Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology
Introduction: There are different strategies for anxiety control in dentistry. The objective of this study was to determine the efficacy and safety of clonidine medication versus placebo to decrease anxiety and pain in third-molar extraction. Methods: a placebo controlled clinical trial, randomized,...
- Autores:
-
Bermúdez-Reyes, Patricia
Támara-Eraso, Ana Karina
Vargas, Jorge William
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- spa
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/9660
- Acceso en línea:
- https://revistas.ucc.edu.co/index.php/od/article/view/550
https://hdl.handle.net/20.500.12494/9660
- Palabra clave:
- Rights
- openAccess
- License
- Derechos de autor 2015 Revista Nacional de Odontología
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| dc.title.eng.fl_str_mv |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| dc.title.spa.fl_str_mv |
Eficacia y seguridad de clonidina versus placebo para ansiedad en odontología |
| dc.title.por.fl_str_mv |
Eficácia e segurança de clonidina versus placebo para ansiedade em odontologia |
| title |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| spellingShingle |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| title_short |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| title_full |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| title_fullStr |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| title_full_unstemmed |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| title_sort |
Efficacy and Safety of Clonidine versus Placebo for Anxiety in Odontology |
| dc.creator.fl_str_mv |
Bermúdez-Reyes, Patricia Támara-Eraso, Ana Karina Vargas, Jorge William |
| dc.contributor.author.none.fl_str_mv |
Bermúdez-Reyes, Patricia Támara-Eraso, Ana Karina Vargas, Jorge William |
| description |
Introduction: There are different strategies for anxiety control in dentistry. The objective of this study was to determine the efficacy and safety of clonidine medication versus placebo to decrease anxiety and pain in third-molar extraction. Methods: a placebo controlled clinical trial, randomized, triple-blind, parallel group design, included 40 healthy patients aged 14 to 40, who would be undergoing third molar surgery, with a score ≥ 13, in accordance with the Modified Dental Anxiety Scale (mdas); there were 20 patients per group who received 150 mcg clonidine and a control group that received the placebo. The groups were randomized in balanced blocks, and the masking consisted of uniform tableting. Primary outcome: change in anxiety according to mdas; secondary outcome: vital signs, change in the pain scale and side effects. Results: decreased anxiety in both groups, with no significant differences between the clonidine group compared with placebo (p = 0.704); in the experimental group average pressure decreased when compared with the placebo (p = 0.033). Conclusion: clonidine is safe, and even though when compared to the placebo showed no significant anxiety reduction, in the clonidine group a decrease in average arterial pressure was observed, which could reflect reduced anxiety, considering its somatic signs. |
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2013 |
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2019-05-14T21:12:59Z |
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2019-05-14T21:12:59Z |
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2013-12-30 |
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Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/resource_type/c_6501 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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https://revistas.ucc.edu.co/index.php/od/article/view/550 10.16925/od.v9i17.550 |
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https://hdl.handle.net/20.500.12494/9660 |
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https://revistas.ucc.edu.co/index.php/od/article/view/550 https://hdl.handle.net/20.500.12494/9660 |
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10.16925/od.v9i17.550 |
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spa |
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https://revistas.ucc.edu.co/index.php/od/article/view/550/534 |
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Derechos de autor 2015 Revista Nacional de Odontología http://creativecommons.org/licenses/by-nc-nd/4.0 |
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info:eu-repo/semantics/openAccess |
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application/pdf |
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Universidad Cooperativa de Colombia |
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Revista Nacional de Odontología; Vol 9 No 17 (2013); 7-15 |
| dc.source.spa.fl_str_mv |
Revista Nacional de Odontología; Vol. 9 Núm. 17 (2013); 7-15 |
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Revista Nacional de Odontología; v. 9 n. 17 (2013); 7-15 |
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2357-4607 1900-3080 |
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Universidad Cooperativa de Colombia |
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Repositorio Institucional Universidad Cooperativa de Colombia |
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Bermúdez-Reyes, PatriciaTámara-Eraso, Ana KarinaVargas, Jorge William2013-12-302019-05-14T21:12:59Z2019-05-14T21:12:59Zhttps://revistas.ucc.edu.co/index.php/od/article/view/55010.16925/od.v9i17.550https://hdl.handle.net/20.500.12494/9660Introduction: There are different strategies for anxiety control in dentistry. The objective of this study was to determine the efficacy and safety of clonidine medication versus placebo to decrease anxiety and pain in third-molar extraction. Methods: a placebo controlled clinical trial, randomized, triple-blind, parallel group design, included 40 healthy patients aged 14 to 40, who would be undergoing third molar surgery, with a score ≥ 13, in accordance with the Modified Dental Anxiety Scale (mdas); there were 20 patients per group who received 150 mcg clonidine and a control group that received the placebo. The groups were randomized in balanced blocks, and the masking consisted of uniform tableting. Primary outcome: change in anxiety according to mdas; secondary outcome: vital signs, change in the pain scale and side effects. Results: decreased anxiety in both groups, with no significant differences between the clonidine group compared with placebo (p = 0.704); in the experimental group average pressure decreased when compared with the placebo (p = 0.033). Conclusion: clonidine is safe, and even though when compared to the placebo showed no significant anxiety reduction, in the clonidine group a decrease in average arterial pressure was observed, which could reflect reduced anxiety, considering its somatic signs.Introducción: para el control de la ansiedad en la atención odontológica existen diferentes estrategias. El objetivo de este trabajo fue determinar la eficacia y la seguridad de la medicación con clonidina versus placebo, para disminuir la ansiedad y el dolor en la extracción de terceros molares. Métodos: ensayo clínico, placebo controlado, aleatorizado, triple ciego y diseño de grupos paralelos; participaron 40 pacientes sanos con edades entre 14 y 40 años, que serían sometidos a cirugía de terceros molares, con puntuación ≥ 13, según la escala de ansiedad dental modificada (mdas); 20 pacientes participaron por grupo y recibieron clonidina de 150 mcg, al control placebo. Se aleatorizaron por bloques balanceados y el enmascaramiento consistió en un tableteado uniforme. Desenlace primario: cambio en la ansiedad, según mdas; secundario: signos vitales, cambio en la escala del dolor y efectos secundarios. Resultados: la ansiedad disminuyó en ambos grupos, sin diferencias significativas entre el grupo clonidina y el grupo placebo (p = 0,704); en el grupo experimental disminuyó la presión media al compararla con la del grupo placebo (p = 0,033). Conclusión: la clonidina es segura, y aunque al compararla con el placebo no mostró diferencias significativas en disminución de la ansiedad, en el grupo que la recibió se observó un descenso en la presión arterial media, lo que puede reflejar menor ansiedad, si consideramos sus signos somáticos.Introdução:para o controle da ansiedade no atendimento odontológico, existem diferentes estratégias. O objetivo deste trabalho foi determinar a eficácia e a segurança do medicamento com clonidina versus placebo, para diminuir a ansiedade e a dor na extração de terceiros molares. Métodos: ensaio clínico, placebo controlado, aleatorizado, triplo-cego e desenho de grupos paralelos; participaram 40 pacientes saudáveis com idade entre 14 e 40 anos, que seriam submetidos à cirurgia de terceiros molares, com pontuação ≥ 13, segundo a escala de ansiedade dental modificada (mdas); 20 pacientes participaram por grupo e receberam clonidina de 150 mcg, ao controle placebo. Aleatorizaram-sepor blocos balanceados e o mascaramento consistiu em um tableteadouniforme. Desenlace primário:mudança na ansiedade, segundomdas;secundário: sinais vitais, mudança na escala da dor e efeitos secundários.Resultados:a ansiedade diminuiu emambos os grupos, sem diferençassignificativas entre o grupo clonidina e o grupo placebo (p =0,704); nogrupo experimental diminuiu a pressão média ao compará-la com a dogrupoplacebo (p = 0,033).Conclusão:a clonidina é segura e, embora ao compará-la com o placebo não tenha mostrado diferenças significativasna diminuição daansiedade, no grupo que a recebeu, observou-se umdescenso na pressão arterial média, o que poderia refletir uma menor ansiedade, se considerássemos seus sinais somáticos. application/pdfspaUniversidad Cooperativa de Colombiahttps://revistas.ucc.edu.co/index.php/od/article/view/550/534Derechos de autor 2015 Revista Nacional de Odontologíahttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Revista Nacional de Odontología; Vol 9 No 17 (2013); 7-15Revista Nacional de Odontología; Vol. 9 Núm. 17 (2013); 7-15Revista Nacional de Odontología; v. 9 n. 17 (2013); 7-152357-46071900-3080Efficacy and Safety of Clonidine versus Placebo for Anxiety in OdontologyEficacia y seguridad de clonidina versus placebo para ansiedad en odontologíaEficácia e segurança de clonidina versus placebo para ansiedade em odontologiaArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionPublication20.500.12494/9660oai:repository.ucc.edu.co:20.500.12494/96602024-07-16 13:32:30.455metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |