Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia
Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural communities and...
- Autores:
-
Murillo Solano, Claribel
López Domínguez, Jaime
Gongora, Rafael
Rojas Gulloso, Andrés Camilo
Usme Ciro, José Aldemar
Perdomo Balaguera, Erick
Herrera, Claudia
Parra Henao, Gabriel
Dumonteil, Eric
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/45596
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/45596
- Palabra clave:
- Trypanosoma
Microbioma
Triatoma
Colombia
Trypanosoma
Microbioma
Triatoma
Colombia
- Rights
- openAccess
- License
- Atribución
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| dc.title.spa.fl_str_mv |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| title |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| spellingShingle |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia Trypanosoma Microbioma Triatoma Colombia Trypanosoma Microbioma Triatoma Colombia |
| title_short |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| title_full |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| title_fullStr |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| title_full_unstemmed |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| title_sort |
Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia |
| dc.creator.fl_str_mv |
Murillo Solano, Claribel López Domínguez, Jaime Gongora, Rafael Rojas Gulloso, Andrés Camilo Usme Ciro, José Aldemar Perdomo Balaguera, Erick Herrera, Claudia Parra Henao, Gabriel Dumonteil, Eric |
| dc.contributor.author.none.fl_str_mv |
Murillo Solano, Claribel López Domínguez, Jaime Gongora, Rafael Rojas Gulloso, Andrés Camilo Usme Ciro, José Aldemar Perdomo Balaguera, Erick Herrera, Claudia Parra Henao, Gabriel Dumonteil, Eric |
| dc.subject.spa.fl_str_mv |
Trypanosoma Microbioma Triatoma Colombia |
| topic |
Trypanosoma Microbioma Triatoma Colombia Trypanosoma Microbioma Triatoma Colombia |
| dc.subject.other.spa.fl_str_mv |
Trypanosoma Microbioma Triatoma Colombia |
| description |
Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural communities and analyzed for blood feeding sources, parasite diversity and gut microbiota composition through a metagenomic and deep sequencing approach. Triatoma dimidiata predominated, followed by Rhodnius prolixus, Triatoma maculata, Rhodnius pallescens, Panstrongylus geniculatus and Eratyrus cuspidatus. Twenty-two species were identified as blood sources, resulting in an integrated transmission network with extensive connectivity among sylvatic and domestic host species. Only TcI parasites were detected, predominantly from TcIb but TcIa was also reported. The close relatedness of T. cruzi strains further supported the lack of separate transmission cycles according to habitats or triatomine species. Triatomine microbiota varied according to species, developmental stage and T. cruzi infection. Bacterial families correlated with the presence/absence of T. cruzi were identified. In conclusion, we identified a domestic transmission cycle encompassing multiple vector species and tightly connected with sylvatic hosts in the SNSM region, rather than an isolated domestic transmission cycle. Therefore, integrated interventions targeting all vector species and their contact with humans should be considered. |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021-06-10 |
| dc.date.accessioned.none.fl_str_mv |
2022-07-07T14:01:56Z |
| dc.date.available.none.fl_str_mv |
2022-07-07T14:01:56Z |
| dc.type.none.fl_str_mv |
Artículos Científicos |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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2045-2322 |
| dc.identifier.uri.spa.fl_str_mv |
10.1038/s41598-021-91783-2 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/45596 |
| dc.identifier.bibliographicCitation.spa.fl_str_mv |
Murillo-Solano C, López-Domínguez J, Gongora R, Rojas-Gulloso A, Usme-Ciro J, et al. Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia. Sci Rep. 2021 Jun 10;11(1):12306. doi: 10.1038/s41598-021-91783-2.https://repository.ucc.edu.co/handle/20.500.12494/45596 |
| identifier_str_mv |
2045-2322 10.1038/s41598-021-91783-2 Murillo-Solano C, López-Domínguez J, Gongora R, Rojas-Gulloso A, Usme-Ciro J, et al. Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia. Sci Rep. 2021 Jun 10;11(1):12306. doi: 10.1038/s41598-021-91783-2.https://repository.ucc.edu.co/handle/20.500.12494/45596 |
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https://hdl.handle.net/20.500.12494/45596 |
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https://www.nature.com/articles/s41598-021-91783-2 |
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Scientific Reports |
| dc.relation.references.spa.fl_str_mv |
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Atribución |
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info:eu-repo/semantics/openAccess |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Marta Richard White |
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Medicina |
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Santa Marta |
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Murillo Solano, ClaribelLópez Domínguez, JaimeGongora, RafaelRojas Gulloso, Andrés CamiloUsme Ciro, José AldemarPerdomo Balaguera, ErickHerrera, ClaudiaParra Henao, GabrielDumonteil, Eric112022-07-07T14:01:56Z2022-07-07T14:01:56Z2021-06-102045-232210.1038/s41598-021-91783-2https://hdl.handle.net/20.500.12494/45596Murillo-Solano C, López-Domínguez J, Gongora R, Rojas-Gulloso A, Usme-Ciro J, et al. Diversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in Colombia. Sci Rep. 2021 Jun 10;11(1):12306. doi: 10.1038/s41598-021-91783-2.https://repository.ucc.edu.co/handle/20.500.12494/45596Chagas disease remains a major neglected disease in Colombia. We aimed to characterize Trypanosoma cruzi transmission networks in the Sierra Nevada de Santa Marta (SNSM) region, to shed light on disease ecology and help optimize control strategies. Triatomines were collected in rural communities and analyzed for blood feeding sources, parasite diversity and gut microbiota composition through a metagenomic and deep sequencing approach. Triatoma dimidiata predominated, followed by Rhodnius prolixus, Triatoma maculata, Rhodnius pallescens, Panstrongylus geniculatus and Eratyrus cuspidatus. Twenty-two species were identified as blood sources, resulting in an integrated transmission network with extensive connectivity among sylvatic and domestic host species. Only TcI parasites were detected, predominantly from TcIb but TcIa was also reported. The close relatedness of T. cruzi strains further supported the lack of separate transmission cycles according to habitats or triatomine species. Triatomine microbiota varied according to species, developmental stage and T. cruzi infection. Bacterial families correlated with the presence/absence of T. cruzi were identified. In conclusion, we identified a domestic transmission cycle encompassing multiple vector species and tightly connected with sylvatic hosts in the SNSM region, rather than an isolated domestic transmission cycle. Therefore, integrated interventions targeting all vector species and their contact with humans should be considered.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000318507https://orcid.org/0000-0002-8093-0544https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000008981jose.usmec@campusucc.edu.cohttps://scholar.google.com.co/citations?user=cU2KyT4AAAAJ&hl=en14Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa MartaRichard WhiteMedicinaSanta Martahttps://www.nature.com/articles/s41598-021-91783-2Scientific ReportsHotez, P. J. et al. An unfolding tragedy of chagas disease in North America. PLoS Negl. Trop. 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Nucleic Acids Res. 42(Database issue), D633–D642. https://doi.org/10.1093/nar/gkt1244 (2014) (PMID: 24288368).TrypanosomaMicrobiomaTriatomaColombiaTrypanosomaMicrobiomaTriatomaColombiaDiversity and interactions among triatomine bugs, their blood feeding sources, gut microbiota and Trypanosoma cruzi in the Sierra Nevada de Santa Marta in ColombiaArtículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/a1fa5ade-11a8-42ab-839b-c4000601fdb1/download8a4605be74aa9ea9d79846c1fba20a33MD54ORIGINAL33. Diversity and interactions among triatomine bugs. Murillo-Solano et al 2021.pdf33. Diversity and interactions among triatomine bugs. 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