HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-exposed seronegatives (HESNs), few studies have focused on de...
- Autores:
-
Hernández López, Juan Carlos
St Laurent G.
Urcuqui-Inchima S.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/49577
- Acceso en línea:
- https://doi.org/10.1007/s12026-015-8748-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f
https://hdl.handle.net/20.500.12494/49577
- Palabra clave:
- ADULT
ARTICLE
AUTACOID
BLOOD
CASPASE RECRUITMENT DOMAIN PROTEIN 15
CELL CULTURE
CLINICAL ARTICLE
COHORT ANALYSIS
CONTROLLED STUDY
CYTOKINE
CYTOKINE PRODUCTION
DDX58 PROTEIN, HUMAN
DEAD BOX PROTEIN
DENDRITIC CELL
EX VIVO STUDY
FEMALE
GENETICS
HUMAN
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
IMMUNOLOGY
IMMUNOMODULATION
INNATE IMMUNITY
INTERLEUKIN 10
INTERLEUKIN 18
INTERLEUKIN 1BETA
INTERLEUKIN 6
MALE
MESSENGER RNA
METABO
MONOCYTE
NOD2 PROTEIN, HUMAN
NONHUMAN
PATHOGENESIS
PATTERN RECOGNITION RECEPTOR
PERIPHERAL BLOOD MONONUCLEAR CELL
PRIORITY JOURNAL
PROTEIN BLOOD LEVEL
PROTEIN EXPRESSION
PROTEIN FUNCTION
RETINOIC ACID INDUCIBLE PROTEIN I
TOLL LIKE RECEPTOR
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TOLL LIKE RECEPTOR 8
TUMOR NECROSIS FACTOR ALPHA
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
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oai:repository.ucc.edu.co:20.500.12494/49577 |
network_acronym_str |
COOPER2 |
network_name_str |
Repositorio UCC |
repository_id_str |
|
spelling |
Hernández López, Juan Carlos St Laurent G.Urcuqui-Inchima S.2023-05-24T16:21:32Z2023-05-24T16:21:32Z01/01/2016https://doi.org/10.1007/s12026-015-8748-8https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f0257277Xhttps://hdl.handle.net/20.500.12494/49577Hernandez Lopez Juan carlos,St Laurent G.,III,Urcuqui-Inchima S..HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?.IMMUNOL RES. 2016. 64. (1):p. 280-290Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-exposed seronegatives (HESNs), few studies have focused on determining the relationship between PRR expression and cytokine production. We have aimed here to evaluate the expression level of PRRs and cytokines in HESNs, HIV-1 patients and healthy donors. Basal PRR expression levels in PBMCs, dendritic cells (DCs) and monocytes, and plasma cytokine levels as well as the PRR ligand-induced cytokine productions were determined by flow cytometry, qPCR and ELISA. Higher TLR2/4 expression in DCs and monocytes from HESNs was observed. Nevertheless, TLR4/8, NOD2 and RIG-I mRNA levels were lower in PBMCs from HESNs than HIV-1-infected patients. Comparable IL-1ß, IL-18 and TNF-a mRNA levels were observed among the groups examined; however, at the protein level, production of IL-1ß, IL-6 and IL-10 was significantly lower in plasma from HESNs than from HIV-1-infected patients. Our results suggest that exposure to HIV-1 without infection could be associated with reduced basal pro-inflammatory responses. Further studies are required to define the cell subsets responsible for these differences and the role of PRRs on protection against HIV-1 infection. © 2015, Springer Science+Business Media New York.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co280-290Humana Press Inc.ADULTARTICLEAUTACOIDBLOODCASPASE RECRUITMENT DOMAIN PROTEIN 15CELL CULTURECLINICAL ARTICLECOHORT ANALYSISCONTROLLED STUDYCYTOKINECYTOKINE PRODUCTIONDDX58 PROTEIN, HUMANDEAD BOX PROTEINDENDRITIC CELLEX VIVO STUDYFEMALEGENETICSHUMANHUMAN IMMUNODEFICIENCY VIRUS 1HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTIONHUMAN IMMUNODEFICIENCY VIRUS ANTIBODYHUMAN IMMUNODEFICIENCY VIRUS INFECTIONIMMUNOLOGYIMMUNOMODULATIONINNATE IMMUNITYINTERLEUKIN 10INTERLEUKIN 18INTERLEUKIN 1BETAINTERLEUKIN 6MALEMESSENGER RNAMETABOMONOCYTENOD2 PROTEIN, HUMANNONHUMANPATHOGENESISPATTERN RECOGNITION RECEPTORPERIPHERAL BLOOD MONONUCLEAR CELLPRIORITY JOURNALPROTEIN BLOOD LEVELPROTEIN EXPRESSIONPROTEIN FUNCTIONRETINOIC ACID INDUCIBLE PROTEIN ITOLL LIKE RECEPTORTOLL LIKE RECEPTOR 2TOLL LIKE RECEPTOR 4TOLL LIKE RECEPTOR 8TUMOR NECROSIS FACTOR ALPHAHIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?Artículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionIMMUNOL RESinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49577oai:repository.ucc.edu.co:20.500.12494/495772024-08-20 16:22:06.532metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
title |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
spellingShingle |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? ADULT ARTICLE AUTACOID BLOOD CASPASE RECRUITMENT DOMAIN PROTEIN 15 CELL CULTURE CLINICAL ARTICLE COHORT ANALYSIS CONTROLLED STUDY CYTOKINE CYTOKINE PRODUCTION DDX58 PROTEIN, HUMAN DEAD BOX PROTEIN DENDRITIC CELL EX VIVO STUDY FEMALE GENETICS HUMAN HUMAN IMMUNODEFICIENCY VIRUS 1 HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY HUMAN IMMUNODEFICIENCY VIRUS INFECTION IMMUNOLOGY IMMUNOMODULATION INNATE IMMUNITY INTERLEUKIN 10 INTERLEUKIN 18 INTERLEUKIN 1BETA INTERLEUKIN 6 MALE MESSENGER RNA METABO MONOCYTE NOD2 PROTEIN, HUMAN NONHUMAN PATHOGENESIS PATTERN RECOGNITION RECEPTOR PERIPHERAL BLOOD MONONUCLEAR CELL PRIORITY JOURNAL PROTEIN BLOOD LEVEL PROTEIN EXPRESSION PROTEIN FUNCTION RETINOIC ACID INDUCIBLE PROTEIN I TOLL LIKE RECEPTOR TOLL LIKE RECEPTOR 2 TOLL LIKE RECEPTOR 4 TOLL LIKE RECEPTOR 8 TUMOR NECROSIS FACTOR ALPHA |
title_short |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
title_full |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
title_fullStr |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
title_full_unstemmed |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
title_sort |
HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status? |
dc.creator.fl_str_mv |
Hernández López, Juan Carlos St Laurent G. Urcuqui-Inchima S. |
dc.contributor.author.none.fl_str_mv |
Hernández López, Juan Carlos St Laurent G. Urcuqui-Inchima S. |
dc.subject.spa.fl_str_mv |
ADULT ARTICLE AUTACOID BLOOD CASPASE RECRUITMENT DOMAIN PROTEIN 15 CELL CULTURE CLINICAL ARTICLE COHORT ANALYSIS CONTROLLED STUDY CYTOKINE CYTOKINE PRODUCTION DDX58 PROTEIN, HUMAN DEAD BOX PROTEIN DENDRITIC CELL EX VIVO STUDY FEMALE GENETICS HUMAN HUMAN IMMUNODEFICIENCY VIRUS 1 HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY HUMAN IMMUNODEFICIENCY VIRUS INFECTION IMMUNOLOGY IMMUNOMODULATION INNATE IMMUNITY INTERLEUKIN 10 INTERLEUKIN 18 INTERLEUKIN 1BETA INTERLEUKIN 6 MALE MESSENGER RNA METABO MONOCYTE NOD2 PROTEIN, HUMAN NONHUMAN PATHOGENESIS PATTERN RECOGNITION RECEPTOR PERIPHERAL BLOOD MONONUCLEAR CELL PRIORITY JOURNAL PROTEIN BLOOD LEVEL PROTEIN EXPRESSION PROTEIN FUNCTION RETINOIC ACID INDUCIBLE PROTEIN I TOLL LIKE RECEPTOR TOLL LIKE RECEPTOR 2 TOLL LIKE RECEPTOR 4 TOLL LIKE RECEPTOR 8 TUMOR NECROSIS FACTOR ALPHA |
topic |
ADULT ARTICLE AUTACOID BLOOD CASPASE RECRUITMENT DOMAIN PROTEIN 15 CELL CULTURE CLINICAL ARTICLE COHORT ANALYSIS CONTROLLED STUDY CYTOKINE CYTOKINE PRODUCTION DDX58 PROTEIN, HUMAN DEAD BOX PROTEIN DENDRITIC CELL EX VIVO STUDY FEMALE GENETICS HUMAN HUMAN IMMUNODEFICIENCY VIRUS 1 HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY HUMAN IMMUNODEFICIENCY VIRUS INFECTION IMMUNOLOGY IMMUNOMODULATION INNATE IMMUNITY INTERLEUKIN 10 INTERLEUKIN 18 INTERLEUKIN 1BETA INTERLEUKIN 6 MALE MESSENGER RNA METABO MONOCYTE NOD2 PROTEIN, HUMAN NONHUMAN PATHOGENESIS PATTERN RECOGNITION RECEPTOR PERIPHERAL BLOOD MONONUCLEAR CELL PRIORITY JOURNAL PROTEIN BLOOD LEVEL PROTEIN EXPRESSION PROTEIN FUNCTION RETINOIC ACID INDUCIBLE PROTEIN I TOLL LIKE RECEPTOR TOLL LIKE RECEPTOR 2 TOLL LIKE RECEPTOR 4 TOLL LIKE RECEPTOR 8 TUMOR NECROSIS FACTOR ALPHA |
description |
Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-exposed seronegatives (HESNs), few studies have focused on determining the relationship between PRR expression and cytokine production. We have aimed here to evaluate the expression level of PRRs and cytokines in HESNs, HIV-1 patients and healthy donors. Basal PRR expression levels in PBMCs, dendritic cells (DCs) and monocytes, and plasma cytokine levels as well as the PRR ligand-induced cytokine productions were determined by flow cytometry, qPCR and ELISA. Higher TLR2/4 expression in DCs and monocytes from HESNs was observed. Nevertheless, TLR4/8, NOD2 and RIG-I mRNA levels were lower in PBMCs from HESNs than HIV-1-infected patients. Comparable IL-1ß, IL-18 and TNF-a mRNA levels were observed among the groups examined; however, at the protein level, production of IL-1ß, IL-6 and IL-10 was significantly lower in plasma from HESNs than from HIV-1-infected patients. Our results suggest that exposure to HIV-1 without infection could be associated with reduced basal pro-inflammatory responses. Further studies are required to define the cell subsets responsible for these differences and the role of PRRs on protection against HIV-1 infection. © 2015, Springer Science+Business Media New York. |
publishDate |
2023 |
dc.date.issued.none.fl_str_mv |
01/01/2016 |
dc.date.accessioned.none.fl_str_mv |
2023-05-24T16:21:32Z |
dc.date.available.none.fl_str_mv |
2023-05-24T16:21:32Z |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://doi.org/10.1007/s12026-015-8748-8 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f |
dc.identifier.issn.spa.fl_str_mv |
0257277X |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/49577 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Hernandez Lopez Juan carlos,St Laurent G.,III,Urcuqui-Inchima S..HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?.IMMUNOL RES. 2016. 64. (1):p. 280-290 |
url |
https://doi.org/10.1007/s12026-015-8748-8 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f https://hdl.handle.net/20.500.12494/49577 |
identifier_str_mv |
0257277X Hernandez Lopez Juan carlos,St Laurent G.,III,Urcuqui-Inchima S..HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?.IMMUNOL RES. 2016. 64. (1):p. 280-290 |
dc.relation.ispartofjournal.spa.fl_str_mv |
IMMUNOL RES |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
280-290 |
dc.publisher.spa.fl_str_mv |
Humana Press Inc. |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814247222300114944 |