Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales

Ehrlichia canis es el patógeno más común detectado en perros domésticos y se ha considerado un agente cosmopolita predominando en áreas tropicales y subtropicales. Los hemopatógenos son de los agentes más importantes en la salud canina y en los últimos años, la ehrlichiosis se ha expandido a nuevas...

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Autores:
Rodríguez González, Andrés Camilo
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
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oai:repository.ucc.edu.co:20.500.12494/53005
Acceso en línea:
https://hdl.handle.net/20.500.12494/53005
Palabra clave:
Erlichiosis
Hemoparasitos
Doxiciclina
Monocitos
TG 2023 MVZ 53005
Erlichiosis
Hemoparasites
Doxycycline
Monocytes
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openAccess
License
Atribución
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network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.none.fl_str_mv Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
title Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
spellingShingle Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
Erlichiosis
Hemoparasitos
Doxiciclina
Monocitos
TG 2023 MVZ 53005
Erlichiosis
Hemoparasites
Doxycycline
Monocytes
title_short Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
title_full Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
title_fullStr Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
title_full_unstemmed Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
title_sort Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales
dc.creator.fl_str_mv Rodríguez González, Andrés Camilo
dc.contributor.advisor.none.fl_str_mv Trujillo Piso, Dunia Yisela
dc.contributor.author.none.fl_str_mv Rodríguez González, Andrés Camilo
dc.subject.none.fl_str_mv Erlichiosis
Hemoparasitos
Doxiciclina
Monocitos
topic Erlichiosis
Hemoparasitos
Doxiciclina
Monocitos
TG 2023 MVZ 53005
Erlichiosis
Hemoparasites
Doxycycline
Monocytes
dc.subject.classification.none.fl_str_mv TG 2023 MVZ 53005
dc.subject.other.none.fl_str_mv Erlichiosis
Hemoparasites
Doxycycline
Monocytes
description Ehrlichia canis es el patógeno más común detectado en perros domésticos y se ha considerado un agente cosmopolita predominando en áreas tropicales y subtropicales. Los hemopatógenos son de los agentes más importantes en la salud canina y en los últimos años, la ehrlichiosis se ha expandido a nuevas regiones. Ehrlichia canis está distribuida globalmente e infecta los monocitos y provoca complicaciones hematológicas asociadas a signos clínicos que pueden llegar a ser graves y en ocasiones mortales. La doxiciclina ha sido el antibiótico utilizado en medicina veterinaria en cualquier etapa de la enfermedad y se ha usado por más de 40 años. Los animales de compañía desempeñan un papel clave al actuar como reservorios y centinelas competentes y existe una gran preocupación mundial con respecto al creciente espectro de enfermedades transmitidas por garrapatas que afectan animales y humanos. El diagnostico se basa en la detección del patógeno y la serología ha tomado una gran importancia y ha permitido un diagnóstico más seguro y con alta especificidad en el patógeno.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-10-17T16:37:56Z
dc.date.available.none.fl_str_mv 2023-10-17T16:37:56Z
dc.date.issued.none.fl_str_mv 2023-10-14
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/53005
dc.identifier.bibliographicCitation.none.fl_str_mv Rodriguez Gonzalez, A. C. (2023). Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales. [Tesis de pregrado, Universidad Cooperative de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/53005
url https://hdl.handle.net/20.500.12494/53005
identifier_str_mv Rodriguez Gonzalez, A. C. (2023). Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales. [Tesis de pregrado, Universidad Cooperative de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/53005
dc.relation.references.none.fl_str_mv Aziz MU, Hussain S, Song B, Ghauri HN, Zeb J, Sparagano OA. Ehrlichiosis in Dogs: A Comprehensive Review about the Pathogen and Its Vectors with Emphasis on South and East Asian Countries. Vet Sci. 2023;10(1).
Kottadamane MR, Dhaliwal PS, Singla L Das, Bansal BK, Uppal SK. Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of punjab. Vet World. 2017;10(2):255–61.
Angkanaporn K, Sanguanwai J, Baiyokvichit TO, Vorrachotvarittorn P, Wongsompong M, Sukhumavasi W. Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes. Vet World. 2022;15(1):1–9.
Ybañez RHD, Ybañez AP, Arnado LLA, Belarmino LMP, Malingin KGF, Cabilete PBC, et al. Detection of Ehrlichia, Anaplasma, and Babesia spp. in dogs in Cebu, Philippines. Vet World. 2018;11(1):14–9.
Piratae S, Senawong P, Chalermchat P, Harnarsa W, Sae-Chue B. Molecular evidence of Ehrlichia canis and Anaplasma platys and the association of infections with hematological responses in naturally infected dogs in Kalasin, Thailand. Vet World. 2019;12(1):131–5.
Pérez-Macchi S, Pedrozo R, Bittencourt P, Müller A. Prevalence, molecular characterization and risk factor analysis of Ehrlichia canis and Anaplasma platys in domestic dogs from Paraguay. Comp Immunol Microbiol Infect Dis [Internet]. 2019;62:31–9. Available from: https://doi.org/10.1016/j.cimid.2018.11.015
Dahmani M, Loudahi A, Mediannikov O, Fenollar F, Raoult D, Davoust B. Molecular detection of Anaplasma platys and Ehrlichia canis in dogs from Kabylie, Algeria. Ticks Tick Borne Dis [Internet]. 2015;6(2):198–203. Available from: http://dx.doi.org/10.1016/j.ttbdis.2014.12.007
Sainz Á, Roura X, Miró G, Estrada-Peña A, Kohn B, Harrus S, et al. Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. Parasites and Vectors. 2015;8(1):1–20.
Pradesh U, Rajesh Kumar Assistant Professor I, Corresponding Author I, Kumar Assistant Professor R, Kumar R, Verma H, et al. Canine ehrlichiosis: A review. ~ 1849 ~ J Entomol Zool Stud [Internet]. 2020;8(2):1849–52. Available from: http://www.entomoljournal.com
Rubio CP, Yilmaz Z, Martínez-Subiela S, Kocaturk M, Hernández-Ruiz J, Yalcin E, et al. Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. Res Vet Sci [Internet]. 2017;115(April):301–6. Available from: http://dx.doi.org/10.1016/j.rvsc.2017.06.004
Di Dona F, Gomes SA, Andriuc RA, Garosi LS, Tauro A. Magnetic resonance findings of meningoencephalitis in a dog seroreactive to Ehrlichia canis in United Kingdom. Vet Rec Case Reports. 2021;9(1).
Palacios M, Arteaga R, Calvo G. High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. Top Companion Anim Med [Internet]. 2017;32(1):28–30. Available from:http://dx.doi.org/10.1053/j.tcam.2017.05.005
Pugliese M, Biondi V, Merola G, Landi A, Passantino A. Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis. Antioxidants. 2022;11(2):1–8.
Asawapattanakul T, Pintapagung T, Piratae S, Juntautsa S, Chancharoen P. Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis. Vet World. 2021;14(9):2325–31.
Rondelli MCH, Munhoz TD, Catandi PB, Freschi CR, Palacios Junior RJG, Machado RZ, et al. Acute and subclinical Ehrlichia canis infection and cortisol response to ACTH stimulation test. Brazilian J Vet Pathol. 2015;8(2):46–50
Dubie T, Mohammed Y, Terefe G, Muktar Y, Tesfaye J. An insight review on canine ehrlichiosis with emphasis on its epidemiology and pathogenesity importance. Glob J Vet Med Res. 2014;2(4):059–67.
Do Rosário CJRM, da Rocha CQ, de Aguiar DM, Lima CAA, Coutinho DF, Melo FA. Anti-ehrlichia properties of the dichloromethane fraction of Ageratum conyzoides associated with doxycycline: In vitro study. Cienc Rural. 2021;51(10).
Santiago Monsalve B, Vanessa Gallego L, Molina VM, Juan Rodas G. Pharmacokinetics and Adverse Effects of Doxycycline in the Treatment of Ehrlichiosis: Theoretical Foundations for Clinical Trials in Canines. Rev MVZ Cordoba. 2017;22:6062–74.
Maiti SK, Thawait VK, Raghuvansi PDS, Dixit A, Naik BS. Therapeutic management of canine ehrlichiosis in a Labrador bitch. Haryana Vet [Internet]. 2014;53(1):74–5. Available from: http://www.luvas.edu.in/download/harvet2014/17.pdf
Eddlestone SM, Diniz PPVP, Neer TM, Gaunt SD, Corstvet R, Cho D, et al. Doxycycline clearance of experimentally induced chronic Ehrlichia canis infection in dogs. J Vet Intern Med. 2007;21(6):1237–42.
Eddleslone SM, Neer TM, Gaunt SD, Corstvet R, Gill A, Hosgood G, et al. Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs. J Vet Intern Med. 2006;20(4):840–4.
Rao LN, Shobhamani B, Rao V, Subramanyam K V. Comparative efficacy of doxycycline and imidocarb diprionate in treatment of ehrlichiosis in dogs. ~ 1304 ~ Pharma Innov J [Internet]. 2022;11(4):1304–9. Available from: http://www.thepharmajournal.com
Mylonakis ME, Harrus S, Breitschwerdt EB. An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). Vet J [Internet]. 2019;246:45–53. Available from: https://doi.org/10.1016/j.tvjl.2019.01.015
Jenkins S, Ketzis JK, Dundas J, Scorpio D. Efficacy of Minocycline in Naturally Occurring Nonacute Ehrlichia canis Infection in Dogs. J Vet Intern Med. 2018;32(1):217–21.
da Silva A de CT, Dos Santos JRS, da Silva RMN, de Santana VL, Martins FS de M, Falcão BMR, et al. Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis. Cienc Rural. 2021;51(3):1–9.
Miranda EA, Han SW, Rim JM, Cho YK, Choi KS, Chae JS. Serological evidence of Anaplasma spp., Borrelia burgdorferi and Ehrlichia canis in dogs from the Republic of Korea by rapid diagnostic test kits. J Vet Sci. 2022;23(2):4–11.
Cabrera-Jaramillo A, Monsalve S, Arroyave E, Rodas JD. Prevalence of Ehrlichia canis and Hepatozoon canis in sheltered dogs in southern Aburrá Valley, Colombia. Rev Colomb Ciencias Pecu. 2022;35(2):82–92
García L, Escarcega A, Ramírez M, Manzanera D, Guevara E, Vaquera M, et al. Immune Monitoring of Paediatric Patients Infected with. Pathogens. 2022;11(1351):18.
Mircean V, Dumitrache MO, Györke A, Pantchev N, Jodies R, Mihalca AD, et al. Seroprevalence and geographic distribution of Dirofilaria immitis and tick-borne infections (Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, and Ehrlichia canis) in dogs from Romania. Vector-Borne Zoonotic Dis. 2012;12(7):595–604.
Chirag M Bhadesiya. Correlation of epidemiology of Rhipicephalus sanguineus and canine ehrlichiosis in nine different localities. Int J Agric Sci Vet medivine. 2015;3:34–5.
Mittal M, Kundu K, Chakravarti S, Mohapatra JK, Nehra K, Sinha VK, et al. Canine Monocytic Ehrlichiosis among working dogs of organised kennels in India: A comprehensive analyses of clinico-pathology, serological and molecular epidemiological approach. Prev Vet Med [Internet]. 2017;147:26–33. Available from: http://dx.doi.org/10.1016/j.prevetmed.2017.08.012
Zhang J, Liu Q, Wang D, Li W, Beugnet F, Zhou J. Epidemiological survey of ticks and tick-borne pathogens in pet dogs in south-eastern China. Parasite. 2017;24.
Brites-Neto J, Duarte KMR, Martins TF. Tick-borne infections in human and animal population worldwide. Vet World. 2015;8(3):301–15.
Motaghipisheh S, Akhtardanesh B, Ghanbarpour R, Aflatoonian MR, Khalili M, Nourollahifard SR, et al. Ehrlichiosis in household dogs and parasitized ticks in Kerman-Iran: Preliminary zoonotic risk assessment. J Arthropod Borne Dis. 2016;10(2):246–52
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spelling Trujillo Piso, Dunia YiselaRodríguez González, Andrés Camilo2023-10-17T16:37:56Z2023-10-17T16:37:56Z2023-10-14https://hdl.handle.net/20.500.12494/53005Rodriguez Gonzalez, A. C. (2023). Dinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animales. [Tesis de pregrado, Universidad Cooperative de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/53005Ehrlichia canis es el patógeno más común detectado en perros domésticos y se ha considerado un agente cosmopolita predominando en áreas tropicales y subtropicales. Los hemopatógenos son de los agentes más importantes en la salud canina y en los últimos años, la ehrlichiosis se ha expandido a nuevas regiones. Ehrlichia canis está distribuida globalmente e infecta los monocitos y provoca complicaciones hematológicas asociadas a signos clínicos que pueden llegar a ser graves y en ocasiones mortales. La doxiciclina ha sido el antibiótico utilizado en medicina veterinaria en cualquier etapa de la enfermedad y se ha usado por más de 40 años. Los animales de compañía desempeñan un papel clave al actuar como reservorios y centinelas competentes y existe una gran preocupación mundial con respecto al creciente espectro de enfermedades transmitidas por garrapatas que afectan animales y humanos. El diagnostico se basa en la detección del patógeno y la serología ha tomado una gran importancia y ha permitido un diagnóstico más seguro y con alta especificidad en el patógeno.Ehrlichia canis is the most common pathogen detected in domestic dogs and has been considered a cosmopolitan agent predominating in tropical and subtropical areas. Hemopathogens are among the most important agents in canine health and in recent years, ehrlichiosis has expanded to new regions that were thought to be free of the disease. Ehrlichia canis is distributed globally and infects monocytes and causes hematological complications associated with clinical signs that can be serious and sometimes fatal. Doxycycline has been the antibiotic used in veterinary medicine at any stage of the disease and has been used for more than 40 years. Companion animals play a key role in acting as reservoirs and competent sentinels and there is great global concern regarding the growing spectrum of tick-borne diseases affecting animals and humans. The diagnosis is based on the detection of the pathogen and serology has taken on great importance and has allowed a safer diagnosis with high specificity in the pathogen.Resumen. -- Objetivo. -- Abtract. -- Introducción. -- Infección y dinámica del patógeno. -- Manejo y soporte terapéutico. -- Importancia en la medicina veterinaria. -- Conclusiones. -- Referencias bibliográficas.andres.rodriguezgo@campusucc.edu.co14 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéErlichiosisHemoparasitosDoxiciclinaMonocitosTG 2023 MVZ 53005ErlichiosisHemoparasitesDoxycyclineMonocytesDinamismo de la Ehrlichiosis Canina y su manejo terapéutico en la medicina de pequeños animalesTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Aziz MU, Hussain S, Song B, Ghauri HN, Zeb J, Sparagano OA. Ehrlichiosis in Dogs: A Comprehensive Review about the Pathogen and Its Vectors with Emphasis on South and East Asian Countries. Vet Sci. 2023;10(1).Kottadamane MR, Dhaliwal PS, Singla L Das, Bansal BK, Uppal SK. Clinical and hematobiochemical response in canine monocytic ehrlichiosis seropositive dogs of punjab. Vet World. 2017;10(2):255–61.Angkanaporn K, Sanguanwai J, Baiyokvichit TO, Vorrachotvarittorn P, Wongsompong M, Sukhumavasi W. Retrospective analysis of canine monocytic ehrlichiosis in Thailand with emphasis on hematological and ultrasonographic changes. Vet World. 2022;15(1):1–9.Ybañez RHD, Ybañez AP, Arnado LLA, Belarmino LMP, Malingin KGF, Cabilete PBC, et al. Detection of Ehrlichia, Anaplasma, and Babesia spp. in dogs in Cebu, Philippines. Vet World. 2018;11(1):14–9.Piratae S, Senawong P, Chalermchat P, Harnarsa W, Sae-Chue B. Molecular evidence of Ehrlichia canis and Anaplasma platys and the association of infections with hematological responses in naturally infected dogs in Kalasin, Thailand. Vet World. 2019;12(1):131–5.Pérez-Macchi S, Pedrozo R, Bittencourt P, Müller A. Prevalence, molecular characterization and risk factor analysis of Ehrlichia canis and Anaplasma platys in domestic dogs from Paraguay. Comp Immunol Microbiol Infect Dis [Internet]. 2019;62:31–9. Available from: https://doi.org/10.1016/j.cimid.2018.11.015Dahmani M, Loudahi A, Mediannikov O, Fenollar F, Raoult D, Davoust B. Molecular detection of Anaplasma platys and Ehrlichia canis in dogs from Kabylie, Algeria. Ticks Tick Borne Dis [Internet]. 2015;6(2):198–203. Available from: http://dx.doi.org/10.1016/j.ttbdis.2014.12.007Sainz Á, Roura X, Miró G, Estrada-Peña A, Kohn B, Harrus S, et al. Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. Parasites and Vectors. 2015;8(1):1–20.Pradesh U, Rajesh Kumar Assistant Professor I, Corresponding Author I, Kumar Assistant Professor R, Kumar R, Verma H, et al. Canine ehrlichiosis: A review. ~ 1849 ~ J Entomol Zool Stud [Internet]. 2020;8(2):1849–52. Available from: http://www.entomoljournal.comRubio CP, Yilmaz Z, Martínez-Subiela S, Kocaturk M, Hernández-Ruiz J, Yalcin E, et al. Serum antioxidant capacity and oxidative damage in clinical and subclinical canine ehrlichiosis. Res Vet Sci [Internet]. 2017;115(April):301–6. Available from: http://dx.doi.org/10.1016/j.rvsc.2017.06.004Di Dona F, Gomes SA, Andriuc RA, Garosi LS, Tauro A. Magnetic resonance findings of meningoencephalitis in a dog seroreactive to Ehrlichia canis in United Kingdom. Vet Rec Case Reports. 2021;9(1).Palacios M, Arteaga R, Calvo G. High-Dose Filgrastim Treatment of Nonregenerative Pancytopenia Associated With Chronic Canine Ehrlichiosis. Top Companion Anim Med [Internet]. 2017;32(1):28–30. Available from:http://dx.doi.org/10.1053/j.tcam.2017.05.005Pugliese M, Biondi V, Merola G, Landi A, Passantino A. Oxidative Stress Evaluation in Dogs Affected with Canine Monocytic Ehrlichiosis. Antioxidants. 2022;11(2):1–8.Asawapattanakul T, Pintapagung T, Piratae S, Juntautsa S, Chancharoen P. Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis. Vet World. 2021;14(9):2325–31.Rondelli MCH, Munhoz TD, Catandi PB, Freschi CR, Palacios Junior RJG, Machado RZ, et al. Acute and subclinical Ehrlichia canis infection and cortisol response to ACTH stimulation test. Brazilian J Vet Pathol. 2015;8(2):46–50Dubie T, Mohammed Y, Terefe G, Muktar Y, Tesfaye J. An insight review on canine ehrlichiosis with emphasis on its epidemiology and pathogenesity importance. Glob J Vet Med Res. 2014;2(4):059–67.Do Rosário CJRM, da Rocha CQ, de Aguiar DM, Lima CAA, Coutinho DF, Melo FA. Anti-ehrlichia properties of the dichloromethane fraction of Ageratum conyzoides associated with doxycycline: In vitro study. Cienc Rural. 2021;51(10).Santiago Monsalve B, Vanessa Gallego L, Molina VM, Juan Rodas G. Pharmacokinetics and Adverse Effects of Doxycycline in the Treatment of Ehrlichiosis: Theoretical Foundations for Clinical Trials in Canines. Rev MVZ Cordoba. 2017;22:6062–74.Maiti SK, Thawait VK, Raghuvansi PDS, Dixit A, Naik BS. Therapeutic management of canine ehrlichiosis in a Labrador bitch. Haryana Vet [Internet]. 2014;53(1):74–5. Available from: http://www.luvas.edu.in/download/harvet2014/17.pdfEddlestone SM, Diniz PPVP, Neer TM, Gaunt SD, Corstvet R, Cho D, et al. Doxycycline clearance of experimentally induced chronic Ehrlichia canis infection in dogs. J Vet Intern Med. 2007;21(6):1237–42.Eddleslone SM, Neer TM, Gaunt SD, Corstvet R, Gill A, Hosgood G, et al. Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs. 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