Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020

Preclinical evidence about the neutrophil-mediated response in exposure to air pollutants is scattered and heterogeneous. This has prevented the consolidation of this research field around relevant models that could advance towards clinical research. The purpose of this study was to systematic revie...

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Autores:
Valderrama, Andrés
Zapata, María Isabel
Hernández López, Juan Carlos
Cardona-Arias, Jaiberth A
Tipo de recurso:
Article of investigation
Fecha de publicación:
2022
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/45953
Acceso en línea:
https://hdl.handle.net/20.500.12494/45953
Palabra clave:
Inflammation
Neutrophils
Air pollutants
Particulate matter
Murine model
Cell cultures
Cytokines
Systematic review
Environmental
Rights
openAccess
License
Atribución
id COOPER2_65c2f2dfcd070bfc16d8c51ea72e0a5f
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/45953
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
title Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
spellingShingle Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
Inflammation
Neutrophils
Air pollutants
Particulate matter
Murine model
Cell cultures
Cytokines
Systematic review
Environmental
title_short Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
title_full Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
title_fullStr Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
title_full_unstemmed Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
title_sort Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980–2020
dc.creator.fl_str_mv Valderrama, Andrés
Zapata, María Isabel
Hernández López, Juan Carlos
Cardona-Arias, Jaiberth A
dc.contributor.author.none.fl_str_mv Valderrama, Andrés
Zapata, María Isabel
Hernández López, Juan Carlos
Cardona-Arias, Jaiberth A
dc.subject.spa.fl_str_mv Inflammation
Neutrophils
Air pollutants
Particulate matter
Murine model
Cell cultures
Cytokines
Systematic review
Environmental
topic Inflammation
Neutrophils
Air pollutants
Particulate matter
Murine model
Cell cultures
Cytokines
Systematic review
Environmental
description Preclinical evidence about the neutrophil-mediated response in exposure to air pollutants is scattered and heterogeneous. This has prevented the consolidation of this research field around relevant models that could advance towards clinical research. The purpose of this study was to systematic review the studies of the neutrophils response to air pollutants, following the recommendations of the Cochrane Collaboration and the PRISMA guide, through 54 search strategies in nine databases. We include 234 studies (in vitro, and in vivo), being more frequent using primary neutrophils, Balb/C and C57BL6/J mice, and Sprague-Dawley and Wistar rats. The most frequent readouts were cell counts, cytokines and histopathology. The temporal analysis showed that in the last decade, the use of mice with histopathological and cytokine measurement have predominated. This systematic review has shown that study of the neutrophils response to air pollutants started 40 years ago, and composed of 100 different preclinical models, 10 pollutants, and 11 immunological outcomes. Mechanisms of neutrophils-mediated immunopathology include cellular activation, ROS production, and proinflammatory effects, leading to cell-death, oxidative stress, and inflammatory infiltrates in lungs. This research will allow consolidating the research efforts in this field, optimizing the study of causal processes, and facilitating the advance to clinical studies.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-07-28T20:01:16Z
dc.date.available.none.fl_str_mv 2022-07-28T20:01:16Z
dc.date.issued.none.fl_str_mv 2022-01-12
dc.type.none.fl_str_mv Artículos Científicos
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.uri.spa.fl_str_mv 10.1016/j.heliyon.2022.e08778
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/45953
dc.identifier.bibliographicCitation.spa.fl_str_mv Valderrama A, Zapata MI, Hernandez JC, Cardona-Arias JA. Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980-2020. Heliyon. 2022 Jan 25;8(1):e08778. doi: 10.1016/j.heliyon.2022.e08778. PMID: 35128092; PMCID: PMC8810373.
identifier_str_mv 10.1016/j.heliyon.2022.e08778
Valderrama A, Zapata MI, Hernandez JC, Cardona-Arias JA. Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980-2020. Heliyon. 2022 Jan 25;8(1):e08778. doi: 10.1016/j.heliyon.2022.e08778. PMID: 35128092; PMCID: PMC8810373.
url https://hdl.handle.net/20.500.12494/45953
dc.relation.isversionof.spa.fl_str_mv https://pubmed.ncbi.nlm.nih.gov/35128092/
dc.relation.ispartofjournal.spa.fl_str_mv Heliyon
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spelling Valderrama, AndrésZapata, María IsabelHernández López, Juan Carlos Cardona-Arias, Jaiberth A8 (1)2022-07-28T20:01:16Z2022-07-28T20:01:16Z2022-01-1210.1016/j.heliyon.2022.e08778https://hdl.handle.net/20.500.12494/45953Valderrama A, Zapata MI, Hernandez JC, Cardona-Arias JA. Systematic review of preclinical studies on the neutrophil-mediated immune response to air pollutants, 1980-2020. Heliyon. 2022 Jan 25;8(1):e08778. doi: 10.1016/j.heliyon.2022.e08778. PMID: 35128092; PMCID: PMC8810373.Preclinical evidence about the neutrophil-mediated response in exposure to air pollutants is scattered and heterogeneous. This has prevented the consolidation of this research field around relevant models that could advance towards clinical research. The purpose of this study was to systematic review the studies of the neutrophils response to air pollutants, following the recommendations of the Cochrane Collaboration and the PRISMA guide, through 54 search strategies in nine databases. We include 234 studies (in vitro, and in vivo), being more frequent using primary neutrophils, Balb/C and C57BL6/J mice, and Sprague-Dawley and Wistar rats. The most frequent readouts were cell counts, cytokines and histopathology. The temporal analysis showed that in the last decade, the use of mice with histopathological and cytokine measurement have predominated. This systematic review has shown that study of the neutrophils response to air pollutants started 40 years ago, and composed of 100 different preclinical models, 10 pollutants, and 11 immunological outcomes. Mechanisms of neutrophils-mediated immunopathology include cellular activation, ROS production, and proinflammatory effects, leading to cell-death, oxidative stress, and inflammatory infiltrates in lungs. This research will allow consolidating the research efforts in this field, optimizing the study of causal processes, and facilitating the advance to clinical studies.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000283088http://orcid.org/0000-0002-9200-5698https://scienti.colciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000011355juankhernandez@gmail.com1-13Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000MedicinaMedellínhttps://pubmed.ncbi.nlm.nih.gov/35128092/Heliyon[1] R.D. Arias-P erez, N.A. Taborda, D.M. Gomez, J.F. Narvaez, J. Porras, J.C. Hernandez, Inflammatory effects of particulate matter air pollution, Environ. Sci. Pollut. Res. (2020) 1–15. [3] M.C. Loaiza-Ceballos, D. Marin-Palma, W. Zapata, J.C. Hernandez, Viral respiratory infections and air pollutants, Air Qual. Atmos. Heal. (2021). 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