Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia

The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domai...

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Autores:: Galvis Ramirez, Manuel
Quintana Castillo, Juan Carlos
Bueno Sánchez, Julio César

Tipo de recurso:: Article of journal

Fecha de publicación:: 2018

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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network_acronym_str	COOPER2
network_name_str	Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
title	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
spellingShingle	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia Glomerular endothelia dysfunction Preeclampsia Heparan sulfate (HS) Systemic inflammatory response Renal damage
title_short	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
title_full	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
title_fullStr	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
title_full_unstemmed	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
title_sort	Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
dc.creator.fl_str_mv	Galvis Ramirez, Manuel Quintana Castillo, Juan Carlos Bueno Sánchez, Julio César
dc.contributor.author.none.fl_str_mv	Galvis Ramirez, Manuel Quintana Castillo, Juan Carlos Bueno Sánchez, Julio César
dc.subject.spa.fl_str_mv	Glomerular endothelia dysfunction Preeclampsia Heparan sulfate (HS) Systemic inflammatory response Renal damage
topic	Glomerular endothelia dysfunction Preeclampsia Heparan sulfate (HS) Systemic inflammatory response Renal damage
description	The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia.
publishDate	2018
dc.date.issued.none.fl_str_mv	2018-10-23
dc.date.accessioned.none.fl_str_mv	2020-01-20T14:08:10Z
dc.date.available.none.fl_str_mv	2020-01-20T14:08:10Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.issn.spa.fl_str_mv	1664-042X
dc.identifier.uri.spa.fl_str_mv	10.3389/fphys.2018.01470
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/16086
dc.identifier.bibliographicCitation.spa.fl_str_mv	Galvis Ramírez M.F., Quintana Castillo J.C. and Bueno Sanchez J.C. (2018) Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 9:1470. doi: 10.3389/fphys.2018.01470. Recuperado de: https://www.frontiersin.org/articles/10.3389/fphys.2018.01470/full
identifier_str_mv	1664-042X 10.3389/fphys.2018.01470 Galvis Ramírez M.F., Quintana Castillo J.C. and Bueno Sanchez J.C. (2018) Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 9:1470. doi: 10.3389/fphys.2018.01470. Recuperado de: https://www.frontiersin.org/articles/10.3389/fphys.2018.01470/full
url	https://hdl.handle.net/20.500.12494/16086
dc.relation.isversionof.spa.fl_str_mv	https://www.frontiersin.org/articles/10.3389/fphys.2018.01470/full
dc.relation.ispartofjournal.spa.fl_str_mv	Frontiers in Physiology
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spelling	Galvis Ramirez, ManuelQuintana Castillo, Juan CarlosBueno Sánchez, Julio César2020-01-20T14:08:10Z2020-01-20T14:08:10Z2018-10-231664-042X10.3389/fphys.2018.01470https://hdl.handle.net/20.500.12494/16086Galvis Ramírez M.F., Quintana Castillo J.C. and Bueno Sanchez J.C. (2018) Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 9:1470. doi: 10.3389/fphys.2018.01470. Recuperado de: https://www.frontiersin.org/articles/10.3389/fphys.2018.01470/fullThe polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=00000298230000-0002-7923-9158https://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000011355juan.quintanac@campusucc.edu.co10Fernanda R. 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F., Wismans, R. G., Lamrani, M., Monnens, L. A., Wevers, R. A., et al. (2007). In vivo degradation of heparan sulfates in the glomerular basement membrane does not result in proteinuria. J. Am. Soc. Nephrol. 18, 823–832. doi: 10.1681/ASN.200607 0692Wijnhoven, T. J., Van Den Hoven, M. J., Ding, H., Van Kuppevelt, T. H., Van Der Vlag, J., Berden, J. H., et al. (2008). Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy. Diabetologia 51, 372–382. doi: 10.1007/s00125-007-0879-6Zaferani, A., Vives, R. R., Van Der Pol, P., Navis, G. J., Daha, M. R., Van Kooten, C., et al. (2012). Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate. J. Biol. Chem. 287, 31471–31481. doi: 10.1074/ jbc.M112.380386Glomerular endothelia dysfunctionPreeclampsiaHeparan sulfate (HS)Systemic inflammatory responseRenal damageNovel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in PreeclampsiaArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationLICENSElicense.txtlicense.txttext/plain; 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Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia

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