HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?

Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-exposed seronegatives (HESNs), few studies have focused on de...

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Autores:
Hernández López, Juan Carlos
St Laurent G.
Urcuqui-Inchima S.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49577
Acceso en línea:
https://doi.org/10.1007/s12026-015-8748-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f
https://hdl.handle.net/20.500.12494/49577
Palabra clave:
ADULT
ARTICLE
AUTACOID
BLOOD
CASPASE RECRUITMENT DOMAIN PROTEIN 15
CELL CULTURE
CLINICAL ARTICLE
COHORT ANALYSIS
CONTROLLED STUDY
CYTOKINE
CYTOKINE PRODUCTION
DDX58 PROTEIN, HUMAN
DEAD BOX PROTEIN
DENDRITIC CELL
EX VIVO STUDY
FEMALE
GENETICS
HUMAN
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
IMMUNOLOGY
IMMUNOMODULATION
INNATE IMMUNITY
INTERLEUKIN 10
INTERLEUKIN 18
INTERLEUKIN 1BETA
INTERLEUKIN 6
MALE
MESSENGER RNA
METABO
MONOCYTE
NOD2 PROTEIN, HUMAN
NONHUMAN
PATHOGENESIS
PATTERN RECOGNITION RECEPTOR
PERIPHERAL BLOOD MONONUCLEAR CELL
PRIORITY JOURNAL
PROTEIN BLOOD LEVEL
PROTEIN EXPRESSION
PROTEIN FUNCTION
RETINOIC ACID INDUCIBLE PROTEIN I
TOLL LIKE RECEPTOR
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TOLL LIKE RECEPTOR 8
TUMOR NECROSIS FACTOR ALPHA
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_4aa93b4cadf3d1a5b8858ac38a63d3bd
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49577
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Hernández López, Juan Carlos St Laurent G.Urcuqui-Inchima S.2023-05-24T16:21:32Z2023-05-24T16:21:32Z01/01/2016https://doi.org/10.1007/s12026-015-8748-8https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f0257277Xhttps://hdl.handle.net/20.500.12494/49577Hernandez Lopez Juan carlos,St Laurent G.,III,Urcuqui-Inchima S..HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?.IMMUNOL RES. 2016. 64. (1):p. 280-290Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-exposed seronegatives (HESNs), few studies have focused on determining the relationship between PRR expression and cytokine production. We have aimed here to evaluate the expression level of PRRs and cytokines in HESNs, HIV-1 patients and healthy donors. Basal PRR expression levels in PBMCs, dendritic cells (DCs) and monocytes, and plasma cytokine levels as well as the PRR ligand-induced cytokine productions were determined by flow cytometry, qPCR and ELISA. Higher TLR2/4 expression in DCs and monocytes from HESNs was observed. Nevertheless, TLR4/8, NOD2 and RIG-I mRNA levels were lower in PBMCs from HESNs than HIV-1-infected patients. Comparable IL-1ß, IL-18 and TNF-a mRNA levels were observed among the groups examined; however, at the protein level, production of IL-1ß, IL-6 and IL-10 was significantly lower in plasma from HESNs than from HIV-1-infected patients. Our results suggest that exposure to HIV-1 without infection could be associated with reduced basal pro-inflammatory responses. Further studies are required to define the cell subsets responsible for these differences and the role of PRRs on protection against HIV-1 infection. © 2015, Springer Science+Business Media New York.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co280-290Humana Press Inc.ADULTARTICLEAUTACOIDBLOODCASPASE RECRUITMENT DOMAIN PROTEIN 15CELL CULTURECLINICAL ARTICLECOHORT ANALYSISCONTROLLED STUDYCYTOKINECYTOKINE PRODUCTIONDDX58 PROTEIN, HUMANDEAD BOX PROTEINDENDRITIC CELLEX VIVO STUDYFEMALEGENETICSHUMANHUMAN IMMUNODEFICIENCY VIRUS 1HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTIONHUMAN IMMUNODEFICIENCY VIRUS ANTIBODYHUMAN IMMUNODEFICIENCY VIRUS INFECTIONIMMUNOLOGYIMMUNOMODULATIONINNATE IMMUNITYINTERLEUKIN 10INTERLEUKIN 18INTERLEUKIN 1BETAINTERLEUKIN 6MALEMESSENGER RNAMETABOMONOCYTENOD2 PROTEIN, HUMANNONHUMANPATHOGENESISPATTERN RECOGNITION RECEPTORPERIPHERAL BLOOD MONONUCLEAR CELLPRIORITY JOURNALPROTEIN BLOOD LEVELPROTEIN EXPRESSIONPROTEIN FUNCTIONRETINOIC ACID INDUCIBLE PROTEIN ITOLL LIKE RECEPTORTOLL LIKE RECEPTOR 2TOLL LIKE RECEPTOR 4TOLL LIKE RECEPTOR 8TUMOR NECROSIS FACTOR ALPHAHIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?Artículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionIMMUNOL RESinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49577oai:repository.ucc.edu.co:20.500.12494/495772024-08-20 16:22:06.532metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
title HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
spellingShingle HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
ADULT
ARTICLE
AUTACOID
BLOOD
CASPASE RECRUITMENT DOMAIN PROTEIN 15
CELL CULTURE
CLINICAL ARTICLE
COHORT ANALYSIS
CONTROLLED STUDY
CYTOKINE
CYTOKINE PRODUCTION
DDX58 PROTEIN, HUMAN
DEAD BOX PROTEIN
DENDRITIC CELL
EX VIVO STUDY
FEMALE
GENETICS
HUMAN
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
IMMUNOLOGY
IMMUNOMODULATION
INNATE IMMUNITY
INTERLEUKIN 10
INTERLEUKIN 18
INTERLEUKIN 1BETA
INTERLEUKIN 6
MALE
MESSENGER RNA
METABO
MONOCYTE
NOD2 PROTEIN, HUMAN
NONHUMAN
PATHOGENESIS
PATTERN RECOGNITION RECEPTOR
PERIPHERAL BLOOD MONONUCLEAR CELL
PRIORITY JOURNAL
PROTEIN BLOOD LEVEL
PROTEIN EXPRESSION
PROTEIN FUNCTION
RETINOIC ACID INDUCIBLE PROTEIN I
TOLL LIKE RECEPTOR
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TOLL LIKE RECEPTOR 8
TUMOR NECROSIS FACTOR ALPHA
title_short HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
title_full HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
title_fullStr HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
title_full_unstemmed HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
title_sort HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
dc.creator.fl_str_mv Hernández López, Juan Carlos
St Laurent G.
Urcuqui-Inchima S.
dc.contributor.author.none.fl_str_mv Hernández López, Juan Carlos
St Laurent G.
Urcuqui-Inchima S.
dc.subject.spa.fl_str_mv ADULT
ARTICLE
AUTACOID
BLOOD
CASPASE RECRUITMENT DOMAIN PROTEIN 15
CELL CULTURE
CLINICAL ARTICLE
COHORT ANALYSIS
CONTROLLED STUDY
CYTOKINE
CYTOKINE PRODUCTION
DDX58 PROTEIN, HUMAN
DEAD BOX PROTEIN
DENDRITIC CELL
EX VIVO STUDY
FEMALE
GENETICS
HUMAN
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
IMMUNOLOGY
IMMUNOMODULATION
INNATE IMMUNITY
INTERLEUKIN 10
INTERLEUKIN 18
INTERLEUKIN 1BETA
INTERLEUKIN 6
MALE
MESSENGER RNA
METABO
MONOCYTE
NOD2 PROTEIN, HUMAN
NONHUMAN
PATHOGENESIS
PATTERN RECOGNITION RECEPTOR
PERIPHERAL BLOOD MONONUCLEAR CELL
PRIORITY JOURNAL
PROTEIN BLOOD LEVEL
PROTEIN EXPRESSION
PROTEIN FUNCTION
RETINOIC ACID INDUCIBLE PROTEIN I
TOLL LIKE RECEPTOR
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TOLL LIKE RECEPTOR 8
TUMOR NECROSIS FACTOR ALPHA
topic ADULT
ARTICLE
AUTACOID
BLOOD
CASPASE RECRUITMENT DOMAIN PROTEIN 15
CELL CULTURE
CLINICAL ARTICLE
COHORT ANALYSIS
CONTROLLED STUDY
CYTOKINE
CYTOKINE PRODUCTION
DDX58 PROTEIN, HUMAN
DEAD BOX PROTEIN
DENDRITIC CELL
EX VIVO STUDY
FEMALE
GENETICS
HUMAN
HUMAN IMMUNODEFICIENCY VIRUS 1
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION
HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY
HUMAN IMMUNODEFICIENCY VIRUS INFECTION
IMMUNOLOGY
IMMUNOMODULATION
INNATE IMMUNITY
INTERLEUKIN 10
INTERLEUKIN 18
INTERLEUKIN 1BETA
INTERLEUKIN 6
MALE
MESSENGER RNA
METABO
MONOCYTE
NOD2 PROTEIN, HUMAN
NONHUMAN
PATHOGENESIS
PATTERN RECOGNITION RECEPTOR
PERIPHERAL BLOOD MONONUCLEAR CELL
PRIORITY JOURNAL
PROTEIN BLOOD LEVEL
PROTEIN EXPRESSION
PROTEIN FUNCTION
RETINOIC ACID INDUCIBLE PROTEIN I
TOLL LIKE RECEPTOR
TOLL LIKE RECEPTOR 2
TOLL LIKE RECEPTOR 4
TOLL LIKE RECEPTOR 8
TUMOR NECROSIS FACTOR ALPHA
description Pattern recognition receptors (PRRs) are involved in direct recognition of viruses, promoting cellular activation and the production of pro-inflammatory cytokines. However, despite the reduced systemic immune activation described in HIV-1-exposed seronegatives (HESNs), few studies have focused on determining the relationship between PRR expression and cytokine production. We have aimed here to evaluate the expression level of PRRs and cytokines in HESNs, HIV-1 patients and healthy donors. Basal PRR expression levels in PBMCs, dendritic cells (DCs) and monocytes, and plasma cytokine levels as well as the PRR ligand-induced cytokine productions were determined by flow cytometry, qPCR and ELISA. Higher TLR2/4 expression in DCs and monocytes from HESNs was observed. Nevertheless, TLR4/8, NOD2 and RIG-I mRNA levels were lower in PBMCs from HESNs than HIV-1-infected patients. Comparable IL-1ß, IL-18 and TNF-a mRNA levels were observed among the groups examined; however, at the protein level, production of IL-1ß, IL-6 and IL-10 was significantly lower in plasma from HESNs than from HIV-1-infected patients. Our results suggest that exposure to HIV-1 without infection could be associated with reduced basal pro-inflammatory responses. Further studies are required to define the cell subsets responsible for these differences and the role of PRRs on protection against HIV-1 infection. © 2015, Springer Science+Business Media New York.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2016
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:32Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:32Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s12026-015-8748-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f
dc.identifier.issn.spa.fl_str_mv 0257277X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49577
dc.identifier.bibliographicCitation.spa.fl_str_mv Hernandez Lopez Juan carlos,St Laurent G.,III,Urcuqui-Inchima S..HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?.IMMUNOL RES. 2016. 64. (1):p. 280-290
url https://doi.org/10.1007/s12026-015-8748-8
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955626129&doi=10.1007%2fs12026-015-8748-8&partnerID=40&md5=0a80b2e9a102fdfa633e5c45cf8e385f
https://hdl.handle.net/20.500.12494/49577
identifier_str_mv 0257277X
Hernandez Lopez Juan carlos,St Laurent G.,III,Urcuqui-Inchima S..HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?.IMMUNOL RES. 2016. 64. (1):p. 280-290
dc.relation.ispartofjournal.spa.fl_str_mv IMMUNOL RES
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 280-290
dc.publisher.spa.fl_str_mv Humana Press Inc.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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