Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia

La demencia frontotemporal (DFT) es una patología neuropsiquiátrica caracterizada por disfunciones en el lóbulo frontal del cerebro, especialmente en tareas de planificación, ejecución e inhibición, con incapacidad para tomar decisiones y manejar diferentes secuencias, afectando también al lóbulo te...

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Autores:: Vergel Hernández, Juliana
Barrera Robledo, María Eugenia
Hurtado González, Carlos Alberto
Marmolejo Escobar, Carlos Steven
Ospina Otalvaro, Sebastián
Sánchez Tobón, Juan David
Arango de la Pava, Pablo Miguel
Álvarez, Juan José

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2021

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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dc.title.spa.fl_str_mv	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
title	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
spellingShingle	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia Atención Funciones ejecutivas Lóbulo frontal Demencia frontotemporal Temporal frontal Memoria Funcionamiento neurocognitivo Reporte de caso Attention Executive functions Frontal lobe Frontal temporal Frontotemporal dementia Memory Neurocognitive functioning Case report
title_short	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
title_full	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
title_fullStr	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
title_full_unstemmed	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
title_sort	Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia
dc.creator.fl_str_mv	Vergel Hernández, Juliana Barrera Robledo, María Eugenia Hurtado González, Carlos Alberto Marmolejo Escobar, Carlos Steven Ospina Otalvaro, Sebastián Sánchez Tobón, Juan David Arango de la Pava, Pablo Miguel Álvarez, Juan José
dc.contributor.author.none.fl_str_mv	Vergel Hernández, Juliana Barrera Robledo, María Eugenia Hurtado González, Carlos Alberto Marmolejo Escobar, Carlos Steven Ospina Otalvaro, Sebastián Sánchez Tobón, Juan David Arango de la Pava, Pablo Miguel Álvarez, Juan José
dc.subject.spa.fl_str_mv	Atención Funciones ejecutivas Lóbulo frontal Demencia frontotemporal Temporal frontal Memoria Funcionamiento neurocognitivo Reporte de caso
topic	Atención Funciones ejecutivas Lóbulo frontal Demencia frontotemporal Temporal frontal Memoria Funcionamiento neurocognitivo Reporte de caso Attention Executive functions Frontal lobe Frontal temporal Frontotemporal dementia Memory Neurocognitive functioning Case report
dc.subject.other.spa.fl_str_mv	Attention Executive functions Frontal lobe Frontal temporal Frontotemporal dementia Memory Neurocognitive functioning Case report
description	La demencia frontotemporal (DFT) es una patología neuropsiquiátrica caracterizada por disfunciones en el lóbulo frontal del cerebro, especialmente en tareas de planificación, ejecución e inhibición, con incapacidad para tomar decisiones y manejar diferentes secuencias, afectando también al lóbulo temporal. El paciente presenta alteraciones para almacenar, consolidar y recordar información. Estos déficits neurocognitivos se acompañan de trastornos neuroconductuales como depresión, ansiedad y apatía que contribuyen al empeoramiento de la calidad de vida, con un alto impacto a nivel individual, social y familiar. Identificar los trastornos neuroconductuales y deterioro neurocognitivo que presenta un paciente con diagnóstico de DFT: caso clínico de enfermedad de baja incidencia y prevalencia en Colombia. Varón de 40 años, con deterioro progresivo de su memoria verbal inmediata, baja fluidez verbal, conducta motora aberrante, impulsividad sexual, alteraciones en sus funciones ejecutivas, especialmente en la planificación de tareas, toma de decisiones e inhibición. menor grado de afectación en su funcionamiento visuoespacial y habilidades visuoconstructivas. Se encontró que el paciente presenta un síndrome disejecutivo severo asociado a un cuadro clínico de DFT, correlacionado con incapacidad para procesar y recordar información, acompañado de trastornos como depresión, ansiedad y apatía. Es necesario generar un plan de neurorrehabilitación funcional que tenga como objetivo mejorar la calidad de vida de estos pacientes. Del mismo modo, es necesario crear nuevas líneas de investigación e intervención que tengan como finalidad crear un mayor campo de heurísticas o nuevas preguntas en este tipo de patologías neurodegenerativas.
publishDate	2021
dc.date.issued.none.fl_str_mv	2021-07
dc.date.accessioned.none.fl_str_mv	2022-09-28T23:35:15Z
dc.date.available.none.fl_str_mv	2022-09-28T23:35:15Z
dc.type.none.fl_str_mv	Artículos Científicos
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dc.identifier.issn.spa.fl_str_mv	1662680X
dc.identifier.uri.spa.fl_str_mv	10.1159/000513851
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/46541
dc.identifier.bibliographicCitation.spa.fl_str_mv	Vergel Hernández J, Barrera Robledo M, E, Hurtado González C, A, Marmolejo Escobar C, S, Ospina Otalvaro S, Sánchez Tobón J, D, Arango de la Pava P, M, Alvarez J, J: Neuropsychiatric Aspects in a Patient Diagnosed with Frontotemporal Dementia: Clinical Case of Low Incidence and Prevalence Disease in Colombia. Case Rep Neurol 2021;13:451-463. doi: 10.1159/000513851
identifier_str_mv	1662680X 10.1159/000513851 Vergel Hernández J, Barrera Robledo M, E, Hurtado González C, A, Marmolejo Escobar C, S, Ospina Otalvaro S, Sánchez Tobón J, D, Arango de la Pava P, M, Alvarez J, J: Neuropsychiatric Aspects in a Patient Diagnosed with Frontotemporal Dementia: Clinical Case of Low Incidence and Prevalence Disease in Colombia. Case Rep Neurol 2021;13:451-463. doi: 10.1159/000513851
url	https://hdl.handle.net/20.500.12494/46541
dc.relation.isversionof.spa.fl_str_mv	https://www.karger.com/Article/FullText/513851#
dc.relation.ispartofjournal.spa.fl_str_mv	Case Reports in Neurology
dc.relation.references.spa.fl_str_mv	Olney NT, Spina S, Miller BL. Frontotemporal dementia. Neurol Clin. 2017;35(2):339–74 Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz AM, Mendez SF, Cappa JM, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006–14. Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, et al. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain. 2017;140:3329–45 Cheran G, Silverman H, Manoochehri M, Goldman J, Lee S, Wu L, et al. Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers. J Neurol Neurosurg Psychiatry. 2018;89:449–55. Ducharme S, Price BH, Dickerson BC. Apathy: a neurocircuit model based on frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2018;89(4):389–96. Shower S. Apathy: a neurocircuit model based on frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2018;89(4):389–96. Chow TW, Binns MA, Cummings JL, Lam I, Black SE, Miller BL, et al. Apathy symptoms profile and behavioral associations in frontotemporal dementia versus dementia of the Alzheimer type. Arch Neurol. 2009;66(7): 888–93 Lobo A, Saz P; Marcos G y el Grupo ZARAMDEMP. Mini: mental status examination. Tea Ediciones; 2001. Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9. Weschsler D. Weschsler memory scale. New York, NY: The Psychological Corporation; 1972. Yesavage JA, Sheikh JI. 9/geriatric depression scale (GDS) recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1–2):165–73 Beck A, Steer R. Manual BAI. Inventario de Ansiedad de Beck. Adaptación española de J. Sanz; 2011. Reitan RM. Trail making test: manual for administration and scoring. Reitan Neuropsychology Laboratory; 1992 Babcock H. An experiment in the measurement of mental deterioration. Arch Psychol. 1930;117:105. Mattis S. Dementia rating scale. Odessa, FL: Psychological Assessment Resources; 1988. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and senile change in brain gray matter in the elderly. Br J Psychiatry. 1968;114(512):797–811. Reisberg B, Ferris SH, de Leon MJ, Crook T. The global impairment scale for the assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136–9. Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991;3(3):243–54. Renzi E, Faglioni P. Normative data and detection power of a shortened version of the token test. Cortex. 1978; 14(1):41–9. Cacho-Gutierrez LJ, García-García R, Arcaya-Navarro J. Una propuesta de aplicación del test del reloj en la enfermedad de Alzheimer. Rev Neurol. 1999;28:648–55. Dubois B, Slachevsk A, Litvan I, Pillon B. The FAB A frontal assessment battery at bedside. Neurology. 2000; 55(11):1621 Cummings JL, Victoroff JI. Noncognitive neuropsychiatric syndromes in Alzheimer’s disease. Neuropsychiatry Neuropsychol Behav Neurol. 1990;3(2):140–58. Lobo A, Pérez-Echeverría MJ, Artal J. Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population. Psychol Med. 1986;16(1):135–40 Mahoney F. Funcionales de evaluación: El índice de Barthel. Del Estado Md Med J. 1965;14:51–65 Powell Lawton M, Brody EM, Saperstein AR. A controlled study of respite service for caregivers of Alzheimer’s patients. Gerontologist. 1989;29(1):8–16. Poos JM, Jiskoot LC, Leijdesdorf SMJ, Seelaar H, Panman JL, van der Ende EL, et al. Cognitive profiles discriminate between genetic variants of behavioral frontotemporal dementia. J Neurol. 2020;267(6):1603–12. Jiskoot LC, Panman JL, van Asseldonk L, Franzen S, Meeter LHH, Donker Kaat L, et al. Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia. J Neurol. 2018;265(6): 1381–92. Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs. 2010;24(5):375–98 Kertesz A, McMonagle P, Blair M, Davidson W, Munoz DG. The evolution and pathology of frontotemporal dementia. Brain. 2005;128:1996–2005. Moll J, Zahn R, de Oliveira-Souza R, Bramati IE, Krueger F, Tura B, et al. Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia. NeuroImage. 2011;54(2):1735– 42 Amodium DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006;7:268–77 Yaling Y, Raine A. Structural and functional prefrontal brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis. Res Psychiatry. 2009;174(2):81–8 Nascimento C, Nunes VP, Diehl Rodriguez R, Takada L, Suemoto CK, Grinberg LT, et al. A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2019;93:269–83. Levenson RW, Sturm VE, Haase CM. Emotional and behavioral symptoms in neurodegenerative disease: a model for studying the neural bases of psychopathology. Annu Rev Clin Psychol. 2014;10:581–606. Spalletta G, Musicco M, Padovani A, Perri R, Fadda L, Canonico V, et al. Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed and untreated Alzheimer’s disease patients. Am J Geriatric Psychiatry. 2010;18(11):1026–35. Powers JP, Massimo L, McMillan CT, Yushkevich PA, Zhang H, Gee JC, et al. White matter disease contributes to apathy and disinhibition in behavioral variant frontotemporal dementia. Cogn Behav Neurol. 2014;27: 206–14 Lansdall C, Coyle-Gilchrist I, Jones P, Vázquez Rodríguez P, Wilcox A, Wehmann E, et al. Apathy and impulsivity in frontotemporal lobar degeneration syndromes. Brain. 2017;140(6):1792–807. Lansdall CJ, Coyle-Gilchrist ITS, Vázquez Rodríguez P, Wehmann E, Robbins TW, et al. Prognostic importance of apathy in syndromes associated with frontotemporal lobar degeneration. Neurology. 2019;92:e1547–57.
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dc.publisher.spa.fl_str_mv	Universidad Cooperativa de Colombia, Facultad de Ciencias Sociales, Psicología, Cali
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spelling	Vergel Hernández, JulianaBarrera Robledo, María EugeniaHurtado González, Carlos AlbertoMarmolejo Escobar, Carlos StevenOspina Otalvaro, SebastiánSánchez Tobón, Juan DavidArango de la Pava, Pablo MiguelÁlvarez, Juan José132022-09-28T23:35:15Z2022-09-28T23:35:15Z2021-071662680X10.1159/000513851https://hdl.handle.net/20.500.12494/46541Vergel Hernández J, Barrera Robledo M, E, Hurtado González C, A, Marmolejo Escobar C, S, Ospina Otalvaro S, Sánchez Tobón J, D, Arango de la Pava P, M, Alvarez J, J: Neuropsychiatric Aspects in a Patient Diagnosed with Frontotemporal Dementia: Clinical Case of Low Incidence and Prevalence Disease in Colombia. Case Rep Neurol 2021;13:451-463. doi: 10.1159/000513851La demencia frontotemporal (DFT) es una patología neuropsiquiátrica caracterizada por disfunciones en el lóbulo frontal del cerebro, especialmente en tareas de planificación, ejecución e inhibición, con incapacidad para tomar decisiones y manejar diferentes secuencias, afectando también al lóbulo temporal. El paciente presenta alteraciones para almacenar, consolidar y recordar información. Estos déficits neurocognitivos se acompañan de trastornos neuroconductuales como depresión, ansiedad y apatía que contribuyen al empeoramiento de la calidad de vida, con un alto impacto a nivel individual, social y familiar. Identificar los trastornos neuroconductuales y deterioro neurocognitivo que presenta un paciente con diagnóstico de DFT: caso clínico de enfermedad de baja incidencia y prevalencia en Colombia. Varón de 40 años, con deterioro progresivo de su memoria verbal inmediata, baja fluidez verbal, conducta motora aberrante, impulsividad sexual, alteraciones en sus funciones ejecutivas, especialmente en la planificación de tareas, toma de decisiones e inhibición. menor grado de afectación en su funcionamiento visuoespacial y habilidades visuoconstructivas. Se encontró que el paciente presenta un síndrome disejecutivo severo asociado a un cuadro clínico de DFT, correlacionado con incapacidad para procesar y recordar información, acompañado de trastornos como depresión, ansiedad y apatía. Es necesario generar un plan de neurorrehabilitación funcional que tenga como objetivo mejorar la calidad de vida de estos pacientes. Del mismo modo, es necesario crear nuevas líneas de investigación e intervención que tengan como finalidad crear un mayor campo de heurísticas o nuevas preguntas en este tipo de patologías neurodegenerativas.Frontotemporal dementia (FTD) is a neuropsychiatric pathology characterized by dysfunctions in the frontal lobe of the brain, especially in planning, execution, and inhibition tasks, with an inability to make decisions and handle different sequences, also affecting the temporal lobe. The patient presents alterations to store, consolidate, and recall information. These neurocognitive deficits are accompanied by neurobehavioral disorders such as depression, anxiety, and apathy that contribute to the worsening of the quality of life, with a high impact on the individual, social, and family level. To identify the neurobehavioral disorders and neurocognitive deterioration that present a patient diagnosed with FTD: clinical case of low incidence and prevalence disease in Colombia. A 40-year-old man, with progressive deterioration of his immediate verbal memory, low verbal fluency, aberrant motor behavior, sexual impulsivity, alterations in his executive functions, especially in planning tasks, decision-making, and inhibition was found to have a lesser degree of affectation in his visuospatial functioning and visuoconstructive abilities. It was found that the patient presents a severe dysexecutive syndrome associated with a clinical picture of FTD, correlated with an inability to process and recall information, accompanied by disorders such as depression, anxiety, and apathy. It is necessary to generate a functional neurorehabilitation plan that aims to improve the quality of life in these patients. In the same way, it is necessary to create new lines of research and intervention that have the purpose to create a greater field of heuristics or new questions in this type of neurodegenerative pathologies.carlos.hurtadog@campusucc.edu.co451–463Universidad Cooperativa de Colombia, Facultad de Ciencias Sociales, Psicología, CaliPsicologíaCalihttps://www.karger.com/Article/FullText/513851#Case Reports in NeurologyOlney NT, Spina S, Miller BL. Frontotemporal dementia. Neurol Clin. 2017;35(2):339–74Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz AM, Mendez SF, Cappa JM, et al. Classification of primary progressive aphasia and its variants. Neurology. 2011;76(11):1006–14.Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, et al. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain. 2017;140:3329–45Cheran G, Silverman H, Manoochehri M, Goldman J, Lee S, Wu L, et al. Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers. J Neurol Neurosurg Psychiatry. 2018;89:449–55.Ducharme S, Price BH, Dickerson BC. Apathy: a neurocircuit model based on frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2018;89(4):389–96.Shower S. Apathy: a neurocircuit model based on frontotemporal dementia. J Neurol Neurosurg Psychiatry. 2018;89(4):389–96.Chow TW, Binns MA, Cummings JL, Lam I, Black SE, Miller BL, et al. Apathy symptoms profile and behavioral associations in frontotemporal dementia versus dementia of the Alzheimer type. Arch Neurol. 2009;66(7): 888–93Lobo A, Saz P; Marcos G y el Grupo ZARAMDEMP. Mini: mental status examination. Tea Ediciones; 2001.Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.Weschsler D. Weschsler memory scale. New York, NY: The Psychological Corporation; 1972.Yesavage JA, Sheikh JI. 9/geriatric depression scale (GDS) recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1–2):165–73Beck A, Steer R. Manual BAI. Inventario de Ansiedad de Beck. Adaptación española de J. Sanz; 2011.Reitan RM. Trail making test: manual for administration and scoring. Reitan Neuropsychology Laboratory; 1992Babcock H. An experiment in the measurement of mental deterioration. Arch Psychol. 1930;117:105.Mattis S. Dementia rating scale. Odessa, FL: Psychological Assessment Resources; 1988.Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and senile change in brain gray matter in the elderly. Br J Psychiatry. 1968;114(512):797–811.Reisberg B, Ferris SH, de Leon MJ, Crook T. The global impairment scale for the assessment of primary degenerative dementia. Am J Psychiatry. 1982;139:1136–9.Marin RS. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991;3(3):243–54.Renzi E, Faglioni P. Normative data and detection power of a shortened version of the token test. Cortex. 1978; 14(1):41–9.Cacho-Gutierrez LJ, García-García R, Arcaya-Navarro J. Una propuesta de aplicación del test del reloj en la enfermedad de Alzheimer. Rev Neurol. 1999;28:648–55.Dubois B, Slachevsk A, Litvan I, Pillon B. The FAB A frontal assessment battery at bedside. Neurology. 2000; 55(11):1621Cummings JL, Victoroff JI. Noncognitive neuropsychiatric syndromes in Alzheimer’s disease. Neuropsychiatry Neuropsychol Behav Neurol. 1990;3(2):140–58.Lobo A, Pérez-Echeverría MJ, Artal J. Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population. Psychol Med. 1986;16(1):135–40Mahoney F. Funcionales de evaluación: El índice de Barthel. Del Estado Md Med J. 1965;14:51–65Powell Lawton M, Brody EM, Saperstein AR. A controlled study of respite service for caregivers of Alzheimer’s patients. Gerontologist. 1989;29(1):8–16.Poos JM, Jiskoot LC, Leijdesdorf SMJ, Seelaar H, Panman JL, van der Ende EL, et al. Cognitive profiles discriminate between genetic variants of behavioral frontotemporal dementia. J Neurol. 2020;267(6):1603–12.Jiskoot LC, Panman JL, van Asseldonk L, Franzen S, Meeter LHH, Donker Kaat L, et al. Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia. J Neurol. 2018;265(6): 1381–92.Rabinovici GD, Miller BL. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs. 2010;24(5):375–98Kertesz A, McMonagle P, Blair M, Davidson W, Munoz DG. The evolution and pathology of frontotemporal dementia. Brain. 2005;128:1996–2005.Moll J, Zahn R, de Oliveira-Souza R, Bramati IE, Krueger F, Tura B, et al. Impairment of prosocial sentiments is associated with frontopolar and septal damage in frontotemporal dementia. NeuroImage. 2011;54(2):1735– 42Amodium DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci. 2006;7:268–77Yaling Y, Raine A. Structural and functional prefrontal brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis. Res Psychiatry. 2009;174(2):81–8Nascimento C, Nunes VP, Diehl Rodriguez R, Takada L, Suemoto CK, Grinberg LT, et al. A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2019;93:269–83.Levenson RW, Sturm VE, Haase CM. Emotional and behavioral symptoms in neurodegenerative disease: a model for studying the neural bases of psychopathology. Annu Rev Clin Psychol. 2014;10:581–606.Spalletta G, Musicco M, Padovani A, Perri R, Fadda L, Canonico V, et al. Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed and untreated Alzheimer’s disease patients. Am J Geriatric Psychiatry. 2010;18(11):1026–35.Powers JP, Massimo L, McMillan CT, Yushkevich PA, Zhang H, Gee JC, et al. White matter disease contributes to apathy and disinhibition in behavioral variant frontotemporal dementia. Cogn Behav Neurol. 2014;27: 206–14Lansdall C, Coyle-Gilchrist I, Jones P, Vázquez Rodríguez P, Wilcox A, Wehmann E, et al. Apathy and impulsivity in frontotemporal lobar degeneration syndromes. Brain. 2017;140(6):1792–807.Lansdall CJ, Coyle-Gilchrist ITS, Vázquez Rodríguez P, Wehmann E, Robbins TW, et al. Prognostic importance of apathy in syndromes associated with frontotemporal lobar degeneration. Neurology. 2019;92:e1547–57.AtenciónFunciones ejecutivasLóbulo frontalDemencia frontotemporalTemporal frontalMemoriaFuncionamiento neurocognitivoReporte de casoAttentionExecutive functionsFrontal lobeFrontal temporalFrontotemporal dementiaMemoryNeurocognitive functioningCase reportNeuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in ColombiaArtículos Científicosinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/6a75f1d8-2266-4317-81c0-e760b5e07f16/download8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINAL513851 (3) (1).pdf513851 (3) (1).pdfapplication/pdf682716https://repository.ucc.edu.co/bitstreams/5bd1020c-8611-416c-987b-78ed9498ea7f/download3eee19d3dc7966f9340b5ba9544ddfc5MD51THUMBNAIL513851 (3) (1).pdf.jpg513851 (3) (1).pdf.jpgGenerated Thumbnailimage/jpeg5551https://repository.ucc.edu.co/bitstreams/0fe7ea9d-61ca-4814-a39c-ef9f11a0916f/downloadbe906cc6420a05ad8940365365120d80MD53TEXT513851 (3) (1).pdf.txt513851 (3) (1).pdf.txtExtracted texttext/plain44056https://repository.ucc.edu.co/bitstreams/0771cef1-4857-488c-8475-bad8bb27e898/downloadb5ab2347f58f5aa2e58e6f97b39b1bfcMD5420.500.12494/46541oai:repository.ucc.edu.co:20.500.12494/465412024-08-10 09:36:12.619restrictedhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.comTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=

Neuropsychiatric aspects in a patient diagnosed with frontotemporal dementia: clinical case of low incidence and prevalence disease in Colombia

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