Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina
La dermatofitosis es una de las enfermedades infectocontagiosas más importantes y frecuentes que se presentan en clínicas veterinarias, la cual afecta los tejidos queratinizados, uñas, pelo y estrato corneo de la piel. La mayor parte de los casos son causados por los géneros Microsporum y Trichophyt...
- Autores:
-
Morales Garzón , Lizeth Pauline
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
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- oai:repository.ucc.edu.co:20.500.12494/52088
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/52088
- Palabra clave:
- Dermatofitosis
Tratamiento
Tópico
Sistémico
Antifúngicos
TG 2023 MVZ 52088
Treatment
Dermatophytosis
Topic
Systemic
Antifungals
- Rights
- openAccess
- License
- Atribución – No comercial – Sin Derivar
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dc.title.none.fl_str_mv |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
title |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
spellingShingle |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina Dermatofitosis Tratamiento Tópico Sistémico Antifúngicos TG 2023 MVZ 52088 Treatment Dermatophytosis Topic Systemic Antifungals |
title_short |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
title_full |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
title_fullStr |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
title_full_unstemmed |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
title_sort |
Discusión frente a la terapeutica topica y sistemica en dermatofitosis canina |
dc.creator.fl_str_mv |
Morales Garzón , Lizeth Pauline |
dc.contributor.advisor.none.fl_str_mv |
Plazas Hernández, Fernely Augusto |
dc.contributor.author.none.fl_str_mv |
Morales Garzón , Lizeth Pauline |
dc.subject.none.fl_str_mv |
Dermatofitosis Tratamiento Tópico Sistémico Antifúngicos |
topic |
Dermatofitosis Tratamiento Tópico Sistémico Antifúngicos TG 2023 MVZ 52088 Treatment Dermatophytosis Topic Systemic Antifungals |
dc.subject.classification.none.fl_str_mv |
TG 2023 MVZ 52088 |
dc.subject.other.none.fl_str_mv |
Treatment Dermatophytosis Topic Systemic Antifungals |
description |
La dermatofitosis es una de las enfermedades infectocontagiosas más importantes y frecuentes que se presentan en clínicas veterinarias, la cual afecta los tejidos queratinizados, uñas, pelo y estrato corneo de la piel. La mayor parte de los casos son causados por los géneros Microsporum y Trichophyton, de acuerdo con su habitad se clasifican como antropofílicos, geofílicos o zoofílicos. Esta patología se transmite por contacto directo con un animal infectado o por fómites, produce descamación, alopecia, enrojecimiento e inflamación. La dermatofitosis es catalogada como una enfermedad zoonótica, es decir que puede infectar al humano. Existen diferentes tratamientos para combatir la dermatofitosis y recopilando la perspectiva de diferentes autores, incluyendo estudios y experimentos realizados a través de los años, comparando y confrontando sus diferentes hipótesis. Varios autores están de acuerdo que principalmente se debe tener en cuenta la especie, los factores de virulencia de la cepa y factores en el huésped (edad, genética, microclima de la piel y enfermedades) para llegar a un adecuado tratamiento, así mismo elegir entre una terapéutica tópica, sistémica o una combinación de ambas. La griseofulvina es uno de los fungistáticos más usados sistémicamente en medicina veterinaria, seguido por el ketoconazol e itraconazol, A su vez los antifúngicos tópicos más relevantes son Enilconazol, azufre de cal y clorhexidina. |
publishDate |
2023 |
dc.date.accessioned.none.fl_str_mv |
2023-07-19T14:12:42Z |
dc.date.available.none.fl_str_mv |
2023-07-19T14:12:42Z |
dc.date.issued.none.fl_str_mv |
2023-07-18 |
dc.type.none.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
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info:eu-repo/semantics/acceptedVersion |
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http://purl.org/coar/resource_type/c_7a1f |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/52088 |
dc.identifier.bibliographicCitation.none.fl_str_mv |
Morales Garzón, L. P. (2023). Discusión frente a la terapéutica tópica y sistémica en dermatofitosis canina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/52088 |
url |
https://hdl.handle.net/20.500.12494/52088 |
identifier_str_mv |
Morales Garzón, L. P. (2023). Discusión frente a la terapéutica tópica y sistémica en dermatofitosis canina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/52088 |
dc.relation.references.none.fl_str_mv |
Romero C, González M. Actualidades de la dermatofitosis en perros y gatos. vanguardia veterinaria; 2022. [internet] https://Www.Vanguardiaveterinaria.Com.Mx/Dermatofitosis-En-Perros-Y-Gatos Instituto for internacional dermatofitosis. The center for food security & public Healt ;2005. Molina D. Aspectos clínicos, diagnósticos y terapéuticos de las dermatofitosis. Enferm Infecc Microbiol Clin; 2011. Boehm T., Mueller R; Dermatophytosis In dogs and cats an update. 2019 Aug 21 Available From: Https://Europepmc.Org/Article/Med/31434126 Cruz C.; Importancia Zoonótica De Las Dermatofitosis En Caninos Y Felinos; 2012 Available From: Https://Repository.Javeriana.Edu.Co/Handle/10554/10379 Rómulo R, Zamora Z, Fernández L. Los Dermatofitos una amenaza zoonótica, Características Generales, Aspectos Clínicos Para Cada Especie; Revista Cenic Ciencias Biológicas. 2022 Available From: Http://Scielo.Sld.Cu/Scielo.Php?Script=Sci_Arttext&Pid=S2221-24502022000100020 Moriello K, Coyner K, Paterson S, Mignon B.; Diagnosis and treatment of dermatophytosis In dogs And Cats. ;2017 Jun 1 Available From: Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1111/Vde.12440 Duclos D. Dermatophytosis. Bsava Manual Of Canine And Feline Dermatology ;2012 Available From: Https://Www.Bsavalibrary.Com/Content/Chapter/10.22233/9781905319886.Chap24 Gnat S, Łagowski D, Nowakiewicz A, Osińska M, Kopiński Ł. population differentiation, antifungal susceptibility, and Host range of trichophyton mentagrophytes isolates causing recalcitrant infections in humans and animals. available From: Https://Doi.Org/10.1007/S10096-020-03952-2 Valdivia L. La dermatofitosis: Clínica, Diagnóstico Y Tratamiento [Internet]. Dermatol Peru . 2003 [Cited 2023 Jan 22]. Available From: Https://Sisbib.Unmsm.Edu.Pe/Bvrevistas/Dermatologia/V13_N1/Derma_Clini.Htm Velandia M. Dermatophytoses In Dogs And Cats | Today’s Veterinary Practice 2017 [Internet]. Available From: Https://Todaysveterinarypractice.Com/Dermatology/Dermatophytoses-In-Dogs-And-Cats/ Harvey R, Mckeever P. Enfermedades De La Piel En Perro Y Gato. GRASS Edicions. 2001 Mattei A, Beber M, Madrid I. Dermatophytosis In Small Animals. 2014 [Cited 2017]; Available From: Www.Symbiosisonline. Orgwww.Symbiosisonlinepublishing.Com Moriello K. Feline Dermatophytosis: Aspects pertinent to disease management In Single And multiple Cat situations [Internet]. journal of feline medicine and surgery 2014 [Cited 2022May 8]. Available From: Https://Sci-Hub.Se/10.1177/1098612x14530215 Esccap. Control De Las Micosis Superficiales En Perros Y Gatos. Guía Esccap No 2 (1a Edición). 2015 Costa M, Passos X, Hasimoto E, Souza L, Miranda A, Lemos J , Oliveira J. Epidemiologia etiologia das dermatofitoses em goiânia, go, Brasil. Rev Soc Bras Med Trop [Internet]. 2002 [Cited 2023 Jan 25];35(1):19–22. Available From: Http://Www.Scielo.Br/J/Rsbmt/A/Kmqywh48l9xqj84yrynw4wj/Abstract/?Lang=Pt Viguié-Vallanet C, Paugam A, Blasco M. Sección Permanente Latinoamericana Dermatofitos Transmitidos Por Animales. 2016 Greene C. Veterinary Quarterly Diagnosis, Therapy, And Prevention Of Common Infectious Diseases In The Dog. [Cited 2021 Jun 10]; Available From: Https://Www.Tandfonline.Com/Action/Journalinformation?Journalcode=Tveq20 Bond R, Middleton D, Scarff D, Lamport A. Chronic Dermatophytosis Due To Microsporum Persicolor Infection In Three Dogs. Journal Of Small Animal Practice [Internet]. 1992 Dec 1. Available From: Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1111/J.1748-5827.1992.Tb01059.X Uribe P, Cardona N. Mecanismos De Adherencia E Invasión De Dermatofitos A La Piel. Ces Medicina [Internet]. 2013 [Cited 2023 Jan 25];27(1):67–75. Available From: Http://Www.Scielo.Org.Co/Scielo.Php?Script=Sci_Arttext&Pid=S0120-87052013000100007&Lng=En&Nrm=Iso&Tlng=Es White-Weithers N, Medleau L. Evaluation Of Topical Therapies For The Treatment Of Dermatophyte-Infected Hairs From Dogs And Cats. J Am Anim Hosp Assoc [Internet]. 1995 [Cited 2023 Jan 25];31(3):250–3. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/7634061/ Carlotti D. Veterinary Quarterly Canine And Feline Superficial Fungal Skin Infections. [Cited 2023 Jan 23]; Available From: Https://Www.Tandfonline.Com/Action/Journalinformation?Journalcode=Tveq20 Nam H, Kim T, Han S, Hyun C. Evaluation of therapeutic efficacy of medical shampoo containing terbinafine hydrochloride and chlorhexidine In dogs With dermatophytosis complicated with bacterial Infection. J Biomed Res [Internet]. 2013 [Cited 2023 Jan 24];154–9. Available From: Http://Dx.Doi.Org/ Márquez S. Cambios Entransaminasas hepáticas inducidas por ketoconazol en tratamiento de dermatofitosis en canis familiaris,distrito de trujillo. Universidad privada Antenor Orrego facultad de ciencias agrariasescuela profesional de Medicina veterinaria y zootecnia. 2016 Da Costa B, Pippi B, Berlitz S, Carvalho A, Teixeira M, Külkamp-Guerreiro I. Evaluation of activity and toxicity of combining clioquinol with ciclopirox and terbinafine in alternative models of dermatophytosis. mycoses [Internet]. 2021 Jul Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/33772895/ D Thienpont. Ketoconazole in experimental candidosis. 1980 [Internet]. [Cited 2023 Jan 25]. Available From: Https://Www.Jstor.Org/Stable/4452462 De Keyser H, Van Den Brande M. Veterinary Quarterly Ketoconazole In The Treatment Of Dermatomycosis In Cats And Dogs. [Cited 2023 Jan 24]; Available From: Https://Www.Tandfonline.Com/Action/Journalinformation?Journalcode=Tveq20 Mejia M, Bedoya G. Descripción de la eficacia del extracto de anamú (Petiveria Alliacea) para el tratamiento antifúngico (Dermatofitosis Canina). Avepa formacion continuada. problemas dermatológicos “Evitemos Caer En La Rutina.” 2013. Grant S, Clissold S. Itraconazole. A Review Of Its Pharmacodynamic And Pharmacokinetic Properties, And Therapeutic Use In Superficial And Systemic Mycoses. Drugs. 1989 Willems L, Van Der Geest R, De Beule K. Itraconazole Oral Solution And Intravenous Formulations: A Review Of Pharmacokinetics And Pharmacodynamics. J Clin Pharm Ther [Internet]. 2001 [Cited 2023 Jan 24];26(3):159–69. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/11422598 Mawby D, Whittemore J, Genger S, Papich M. Bioequivalence Of Orally Administered Generic, Compounded, And Innovator-Formulated Itraconazole In Healthy Dogs. J Vet Intern Med. 2014;28(1):72–7 Sun D, Kang E, Beom Ss, Jun H, Lee Sh, Lee Kc, Et Al. Interspecies Comparison Of The Oral Absorption Of Itraconazole In Laboratory Animals. Arch Pharm Res [Internet]. 2002 Jun 30 [Cited 2023 Jan 24];25(3):387–91. Available From: Https://Link.Springer.Com/Article/10.1007/Bf02976644 Legendre A, Rohrbach B, Toal R, Rinaldi M, Grace L, Jones J. Treatment Of Blastomycosis With Itraconazole In 112 Dogs. J Vet Intern Med [Internet]. 1996 [Cited 2023 Jan 24];10(6):365–71. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/8947868/ Van Cauteren H, Heykants J, De Coster R, Cauwenbergh G. Itraconazole: Pharmacologic Studies In Animals And Humans. Rev Infect Dis [Internet]. 1987 [Cited 2023 Jan 24];9 Suppl 1. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/3027845/ Yamada C, Hasegawa A, Pal M, Ono K, Kitamura C, Takahashi H. Trichophyton Rubrum Infection In A Dog. Nippon Ishinkin Gakkai Zasshi. 1991 Jan 15;32(1):67–71. Oxford A, Raistrick H, Simonart P. Studies In The Biochemistry Of Micro-Organisms: Griseofulvin, C(17)H(17)O(6)Cl, A Metabolic Product Of Penicillium Griseo-Fulvum Dierckx. Biochem J [Internet]. 1939 Feb 1 [Cited 2023 Jan 24];33(2):240–8. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/16746904/ Nall Eg. Biochemical Studies On The Metabolism Of Griseofulvin. Ama Arch Derm [Internet]. 1960 May 1 Available From: Https://Jamanetwork.Com/Journals/Jamadermatology/Fullarticle/526226 Di Williams. Oral Treatment Of Ringworm With Griseofulvin. 1958 [Internet]. Available From: Https://Sci-Hub.Ru/10.1016/S0140-6736(58)92363-8 Perea S, Fothergill Aw, Sutton Da, Rinaldi Mg. Comparison Of In Vitro Activities Of Voriconazole And Five Established Antifungal Agents Against Different Species Of Dermatophytes Using A Broth Macrodilution Method. J Clin Microbiol [Internet]. 2001 Available From: Https://Journals.Asm.Org/Doi/10.1128/Jcm.39.1.385-388.2001 Hofbauer B, Leitner I, Ryder Ns. In Vitro Susceptibility Of Microsporum Canis And Other Dermatophyte Isolates From Veterinary Infections During Therapy With Terbinafine Or Griseofulvin. Med Mycol [Internet]. 2002 [Cited 2023 Jan 25];40(2):179–83. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/12058731/ J. Riviere, M. Papich. (Pdf) Veterinary Pharmacology And Therapeutics- [Internet]. Vet Help - Academia.Edu. 2017 [Cited 2023 May 8]. Available From: Https://Www.Academia.Edu/45666571/Veterinary_Pharmacology_And_Therapeutics_J_Riviere_M_Papich Luis J, Cossio R. Falla Terapeutica De Dermatofitosis Canina Y Felina. Escuela Universitaria Posgrado Facultad Ciencias Veterinarias. 2021 Vanden Bossche H, Engelen M, Rochette F. Antifungal Agents Of Use In Animal Health – Chemical, Biochemical And Pharmacological Aspects. J Vet Pharmacol Ther [Internet]. 2003 . Available From: Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1046/J.1365-2885.2003.00456.X Cabañes Fj. Micosis Y Zoonosis: Cryptococcus Spp. Rev Iberoam Micol. 2008 Mar 1;25(1):S1–3. Inga Villanueva Cm. Tintura De Ajo (Allium Sativum) Como Tratamiento De Dermatofitosis En Perros (Canis Lupus Familiaris). 2014 Available From: Https://Repositorio.Uap.Edu.Pe/Xmlui/Handle/20.500.12990/2451 Wildfeuer, H, Seid, I, Paule A, Haberreiter. In Vitroevaluation Of Voriconazole Against Clinical Isolates Of Yeasts, Moulds And Dermatophytes In Comparison With Itraconazole, Ketoconazole, Amphotericin B And Griseofulvin. [Internet]. 2015 .Available From: Https://Sci-Hub.Ru/10.1111/J.1439-0507.1998.Tb00344.X Concepción R., Castro L, Martínez S. Artículos De Revisión Efectos Terapéuticos Del Ajo (Allium Sativum). 2016 Yang C, Li L, Yang L, Lu H, Wang S, Sun G. Anti-Obesity And Hypolipidemic Effects Of Garlic Oil And Onion Oil In Rats Fed A High-Fat Diet. Nutr Metab (Lond) [Internet]. 2018 Jun 20 Available From: Https://Nutritionandmetabolism.Biomedcentral.Com/Articles/10.1186/S12986-018-0275-X Gail Mh, You Wc. A Factorial Trial Including Garlic Supplements Assesses Effect In Reducing Precancerous Gastric Lesions. J Nutr [Internet]. 2006 |
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Plazas Hernández, Fernely AugustoMorales Garzón , Lizeth Pauline2023-07-19T14:12:42Z2023-07-19T14:12:42Z2023-07-18https://hdl.handle.net/20.500.12494/52088Morales Garzón, L. P. (2023). Discusión frente a la terapéutica tópica y sistémica en dermatofitosis canina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/52088La dermatofitosis es una de las enfermedades infectocontagiosas más importantes y frecuentes que se presentan en clínicas veterinarias, la cual afecta los tejidos queratinizados, uñas, pelo y estrato corneo de la piel. La mayor parte de los casos son causados por los géneros Microsporum y Trichophyton, de acuerdo con su habitad se clasifican como antropofílicos, geofílicos o zoofílicos. Esta patología se transmite por contacto directo con un animal infectado o por fómites, produce descamación, alopecia, enrojecimiento e inflamación. La dermatofitosis es catalogada como una enfermedad zoonótica, es decir que puede infectar al humano. Existen diferentes tratamientos para combatir la dermatofitosis y recopilando la perspectiva de diferentes autores, incluyendo estudios y experimentos realizados a través de los años, comparando y confrontando sus diferentes hipótesis. Varios autores están de acuerdo que principalmente se debe tener en cuenta la especie, los factores de virulencia de la cepa y factores en el huésped (edad, genética, microclima de la piel y enfermedades) para llegar a un adecuado tratamiento, así mismo elegir entre una terapéutica tópica, sistémica o una combinación de ambas. La griseofulvina es uno de los fungistáticos más usados sistémicamente en medicina veterinaria, seguido por el ketoconazol e itraconazol, A su vez los antifúngicos tópicos más relevantes son Enilconazol, azufre de cal y clorhexidina.Dermatophytosis is one of the most important and frequent infectious diseases that occur in veterinary clinics, which affects keratinized tissues, nails, hair, and the stratum corneum of the skin. Most of the cases are caused by the genera Microsporum and Trichophyton, according to their habitat they are classified as anthropophilic, geophilic or zoophilic. This pathology is transmitted by direct contact with an infected animal or by fomites, it produces desquamation, alopecia, redness and inflammation. Dermatophytosis is classified as a zoonotic disease, that is, it can infect humans. There are different treatments to combat dermatophytosis and compiling the perspective of different authors, including studies and experiments carried out over the years, comparing and confronting their different hypotheses. Several authors agree that the species, the virulence factors of the strain and factors in the host (age, genetics, skin microclimate and diseases) must be taken into account in order to arrive at an adequate treatment, as well as choose between a topical, systemic therapy or a combination of both. Griseofulvin is one of the most systemically used fungistatic in veterinary medicine, followed by ketoconazole and itraconazole. In turn, the most relevant topical antifungals are Enilconazole, lime sulfur, chlorhexidine.Resumen. -- Introducción. -- Etiología. -- Discusión Frente A La Terapéutica. -- Conclusiones. -- Referencias.lizeth.moralesg@campusucc.edu.co19 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéDermatofitosisTratamientoTópicoSistémicoAntifúngicosTG 2023 MVZ 52088TreatmentDermatophytosisTopicSystemicAntifungalsDiscusión frente a la terapeutica topica y sistemica en dermatofitosis caninaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Romero C, González M. Actualidades de la dermatofitosis en perros y gatos. vanguardia veterinaria; 2022. [internet] https://Www.Vanguardiaveterinaria.Com.Mx/Dermatofitosis-En-Perros-Y-GatosInstituto for internacional dermatofitosis. The center for food security & public Healt ;2005.Molina D. Aspectos clínicos, diagnósticos y terapéuticos de las dermatofitosis. Enferm Infecc Microbiol Clin; 2011.Boehm T., Mueller R; Dermatophytosis In dogs and cats an update. 2019 Aug 21 Available From: Https://Europepmc.Org/Article/Med/31434126Cruz C.; Importancia Zoonótica De Las Dermatofitosis En Caninos Y Felinos; 2012 Available From: Https://Repository.Javeriana.Edu.Co/Handle/10554/10379Rómulo R, Zamora Z, Fernández L. Los Dermatofitos una amenaza zoonótica, Características Generales, Aspectos Clínicos Para Cada Especie; Revista Cenic Ciencias Biológicas. 2022 Available From: Http://Scielo.Sld.Cu/Scielo.Php?Script=Sci_Arttext&Pid=S2221-24502022000100020Moriello K, Coyner K, Paterson S, Mignon B.; Diagnosis and treatment of dermatophytosis In dogs And Cats. ;2017 Jun 1 Available From: Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1111/Vde.12440Duclos D. Dermatophytosis. Bsava Manual Of Canine And Feline Dermatology ;2012 Available From: Https://Www.Bsavalibrary.Com/Content/Chapter/10.22233/9781905319886.Chap24Gnat S, Łagowski D, Nowakiewicz A, Osińska M, Kopiński Ł. population differentiation, antifungal susceptibility, and Host range of trichophyton mentagrophytes isolates causing recalcitrant infections in humans and animals. available From: Https://Doi.Org/10.1007/S10096-020-03952-2Valdivia L. La dermatofitosis: Clínica, Diagnóstico Y Tratamiento [Internet]. Dermatol Peru . 2003 [Cited 2023 Jan 22]. Available From: Https://Sisbib.Unmsm.Edu.Pe/Bvrevistas/Dermatologia/V13_N1/Derma_Clini.HtmVelandia M. Dermatophytoses In Dogs And Cats | Today’s Veterinary Practice 2017 [Internet]. Available From: Https://Todaysveterinarypractice.Com/Dermatology/Dermatophytoses-In-Dogs-And-Cats/Harvey R, Mckeever P. Enfermedades De La Piel En Perro Y Gato. GRASS Edicions. 2001Mattei A, Beber M, Madrid I. Dermatophytosis In Small Animals. 2014 [Cited 2017]; Available From: Www.Symbiosisonline. Orgwww.Symbiosisonlinepublishing.ComMoriello K. Feline Dermatophytosis: Aspects pertinent to disease management In Single And multiple Cat situations [Internet]. journal of feline medicine and surgery 2014 [Cited 2022May 8]. Available From: Https://Sci-Hub.Se/10.1177/1098612x14530215Esccap. Control De Las Micosis Superficiales En Perros Y Gatos. Guía Esccap No 2 (1a Edición). 2015Costa M, Passos X, Hasimoto E, Souza L, Miranda A, Lemos J , Oliveira J. Epidemiologia etiologia das dermatofitoses em goiânia, go, Brasil. Rev Soc Bras Med Trop [Internet]. 2002 [Cited 2023 Jan 25];35(1):19–22. Available From: Http://Www.Scielo.Br/J/Rsbmt/A/Kmqywh48l9xqj84yrynw4wj/Abstract/?Lang=PtViguié-Vallanet C, Paugam A, Blasco M. Sección Permanente Latinoamericana Dermatofitos Transmitidos Por Animales. 2016Greene C. Veterinary Quarterly Diagnosis, Therapy, And Prevention Of Common Infectious Diseases In The Dog. [Cited 2021 Jun 10]; Available From: Https://Www.Tandfonline.Com/Action/Journalinformation?Journalcode=Tveq20Bond R, Middleton D, Scarff D, Lamport A. Chronic Dermatophytosis Due To Microsporum Persicolor Infection In Three Dogs. Journal Of Small Animal Practice [Internet]. 1992 Dec 1. Available From: Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1111/J.1748-5827.1992.Tb01059.XUribe P, Cardona N. Mecanismos De Adherencia E Invasión De Dermatofitos A La Piel. Ces Medicina [Internet]. 2013 [Cited 2023 Jan 25];27(1):67–75. Available From: Http://Www.Scielo.Org.Co/Scielo.Php?Script=Sci_Arttext&Pid=S0120-87052013000100007&Lng=En&Nrm=Iso&Tlng=EsWhite-Weithers N, Medleau L. Evaluation Of Topical Therapies For The Treatment Of Dermatophyte-Infected Hairs From Dogs And Cats. J Am Anim Hosp Assoc [Internet]. 1995 [Cited 2023 Jan 25];31(3):250–3. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/7634061/Carlotti D. Veterinary Quarterly Canine And Feline Superficial Fungal Skin Infections. [Cited 2023 Jan 23]; Available From: Https://Www.Tandfonline.Com/Action/Journalinformation?Journalcode=Tveq20Nam H, Kim T, Han S, Hyun C. Evaluation of therapeutic efficacy of medical shampoo containing terbinafine hydrochloride and chlorhexidine In dogs With dermatophytosis complicated with bacterial Infection. J Biomed Res [Internet]. 2013 [Cited 2023 Jan 24];154–9. Available From: Http://Dx.Doi.Org/Márquez S. Cambios Entransaminasas hepáticas inducidas por ketoconazol en tratamiento de dermatofitosis en canis familiaris,distrito de trujillo. Universidad privada Antenor Orrego facultad de ciencias agrariasescuela profesional de Medicina veterinaria y zootecnia. 2016Da Costa B, Pippi B, Berlitz S, Carvalho A, Teixeira M, Külkamp-Guerreiro I. Evaluation of activity and toxicity of combining clioquinol with ciclopirox and terbinafine in alternative models of dermatophytosis. mycoses [Internet]. 2021 Jul Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/33772895/D Thienpont. Ketoconazole in experimental candidosis. 1980 [Internet]. [Cited 2023 Jan 25]. Available From: Https://Www.Jstor.Org/Stable/4452462De Keyser H, Van Den Brande M. Veterinary Quarterly Ketoconazole In The Treatment Of Dermatomycosis In Cats And Dogs. [Cited 2023 Jan 24]; Available From: Https://Www.Tandfonline.Com/Action/Journalinformation?Journalcode=Tveq20Mejia M, Bedoya G. Descripción de la eficacia del extracto de anamú (Petiveria Alliacea) para el tratamiento antifúngico (Dermatofitosis Canina).Avepa formacion continuada. problemas dermatológicos “Evitemos Caer En La Rutina.” 2013.Grant S, Clissold S. Itraconazole. A Review Of Its Pharmacodynamic And Pharmacokinetic Properties, And Therapeutic Use In Superficial And Systemic Mycoses. Drugs. 1989Willems L, Van Der Geest R, De Beule K. Itraconazole Oral Solution And Intravenous Formulations: A Review Of Pharmacokinetics And Pharmacodynamics. J Clin Pharm Ther [Internet]. 2001 [Cited 2023 Jan 24];26(3):159–69. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/11422598Mawby D, Whittemore J, Genger S, Papich M. Bioequivalence Of Orally Administered Generic, Compounded, And Innovator-Formulated Itraconazole In Healthy Dogs. J Vet Intern Med. 2014;28(1):72–7Sun D, Kang E, Beom Ss, Jun H, Lee Sh, Lee Kc, Et Al. Interspecies Comparison Of The Oral Absorption Of Itraconazole In Laboratory Animals. Arch Pharm Res [Internet]. 2002 Jun 30 [Cited 2023 Jan 24];25(3):387–91. Available From: Https://Link.Springer.Com/Article/10.1007/Bf02976644Legendre A, Rohrbach B, Toal R, Rinaldi M, Grace L, Jones J. Treatment Of Blastomycosis With Itraconazole In 112 Dogs. J Vet Intern Med [Internet]. 1996 [Cited 2023 Jan 24];10(6):365–71. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/8947868/Van Cauteren H, Heykants J, De Coster R, Cauwenbergh G. Itraconazole: Pharmacologic Studies In Animals And Humans. Rev Infect Dis [Internet]. 1987 [Cited 2023 Jan 24];9 Suppl 1. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/3027845/Yamada C, Hasegawa A, Pal M, Ono K, Kitamura C, Takahashi H. Trichophyton Rubrum Infection In A Dog. Nippon Ishinkin Gakkai Zasshi. 1991 Jan 15;32(1):67–71.Oxford A, Raistrick H, Simonart P. Studies In The Biochemistry Of Micro-Organisms: Griseofulvin, C(17)H(17)O(6)Cl, A Metabolic Product Of Penicillium Griseo-Fulvum Dierckx. Biochem J [Internet]. 1939 Feb 1 [Cited 2023 Jan 24];33(2):240–8. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/16746904/Nall Eg. Biochemical Studies On The Metabolism Of Griseofulvin. Ama Arch Derm [Internet]. 1960 May 1 Available From: Https://Jamanetwork.Com/Journals/Jamadermatology/Fullarticle/526226Di Williams. Oral Treatment Of Ringworm With Griseofulvin. 1958 [Internet]. Available From: Https://Sci-Hub.Ru/10.1016/S0140-6736(58)92363-8Perea S, Fothergill Aw, Sutton Da, Rinaldi Mg. Comparison Of In Vitro Activities Of Voriconazole And Five Established Antifungal Agents Against Different Species Of Dermatophytes Using A Broth Macrodilution Method. J Clin Microbiol [Internet]. 2001 Available From: Https://Journals.Asm.Org/Doi/10.1128/Jcm.39.1.385-388.2001Hofbauer B, Leitner I, Ryder Ns. In Vitro Susceptibility Of Microsporum Canis And Other Dermatophyte Isolates From Veterinary Infections During Therapy With Terbinafine Or Griseofulvin. Med Mycol [Internet]. 2002 [Cited 2023 Jan 25];40(2):179–83. Available From: Https://Pubmed.Ncbi.Nlm.Nih.Gov/12058731/J. Riviere, M. Papich. (Pdf) Veterinary Pharmacology And Therapeutics- [Internet]. Vet Help - Academia.Edu. 2017 [Cited 2023 May 8]. Available From: Https://Www.Academia.Edu/45666571/Veterinary_Pharmacology_And_Therapeutics_J_Riviere_M_PapichLuis J, Cossio R. Falla Terapeutica De Dermatofitosis Canina Y Felina. Escuela Universitaria Posgrado Facultad Ciencias Veterinarias. 2021Vanden Bossche H, Engelen M, Rochette F. Antifungal Agents Of Use In Animal Health – Chemical, Biochemical And Pharmacological Aspects. J Vet Pharmacol Ther [Internet]. 2003 . Available From: Https://Onlinelibrary.Wiley.Com/Doi/Full/10.1046/J.1365-2885.2003.00456.XCabañes Fj. Micosis Y Zoonosis: Cryptococcus Spp. Rev Iberoam Micol. 2008 Mar 1;25(1):S1–3.Inga Villanueva Cm. Tintura De Ajo (Allium Sativum) Como Tratamiento De Dermatofitosis En Perros (Canis Lupus Familiaris). 2014 Available From: Https://Repositorio.Uap.Edu.Pe/Xmlui/Handle/20.500.12990/2451Wildfeuer, H, Seid, I, Paule A, Haberreiter. In Vitroevaluation Of Voriconazole Against Clinical Isolates Of Yeasts, Moulds And Dermatophytes In Comparison With Itraconazole, Ketoconazole, Amphotericin B And Griseofulvin. [Internet]. 2015 .Available From: Https://Sci-Hub.Ru/10.1111/J.1439-0507.1998.Tb00344.XConcepción R., Castro L, Martínez S. Artículos De Revisión Efectos Terapéuticos Del Ajo (Allium Sativum). 2016Yang C, Li L, Yang L, Lu H, Wang S, Sun G. Anti-Obesity And Hypolipidemic Effects Of Garlic Oil And Onion Oil In Rats Fed A High-Fat Diet. Nutr Metab (Lond) [Internet]. 2018 Jun 20 Available From: Https://Nutritionandmetabolism.Biomedcentral.Com/Articles/10.1186/S12986-018-0275-XGail Mh, You Wc. A Factorial Trial Including Garlic Supplements Assesses Effect In Reducing Precancerous Gastric Lesions. 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