Leptospira interrogans, Factores de Virulencia

La leptospirosis es una enfermedad zoonótica de distribución mundial cuyo agente causal es una espiroqueta gram negativa del género Leptospira y la especie a tratar en este caso es: L. interrogans que puede afectar cualquier especie animal y a los humanos. La manera como la leptospira interrogans ca...

Full description

Autores:: Reina Alzate, Ana María

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2023

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

id	COOPER2_5e358de7e4a9740eafcb51f7988f308e
oai_identifier_str	oai:repository.ucc.edu.co:20.500.12494/49194
network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
dc.title.none.fl_str_mv	Leptospira interrogans, Factores de Virulencia
title	Leptospira interrogans, Factores de Virulencia
spellingShingle	Leptospira interrogans, Factores de Virulencia Leptospira, icterhemorragiae Lipopolisacáridos Membrana externa LipL32 TG 2023 MVZ 49194 Leptospira icterhemorrhagiae lipopolysaccharides Outer membrane LipL32
title_short	Leptospira interrogans, Factores de Virulencia
title_full	Leptospira interrogans, Factores de Virulencia
title_fullStr	Leptospira interrogans, Factores de Virulencia
title_full_unstemmed	Leptospira interrogans, Factores de Virulencia
title_sort	Leptospira interrogans, Factores de Virulencia
dc.creator.fl_str_mv	Reina Alzate, Ana María
dc.contributor.advisor.none.fl_str_mv	Plazas Hernández, Fernely Augusto Sánchez Bonilla, María del Pilar
dc.contributor.author.none.fl_str_mv	Reina Alzate, Ana María
dc.subject.none.fl_str_mv	Leptospira, icterhemorragiae Lipopolisacáridos Membrana externa LipL32
topic	Leptospira, icterhemorragiae Lipopolisacáridos Membrana externa LipL32 TG 2023 MVZ 49194 Leptospira icterhemorrhagiae lipopolysaccharides Outer membrane LipL32
dc.subject.classification.none.fl_str_mv	TG 2023 MVZ 49194
dc.subject.other.none.fl_str_mv	Leptospira icterhemorrhagiae lipopolysaccharides Outer membrane LipL32
description	La leptospirosis es una enfermedad zoonótica de distribución mundial cuyo agente causal es una espiroqueta gram negativa del género Leptospira y la especie a tratar en este caso es: L. interrogans que puede afectar cualquier especie animal y a los humanos. La manera como la leptospira interrogans causa infecciones es a través de dos mecanismos Tiene factores de virulencia asociados a la Leptospira de especies patógenas los cuales pueden ser; endotoxinas, hemolisinas (también llamadas esfingomielinasas), termolisinas, fosfolipasa y proteínas superficiales de adherencia. Se reporta en la literatura lipoproteínas presentes en la membrana externa de la bacteria entre las cuales se identifica LipL32 que solo está presente en las especies patógenas como Leptospira icterhemorragiae, la cual es una buena candidata para la elaboración tanto de la vacuna como desarrollo de técnicas diagnósticas. La inmunidad generada es principalmente la humoral, la bacteria tiene un periodo de incubación de 4 a 10 días, se disemina en hígado, riñones, pulmones, placenta y SNC. El objetivo de este artículo es dar a conocer los diferentes factores de virulencia que intervienen en el desarrollo de la enfermedad.
publishDate	2023
dc.date.accessioned.none.fl_str_mv	2023-04-25T12:35:49Z
dc.date.available.none.fl_str_mv	2023-04-25T12:35:49Z
dc.date.issued.none.fl_str_mv	2023-04-24
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
format	http://purl.org/coar/resource_type/c_7a1f
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/49194
dc.identifier.bibliographicCitation.none.fl_str_mv	Reina Alzate, A. M. (2023). Leptospira interrogans, factores de virulencia. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/49194
url	https://hdl.handle.net/20.500.12494/49194
identifier_str_mv	Reina Alzate, A. M. (2023). Leptospira interrogans, factores de virulencia. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/49194
dc.relation.references.none.fl_str_mv	Santos JG. Manual de Diagnostico Microbiologico de Leptospira interrogans [Internet]. Universidad Nacional Autonoma de Mexico; 2013. Available from: https://www.zaragoza.unam.mx/wp-content/Portal2015/Licenciaturas/qfb/tesis/tesis_godinez_santos.pdf Arias RS. Evaluación del Medio emjh Convencional y Modificado Sobre la Cinética de Crecimiento y la Expresión de Genes de Patogenicidad en Cepas de Leptospira interrogans serovar icterohaemorrhagiae. 2012; Nagel AG. Caracterización molecular y celular de la virulencia de un clon mayoritario de Leptospira interrogans en Argentina . [Internet]. Universidad de Buenos Aires; 2019. Available from: https://bibliotecadigital.exactas.uba.ar/download/tesis/tesis_n6944_Nagel.pdf José L, Aroca G, Accini JL, Pérez R, Rodelo E, Dau H. Leptospirosis ictérica : Síndrome de Weil ´ s. 2004; Available from: https://www.redalyc.org/pdf/817/81719004.pdf Teodoro PH. Caracterizações Biológicas Das Proteínas Lipl32 E Hlyx De Leptospira Interrogans Sorovar Copenhageni [Internet]. Instituto Butantan; 2009. Available from: https://www.teses.usp.br/teses/disponiveis/87/87131/tde-13082009-121116/publico/PricilaHaukTeodoro_Doutorado.pdf Méndez Rodríguez, Iván Alberto; Pachón Barinas DP. Leptospirosis en Humanos. 2004; Available from: https://www.redalyc.org/pdf/910/91012106.pdf Méndez Rodríguez, Iván Alberto; Pachón Barinas DP. Leptospirosis en Humanos. 2004; Available from: https://www.redalyc.org/pdf/910/91012106.pdf Tatiana Cedola M. Estudio de mecanismo de la inmunidad innata en la patogénesis de la leptospirosis. 2014;117. Available from: http://sedici.unlp.edu.ar/bitstream/handle/10915/34728/Documento_completo.pdf?sequence=5&isAllowed=y Peña MV, Ensenada. Función de las porinas de Salmonella enterica serovar [Internet]. Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California; 2016. Available from: https://cicese.repositorioinstitucional.mx/jspui/bitstream/1007/659/1/244391.pdf Callejas AMG. Leptospirosis: Conocimiento de la Patologia y Propuesta de Diagnostico [Internet]. Universidad Distrital Fransisco Jose de Caldas; Available from: https://repository.udistrital.edu.co/bitstream/handle/11349/2898/GarcíaCallejasAnaMaría2015 .pdf?sequence=1&isAllowed=y Chen L, Xiong Z, Sun L, Yang J, Jin Q. VFDB 2012 update: Toward the genetic diversity and molecular evolution of bacterial virulence factors. Nucleic Acids Res. 2012;40(D1):641–5. Chuva Castillo P, Castillo Hidalgo E. Leptospirosis una enfermedad zoonótica, breve revisión de la situación en el Ecuador. Anatomía Digit. 2022;5(3):292–305. King AM, Bartpho T, Sermswan RW, Bulach DM, Eshghi A, Picardeau M, et al. Leptospiral outer membrane protein lipl41 is not essential for acute leptospirosis but requires a small chaperone protein, lep, for stable expression. Infect Immun. 2013;81(8):2768–76. Gomes-Solecki M, Santecchia I, Werts C. Animal models of leptospirosis: Of mice and hamsters. Front Immunol. 2017;8(FEB). Nieves C. Estudios genómicos y moleculares de bacterias del género Leptospira: análisis de la variabilidad genética y contribución en diagnóstico y tipificación. Pedeciba [Internet]. 2018;1–176. Available from: https://www.colibri.udelar.edu.uy/jspui/handle/20.500.12008/23242 Nally JE, Whitelegge JP, Bassilian S, Blanco DR, Lovett MA. Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infection. Infect Immun. 2007;75(2):766–73. Pinne M, Haake DA. LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: Presentation of New Data and Reevaluation of Previous Studies. PLoS One [Internet]. 2013;8(1). Available from: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051025&type=printable Lin X, Zhao J, Qian J, Mao Y, Pan J, Li L, et al. Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogans. Clin Vaccine Immunol [Internet]. 2010;17(5):778–83. Available from: file:///C:/Users/ MARIA/Downloads/Identification_of_Immunodominant_B-_and_T-Cell_Com.pdf Shang ES, Summers TA, Haake DA. Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species. Infect Immun [Internet]. 1996;64(6):2322–30. Available from: https://www.researchgate.net/publication/42255258_Identification_of_Immunodominant_B-_and_T-Cell_Combined_Epitopes_in_Outer_Membrane_Lipoproteins_LipL32_and_LipL21_of_Leptospira_interrogans Barnett JK, Barnett D, Bolin CA, Summers TA, Wagar EA, Cheville NF, et al. Expression and distribution of leptospiral outer membrane components during renal infection of hamsters. Infect Immun. 1999;67(2):853–61. Murphy TF, Bartos LC. Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect Immun [Internet]. 1988;56(10):2673–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC259628/ Haake DA, Wolfram RZ. The Leptospiral Outer Membrane. 2015. Murray GL. The molecular basis of leptospiral pathogenesis. Vol. 387, Current Topics in Microbiology and Immunology. 2015. 139–185 p. Koizumi N, Watanabe H. Leptospiral immunoglobulin-like proteins elicit protective immunity. 2004;22:1545–52. Cullen PA, Cordwell SJ, Bulach DM, Haake DA, Adler B. Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai. Infect Immun. 2002;70(5):2311–8. Burth P, Silva AR. Leptospira and Inflammation. 2012;2012. Oliveira R, Morais ZM De, Gonc AP. Characterization of Novel OmpA-Like Protein of Leptospira interrogans That Binds Extracellular Matrix Molecules and Plasminogen. 2011;6(7). Sluys V. Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis. Society [Internet]. 2004;186(7):2164–72. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=374407&tool=pmcentrez&rendertype=abstract Kumar S, Stecher G, Tamura K. MEGA7 : Molecular Evolutionary Genetics Analysis Version 7 . 0 for Bigger Datasets. 2016;33(7):1870–4. Manuel J, Ortega R. Inmunogenicidad de una vacuna elaborada con proteínas de membranas externas de una cepa de Leptospira interrogans serovariedad Canicola (LOCaS46). Universidad Nacional Autonoma de Mexico; 2012. Zhang Y, Bao L, Zhu H, Huang B, Zhang H. OmpA-like protein Loa22 from Leptospira interrogans serovar Lai is cytotoxic to cultured rat renal cells and promotes inflammatory responses. 2010;42(1):70–9. Kassegne K, Hu W, Ojcius DM, Sun D, Ge Y, Zhao J, et al. Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic leptospira species. J Infect Dis. 2014;209(7):1105–15. Lee J, Kim I. Pregnancy loss in dairy cows : the contributing factors , the effects on reproductive performance and the economic impact. 2007;8:283–8. Haake DA, Chao G, Zuerner RL, Barnett JK, Barnett D, Mazel M, et al. The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection. Infect Immun. 2015;68(4):2276–85. Ren S, Fu G, Jiang X, Zeng R. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. 2003;422(April). Forero NID. Caracterización De Determinantes Antigénicos Con Reactividad Cruzada Entre Especies Patógenas (P1) E Intermedias (P2) Del Género Leptospira De La Colección De Microorganismos Con Interés En Salud Animal (Cmisa) Del Banco De Microorganismos De Agrosavia. Universidad del bosque; 2021. Barbosa AS. Strategies used by Leptospira spirochetes to evade the host complement system. 2020;1–12. S. Faine, B. Adler, C. Bolin PP (Eds. . Leptospira and Leptospirosis. In: Veterinary Microbiology. 2001. p. 391–2. Zamora AJC, Fonseca DC, López YG. Leptospirosis y enfermedad de Weil. 2020;5(3). Available from: https://revistamedicasinergia.com/index.php/rms/article/view/346/740 Transactions S. Structural and functional studies of complement inhibitor C4b-binding protein . Why look into complement regulators ? The complement system was first described over a. 2022; Meri T, Murgia R, Stefanel P, Meri S, Cinco M. Regulation of complement activation at the C3-level by serum resistant leptospires. 2005;39:139–47. Barbosa AS, Abreu PAE, Neves FO, Atzingen M V, Watanabe M, Vieira L, et al. A Newly Identified Leptospiral Adhesin Mediates Attachment to Laminin ᰔ. 2006;74(11):6356–64. Stevenson B, Choy HA, Pinne M, Rotondi ML, Miller MC, Demoll E, et al. Leptospira interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin , Laminin and Regulators of Complement. 2007;(11). Ramírez-García R, Agudelo- Flórez P, Acevedo-Sáenz L. Inmunología de la leptospirosis. CES Med. 2019;33(3):192–200. Fraga TR, Isaac L, Barbosa AS. Complement evasion by pathogenic Leptospira. Front Immunol [Internet]. 2016;7(DEC):1–7. Available from: https://com-mendeley-prod-publicsharing-pdfstore.s3.eu-west-1.amazonaws.com/cc61-PUBMED/10.3389/fimmu.2016.00623/fimmu_07_00623_pdf.pdf?X-Amz-Security Toma C, Okura N, Takayama C, Suzuki T. Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages. Cell Microbiol [Internet]. 2011;13(11):1783–92. Available from: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1462-5822.2011.01660.x Masmela A, Gutiérrez C. Leptospirosis bovina enfocado en el potencial zoonótico, alternativas de control y tratamiento. 2021; Borregaard N. Neutrophils, from Marrow to Microbes. Immunity [Internet]. 2010;33(5):657–70. Available from: http://dx.doi.org/10.1016/j.immuni.2010.11.011 Li S, Ojcius DM, Liao S, Li L, Xue F, Dong H, et al. Replication or death: Distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin. Innate Immun [Internet]. 2010;16(2):80–92. Available from: file:///C:/Users/ANA MARIA/Downloads/1753425909105580.pdf Cagliero J, Villanueva SYAM, Matsui M. Leptospirosis pathophysiology: Into the storm of cytokines. Front Cell Infect Microbiol. 2018;8(JUN):1–8. Cinco M. New insights into the pathogenicity of leptospires: Evasion of host defences. New Microbiol. 2010;33(4):283–92. Picardeau M. Leptospira and Leptospirosis. Vol. 2134, Methods in Molecular Biology. 2020. 271–275 p.
dc.rights.license.none.fl_str_mv	Atribución – No comercial – Sin Derivar
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv	http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv	Atribución – No comercial – Sin Derivar http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.extent.none.fl_str_mv	22 p.
dc.publisher.none.fl_str_mv	Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Ibagué
dc.publisher.program.none.fl_str_mv	Medicina veterinaria y zootecnia
dc.publisher.place.none.fl_str_mv	Ibagué
publisher.none.fl_str_mv	Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, Ibagué
institution	Universidad Cooperativa de Colombia
bitstream.url.fl_str_mv	https://repository.ucc.edu.co/bitstreams/bb581ffe-0dd5-46bc-a8f9-ba5e8af6ac4d/download https://repository.ucc.edu.co/bitstreams/502d809d-a188-4118-a575-d2a162847f5b/download https://repository.ucc.edu.co/bitstreams/ba7d0fbf-4cf8-4dbf-8366-085d733e89ba/download https://repository.ucc.edu.co/bitstreams/31818bde-edb3-4ced-97ca-0fcc1dea5aa5/download https://repository.ucc.edu.co/bitstreams/a51a62d3-ed7d-4e75-a7d5-50de93d6a958/download https://repository.ucc.edu.co/bitstreams/61ffd465-7e46-48af-addc-da246e2f7d24/download https://repository.ucc.edu.co/bitstreams/fdac4a4f-32f9-4a5e-a9c2-08d158ed0ae4/download https://repository.ucc.edu.co/bitstreams/b88c34f1-bd2c-4148-b54f-d9c060cf600a/download https://repository.ucc.edu.co/bitstreams/98266690-2721-4241-8d7d-85f6d61a7789/download https://repository.ucc.edu.co/bitstreams/310a0736-09c0-49a6-a1c7-28cc726fd58c/download
bitstream.checksum.fl_str_mv	eac5c747e8f382b6bf5d149f337f4cce 98ed0f01e285ffbfa076c7dd8d2f7ed3 3e1734c8a9f3e2947967736de06a597e 3bce4f7ab09dfc588f126e1e36e98a45 6d93d3216dc4a7f5df47d4876fbec4d3 a87df565a08ee69e8e079a9efc4ce480 6ccbedd354761622d890652193314e5c 63ee9192b6f47aab33c52883193cf298 1fa06c79dcca8e304ab826defc365c36 e8c702ff5777f3e95f60df387c51d09d
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
_version_	1814246761675358208
spelling	Plazas Hernández, Fernely AugustoSánchez Bonilla, María del PilarReina Alzate, Ana María2023-04-25T12:35:49Z2023-04-25T12:35:49Z2023-04-24https://hdl.handle.net/20.500.12494/49194Reina Alzate, A. M. (2023). Leptospira interrogans, factores de virulencia. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional UCC. https://repository.ucc.edu.co/handle/20.500.12494/49194La leptospirosis es una enfermedad zoonótica de distribución mundial cuyo agente causal es una espiroqueta gram negativa del género Leptospira y la especie a tratar en este caso es: L. interrogans que puede afectar cualquier especie animal y a los humanos. La manera como la leptospira interrogans causa infecciones es a través de dos mecanismos Tiene factores de virulencia asociados a la Leptospira de especies patógenas los cuales pueden ser; endotoxinas, hemolisinas (también llamadas esfingomielinasas), termolisinas, fosfolipasa y proteínas superficiales de adherencia. Se reporta en la literatura lipoproteínas presentes en la membrana externa de la bacteria entre las cuales se identifica LipL32 que solo está presente en las especies patógenas como Leptospira icterhemorragiae, la cual es una buena candidata para la elaboración tanto de la vacuna como desarrollo de técnicas diagnósticas. La inmunidad generada es principalmente la humoral, la bacteria tiene un periodo de incubación de 4 a 10 días, se disemina en hígado, riñones, pulmones, placenta y SNC. El objetivo de este artículo es dar a conocer los diferentes factores de virulencia que intervienen en el desarrollo de la enfermedad.Leptospirosis is a zoonotic disease with worldwide distribution whose causal agent is a gram-negative spirochete of the genus Leptospira and the species to be treated in this case is: L. interrogans, which can affect any animal species and humans. It has virulence faxtors associated with the Leptospira of pathogenic species which can be; endotoxins, hemolysins, phingomyelinase, phospholipase, and surface adhesion proteins. Lipoproteins present in the outer membrane of the bacteria are reported in the literature, among which LipL32 is identified, which is only present in pathogenic species such as Leptospira icterhemorragiae, which is a good candidate for the preparation of both the vaccine and the development of diagnostic techniques. The immunity generated is mainly humoral, the bacterium has an incubation period of 4 to 10 days, it spreads in the liver, kidneys, lungs, placenta and CNS. The aim of this article is to present the different virulence factors involved in the development of the disease.anam.reina@campusucc.edu.co22 p.Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaIbaguéLeptospira, icterhemorragiaeLipopolisacáridosMembrana externaLipL32TG 2023 MVZ 49194Leptospira icterhemorrhagiaelipopolysaccharidesOuter membraneLipL32Leptospira interrogans, Factores de VirulenciaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionAtribución – No comercial – Sin Derivarinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Santos JG. Manual de Diagnostico Microbiologico de Leptospira interrogans [Internet]. Universidad Nacional Autonoma de Mexico; 2013. Available from: https://www.zaragoza.unam.mx/wp-content/Portal2015/Licenciaturas/qfb/tesis/tesis_godinez_santos.pdfArias RS. Evaluación del Medio emjh Convencional y Modificado Sobre la Cinética de Crecimiento y la Expresión de Genes de Patogenicidad en Cepas de Leptospira interrogans serovar icterohaemorrhagiae. 2012;Nagel AG. Caracterización molecular y celular de la virulencia de un clon mayoritario de Leptospira interrogans en Argentina . [Internet]. Universidad de Buenos Aires; 2019. Available from: https://bibliotecadigital.exactas.uba.ar/download/tesis/tesis_n6944_Nagel.pdfJosé L, Aroca G, Accini JL, Pérez R, Rodelo E, Dau H. Leptospirosis ictérica : Síndrome de Weil ´ s. 2004; Available from: https://www.redalyc.org/pdf/817/81719004.pdfTeodoro PH. Caracterizações Biológicas Das Proteínas Lipl32 E Hlyx De Leptospira Interrogans Sorovar Copenhageni [Internet]. Instituto Butantan; 2009. Available from: https://www.teses.usp.br/teses/disponiveis/87/87131/tde-13082009-121116/publico/PricilaHaukTeodoro_Doutorado.pdfMéndez Rodríguez, Iván Alberto; Pachón Barinas DP. Leptospirosis en Humanos. 2004; Available from: https://www.redalyc.org/pdf/910/91012106.pdfMéndez Rodríguez, Iván Alberto; Pachón Barinas DP. Leptospirosis en Humanos. 2004; Available from: https://www.redalyc.org/pdf/910/91012106.pdfTatiana Cedola M. Estudio de mecanismo de la inmunidad innata en la patogénesis de la leptospirosis. 2014;117. Available from: http://sedici.unlp.edu.ar/bitstream/handle/10915/34728/Documento_completo.pdf?sequence=5&isAllowed=yPeña MV, Ensenada. Función de las porinas de Salmonella enterica serovar [Internet]. Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California; 2016. Available from: https://cicese.repositorioinstitucional.mx/jspui/bitstream/1007/659/1/244391.pdfCallejas AMG. Leptospirosis: Conocimiento de la Patologia y Propuesta de Diagnostico [Internet]. Universidad Distrital Fransisco Jose de Caldas; Available from: https://repository.udistrital.edu.co/bitstream/handle/11349/2898/GarcíaCallejasAnaMaría2015 .pdf?sequence=1&isAllowed=yChen L, Xiong Z, Sun L, Yang J, Jin Q. VFDB 2012 update: Toward the genetic diversity and molecular evolution of bacterial virulence factors. Nucleic Acids Res. 2012;40(D1):641–5.Chuva Castillo P, Castillo Hidalgo E. Leptospirosis una enfermedad zoonótica, breve revisión de la situación en el Ecuador. Anatomía Digit. 2022;5(3):292–305.King AM, Bartpho T, Sermswan RW, Bulach DM, Eshghi A, Picardeau M, et al. Leptospiral outer membrane protein lipl41 is not essential for acute leptospirosis but requires a small chaperone protein, lep, for stable expression. Infect Immun. 2013;81(8):2768–76.Gomes-Solecki M, Santecchia I, Werts C. Animal models of leptospirosis: Of mice and hamsters. Front Immunol. 2017;8(FEB).Nieves C. Estudios genómicos y moleculares de bacterias del género Leptospira: análisis de la variabilidad genética y contribución en diagnóstico y tipificación. Pedeciba [Internet]. 2018;1–176. Available from: https://www.colibri.udelar.edu.uy/jspui/handle/20.500.12008/23242Nally JE, Whitelegge JP, Bassilian S, Blanco DR, Lovett MA. Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infection. Infect Immun. 2007;75(2):766–73.Pinne M, Haake DA. LipL32 Is a Subsurface Lipoprotein of Leptospira interrogans: Presentation of New Data and Reevaluation of Previous Studies. PLoS One [Internet]. 2013;8(1). Available from: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051025&type=printableLin X, Zhao J, Qian J, Mao Y, Pan J, Li L, et al. Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogans. Clin Vaccine Immunol [Internet]. 2010;17(5):778–83. Available from: file:///C:/Users/ MARIA/Downloads/Identification_of_Immunodominant_B-_and_T-Cell_Com.pdfShang ES, Summers TA, Haake DA. Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species. Infect Immun [Internet]. 1996;64(6):2322–30. Available from: https://www.researchgate.net/publication/42255258_Identification_of_Immunodominant_B-_and_T-Cell_Combined_Epitopes_in_Outer_Membrane_Lipoproteins_LipL32_and_LipL21_of_Leptospira_interrogansBarnett JK, Barnett D, Bolin CA, Summers TA, Wagar EA, Cheville NF, et al. Expression and distribution of leptospiral outer membrane components during renal infection of hamsters. Infect Immun. 1999;67(2):853–61.Murphy TF, Bartos LC. Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect Immun [Internet]. 1988;56(10):2673–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC259628/Haake DA, Wolfram RZ. The Leptospiral Outer Membrane. 2015.Murray GL. The molecular basis of leptospiral pathogenesis. Vol. 387, Current Topics in Microbiology and Immunology. 2015. 139–185 p.Koizumi N, Watanabe H. Leptospiral immunoglobulin-like proteins elicit protective immunity. 2004;22:1545–52.Cullen PA, Cordwell SJ, Bulach DM, Haake DA, Adler B. Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai. Infect Immun. 2002;70(5):2311–8.Burth P, Silva AR. Leptospira and Inflammation. 2012;2012.Oliveira R, Morais ZM De, Gonc AP. Characterization of Novel OmpA-Like Protein of Leptospira interrogans That Binds Extracellular Matrix Molecules and Plasminogen. 2011;6(7).Sluys V. Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis. Society [Internet]. 2004;186(7):2164–72. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=374407&tool=pmcentrez&rendertype=abstractKumar S, Stecher G, Tamura K. MEGA7 : Molecular Evolutionary Genetics Analysis Version 7 . 0 for Bigger Datasets. 2016;33(7):1870–4.Manuel J, Ortega R. Inmunogenicidad de una vacuna elaborada con proteínas de membranas externas de una cepa de Leptospira interrogans serovariedad Canicola (LOCaS46). Universidad Nacional Autonoma de Mexico; 2012.Zhang Y, Bao L, Zhu H, Huang B, Zhang H. OmpA-like protein Loa22 from Leptospira interrogans serovar Lai is cytotoxic to cultured rat renal cells and promotes inflammatory responses. 2010;42(1):70–9.Kassegne K, Hu W, Ojcius DM, Sun D, Ge Y, Zhao J, et al. Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic leptospira species. J Infect Dis. 2014;209(7):1105–15.Lee J, Kim I. Pregnancy loss in dairy cows : the contributing factors , the effects on reproductive performance and the economic impact. 2007;8:283–8.Haake DA, Chao G, Zuerner RL, Barnett JK, Barnett D, Mazel M, et al. The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection. Infect Immun. 2015;68(4):2276–85.Ren S, Fu G, Jiang X, Zeng R. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. 2003;422(April).Forero NID. Caracterización De Determinantes Antigénicos Con Reactividad Cruzada Entre Especies Patógenas (P1) E Intermedias (P2) Del Género Leptospira De La Colección De Microorganismos Con Interés En Salud Animal (Cmisa) Del Banco De Microorganismos De Agrosavia. Universidad del bosque; 2021.Barbosa AS. Strategies used by Leptospira spirochetes to evade the host complement system. 2020;1–12.S. Faine, B. Adler, C. Bolin PP (Eds. . Leptospira and Leptospirosis. In: Veterinary Microbiology. 2001. p. 391–2.Zamora AJC, Fonseca DC, López YG. Leptospirosis y enfermedad de Weil. 2020;5(3). Available from: https://revistamedicasinergia.com/index.php/rms/article/view/346/740Transactions S. Structural and functional studies of complement inhibitor C4b-binding protein . Why look into complement regulators ? The complement system was first described over a. 2022;Meri T, Murgia R, Stefanel P, Meri S, Cinco M. Regulation of complement activation at the C3-level by serum resistant leptospires. 2005;39:139–47.Barbosa AS, Abreu PAE, Neves FO, Atzingen M V, Watanabe M, Vieira L, et al. A Newly Identified Leptospiral Adhesin Mediates Attachment to Laminin ᰔ. 2006;74(11):6356–64.Stevenson B, Choy HA, Pinne M, Rotondi ML, Miller MC, Demoll E, et al. Leptospira interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin , Laminin and Regulators of Complement. 2007;(11).Ramírez-García R, Agudelo- Flórez P, Acevedo-Sáenz L. Inmunología de la leptospirosis. CES Med. 2019;33(3):192–200.Fraga TR, Isaac L, Barbosa AS. Complement evasion by pathogenic Leptospira. Front Immunol [Internet]. 2016;7(DEC):1–7. Available from: https://com-mendeley-prod-publicsharing-pdfstore.s3.eu-west-1.amazonaws.com/cc61-PUBMED/10.3389/fimmu.2016.00623/fimmu_07_00623_pdf.pdf?X-Amz-SecurityToma C, Okura N, Takayama C, Suzuki T. Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages. Cell Microbiol [Internet]. 2011;13(11):1783–92. Available from: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1462-5822.2011.01660.xMasmela A, Gutiérrez C. Leptospirosis bovina enfocado en el potencial zoonótico, alternativas de control y tratamiento. 2021;Borregaard N. Neutrophils, from Marrow to Microbes. Immunity [Internet]. 2010;33(5):657–70. Available from: http://dx.doi.org/10.1016/j.immuni.2010.11.011Li S, Ojcius DM, Liao S, Li L, Xue F, Dong H, et al. Replication or death: Distinct fates of pathogenic Leptospira strain Lai within macrophages of human or mouse origin. Innate Immun [Internet]. 2010;16(2):80–92. Available from: file:///C:/Users/ANA MARIA/Downloads/1753425909105580.pdfCagliero J, Villanueva SYAM, Matsui M. Leptospirosis pathophysiology: Into the storm of cytokines. Front Cell Infect Microbiol. 2018;8(JUN):1–8.Cinco M. New insights into the pathogenicity of leptospires: Evasion of host defences. New Microbiol. 2010;33(4):283–92.Picardeau M. Leptospira and Leptospirosis. Vol. 2134, Methods in Molecular Biology. 2020. 271–275 p.PublicationORIGINAL2023_leptospira_interrogans_factores-FormatoLicenciaUso.pdf2023_leptospira_interrogans_factores-FormatoLicenciaUso.pdfLicencia de usoapplication/pdf1052688https://repository.ucc.edu.co/bitstreams/bb581ffe-0dd5-46bc-a8f9-ba5e8af6ac4d/downloadeac5c747e8f382b6bf5d149f337f4cceMD512023_leptospira_interrogans_factores-ActaSustentacion.pdf2023_leptospira_interrogans_factores-ActaSustentacion.pdfActa de sustentaciónapplication/pdf143154https://repository.ucc.edu.co/bitstreams/502d809d-a188-4118-a575-d2a162847f5b/download98ed0f01e285ffbfa076c7dd8d2f7ed3MD522023_leptospira_interrogans_factores.pdf2023_leptospira_interrogans_factores.pdfTrabajo de gradosapplication/pdf221858https://repository.ucc.edu.co/bitstreams/ba7d0fbf-4cf8-4dbf-8366-085d733e89ba/download3e1734c8a9f3e2947967736de06a597eMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-84334https://repository.ucc.edu.co/bitstreams/31818bde-edb3-4ced-97ca-0fcc1dea5aa5/download3bce4f7ab09dfc588f126e1e36e98a45MD54TEXT2023_leptospira_interrogans_factores-FormatoLicenciaUso.pdf.txt2023_leptospira_interrogans_factores-FormatoLicenciaUso.pdf.txtExtracted texttext/plain6https://repository.ucc.edu.co/bitstreams/a51a62d3-ed7d-4e75-a7d5-50de93d6a958/download6d93d3216dc4a7f5df47d4876fbec4d3MD552023_leptospira_interrogans_factores-ActaSustentacion.pdf.txt2023_leptospira_interrogans_factores-ActaSustentacion.pdf.txtExtracted texttext/plain1265https://repository.ucc.edu.co/bitstreams/61ffd465-7e46-48af-addc-da246e2f7d24/downloada87df565a08ee69e8e079a9efc4ce480MD572023_leptospira_interrogans_factores.pdf.txt2023_leptospira_interrogans_factores.pdf.txtExtracted texttext/plain31890https://repository.ucc.edu.co/bitstreams/fdac4a4f-32f9-4a5e-a9c2-08d158ed0ae4/download6ccbedd354761622d890652193314e5cMD59THUMBNAIL2023_leptospira_interrogans_factores-FormatoLicenciaUso.pdf.jpg2023_leptospira_interrogans_factores-FormatoLicenciaUso.pdf.jpgGenerated Thumbnailimage/jpeg10059https://repository.ucc.edu.co/bitstreams/b88c34f1-bd2c-4148-b54f-d9c060cf600a/download63ee9192b6f47aab33c52883193cf298MD562023_leptospira_interrogans_factores-ActaSustentacion.pdf.jpg2023_leptospira_interrogans_factores-ActaSustentacion.pdf.jpgGenerated Thumbnailimage/jpeg9692https://repository.ucc.edu.co/bitstreams/98266690-2721-4241-8d7d-85f6d61a7789/download1fa06c79dcca8e304ab826defc365c36MD582023_leptospira_interrogans_factores.pdf.jpg2023_leptospira_interrogans_factores.pdf.jpgGenerated Thumbnailimage/jpeg12137https://repository.ucc.edu.co/bitstreams/310a0736-09c0-49a6-a1c7-28cc726fd58c/downloade8c702ff5777f3e95f60df387c51d09dMD51020.500.12494/49194oai:repository.ucc.edu.co:20.500.12494/491942024-08-09 12:53:54.442restrictedhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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

Leptospira interrogans, Factores de Virulencia

Publicaciones similares