Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation

La solubilidad en equilibrio de la sulfamerazina (SMR) en etilenglicol puro (EG) y diecinueve {(EG) (1) + agua (2)} mezclas se reporta a temperaturas de (278.15 a 318.15) K. Solubilidad en fracción molar de SMR ( x 3 ) aumenta con el aumento de la temperatura y también aumenta con el aumento de la p...

Full description

Autores:
Vargas-Santana, Martha Sofía
Cruz-González, Ana María
Ortiz, Claudia Patricia
Delgado, Daniel Ricardo
Martínez, Fleming
Peña, María Ángeles
Acree Jr., William E.
Jouyban, Abolghasem
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/46637
Acceso en línea:
https://hdl.handle.net/20.500.12494/46637
Palabra clave:
sulfamerazina
{Etilenglicol (1) + agua (2)} mezclas
Solubilidad
Modelo Jouyban-Acree
Solucion preferencial
IKBI
Q1
Sulfamerazine
{Ethylene glycol (1) + water (2)} mixtures
Solubility
Jouyban-Acree model
Preferential solvation
IKBI
Rights
closedAccess
License
Atribución – No comercial
id COOPER2_502225a7959c04dc0308f344d14b73f5
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/46637
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
title Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
spellingShingle Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
sulfamerazina
{Etilenglicol (1) + agua (2)} mezclas
Solubilidad
Modelo Jouyban-Acree
Solucion preferencial
IKBI
Q1
Sulfamerazine
{Ethylene glycol (1) + water (2)} mixtures
Solubility
Jouyban-Acree model
Preferential solvation
IKBI
title_short Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
title_full Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
title_fullStr Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
title_full_unstemmed Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
title_sort Solubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation
dc.creator.fl_str_mv Vargas-Santana, Martha Sofía
Cruz-González, Ana María
Ortiz, Claudia Patricia
Delgado, Daniel Ricardo
Martínez, Fleming
Peña, María Ángeles
Acree Jr., William E.
Jouyban, Abolghasem
dc.contributor.advisor.none.fl_str_mv Delgado, Daniel Ricardo
dc.contributor.author.none.fl_str_mv Vargas-Santana, Martha Sofía
Cruz-González, Ana María
Ortiz, Claudia Patricia
Delgado, Daniel Ricardo
Martínez, Fleming
Peña, María Ángeles
Acree Jr., William E.
Jouyban, Abolghasem
dc.subject.spa.fl_str_mv sulfamerazina
{Etilenglicol (1) + agua (2)} mezclas
Solubilidad
Modelo Jouyban-Acree
Solucion preferencial
IKBI
topic sulfamerazina
{Etilenglicol (1) + agua (2)} mezclas
Solubilidad
Modelo Jouyban-Acree
Solucion preferencial
IKBI
Q1
Sulfamerazine
{Ethylene glycol (1) + water (2)} mixtures
Solubility
Jouyban-Acree model
Preferential solvation
IKBI
dc.subject.classification.spa.fl_str_mv Q1
dc.subject.other.spa.fl_str_mv Sulfamerazine
{Ethylene glycol (1) + water (2)} mixtures
Solubility
Jouyban-Acree model
Preferential solvation
IKBI
description La solubilidad en equilibrio de la sulfamerazina (SMR) en etilenglicol puro (EG) y diecinueve {(EG) (1) + agua (2)} mezclas se reporta a temperaturas de (278.15 a 318.15) K. Solubilidad en fracción molar de SMR ( x 3 ) aumenta con el aumento de la temperatura y también aumenta con el aumento de la proporción de EG. Varía de 1,71 × 10 −5 en agua pura a 7,78 × 10 −4en EG puro a 298,15 K. El comportamiento de la solubilidad se correlacionó mediante el modelo logarítmico lineal extendido de Yalkowsky, el modelo Jouyban-Acree y el modelo Jouyban-Acree-van't Hoff y las desviaciones porcentuales medias obtenidas son 80,1 %, 6,7 % y 6,6%, respectivamente. A partir de la variación de la solubilidad con la temperatura, se realizó el análisis termodinámico aparente de los procesos de disolución y mezcla en todas las mezclas y solventes puros. A partir de los cálculos de integrales inversas de Kirkwood-Buff (IKBI) se observa que SMR exhibe parámetros de solvatación preferenciales negativos bajos por EG en mezclas ricas en agua. De lo contrario, SMR se solvata preferentemente por EG en el intervalo (0.24 < x 1 < 1.00).
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-09-01
dc.date.accessioned.none.fl_str_mv 2022-10-06T20:04:12Z
dc.date.available.none.fl_str_mv 2022-10-06T20:04:12Z
2024-12-01
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.issn.spa.fl_str_mv 0167-7322
dc.identifier.uri.spa.fl_str_mv 10.1016/j.molliq.2021.116330
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/46637
dc.identifier.bibliographicCitation.spa.fl_str_mv Solubility of sulfamerazine in (ethylene glycol+ water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation MS Vargas-Santana, AM Cruz-González, CP Ortiz, DR Delgado, ... Journal of Molecular Liquids 337, 116330
identifier_str_mv 0167-7322
10.1016/j.molliq.2021.116330
Solubility of sulfamerazine in (ethylene glycol+ water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation MS Vargas-Santana, AM Cruz-González, CP Ortiz, DR Delgado, ... Journal of Molecular Liquids 337, 116330
url https://hdl.handle.net/20.500.12494/46637
dc.relation.isversionof.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0167732221010540#!
dc.relation.ispartofjournal.spa.fl_str_mv Journal of Molecular Liquids
dc.relation.references.spa.fl_str_mv J.T. Rubino, Cosolvents and cosolvency, in: J.C. Swarbrick, J. Boylan (editors), Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York (NY), 1988, vol. 3, p. 375-398.
S.H. Yalkowsky, Solubility and Solubilization in Aqueous Media, American Chemical Society and Oxford University Press, New York (NY), 1999.
P. Bustamante, B. Escalera, A. Martin, E. Selles A modification of the extended Hildebrand approach to predict the solubility of structurally related drugs in solvent mixtures J. Pharm. Pharmacol., 45 (1993), pp. 253-257
S. Romero, A. Reillo, B. Escalera, P. Bustamante The behaviour of paracetamol in mixtures of aprotic and amphiprotic-aprotic solvents. Relationship of solubility curves to specific and nonspecific interactions Chem. Pharm. Bull (Tokyo), 44 (1996), pp. 1061-1066
P. Bustamante, S. Romero, A. Peña, B. Escalera, A. Reillo Nonlinear enthalpy-entropy compensation for the solubility of drugs in solvent mixtures: Paracetamol, acetanilide and nalidixic acid in dioxane-water J. Pharm. Sci., 87 (1998), pp. 1590-1596
Y. Marcus On the preferential solvation of drugs and PAHs in binary solvent mixtures J. Mol. Liq., 140 (2008), pp. 61-67
Y. Marcus Preferential solvation of drugs in binary solvent mixtures Pharm. Anal. Acta, 8 (2017), p. 1000537
D.R. Delgado, F. Martínez Solubility and solution thermodynamics of sulfamerazine and sulfamethazine in some ethanol + water mixtures Fluid Phase Equilib., 360 (2013), pp. 88-96
D.R. Delgado, F. Martínez Solubility and solution thermodynamics of some sulfonamides in 1-propanol + water mixtures J. Solution Chem., 43 (2014), pp. 836-852
dc.rights.license.none.fl_str_mv Atribución – No comercial
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
rights_invalid_str_mv Atribución – No comercial
http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
dc.format.extent.spa.fl_str_mv 15
dc.coverage.temporal.spa.fl_str_mv 337
dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, Neiva
Elsevier
dc.publisher.program.spa.fl_str_mv Ingeniería Civil
dc.publisher.place.spa.fl_str_mv Neiva
institution Universidad Cooperativa de Colombia
bitstream.url.fl_str_mv https://repository.ucc.edu.co/bitstreams/78e08f19-1a98-45c5-972b-63b55d1581fa/download
https://repository.ucc.edu.co/bitstreams/477ac31a-dfd5-4579-b4bb-9ac8de709dcc/download
https://repository.ucc.edu.co/bitstreams/39575916-90ed-4b58-be3a-1b0f2a28fceb/download
https://repository.ucc.edu.co/bitstreams/171222bd-6982-4dbf-a8f3-1c171ae89738/download
bitstream.checksum.fl_str_mv f61f86ef1a933bc80860f22cec742502
8a4605be74aa9ea9d79846c1fba20a33
9afcfc76ee3367cd8810e6af3a18ead5
7590ea6d1c95c6550bb0110057da2404
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814246984526069760
spelling Delgado, Daniel RicardoVargas-Santana, Martha SofíaCruz-González, Ana MaríaOrtiz, Claudia PatriciaDelgado, Daniel RicardoMartínez, FlemingPeña, María ÁngelesAcree Jr., William E.Jouyban, Abolghasem3372022-10-06T20:04:12Z2024-12-012022-10-06T20:04:12Z2021-09-010167-732210.1016/j.molliq.2021.116330https://hdl.handle.net/20.500.12494/46637Solubility of sulfamerazine in (ethylene glycol+ water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvation MS Vargas-Santana, AM Cruz-González, CP Ortiz, DR Delgado, ... Journal of Molecular Liquids 337, 116330La solubilidad en equilibrio de la sulfamerazina (SMR) en etilenglicol puro (EG) y diecinueve {(EG) (1) + agua (2)} mezclas se reporta a temperaturas de (278.15 a 318.15) K. Solubilidad en fracción molar de SMR ( x 3 ) aumenta con el aumento de la temperatura y también aumenta con el aumento de la proporción de EG. Varía de 1,71 × 10 −5 en agua pura a 7,78 × 10 −4en EG puro a 298,15 K. El comportamiento de la solubilidad se correlacionó mediante el modelo logarítmico lineal extendido de Yalkowsky, el modelo Jouyban-Acree y el modelo Jouyban-Acree-van't Hoff y las desviaciones porcentuales medias obtenidas son 80,1 %, 6,7 % y 6,6%, respectivamente. A partir de la variación de la solubilidad con la temperatura, se realizó el análisis termodinámico aparente de los procesos de disolución y mezcla en todas las mezclas y solventes puros. A partir de los cálculos de integrales inversas de Kirkwood-Buff (IKBI) se observa que SMR exhibe parámetros de solvatación preferenciales negativos bajos por EG en mezclas ricas en agua. De lo contrario, SMR se solvata preferentemente por EG en el intervalo (0.24 < x 1 < 1.00).The equilibrium solubility of sulfamerazine (SMR) in neat ethylene glycol (EG) and nineteen {(EG) (1) + water (2)} mixtures is reported at temperatures from (278.15 to 318.15) K. Mole fraction solubility of SMR (x3) increases with temperature arising and also increases with the EG proportion increasing. It varies from 1.71 × 10−5 in neat water to 7.78 × 10−4 in neat EG at 298.15 K. Solubility behavior was correlated by the extended log-linear model of Yalkowsky, the Jouyban-Acree model, and Jouyban-Acree-van’t Hoff model and the obtained mean percentage deviations are 80.1%, 6.7% and 6.6%, respectively. From the variation of solubility with temperature, the apparent thermodynamic analysis of dissolution and mixing processes was performed in all the mixtures and neat solvents. From inverse Kirkwood-Buff integrals (IKBI) calculations is observed that SMR exhibits low negative preferential solvation parameters by EG in water-rich mixtures. Otherwise, SMR is preferentially solvated by EG in the interval (0.24 < x1 < 1.00).Highlights Abstract Keywords 1. Introduction 2. Experimental 3. Results and discussion 4. Conclusions CRediT authorship contribution statement Declaration of Competing Interest Acknowledgements Appendix A. Supplementary material Referenceshttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001402116https://orcid.org/0000-0002-4835-9739https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000004151danielr.delgado@campusucc.edu.cohttps://scholar.google.com/citations?hl=es&user=OW0mejcAAAAJ&view_op=list_works&sortby=pubdate15Universidad Cooperativa de Colombia, Facultad de Ingenierías, Ingeniería Civil, NeivaElsevierIngeniería CivilNeivahttps://www.sciencedirect.com/science/article/abs/pii/S0167732221010540#!Journal of Molecular LiquidsJ.T. Rubino, Cosolvents and cosolvency, in: J.C. Swarbrick, J. Boylan (editors), Encyclopedia of Pharmaceutical Technology, Marcel Dekker, New York (NY), 1988, vol. 3, p. 375-398.S.H. Yalkowsky, Solubility and Solubilization in Aqueous Media, American Chemical Society and Oxford University Press, New York (NY), 1999.P. Bustamante, B. Escalera, A. Martin, E. Selles A modification of the extended Hildebrand approach to predict the solubility of structurally related drugs in solvent mixtures J. Pharm. Pharmacol., 45 (1993), pp. 253-257S. Romero, A. Reillo, B. Escalera, P. Bustamante The behaviour of paracetamol in mixtures of aprotic and amphiprotic-aprotic solvents. Relationship of solubility curves to specific and nonspecific interactions Chem. Pharm. Bull (Tokyo), 44 (1996), pp. 1061-1066P. Bustamante, S. Romero, A. Peña, B. Escalera, A. Reillo Nonlinear enthalpy-entropy compensation for the solubility of drugs in solvent mixtures: Paracetamol, acetanilide and nalidixic acid in dioxane-water J. Pharm. Sci., 87 (1998), pp. 1590-1596Y. Marcus On the preferential solvation of drugs and PAHs in binary solvent mixtures J. Mol. Liq., 140 (2008), pp. 61-67Y. Marcus Preferential solvation of drugs in binary solvent mixtures Pharm. Anal. Acta, 8 (2017), p. 1000537D.R. Delgado, F. Martínez Solubility and solution thermodynamics of sulfamerazine and sulfamethazine in some ethanol + water mixtures Fluid Phase Equilib., 360 (2013), pp. 88-96D.R. Delgado, F. Martínez Solubility and solution thermodynamics of some sulfonamides in 1-propanol + water mixtures J. Solution Chem., 43 (2014), pp. 836-852sulfamerazina{Etilenglicol (1) + agua (2)} mezclasSolubilidadModelo Jouyban-AcreeSolucion preferencialIKBIQ1Sulfamerazine{Ethylene glycol (1) + water (2)} mixturesSolubilityJouyban-Acree modelPreferential solvationIKBISolubility of sulfamerazine in (ethylene glycol + water) mixtures: Measurement, correlation, dissolution thermodynamics and preferential solvationArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAtribución – No comercialinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublicationORIGINALSolubility of sulfamerazine in (ethylene glycol + water) mixtures Measurement, correlation, dissolution thermodynamics and preferential solvation.pdfSolubility of sulfamerazine in (ethylene glycol + water) mixtures Measurement, correlation, dissolution thermodynamics and preferential solvation.pdfArticuloapplication/pdf767697https://repository.ucc.edu.co/bitstreams/78e08f19-1a98-45c5-972b-63b55d1581fa/downloadf61f86ef1a933bc80860f22cec742502MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/477ac31a-dfd5-4579-b4bb-9ac8de709dcc/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILSolubility of sulfamerazine in (ethylene glycol + water) mixtures Measurement, correlation, dissolution thermodynamics and preferential solvation.pdf.jpgSolubility of sulfamerazine in (ethylene glycol + water) mixtures Measurement, correlation, dissolution thermodynamics and preferential solvation.pdf.jpgGenerated Thumbnailimage/jpeg5886https://repository.ucc.edu.co/bitstreams/39575916-90ed-4b58-be3a-1b0f2a28fceb/download9afcfc76ee3367cd8810e6af3a18ead5MD53TEXTSolubility of sulfamerazine in (ethylene glycol + water) mixtures Measurement, correlation, dissolution thermodynamics and preferential solvation.pdf.txtSolubility of sulfamerazine in (ethylene glycol + water) mixtures Measurement, correlation, dissolution thermodynamics and preferential solvation.pdf.txtExtracted texttext/plain68470https://repository.ucc.edu.co/bitstreams/171222bd-6982-4dbf-a8f3-1c171ae89738/download7590ea6d1c95c6550bb0110057da2404MD5420.500.12494/46637oai:repository.ucc.edu.co:20.500.12494/466372024-08-20 16:19:41.918open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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