journal of Endodontics, 39, 319–326.Xie, Y., Lu, F., Hong, Y., He, J. & Lin, Y. (2021) Revascularisation versus apexification for treatment of immature teeth based on periapical healing and root development: a systematic review and meta-analysis. European Journal of Paediatric Dentistry, 22, 207–214.dientes necróticos inmaduroslesión periapicalmateriales regenerativosandamiosimmature necrotic teethperiapical lesionregenerative materialsscaffoldsUse of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella reviewArtículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribución – No comercial – Compartir igualinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINAL2022-caviedesbuchelijavermunozalvearhernandariolopezmoncayoluis fernando-Use_of_scaffolds_and_regenerative_materials_for_the_treatment_of_immature_necrotic_permanent_teeth_with_periapical_lesion_Umbrella_review-FormatoPublicacionWeb.pdf2022-caviedesbuchelijavermunozalvearhernandariolopezmoncayoluis 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