Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)

Introduction: Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite, considered as a serious public health problem worldwide. The extracts of the medicinal plant, Renealmia alpina, have been used traditionally by indigenous people...

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Autores:
Patiño A.C.
López J.
Aristizábal M.
Quintana Castillo, Juan carlos
Benjumea D.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49731
Acceso en línea:
https://doi.org/10.7705/biomedica.v32i3.591
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877062604&doi=10.7705%2fbiomedica.v32i3.591&partnerID=40&md5=6e0129e95f64e51fb2043a1792ceb5f8
https://hdl.handle.net/20.500.12494/49731
Palabra clave:
ACETATES
ACETIC ACID DERIVATIVE
ACETIC ACID ETHYL ESTER
ALCOHOL
ALPINIA
ANALGESIC AGENT
ANALGESICS
ANIMAL
ANIMALIA
ANIMALS
ARTICLE
BAGG ALBINO MOUSE
BLOOD CLOTTING
BLOOD COAGULATION
BOTHROPS
BOTHROPS ASPER
COMPARATIVE STUDY
CROTALID VENOMS
CHEMISTRY
DICHLOROMETHANE
DRUG ANTAGONISM
DRUG EFFECT
DRUG EVALUATION, PRECLINICAL
DRUG SCREENING
ETHANOL
FEMALE
HEMOLYSIS
HEXANE
HEXANES
ISOLATION AND PURIFICATION
MALE
METHANOL
METHYLENE CHLORIDE
MICE, INBRED BALB C
PHYTOTHERAPY
PLANT EXTRACT
PLANT EXTRACTS
PLANT LEAF
PLANT LEAVES
PROTEIN DEGRADATION
PROTEOLYSIS
RENEALMIA
RENEALMIA ALPINIA
SNAKE BITES
SNAKE VENOM
SNAKEBITE
SOLVENT
SOLVENTS
ZINGIBERACEAE
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_4c86794ea35dab506b3360507920ba53
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49731
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Patiño A.C.López J.Aristizábal M.Quintana Castillo, Juan carlosBenjumea D.2023-05-24T16:21:40Z2023-05-24T16:21:40Z01/01/2012https://doi.org/10.7705/biomedica.v32i3.591https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877062604&doi=10.7705%2fbiomedica.v32i3.591&partnerID=40&md5=6e0129e95f64e51fb2043a1792ceb5f801204157https://hdl.handle.net/20.500.12494/49731Patiño A.C.,López J.,Aristizábal M.,Quintana Castillo Juan carlos,Benjumea D..Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná).Biomedica: Revista Del Instituto Nacional De Salud. 2012. 32. (3):p. 365-374Introduction: Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite, considered as a serious public health problem worldwide. The extracts of the medicinal plant, Renealmia alpina, have been used traditionally by indigenous people of Chocó (Colombia) against Bothrops asper snakebite, a snake responsible for the majority of snakebite accidents in Colombia. Objective: The ability of extracts of R. alpinia leaves was tested for its ability to neutralize the hemorrhagic, coagulant and proteolytic effects of the snakebite venom of B. asper. Materials and methods: The acute toxicity tests and analgesic activity of R. alpina were evaluated in vivo. In addition, tests were undertaken in in vitro conditions to demonstrate inhibition of coagulant, haemolytic and proteolytic activity of the B. asper venom. Results: Renealmia alpinia extracts had no toxic effects in experimental animals and also provided analgesic and antiophidian effects and protection against the lethal effects of the venom of B. asper. Conclusion: Renealmia. alpinia was an effective therapeutic alternative in association with antivenom treatment in the event of a B. asper snakebite accident. It was demonstrated to protect against the lethal effects and provided analgesic properties as well.0000-0002-7923-9158juan.quintanac@campusucc.edu.co365-374Instituto Nacional de SaludACETATESACETIC ACID DERIVATIVEACETIC ACID ETHYL ESTERALCOHOLALPINIAANALGESIC AGENTANALGESICSANIMALANIMALIAANIMALSARTICLEBAGG ALBINO MOUSEBLOOD CLOTTINGBLOOD COAGULATIONBOTHROPSBOTHROPS ASPERCOMPARATIVE STUDYCROTALID VENOMSCHEMISTRYDICHLOROMETHANEDRUG ANTAGONISMDRUG EFFECTDRUG EVALUATION, PRECLINICALDRUG SCREENINGETHANOLFEMALEHEMOLYSISHEXANEHEXANESISOLATION AND PURIFICATIONMALEMETHANOLMETHYLENE CHLORIDEMICE, INBRED BALB CPHYTOTHERAPYPLANT EXTRACTPLANT EXTRACTSPLANT LEAFPLANT LEAVESPROTEIN DEGRADATIONPROTEOLYSISRENEALMIARENEALMIA ALPINIASNAKE BITESSNAKE VENOMSNAKEBITESOLVENTSOLVENTSZINGIBERACEAEEfecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)Artículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionBiomedica: Revista Del Instituto Nacional De Saludinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49731oai:repository.ucc.edu.co:20.500.12494/497312024-08-20 16:19:53.248metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
title Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
spellingShingle Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
ACETATES
ACETIC ACID DERIVATIVE
ACETIC ACID ETHYL ESTER
ALCOHOL
ALPINIA
ANALGESIC AGENT
ANALGESICS
ANIMAL
ANIMALIA
ANIMALS
ARTICLE
BAGG ALBINO MOUSE
BLOOD CLOTTING
BLOOD COAGULATION
BOTHROPS
BOTHROPS ASPER
COMPARATIVE STUDY
CROTALID VENOMS
CHEMISTRY
DICHLOROMETHANE
DRUG ANTAGONISM
DRUG EFFECT
DRUG EVALUATION, PRECLINICAL
DRUG SCREENING
ETHANOL
FEMALE
HEMOLYSIS
HEXANE
HEXANES
ISOLATION AND PURIFICATION
MALE
METHANOL
METHYLENE CHLORIDE
MICE, INBRED BALB C
PHYTOTHERAPY
PLANT EXTRACT
PLANT EXTRACTS
PLANT LEAF
PLANT LEAVES
PROTEIN DEGRADATION
PROTEOLYSIS
RENEALMIA
RENEALMIA ALPINIA
SNAKE BITES
SNAKE VENOM
SNAKEBITE
SOLVENT
SOLVENTS
ZINGIBERACEAE
title_short Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
title_full Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
title_fullStr Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
title_full_unstemmed Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
title_sort Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná)
dc.creator.fl_str_mv Patiño A.C.
López J.
Aristizábal M.
Quintana Castillo, Juan carlos
Benjumea D.
dc.contributor.author.none.fl_str_mv Patiño A.C.
López J.
Aristizábal M.
Quintana Castillo, Juan carlos
Benjumea D.
dc.subject.spa.fl_str_mv ACETATES
ACETIC ACID DERIVATIVE
ACETIC ACID ETHYL ESTER
ALCOHOL
ALPINIA
ANALGESIC AGENT
ANALGESICS
ANIMAL
ANIMALIA
ANIMALS
ARTICLE
BAGG ALBINO MOUSE
BLOOD CLOTTING
BLOOD COAGULATION
BOTHROPS
BOTHROPS ASPER
COMPARATIVE STUDY
CROTALID VENOMS
CHEMISTRY
DICHLOROMETHANE
DRUG ANTAGONISM
DRUG EFFECT
DRUG EVALUATION, PRECLINICAL
DRUG SCREENING
ETHANOL
FEMALE
HEMOLYSIS
HEXANE
HEXANES
ISOLATION AND PURIFICATION
MALE
METHANOL
METHYLENE CHLORIDE
MICE, INBRED BALB C
PHYTOTHERAPY
PLANT EXTRACT
PLANT EXTRACTS
PLANT LEAF
PLANT LEAVES
PROTEIN DEGRADATION
PROTEOLYSIS
RENEALMIA
RENEALMIA ALPINIA
SNAKE BITES
SNAKE VENOM
SNAKEBITE
SOLVENT
SOLVENTS
ZINGIBERACEAE
topic ACETATES
ACETIC ACID DERIVATIVE
ACETIC ACID ETHYL ESTER
ALCOHOL
ALPINIA
ANALGESIC AGENT
ANALGESICS
ANIMAL
ANIMALIA
ANIMALS
ARTICLE
BAGG ALBINO MOUSE
BLOOD CLOTTING
BLOOD COAGULATION
BOTHROPS
BOTHROPS ASPER
COMPARATIVE STUDY
CROTALID VENOMS
CHEMISTRY
DICHLOROMETHANE
DRUG ANTAGONISM
DRUG EFFECT
DRUG EVALUATION, PRECLINICAL
DRUG SCREENING
ETHANOL
FEMALE
HEMOLYSIS
HEXANE
HEXANES
ISOLATION AND PURIFICATION
MALE
METHANOL
METHYLENE CHLORIDE
MICE, INBRED BALB C
PHYTOTHERAPY
PLANT EXTRACT
PLANT EXTRACTS
PLANT LEAF
PLANT LEAVES
PROTEIN DEGRADATION
PROTEOLYSIS
RENEALMIA
RENEALMIA ALPINIA
SNAKE BITES
SNAKE VENOM
SNAKEBITE
SOLVENT
SOLVENTS
ZINGIBERACEAE
description Introduction: Traditional medicine is an invaluable source of research into new medicines as a supplement for the treatment of snakebite, considered as a serious public health problem worldwide. The extracts of the medicinal plant, Renealmia alpina, have been used traditionally by indigenous people of Chocó (Colombia) against Bothrops asper snakebite, a snake responsible for the majority of snakebite accidents in Colombia. Objective: The ability of extracts of R. alpinia leaves was tested for its ability to neutralize the hemorrhagic, coagulant and proteolytic effects of the snakebite venom of B. asper. Materials and methods: The acute toxicity tests and analgesic activity of R. alpina were evaluated in vivo. In addition, tests were undertaken in in vitro conditions to demonstrate inhibition of coagulant, haemolytic and proteolytic activity of the B. asper venom. Results: Renealmia alpinia extracts had no toxic effects in experimental animals and also provided analgesic and antiophidian effects and protection against the lethal effects of the venom of B. asper. Conclusion: Renealmia. alpinia was an effective therapeutic alternative in association with antivenom treatment in the event of a B. asper snakebite accident. It was demonstrated to protect against the lethal effects and provided analgesic properties as well.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2012
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:40Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:40Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.7705/biomedica.v32i3.591
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877062604&doi=10.7705%2fbiomedica.v32i3.591&partnerID=40&md5=6e0129e95f64e51fb2043a1792ceb5f8
dc.identifier.issn.spa.fl_str_mv 01204157
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49731
dc.identifier.bibliographicCitation.spa.fl_str_mv Patiño A.C.,López J.,Aristizábal M.,Quintana Castillo Juan carlos,Benjumea D..Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná).Biomedica: Revista Del Instituto Nacional De Salud. 2012. 32. (3):p. 365-374
url https://doi.org/10.7705/biomedica.v32i3.591
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877062604&doi=10.7705%2fbiomedica.v32i3.591&partnerID=40&md5=6e0129e95f64e51fb2043a1792ceb5f8
https://hdl.handle.net/20.500.12494/49731
identifier_str_mv 01204157
Patiño A.C.,López J.,Aristizábal M.,Quintana Castillo Juan carlos,Benjumea D..Efecto inhibitorio de extractos de renealmia alpinia rottb. maas (Zingiberaceae) sobre el veneno de bothrops asper (mapaná).Biomedica: Revista Del Instituto Nacional De Salud. 2012. 32. (3):p. 365-374
dc.relation.ispartofjournal.spa.fl_str_mv Biomedica: Revista Del Instituto Nacional De Salud
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 365-374
dc.publisher.spa.fl_str_mv Instituto Nacional de Salud
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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